Topological semimetals host electronic structures with several band-contact points or lines and are generally expected to exhibit strong topological responses. Up to now, most work has been limited ...to non-magnetic materials and the interplay between topology and magnetism in this class of quantum materials has been largely unexplored. Here we utilize theoretical calculations, magnetotransport and angle-resolved photoemission spectroscopy to propose Fe
GeTe
, a van der Waals material, as a candidate ferromagnetic (FM) nodal line semimetal. We find that the spin degree of freedom is fully quenched by the large FM polarization, but the line degeneracy is protected by crystalline symmetries that connect two orbitals in adjacent layers. This orbital-driven nodal line is tunable by spin orientation due to spin-orbit coupling and produces a large Berry curvature, which leads to a large anomalous Hall current, angle and factor. These results demonstrate that FM topological semimetals hold significant potential for spin- and orbital-dependent electronic functionalities.
Transition-metal dichalcogenides (TMDs) are renowned for their rich and varied bulk properties, while their single-layer variants have become one of the most prominent examples of two-dimensional ...materials beyond graphene. Their disparate ground states largely depend on transition metal d-electron-derived electronic states, on which the vast majority of attention has been concentrated to date. Here, we focus on the chalcogen-derived states. From density-functional theory calculations together with spin- and angle-resolved photoemission, we find that these generically host a co-existence of type-I and type-II three-dimensional bulk Dirac fermions as well as ladders of topological surface states and surface resonances. We demonstrate how these naturally arise within a single p-orbital manifold as a general consequence of a trigonal crystal field, and as such can be expected across a large number of compounds. Already, we demonstrate their existence in six separate TMDs, opening routes to tune, and ultimately exploit, their topological physics.
Spin-orbit coupling results in technologically-crucial phenomena underlying magnetic devices like magnetic memories and energy-efficient motors. In heavy element materials, the strength of spin-orbit ...coupling becomes large to affect the overall electronic nature and induces novel states such as topological insulators and spin-orbit-integrated Mott states. Here we report an unprecedented charge-ordering cascade in IrTe2 without the loss of metallicity, which involves localized spin-orbit Mott states with diamagnetic Ir(4+)-Ir(4+) dimers. The cascade in cooling, uncompensated in heating, consists of first order-type consecutive transitions from a pure Ir(3+) phase to Ir(3+)-Ir(4+) charge-ordered phases, which originate from Ir 5d to Te 5p charge transfer involving anionic polymeric bond breaking. Considering that the system exhibits superconductivity with suppression of the charge order by doping, analogously to cuprates, these results provide a new electronic paradigm of localized charge-ordered states interacting with itinerant electrons through large spin-orbit coupling.
Highlights • Long non-coding RNAs (lncRNAs) are involved in various processes of gene regulation. • LncRNAs can be sub-divided based on their genomic organizations. • LncRNAs can be targeted in cis , ...cis by chromatin looping, and trans. • LncRNAs are enriched in the brain. • LncRNAs might modulate a wide range of aspects in neural functions and development.
We present (sub)millimeter imaging at 0 5 resolution of the massive star-forming region G358.93−0.03 acquired in multiple epochs at 2 and 3 months following the recent flaring of its 6.7 GHz CH3OH ...maser emission. Using the Submillimeter Array and Atacama Large Millimeter/submillimeter Array, we have discovered 14 new Class II CH3OH maser lines ranging in frequency from 199 to 361 GHz, which originate mostly from = 1 torsionally excited transitions and include one = 2 transition. The latter detection provides the first observational evidence that Class II maser pumping involves levels in the = 2 state. The masers are associated with the brightest continuum source (MM1), which hosts a line-rich hot core. The masers present a consistent curvilinear spatial velocity pattern that wraps around MM1, suggestive of a coherent physical structure 1200 au in extent. In contrast, the thermal lines exhibit a linear pattern that crosses MM1 but at progressive position angles that appear to be a function of either increasing temperature or decreasing optical depth. The maser spectral profiles evolved significantly over one month, and the intensities dropped by factors of 3.0-7.2, with the = 2 line showing the largest change. A small area of maser emission from only the highest excitation lines closest to MM1 has disappeared. There are seven additional dust continuum sources in the protocluster, including another hot core (MM3). We do not find evidence for a significant change in (sub)millimeter continuum emission from any of the sources during the one month interval, and the total protocluster emission remains comparable to prior single-dish measurements.
