A 1:1 inclusion complex between
p
-(
N,N
-diphenylamino)benzoic acid methyl ester (DPABME) molecule and α-cyclodextrin (α-CD) in aqueous solution is formed with a stabilization constant of ca. ...45.65 ± 3.59 M
−1
at 25 °C. The formation of the complex is accompanied by enhancement of the long wavelength fluorescence at 510 nm (attributed to intramolecular charge transfer (ICT) due to twisting) relative to the normal fluorescence at 420 nm. In water, the long-wavelength fluorescence is hidden under the red tail of the normal fluorescence band due to quenching by non-radiative transition. Inclusion by CD reduces quenching and thus constitutes a driving force for DPABME to emit at longer wavelength via ICT process.
OBJECTIVE: Data regarding the prevalence of Helicobacter pylori infection and its potential risk factors among schoolchildren from the Middle East is scarce.
METHODS: An enzyme‐linked immunosorbent ...assay was used to investigate H. pylori status in four groups of children: The first and second groups, 50 children each (25 boys, 25 girls) included children from high socioeconomic class (group 1 = 6 years old; group 2 = 9 years old). The third and fourth groups were sex‐ and age‐matched, but from low socioeconomic class. To evaluate the association between the seroprevalence of H. pylori and selected risk factors, odds ratios (crude and adjusted) were calculated using multiple regression analysis.
RESULTS: Overall seroprevalence rate was 55.5%. Seropositivity was 42%, 52%, 60%, and 68% for groups 1, 2, 3, and 4, respectively. Age and sex were not significantly associated with H. pylori seropositivity. In the final logistic regression model, which was adjusted for age and sex, the following risk factors were found to be significantly associated with seropositivity: living in rural areas (P = 0.015), poor sanitation (P < 0.001), overcrowding (P = 0.014), low maternal educational level (P = 0.010) and low socioeconomic status (P = 0.011).
CONCLUSIONS: The prevalence of H. pylori infection in Jordanian schoolchildren is high, suggesting that most acquisition occurs before the age of 6 years. The seroprevalence for H. pylori increases with social deprivation.
