This article analyzes the reform in England and Wales that changed the secondary school system from a selective type (with grammar and secondary modern schools) to a comprehensive type during the ...period 1965 - 74. It presents evidence of two possible middle-class tactics: resistance to the reform and using the reform to protect the middle-class advantage. Resistance took the forms of keeping grammar schools from being transformed into comprehensives and maintaining high middle- class enrollments in grammar schools and in private schools. Organizing the comprehensive system to the advantage of the middle class involved establishing some comprehensives without sixth forms and making it less likely that middle-class children would attend them. Enrollment patterns of a national sample are used to show how the middle class retained an advantage even as the types of schools were being changed. (DIPF/Abstract übernommen)
Crafting usable knowledge for sustainable development Clark, William C.; van Kerkhoff, Lorrae; Lebel, Louis ...
Proceedings of the National Academy of Sciences - PNAS,
04/2016, Letnik:
113, Številka:
17
Journal Article
Recenzirano
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This paper distills core lessons about how researchers (scientists, engineers, planners, etc.) interested in promoting sustainable development can increase the likelihood of producing usable ...knowledge. We draw the lessons from both practical experience in diverse contexts around the world and from scholarly advances in understanding the relationships between science and society. Many of these lessons will be familiar to those with experience in crafting knowledge to support action for sustainable development. However, few are included in the formal training of researchers. As a result, when scientists and engineers first venture out of the laboratory or library with the goal of linking their knowledge with action, the outcome has often been ineffectiveness and disillusionment. We therefore articulate here a core set of lessons that we believe should become part of the basic training for researchers interested in crafting usable knowledge for sustainable development. These lessons entail at least four things researchers should know, and four things they should do. The knowing lessons involve understanding the coproduction relationships through which knowledge making and decision making shape one another in social–environmental systems. We highlight the lessons that emerge from examining those coproduction relationships through the ICAP lens, viewing them from the perspectives of Innovation systems, Complex systems, Adaptive systems, and Political systems. The doing lessons involve improving the capacity of the research community to put its understanding of coproduction into practice. We highlight steps through which researchers can help build capacities for stakeholder collaboration, social learning, knowledge governance, and researcher training.
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated ...with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases.
Light transmission aggregometry (LTA) is considered the gold standard method for evaluation of platelet function. However, there are a lot of variation in protocols (pre-analytical procedures and ...agonist concentrations) and results. The aim of our study was to establish a national LTA protocol, to investigate the effect of standardization and to define national reference values for LTA. The SSC guideline was used as base for a national procedure. Almost all recommendations of the SSC were followed e.g. no adjustment of PRP, citrate concentration of 109 mM, 21 needle gauge, fasting, resting time for whole blood and PRP, centrifugation time, speed and agonists concentrations. LTA of healthy volunteers was measured in a total of 16 hospitals with 5 hospitals before and after standardization. Results of more than 120 healthy volunteers (maximum aggregation %) were collected, with participating laboratories using 4 different analyzers with different reagents. Use of low agonist concentrations showed high variation before and after standardization, with the exception of collagen. For most high agonist concentrations (ADP, collagen, ristocetin, epinephrine and arachidonic acid) variability in healthy subjects decreased after standardization. We can conclude that a standardized Dutch protocol for LTA, based on the SSC guideline, does not result in smaller variability in healthy volunteers for all agonist concentrations.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Despite national implementation of several high impact interventions and innovations to bolster tuberculosis (TB) detection and improve quality of TB services in Zambia, notifications have been ...declining since 2004. A countrywide data quality assessment (DQA) of Zambia's National TB and Leprosy Programme (NTLP) was undertaken to quantify the degree to which undernotification and underreporting of TB notifications may be occurring.
The NTLP conducted a retrospective DQA of health facilities in high burden districts in all ten Zambian provinces. Multiple routine programmatic data sources were triangulated through a multi-step verification process to enumerate the total number of unique TB patients diagnosed between 1st January and 31st August 2019; both bacteriologically confirmed and clinically diagnosed TB patients were included. Undernotification was defined as the number of TB patients identified through the DQA that were not documented in facility treatment registers, while underreporting was defined as the number of notified TB cases not reported to the NTLP.
Overall, 265 health facilities across 55 districts were assessed from which 28,402 TB patients were identified; 94.5% of TB patients were ≥ 15 years old, 65.1% were male, 52.0% were HIV-positive, and 89.6% were a new/relapse case. Among all TB cases, 32.8% (95%CI: 32.2-33.3) were unnotified. Undernotification was associated with age ≥ 15 years old (adjusted prevalence odds ratio aPOR = 2.4 95%CI: 2.0-2.9), HIV-positive status (aPOR = 1.6 95%CI: 1.5-1.8), being a new/relapse TB case (aPOR = 17.5 95%CI: 13.4-22.8), being a clinically diagnosed TB case (aPOR = 4.2 95%CI:3.8-4.6), and being diagnosed at a hospital (range, aPOR = 1.5 95%CI: 1.3-1.6 to 2.6 95%CI: 2.3-2.9). There was substantial heterogeneity in the proportion of unnotified TB cases by province (range, 18.2% to 43.6%). In a sub-analysis among 22,199 TB patients with further data available, 55.9% (95%CI: 55.2-56.6) were notified and reported to the NTLP, 32.8% (95%CI: 32.2-33.4) were unnotified, and 11.3% (95%CI: 10.9-11.7) went unreported to the NTLP.
