Coronary artery disease (CAD) is a multifactorial disease in which inflammation plays a central role.This study aimed to investigate the association of inflammatory markers such as the neutrophil to ...lymphocyte ratio (NLR),the Global Registry of Acute Coronary Events (GRACE) score with in-hospital mortality of elderly patients with acute myocardial infarction (AMI) in an attempt to explore the prognostic value of these indices for elderly AMI patients.One thousand consecutive CAD patients were divided into two groups based on age 60.The laboratory and clinical characteristics were assessed retrospectively by reviewing the medical records.The NLR and GRACE score were calculated.In the elderly (≥60 years),patients with non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) had significantly higher NLR than did those with unstable angina (UA) and stable angina pectoris (SAP) (P＜0.01).The NLR was considerably elevated in older AMI patients compared with their younger counterparts (＜60 years) (P＜0.05).In elderly AMI patients,the NLR was considerably higher in the high-risk group than in both the low-risk and medium-risk groups based on the GRACE score (P＜0.05 and P＜0.01,respectively),and the NLR was positively correlated with the GRACE score (r=0.322,P＜0.001).Either the NLR level or the GRACE score was significantly higher in the death group than in the surviving group (P＜0.05).By curve receiver operator characteristic curve (ROC) analysis,the optimal cut-off levels of 9.41 for NLR and 174 for GRACE score predicted in-hospital death ROC area under the curve (AUC) 0.771 and 0.787,respectively,P＜0.001.It was concluded that an elevated NLR is a potential predictor of in-hospital mortality in elderly patients with AMI.
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The complex containing Zn2+ exhibits a hcb (3,3)-connected 2D network with the point symbol (63) and further forms a supramolecular 3D structure via hydrogen bonds. And the complex ...containing Cd2+ reveals a 1D straight chain constructed by units of Cd(1)N2I4 and hydrogen bonding further leads to the formation of supramolecular 3D system.
Two new d10 metal coordination polymers (CPs), Zn(L)NO3n (1) and Cd(L)I2n (2) (L = 4-(3-Pyridyl)-2H-1,2,3-triazole), have been designed and synthesized from ZnII/CdII ions and the rigid L ligand. The CPs 1 and 2 have been structurally characterized by single-crystal X-ray diffraction analyses, elemental analysis, IR spectroscopy, powder X-ray diffraction (PXRD) and thermal gravimetric analyses (TGA). CP 1 exhibits a hcb (3,3)-connected 2D network with the point symbol (63) and further forms a supramolecular 3D structure via hydrogen bonds. CP 2 reveals a 1D straight chain constructed by units of Cd(1)N2I4 and hydrogen bonding leads to the formation of supramolecular 3D system. In addition, time-dependent density functional theory calculations with B3LYP functional were performed on L, CPs 1 and 2 to rationalize their experimental absorption spectra. The luminescence properties of L, CPs 1 and 2 in solid-state and different solvents have been also investigated.
Tantalum carbide (TaC) nanofibers and coatings were synthesized using multiwall carbon nanotubes (MWCNTs) with different structures as templates and the carbon source in a KCl-LiCl molten salt ...mixture (41.2/58.8 mol/mol). The TaC and MWCNTs were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and selected area electron diffraction. Results indicate that the microstructure of the MWCNTs has a distinct influence on the formation of a TaC coating on the MWCNTs. MWCNTs heat-treated at 2 900 °C have a higher crystallinity and are harder to react with Ta to form TaC than those without the heat-treatment. The formation of TaC nanofibers or TaC coatings on MWCNTs is dependent on the molar ratio of tantalum to carbon nanotubes. The morphology of the polycrystalline cubic TaC nanofibers and the TaC coating is similar to that of MWCNTs. The reaction time and temperature have a great influence on the conversion of carbon to TaC and its crystallite size.
