In this study we investigated whether an Internet-based computerized cognitive behavioral therapy (iCBT) program can decrease the risk of DSM-IV-TR major depressive episodes (MDE) during a 12-month ...follow-up of a randomized controlled trial of Japanese workers.
Participants were recruited from one company and three departments of another company. Those participants who did not experience MDE in the past month were randomly allocated to intervention or control groups (n = 381 for each). A 6-week, six-lesson iCBT program was provided to the intervention group. While the control group only received the usual preventive mental health service for the first 6 months, the control group was given a chance to undertake the iCBT program after a 6-month follow-up. The primary outcome was a new onset of DSM-IV-TR MDE during the 12-month follow-up, as assessed by means of the web version of the WHO Composite International Diagnostic Interview (CIDI), version 3.0 depression section.
The intervention group had a significantly lower incidence of MDE at the 12-month follow-up than the control group (Log-rank χ2 = 7.04, p < 0.01). The hazard ratio for the intervention group was 0.22 (95% confidence interval 0.06-0.75), when estimated by the Cox proportional hazard model.
The present study demonstrates that an iCBT program is effective in preventing MDE in the working population. However, it should be noted that MDE was measured by self-report, while the CIDI can measure the episodes more strictly following DSM-IV criteria.
The GRAPES-3 muon telescope located in Ooty, India records rapid (∼10 min) variations in the muon intensity during major thunderstorms. Out of a total of 184 thunderstorms recorded during the ...interval of April 2011-December 2014, the one on December 1, 2014 produced a massive potential of 1.3 GV. The electric field measured by four well-separated (up to 6 km) monitors on the ground was used to help estimate some of the properties of this thundercloud, including its altitude and area that were found to be 11.4 km above mean sea level and ≥380 km^{2}, respectively. A charging time of 6 min to reach 1.3 GV implied the delivery of a power of ≥2 GW by this thundercloud that was moving at a speed of ∼60 km h^{-1}. This work possibly provides the first direct evidence for the generation of gigavolt potentials in thunderclouds that could also possibly explain the production of highest-energy (100 MeV) gamma rays in the terrestrial gamma-ray flashes.
Highlights • Long maternal separation (LMS) does not alter motor activity or corticosterone levels. • In LMS females, chronic EtOH increases DA and 5-HT levels in frontal cortex. • In LMS males, ...chronic EtOH increased levels of hippocampal monoamines and metabolites. • Corticosterone response to chronic EtOH was higher in LMS males than in AFR counterparts.
The GRAPES-3 tracking muon telescope in Ooty, India measures muon intensity at high cutoff rigidities (15-24 GV) along nine independent directions covering 2.3 sr. The arrival of a coronal mass ...ejection on 22 June 2015 18:40 UT had triggered a severe G4-class geomagnetic storm (storm). Starting 19:00 UT, the GRAPES-3 muon telescope recorded a 2 h high-energy (∼20 GeV) burst of galactic cosmic rays (GCRs) that was strongly correlated with a 40 nT surge in the interplanetary magnetic field (IMF). Simulations have shown that a large (17×) compression of the IMF to 680 nT, followed by reconnection with the geomagnetic field (GMF) leading to lower cutoff rigidities could generate this burst. Here, 680 nT represents a short-term change in GMF around Earth, averaged over 7 times its volume. The GCRs, due to lowering of cutoff rigidities, were deflected from Earth's day side by ∼210° in longitude, offering a natural explanation of its night-time detection by the GRAPES-3. The simultaneous occurrence of the burst in all nine directions suggests its origin close to Earth. It also indicates a transient weakening of Earth's magnetic shield, and may hold clues for a better understanding of future superstorms that could cripple modern technological infrastructure on Earth, and endanger the lives of the astronauts in space.