The findings from Zambia's first countrywide TB programme DQA demonstrate substantial undernotification and underreporting of TB cases across all provinces. This underscores the urgent need to implement a robust and integrated data management system to facilitate timely registration and reporting of all TB patients who are diagnosed and treated.
Celotno besedilo
Dostopno za:
CEKLJ, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The science-based management of natural resources requires knowledge exchange between scientists and environmental decision-makers, however, this exchange remains a significant challenge. Rather, ...evidence suggests that decision-makers rely on individual experience or other secondary sources of knowledge in isolation from scientific evidence when formulating decisions, potentially compromising the effectiveness of their decisions. As a result a new field of research broadly characterised as ‘knowledge exchange’ has emerged, focused largely on identifying and overcoming the barriers to knowledge exchange among scientists and decision-makers. More recently knowledge exchange research has also begun to explore the relationship between science and decision-making specifically in relation to marine ecosystems and resources. The aim of this paper is to review the literature in relation to knowledge exchange for natural resource management, with a focus on recent evidence in relation to the management of marine resources. This review identifies critical barriers inhibiting knowledge exchange among marine scientists and decisions-makers, such as the inaccessibility of science to decision-makers as well as institutional barriers that limit the extent to which scientists and decision-makers can prioritise knowledge exchange activities. Options for overcoming these barriers, such as novel approaches to knowledge exchange (e.g. – knowledge co-production, knowledge brokers and boundary organisations) and the enabling environments and institutional reforms needed to complement efforts to improve knowledge exchange, are also identified. This review concludes by articulating the gaps in our understanding of knowledge exchange, to help guide future research in this field and improve the sustainable management of marine resources.
•Integration of science into marine management decisions is a significant challenge.•Adaptive governance of marine resources depends on timely knowledge exchange.•Institutional impediments and science inaccessibility limit knowledge exchange.•Improved knowledge exchange can occur through formal and informal structures.•Strategies for improved knowledge exchange are discussed.
The Special Feature led by Sutherland, Dicks, Everard, and Geneletti (Methods Ecology and Evolution, 9, 7–9, 2018) sought to highlight the importance of “qualitative methods” for conservation. The ...intention is welcome, and the collection makes many important contributions. Yet, the articles presented a limited perspective on the field, with a focus on objectivist and instrumental methods, omitting discussion of some broader philosophical and methodological considerations crucial to social science research. Consequently, the Special Feature risks narrowing the scope of social science research and, potentially, reducing its quality and usefulness. In this article, we seek to build on the strengths of the articles of the Special Feature by drawing in a discussion on social science research philosophy, methodology, and methods.
We start with a brief discussion on the value of thinking about data as being qualitative (i.e., text, image, or numeric) or quantitative (i.e., numeric), not methods or research. Thinking about methods as qualitative can obscure many important aspects of research design by implying that “qualitative methods” somehow embody a particular set of assumptions or principles. Researchers can bring similar, or very different, sets of assumptions to their research design, irrespective of whether they collect qualitative or quantitative data.
We clarify broad concepts, including philosophy, methodology, and methods, explaining their role in social science research design. Doing so provides us with an opportunity to examine some of the terms used across the articles of the Special Feature (e.g., bias), revealing that they are used in ways that could be interpreted as being inconsistent with their use in a number of applications of social science.
We provide worked examples of how social science research can be designed to collect qualitative data that not only understands decision‐making processes, but also the unique social–ecological contexts in which it takes place. These examples demonstrate the importance of coherence between philosophy, methodology, and methods in research design, and the importance of reflexivity throughout the research process.
We conclude with encouragement for conservation social scientists to explore a wider range of qualitative research approaches, providing guidance for the selection and application of social science methods for ecology and conservation.
Glutamatergic projections of the thalamic rostral intralaminar nuclei of the thalamus (rILN) innervate the dorsal striatum (DS) and are implicated in dopamine (DA)-dependent incubation of drug ...seeking. However, the mechanism by which rILN signaling modulates reward seeking and striatal DA release is unknown. We find that activation of rILN inputs to the DS drives cholinergic interneuron burst-firing behavior and DA D2 receptor-dependent post-burst pauses in cholinergic interneuron firing. In vivo, optogenetic activation of this pathway drives reinforcement in a DA D1 receptor-dependent manner, and chemogenetic suppression of the rILN reduces dopaminergic nigrostriatal terminal activity as measured by fiber photometry. Altogether, these data provide evidence that the rILN activates striatal cholinergic interneurons to enhance the pursuit of reward through local striatal DA release and introduce an additional level of complexity in our understanding of striatal DA signaling.
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•The rostral intralaminar nuclei of the thalamus (rILN) project to the dorsal striatum•Glutamatergic rILN projections induce local dopamine release in the dorsal striatum•rILN activity suppression correlates with reduced nigrostriatal activity and movement•rILN terminal activation supports behavioral reinforcement
Cover et al. identify a glutamatergic thalamostriatal pathway that locally elicits striatal dopamine release to drive reward-related behavior in mice.
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