The continuing threat of dengue fever necessitates a comprehensive characterisation of its epidemiological trends. Phylogenetic and recombination events were reconstructed based on 100 worldwide ...dengue virus (DENV) type 1 genome sequences with an outgroup (prototypes of DENV2-4). The phylodynamic characteristics and site-specific variation were then analysed using data without the outgroup. Five genotypes (GI-GV) and a ladder-like structure with short terminal branch topology were observed in this study. Apparently, the transmission of DENV1 was geographically random before gradual localising with human activity as GI-GIII in South Asia, GIV in the South Pacific, and GV in the Americas. Genotypes IV and V have recently shown higher population densities compared to older genotypes. All codon regions and all tree branches were skewed toward a negative selection, which indicated that their variation was restricted by protein function. Notably, multi-epistatic interaction sites were found in both PrM 221 and NS3 1730. Recombination events accumulated in regions E, NS3-NS4A, and particularly in region NS5. The estimated coevolution pattern also highlights the need for further study of the biological role of protein PrM 221 and NS3 1730. The recent transmission of emergent GV sublineages into Central America and Europe mandates closely monitoring of genotype interaction and succession.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Using cheap and available natural flake graphite with high crystallinity and mesophase pitch as raw materials, graphite block materials with high bulk density, highly preferred orientation and high ...thermal conductivity, were prepared by a hot-press molding at mild temperatures and subsequent carbonization and graphitization treatments at high temperatures. XRD, SEM and PLM analyses indicate that the prepared graphite block has a highly preferred structural orientation, the graphitic layers of the graphite flakes inside are clearly oriented perpendicular to the hot-pressing direction. The components of various sized flake graphite and different types of pitch binders, and the proportions of raw materials, as well as the preparation process parameters(including hot-pressing temperature and pressure, heat treatment temperature, etc.), have great influences on the room-temperature in-plane thermal conductivity of the resultant graphite blocks. Graphitized blocks prepared from 86wt% NG(+32 mesh) and 14wt% AR mesophase pitch through hot-pressed at 500℃ at a fixed pressure of 10 MPa for 5 h and subsequently underwent 1000℃ carbonization and 2800℃ graphitization, have a good comprehensive thermophysical property. Their bulk density reaches above 1.91 g/m3, and room-temperature in-plane thermal conductivity is measured as high as 550 W/(m·K), and improved to 620 W/(m·K) after 3000℃ graphitization treatment.
Poloxamer-188 (P188) is a nonionic triblock linear copolymer that can be used as a pharmaceutical excipient because of its amphiphilic nature. This study investigated whether P188 can act as an ...adjuvant to improve the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) subunit vaccine. BALB/c mice were vaccinated twice with the RBD antigen alone or in combination with P188 or MF59 (a commercial adjuvant for comparison purposes). The resulting humoral and cellular immunity were assessed. Results showed that P188 helped elicit higher neutralizing activity than MF59 after vaccination. P188 induced significant humoral immune response, along with type 1 T helper (Th1) and type 2 T helper (Th2) cellular immune response when compared with MF59 due to repressing p38MAPK phosphorylation. Furthermore, P188 did not result in adverse effects such as fibrosis of liver or kidney after vaccination. In conclusion, P188 is a novel adjuvant that may be used for safe and effective immune enhancement of the SARS-CoV-2 RBD antigen.
To elucidate the epidemiological relationships between ND outbreaks and genetic lineages, a portion of the F gene (535
bp) and the full-length HN gene (1922
bp) of recent Taiwanese NDVs isolated in ...2002–2008 was amplified by reverse transcription (RT)-polymerase chain reaction (PCR) and sequenced. Only a portion of above amplified PCR products of the F and HN genes (374 and 1713
bp) and their deduced amino acid residues were compared with the other 60 NDVs retrieved from GenBank. Most (29/30) of the recent Taiwanese isolates were clustered in subgenotype VIIe while only one isolate was classified as subgenotype VIIc. All the 29 isolates of subgenotype VIIe were further subclassified and termed provisionally as sub-subgenotypes VIIe2 (13 isolates), VIIe3 (5 isolates), and VIIe4 (11 isolates). The sub-subgenotype VIIe2 isolates possessing the motif
112R-R-Q-K-R-F
117 and amino acid residue substitutions at positions 23 (L to F) and 90 (T to A) were collected during 2002–2005. The sub-subgenotype VIIe3 isolates possessing the motif
112R-R-K-K-R-F
117 and amino acid residue substitutions at positions 74 (E to G) and 75 (A to G) within epitopes and 114 (Q to K) within cleavage site of F protein were collected during 2003–2006. The sub-subgenotype VIIe4 isolates possessing the motif
112R-R-Q-K-R-F
117 and amino acid residue substitutions at positions 23 (L to F), 26 (I to T), and 90 (T to A) were collected during 2007–2008. All the NDV isolates in this study exhibited a high intra-cerebral pathogenicity index (ICPI), they were all classified as velogenic type of NDVs. The sub-subgenotype VIIe2 and VIIe4 viruses are now dominant and have been implicatd in most of the recent ND outbreaks in Taiwan. Phylogenetic analysis of these isolates revealed that they may have evolved from previously reported local strains (VIIe1). This finding is essential for improving the disease control strategies and development of vaccines for ND.
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