Aims. A Forbush decrease (FD) is a transient decrease followed by a gradual recovery in the observed galactic cosmic ray intensity. We seek to understand the relationship between the FDs and ...near-Earth interplanetary magnetic field (IMF) enhancements associated with solar coronal mass ejections (CMEs). Methods. We used muon data at cutoff rigidities ranging from 14 to 24 GV from the GRAPES-3 tracking muon telescope to identify FD events. We selected those FD events that have a reasonably clean profile, and magnitude >0.25%. We used IMF data from ACE/WIND spacecrafts. We looked for correlations between the FD profile and that of the one-hour averaged IMF. We wanted to find out whether if the diffusion of high-energy protons into the large scale magnetic field is the cause of the lag observed between the FD and the IMF. Results. The enhancement of the IMF associated with FDs occurs mainly in the shock-sheath region, and the turbulence level in the magnetic field is also enhanced in this region. The observed FD profiles look remarkably similar to the IMF enhancement profiles. The FDs typically lag behind the IMF enhancement by a few hours. The lag corresponds to the time taken by high-energy protons to diffuse into the magnetic field enhancement via cross-field diffusion. Conclusions. Our findings show that high-rigidity FDs associated with CMEs are caused primarily by the cumulative diffusion of protons across the magnetic field enhancement in the turbulent sheath region between the shock and the CME.
Abstract
GRAPES-3 is a mid-altitude (2200 m) and near-equatorial (11.°4N) air shower array, overlapping in its field of view for cosmic-ray observations with experiments that are located in the ...Northern and Southern Hemispheres. We analyze a sample of 3.7 × 10
9
cosmic-ray events collected by the GRAPES-3 experiment between 2013 January 1 and 2016 December 31 with a median energy of ∼16 TeV for study of small-scale (<60°) angular-scale anisotropies. We observed two structures, labeled A and B, that deviate from the expected isotropic distribution of cosmic rays in a statistically significant manner. Structure A spans 50°–80° in R.A. and from −15° to 30° in decl. The relative excess observed in structure A is at the level of (6.5 ± 1.3) × 10
−4
with a statistical significance of 6.8 standard deviations. Structure B is observed in the R.A. range 110°–140° and at decl. from −10° to 30°. The relative excess observed in this region is at the level of (4.9 ± 1.4) × 10
−4
with a statistical significance of 4.7 standard deviations. These structures are consistent with those reported by Milagro, ARGO-YBJ, and HAWC. These observations could provide a better understanding of the sources of cosmic rays, their propagation, and the magnetic structures in our Galaxy.
Aims. We seek to identify the primary agents causing Forbush decreases (FDs) in high-rigidity cosmic rays observed from the Earth. In particular, we ask if these FDs are caused mainly by coronal mass ...ejections (CMEs) from the Sun that are directed towards the Earth, or by their associated shocks. Methods. We used the muon data at cutoff rigidities ranging from 14 to 24 GV from the GRAPES-3 tracking muon telescope to identify FD events. We selected those FD events that have a reasonably clean profile, and can be reasonably well associated with an Earth-directed CME and its associated shock. We employed two models: one that considers the CME as the sole cause of the FD (the CME-only model) and one that considers the shock as the only agent causing the FD (the shock-only model). We used an extensive set of observationally determined parameters for both models. The only free parameter in these models is the level of MHD turbulence in the sheath region, which mediates cosmic ray diffusion (into the CME for the CME-only model, and across the shock sheath for the shock-only model). Results. We find that good fits to the GRAPES-3 multi-rigidity data using the CME-only model require turbulence levels in the CME sheath region that are only slightly higher than those estimated for the quiescent solar wind. On the other hand, reasonable model fits with the shock-only model require turbulence levels in the sheath region that are an order of magnitude higher than those in the quiet solar wind. Conclusions. This observation naturally leads to the conclusion that the Earth-directed CMEs are the primary contributors to FDs observed in high-rigidity cosmic rays.
Hospital outbreaks of antimicrobial-resistant (AMR) bacteria should be detected and controlled as early as possible.
To develop a framework for automatic detection of AMR outbreaks in hospitals.