With 7 figures and 6 tables ABSTRACT: Garlic is widely consumed for its culinary and medical benefits. Six hundred and thirteen accessions of garlic and its relatives with diverse origin were ...evaluated for genetic diversity at eight recently novel simple sequence repeat loci in this study. A total of 113 alleles were detected, the average allelic richness was 14.1 alleles per locus. Using a heuristic approach, a core set of 95 accessions was successfully developed, which showed 100% coverage of alleles with minimum redundancy. The model-based structure analysis here revealed the presence of four subpopulations in the selected core set, which was basically consistent with clustering based on the genetic distance. The analysis of molecular variance based on this core set showed that between-population component of genetic variance is <15.6% in contrast to 84.4% for the within population component. Overall FST value was 0.1560, indicating a moderate differentiation among the four groups. These results will provide an effective aid for future allele mining, association genetics, mapping and cloning gene(s), germplasm conservation, and improvement programs.
Context.
Class II methanol masers are signposts of massive young stellar objects (MYSOs). Recent evidence shows that flares of these masers are driven by MYSO accretion bursts. Thus, maser monitoring ...can be used to identify such bursts which are hard to discover otherwise. Infrared observations reveal burst-induced changes in the spectral energy distribution (first and foremost a luminosity increase), which provide valuable information on a very intense phase of high-mass star formation.
Aims.
In mid-January 2019, flaring of the 6.7 GHz CH
3
OH maser (hereafter maser) of the MYSO G358.93-0.03 (hereafter G358) was reported. The international maser community initiated an extensive observational campaign which revealed extraordinary maser activity and yielded the detection of numerous new masering transitions. Interferometric imaging with the Atacama Large Millimeter/submillimeter Array and the Submillimeter Array resolved the maser emitting core of the star forming region and proved the association of the masers with the brightest continuum source (MM1), which hosts a hot molecular core. These observations, however, failed to detect a significant rise in the (sub)millimeter dust continuum emission. Therefore, we performed near-infrared (NIR) and far-infrared (FIR) observations to prove or disprove whether the CH
3
OH flare was driven by an accretion burst.
Methods.
NIR imaging with the Gamma-Ray Burst Optical/Near-infrared Detector has been acquired and integral-field spectroscopy with the Field-Imaging Far-Infrared Line Spectrometer (FIFI-LS) aboard the Stratospheric Observatory for Infrared Astronomy (SOFIA) was carried out on two occasions to detect possible counterparts to the (sub)millimeter sources and compare their photometry to archival measurements. The comparison of pre-burst and burst spectral energy distributions is of crucial importance to judge whether a substantial luminosity increase, caused by an accretion burst, is present and if it triggered the maser flare. Radiative transfer modeling of the spectral energy distribution (SED) of the dust continuum emission at multiple epochs provides valuable information on the bursting MYSO.
Results.
The FIR fluxes of MM1 measured with FIFI-LS exceed those from
Herschel
significantly, which clearly confirms the presence of an accretion burst. The second epoch data, taken about 16 months later, still show increased fluxes. Our radiative transfer modeling yielded major burst parameters and suggests that the MYSO features a circumstellar disk which might be transient. From the pre-burst, burst, and post-burst SEDs, conclusions on heating and cooling time-scales could be drawn. Circumstances of the burst-induced maser relocation have been explored.
Conclusions.
The verification of the accretion burst from G358 is another confirmation that Class II methanol maser flares represent an alert for such events. Thus, monitoring of these masers greatly enhances the chances of identifying MYSOs during periods of intense growth. The few events known to date already indicate that there is a broad range in burst strength and duration as well as environmental characteristics. The G358 event is the shortest and least luminous accretion burst known to date. According to models, bursts of this kind occur most often.
This study quantifies the wide-ranging health care costs affecting patients living with IBD, including the annualized direct and indirect costs of care for patients with IBD, the longitudinal drivers ...of these costs, and the cost of care for newly diagnosed patients.
Abstract
Background
The Crohn’s & Colitis Foundation’s Cost of Inflammatory Bowel Disease (IBD) Care Initiative seeks to quantify the wide-ranging health care costs affecting patients living with IBD. We aimed to (1) describe the annualized direct and indirect costs of care for patients with Crohn’s disease (CD) or ulcerative colitis (UC), (2) determine the longitudinal drivers of these costs, and (3) characterize the cost of care for newly diagnosed patients.
