Mechanically durable stretchable transistors are fabricated using carbon nanotube electrical components and tough thermoplastic elastomers. After an initial conditioning step, the electrical ...characteristics remain constant with strain. The strain‐dependent characteristics are similar in orthogonal stretching directions. Devices can be impacted with a hammer and punctured with a needle while remaining functional and stretchable.
Given that the performance of a lithium–oxygen battery (LOB) is determined by the electrochemical reactions occurring on the cathode, the development of advanced cathode nanoarchitectures is of great ...importance for the realization of high‐energy‐density, reversible LOBs. Herein, a robust cathode design is proposed for LOBs based on a dual‐phasic carbon nanoarchitecture. The cathode is composed of an interwoven network of porous metal–organic framework (MOF) derived carbon (MOF‐C) and conductive carbon nanotubes (CNTs). The dual‐phasic nanoarchitecture incorporates the advantages of both components: MOF‐C provides a large surface area for the oxygen reactions and a large pore volume for Li2O2 storage, and CNTs provide facile pathways for electron and O2 transport as well as additional void spaces for Li2O2 accommodation. It is demonstrated that the synergistic nanoarchitecturing of the dual‐phasic MOF‐C/CNT material results in promising electrochemical performance of LOBs, as evidenced by a high discharge capacity of ≈10 050 mAh g−1 and a stable cycling performance over 75 cycles.
A dual‐phasic carbon nanoarchitecture based on an interwoven network of metal–organic framework (MOF) derived carbon (MOF‐C) and carbon nanotubes (CNTs) is proposed as a cathode for rechargeable lithium–oxygen batteries. The synergistic nanoarchitecturing of the high surface area, porous MOF‐C, and conductive CNTs leads to a considerable improvement in the specific capacity, rate‐performance, and cycle lifetime of the batteries.
Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive stenosis of large intracranial arteries and a hazy network of basal collaterals called moyamoya vessels. A ...polymorphism (R4810K) in the
Ring Finger Protein 213
(
RNF213
) gene, at chromosome 17q25.3, is the strongest genetic susceptibility factor for MMD in East Asian populations. MMD was regarded prevalent in childhood and in East Asian populations. However, the so-called MMD could represent only the tip of the iceberg. MMD is increasingly reported in adult patients and in Western populations. Moreover, the
RNF213
variant was recently reported to be associated with non-MMD disorders, such as intracranial atherosclerosis and systemic vasculopathy (e.g., peripheral pulmonary artery stenosis and renal artery stenosis). In this review, we summarize the spectrums of
RNF213
vasculopathy in terms of clinical and genetic phenotypes. Continuous efforts are required for pathophysiology-based diagnoses and treatment, which will benefit from collaboration between clinicians and researchers, and between stroke and vascular physicians.
The applicability of a soft magnetic composite (SMC) material to a new double-sided buried-type interior permanent-magnet flat linear brushless motor (IPM-FLBM) with slot-phase shift is presented ...through the steady-state performance improvement in this paper. The IPM-FLBM using a conventional electrical solid steel is used as a base model prototype for the performance comparison. The analytic models for armature resistance, inductances of series-connected asymmetric dual three-phase windings, no-load flux linkages, and back electromotive forces (back EMFs) are investigated to derive a closed-form equation for the thrust force. The magnetic field capability due to the design parameter changes of the new SMC prototype is analyzed using two simplified nonlinear magnetic equivalent circuit (MEC) models, comparing with the base model prototype. The iron and copper losses of the SMC prototype also are investigated in terms of the thermal limitation. The steady-state performance enhanced by the reduced air-gap size is experimentally validated through the comparison of the static thrust force with that of the base model prototype.
Abstract We present a cationic polymer architecture composed of phenylboronic acid (PBA), sugar-installed polyethylenimine (PEI), and polyethylene glycol (PEG). The chemical bonding of PBA with the ...diol in the sugar enabled the crosslinking of low-molecular-weight (MW) PEI to form high-MW PEI, resulting in strong interaction with anionic DNA for gene delivery. Inside the cell, the binding of PBA and sugar was disrupted by either acidic endosomal pH or intracellular ATP, so gene payloads were released effectively. This dual stimuli-responsive gene release drove the polymer to deliver DNA for high transfection efficiency with low cytotoxicity. In addition, PBA moiety with PEGylation facilitated the binding of polymer/DNA polyplexes to sialylated glycoprotein which is overexpressed on the tumor cell membrane, and thus provided high tumor targeting ability. Therapeutic application of our polymer was demonstrated as an anti-angiogenic gene delivery agent for tumor growth inhibition. Our judicious designed polymer structure based on PBA provides enormous potential as a gene delivery agent for effective gene therapy by stimuli-responsiveness and tumor targeting.
Both intracranial atherosclerotic stenosis (ICAS) and moyamoya disease (MMD) are prevalent in Asians. We hypothesized that the Ring Finger protein 213 gene polymorphism (RNF213), a susceptibility ...locus for MMD in East Asians, is also a susceptibility gene for ICAS in patients whose diagnosis had been confirmed by conventional angiography (absence of basal collaterals) and high-resolution MRI (HR-MRI, presence of plaque).