...Japan Nosocomial Infections Surveillance (JANIS) is one of the largest national AMR surveillance systems in the world. For this study, all bacterial data in the JANIS database were extracted between 2011 and 2016. WHONET, a free software for the management of microbiology data, and SaTScan, a free cluster detection tool embedded in WHONET, were used to analyse 2015–2016 data of eligible hospitals. Manual evaluation and validation of 10 representative hospitals around Japan were then performed using 2011–2016 data.
Data from 1031 hospitals were studied; mid-sized (200–499 beds) hospitals accounted for 60%, followed by large hospitals (≥500 beds; 24%) and small hospitals (<200 beds; 16%). More clusters were detected in large hospitals. Most of the clusters included five or fewer patients. From the in-depth analysis of 10 hospitals, ∼80% of the detected clusters were unrecognized by infection control staff because the bacterial species involved were not included in the priority pathogen list for routine surveillance. In two hospitals, clusters of more susceptible isolates were detected before outbreaks of more resistant pathogens.
WHONET-SaTScan can automatically detect clusters of epidemiologically related patients based on isolate resistance profiles beyond lists of high-priority AMR pathogens. If clusters of more susceptible isolates can be detected, it may allow early intervention in infection control practices before outbreaks of more resistant pathogens occur.
To report results from our phase II study of stereotactic body radiotherapy (SBRT) delivering 36 Gy in 4 fractions for patients with localized prostate cancer.
We enrolled 55 patients treated with ...SBRT delivering 36 Gy in 4 fractions between 2015 to 2018. All patients were categorized as low-risk (n = 4), intermediate-risk (n = 31) or high-risk (n = 20) according to National Comprehensive Cancer Network criteria. Median age was 73 years (range 54-86 years). Two-thirds of patients (n = 37) had received androgen-deprivation therapy for 3-46 months (median, 31 months). Median duration of follow-up was 36 months (range 1-54 months). We used Radiation Therapy Oncology Group and National Cancer Institute-Common Toxicity Criteria version 4 for toxicity assessments. Quality of life (QOL) outcomes were also evaluated using the Expanded Prostate Cancer Index Composite (EPIC).
Protocol treatments were completed for all patients. Six patients experienced biochemical failures. Among these six patients, three patients experienced clinical failure. One patient showed bone metastasis before biochemical failure. One patient died of gastric cancer. The 3-year biochemical control rate was 89.8%. Acute grade 2 genitourinary (GU) and gastrointestinal (GI) toxicities were observed in 5 patients (9%) and 6 patients (11%), respectively. No grade 3 or higher acute toxicities were observed. Late grade 2 GU and GI toxicities were observed in 7 patients (13%) and 4 patients (7%), respectively. Late grade 3 GU and GI toxicities were observed in 1 patient (1.8%) each. EPIC scores decreased slightly during the acute phase and recovered within 3 months after treatment.
Our phase II study showed that SBRT delivering 36 Gy in 4 fractions was safe and effective with favorable QOL outcomes, although this regimen showed slightly more severe toxicities compared to current standards.
In this experiment, we studied the effects of breed differences on the protein expression of adipogenic transcription factors, the C/EBP family (C/EBPα, C/EBPβ-LAP, C/EBPβ-LIP and C/EBPδ) and PPARγ, ...in the adipose tissues of Japanese Black (
Wagyu) and Holstein steers from various anatomical sites (subcutaneous, intermuscular, and mesenteric) at different fattening periods (19 and 24 months of age). The expression of C/EBPβ-LAP and C/EBPα in the mesenteric fat tissue of
Wagyu at 19 months of age was significantly higher than that of Holstein. The expression of C/EBPδ in the subcutaneous, intermuscular and mesenteric fat tissue of
Wagyu at 19 months of age was significantly higher than that of Holstein. The plasma insulin concentrations of
Wagyu steers at 19 months of age tended to be higher than those of Holstein. No significant differences in the expression of the adipogenic transcription factors and plasma insulin concentration were observed between the breeds at 24 months of age. These results suggest the existence of breed difference on the expression of the C/EBP family between fattening
Wagyu and Holstein steers at 19 months of age, whereas breed difference might have disappeared before 24 months of age.
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