Amyloidosis is a heterogeneous group of disorders that are characterized by extracellular deposition of misfolded and aggregated autologous proteins leading to organ dysfunction. Amyloid deposits ...produce diverse clinical syndromes depending on their type, location, and the amount of deposition. Clinical and imaging features of amyloidosis in various organ systems are described.
Isolated cells from pituitaries of nonlaying hens were incubated in vitro with and without estradiol-17 beta (E2), and the amount of progesterone receptor binding in the cytosolic fraction of the ...cells was measured by an exchange assay. When the cells were incubated with 1.0 ng E2 for 1, 2, or 4 h, the progesterone receptor bindings were increased. The bindings were not increased when incubated together with cycloheximide, actinomycin-D, or alpha-amanitin. The results suggested that the cytosolic progesterone receptor binding of pituitary cells was enhanced by the action of estrogen through a protein-synthesizing pathway
Recent studies have suggested that cell adhesion plays an important role in the development and regulation of inflammation. To elucidate the mechanisms of regulation of adhesion molecule expression ...by cytokines in psoriatic lesions, we compared the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, and P-selectin immunohistochemically in involved and uninvolved psoriatic skin with the expression of these molecules in normal skin, and measured the amounts of tumor necrosis factor-alpha, interferon-gamma, interleukin-1alpha, and interleukin-1beta in the supernatant of freeze-thawed skin specimens using an enzyme-linked immunosorbent assay. There was strong staining for P-selectin on endothelial cells from involved skin. There was also strong staining for intercellular adhesion molecule-1 on keratinocytes, dermal infiltrates, and endothelial cells from involved skin and on endothelial cells from uninvolved skin, and strong staining for vascular cell adhesion molecule-1 on dermal dendritic cells and fibroblasts and for E-selectin on endothelial cells from involved skin. Large amounts of tumor necrosis factor-alpha were detected in six out of ten specimens of involved skin, but not in uninvolved or normal skin, although interferon-gamma was detected in both involved and uninvolved skin to the same extent. Neither interleukin-1alpha nor interleukin-1beta was detected in involved skin. There was strong staining for tumor necrosis factor-alpha on keratinocytes and endothelial cells from involved skin. These findings suggest that tumor necrosis factor-alpha might play an important role in the induction of vascular adhesion molecules in psoriatic lesions.
Abstract Background This study aimed to assess chronic-phase suppression of neointimal proliferation and arterial healing following paclitaxel-coated (PTX) and bare metal stent (BMS) implantation in ...the superficial femoral artery using optical coherence tomography (OCT). Methods Twenty-five patients with 68 stents underwent an 8-month OCT follow-up. Besides standard OCT variables, neointimal characterization and frequencies of peri-strut low-intensity area (PLIA), macrophage accumulation, and in-stent thrombi were evaluated. Results The mean neointimal thickness was significantly less with PTX stents (544.9 ± 202.2 μm vs. 865.0 ± 230.6 μm, p < 0.0001). The covered and uncovered strut frequencies were significantly smaller and larger, respectively, in the PTX stent group vs. the BMS group (93.7% vs. 99.4%; p < 0.0001, 4.0% vs. 0.4%; p < 0.0001, respectively). Heterogeneous neointima was only observed in the PTX stent group (12.5% vs. 0%, p = 0.017). The frequencies of PLIA and macrophage accumulation were significantly greater in the PTX stent group (87.2% vs. 67.6%, p = 0.001 and 46% vs. 9.1%, p = 0.003, respectively). Conclusion After 8 months, reduced neointimal proliferation was observed with PTX stent implantation. On the other hand, delayed arterial healing was observed compared with BMS.
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