We analyzed 532 consecutive patients with ischemic events in the middle cerebral artery (MCA) distribution and relevant stenotic lesion on the distal internal carotid artery or proximal MCA, but no demonstrable carotid or cardiac embolism sources. Additional angiography was performed on 370 (69.5%) patients and HR-MRI on 283 (53.2%) patients.
Based on angiographic and HR-MRI findings, 234 patients were diagnosed with ICAS and 288 with MMD. The RNF213 variant was observed in 50 (21.4%) ICAS patients and in 119 (69.1%) MMD patients. The variant was observed in 25.2% of patients with HR-MRI-confirmed ICAS. Similarly, 15.8% of ICAS patients in whom MMD was excluded by angiography had this variant. Among the ICAS patients, RNF213 variant carriers were younger and more likely to have a family history of MMD than non-carriers were. Multivariate testing showed that only the age of ICAS onset was independently associated with the RNF213 variant (odds ratio, 0.97; 95% CI, 0.944-0.99).
RNF213 is a susceptibility gene not only for MMD but also for ICAS in East Asians. Further studies are needed on RNF213 variants in ICAS patients outside East Asian populations.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
New detent-force minimization methodologies for a 6/4 double-sided interior permanent-magnet flat linear brushless motor configured with alternate teeth windings are presented in this paper. Based on ...the superposition principle, the end-effect and cogging forces are separately minimized using two different techniques. The end-effect force is reduced by a new 2-D optimization using the step-shaped end frames in the slotless stators. The cogging force is minimized through a destructive interference using the slot-phase shift between the upper and lower stators. Each technique is verified experimentally, and the optimal design parameters are formulated using Fourier series. The total detent-force reduction of 94% is achieved as compared with the base model. The steady-state force after applying these new detent-force-free techniques is demonstrated with actual measurements, and also compared with the finite-element analysis result and analytic solution.
Tactile pressure sensors as flexible bioelectronic devices have been regarded as the key component for recently emerging applications in electronic skins, health-monitoring devices, or human–machine ...interfaces. However, their narrow range of sensible pressure and their difficulty in forming high integrations represent major limitations for various potential applications. Herein, we report fully integrated, active-matrix arrays of pressure-sensitive MoS2 transistors with mechanoluminescent layers and air dielectrics for wide detectable range from footsteps to cellular motions. The inclusion of mechanoluminescent materials as well as air spaces can increase the sensitivity significantly over entire pressure regimes. In addition, the high integration capability of these active-matrix sensory circuitries can enhance their spatial resolution to the level sufficient to analyze the pressure distribution in a single cardiomyocyte. We envision that these wide-range pressure sensors will provide a new strategy toward next-generation electronics at biomachine interfaces to monitor various mechanical and biological phenomena at single-cell resolution.
Achieving remission following initial antidepressant therapy in patients with major depressive disorder (MDD) is an important clinical result. Making predictions based on genetic markers holds ...promise for improving the remission rate. However, genetic variants found in previous genetic studies do not provide robust evidence to aid pharmacogenetic decision-making in clinical settings. Thus, the objective of this study was to perform whole-genome sequencing (WGS) using genomic DNA to identify genetic variants associated with the treatment outcomes of selective serotonin reuptake inhibitors (SSRIs). We performed WGS on 100 patients with MDD who were treated with escitalopram (discovery set: 36 remitted and 64 non-remitted). The findings were applied to an additional 553 patients with MDD who were treated with SSRIs (replication set: 185 remitted and 368 non-remitted). A novel loss-of-function variant (rs3213755) in keratin-associated protein 1-1 (KRTAP1-1) was identified in this study. This rs3213755 variant was significantly associated with remission following antidepressant treatment (p = 0.0184, OR 3.09, 95% confidence interval CI 1.22-7.80 in the discovery set; p = 0.00269, OR 1.75, 95% CI 1.22-2.53 in the replication set). Moreover, the expression level of KRTAP1-1 in surgically resected human temporal lobe samples was significantly associated with the rs3213755 genotype. WGS studies on a larger sample size in various ethnic groups are needed to investigate genetic markers useful in the pharmacogenetic prediction of remission following antidepressant treatment.
This study aimed to validate the 2022 European LeukemiaNet (ELN) risk stratification for acute myeloid leukemia (AML). A total of 624 newly diagnosed AML patients from 1998 to 2014 were included in ...the analysis. Genetic profiling was conducted using targeted deep sequencing of 45 genes based on recurrent driver mutations. In total, 134 (21.5%) patients had their risk classification reassessed according to the 2022 ELN risk stratification. Among those initially classified as having a favorable risk in 2017 (n = 218), 31 and 3 patients were reclassified as having intermediate risk or adverse risk, respectively. Among the three subgroups, the 2022 ELN favorable-risk group showed significantly longer survival outcomes than the other groups. Within the 2017 ELN intermediate-risk group (n = 298), 21 and 46 patients were reclassified as having favorable risk or adverse risk, respectively, and each group showed significant stratifications in survival outcomes. Some patients initially classified as having adverse risk in 2017 were reclassified into the intermediate-risk group (33 of 108 patients), but no prognostic improvements were observed in this group. A multivariable analysis identified the 2022 ELN risk stratification, age, and receiving allogeneic hematopoietic cell transplantation as significant prognostic factors for survival. The 2022 ELN risk stratification enables more precise decisions for proceeding with allogeneic hematopoietic cell transplantation for AML patients.
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