Methods
We analyzed the Optum Research Database from the years 2007 to 2016, representing commercially insured and Medicare Advantage–insured patients in the United States. Inclusion for the study was limited to those who had continuous enrollment with medical and pharmacy benefit coverage for at least 24 months (12 months before through 12 months after the index date of diagnosis). The value of patient time spent on health care was calculated as number of workplace hours lost due to health care encounters multiplied by the patients’ estimated average wage derived from the Bureau of Labor Statistics. Comparisons between IBD patients and non-IBD patients were analyzed based on demographics, health plan type, and length of follow-up. We used generalized linear models to estimate the association between total annual costs and various patient variables.
Results
There were 52,782 IBD patients (29,062 UC; 23,720 CD) included in the analysis (54.1% females). On a per-annual basis, patients with IBD incurred a greater than 3-fold higher direct cost of care compared with non-IBD controls ($22,987 vs $6956 per-member per-year paid claims) and more than twice the out-of-pocket costs ($2213 vs $979 per-year reported costs), with all-cause IBD costs rising after 2013. Patients with IBD also experienced significantly higher costs associated with time spent on health care as compared with controls. The burden of costs was most notable in the first year after initial IBD diagnosis (mean = $26,555). The study identified several key drivers of cost for IBD patients: treatment with specific therapeutics (biologics, opioids, or steroids); ED use; and health care services associated with relapsing disease, anemia, or mental health comorbidity.
Conclusion
The costs of care for IBD have increased in the last 5 years and are driven by specific therapeutics and disease features. In addition, compared with non-IBD controls, IBD patients are increasingly incurring higher costs associated with health care utilization, out-of-pocket expenditures, and workplace productivity losses. There is a pressing need for cost-effective strategies to address these burdens on patients and families affected by IBD.
Video Abstract
10.1093/ibd/izz104_video1
Video Abstract
izz104.video1
6039344358001
We use an ultrahigh‐resolution 15‐T Fourier transform ion cyclotron resonance mass spectrometer to elucidate the compositional changes in Arctic organic aerosols collected at Ny‐Ålesund, Svalbard, in ...May 2015. The Fourier transform ion cyclotron resonance mass spectrometer analysis of airborne organic matter provided information on the molecular compositions of aerosol particles collected during the Arctic spring period. The air mass transport history, combined with satellite‐derived geographical information and chlorophyll concentration data, revealed that the molecular compositions of organic aerosols drastically differed depending on the origin of the potential source region. The protein and lignin compound populations contributed more than 70% of the total intensity of assigned molecules when the air masses mainly passed over the ocean region. Interestingly, the intensity of microbe‐derived organics (protein and carbohydrate compounds) was positively correlated with the air mass exposure to phytoplankton biomass proxied as chlorophyll. Furthermore, the intensities of lignin and unsaturated hydrocarbon compounds, typically derived from terrestrial vegetation, increased with an increase in the advection time of the air mass over the ocean domain. These results suggest that the accumulation of dissolved biogenic organics in the Arctic Ocean possibly derived from both phytoplankton and terrestrial vegetation could significantly influence the chemical properties of Arctic organic aerosols during a productive spring period. The interpretation of molecular changes in organic aerosols using an ultrahigh‐resolution mass spectrometer could provide deep insight for understanding organic aerosols in the atmosphere over the Arctic and the relationship of organic aerosols with biogeochemical processes in terms of aerosol formation and environmental changes.
Key Points
The molecular compositions of Arctic organic aerosols were identified using an ultrahigh‐resolution mass spectrometer (15T FT‐ICR MS)
The molecular characteristics of Arctic organic aerosols showed distinct differences depending on their potential source origin
The accumulation of biogenic organics in Arctic surface water could significantly influence the chemical properties of Arctic aerosols
A mesocosm experiment was conducted to evaluate the influence of photosynthetic performance on the energetic balance of coastal phytoplankton, in relation to community production and autotrophic ...phytoplankton biomass in future coastal oceans. Natural phytoplankton assemblages were incubated in field mesocosms under ambient condition (control: ca. 400 μatm CO2 and ambient temperature), and two sets of potential future ocean conditions (acidification: ca. 900 μatm CO2 and ambient temperature; greenhouse: ca. 900 μatm CO2 and 3 °C warmer). The photosynthetic performances were estimated by in vivo fluorometry (effective quantum yield (ΦPSII), steady-state light response curves (LCs)) and in situ incorporation of 14C (photosynthesis-irradiance curves). The ΦPSII and rETRm,LC (relative maximum electron transport rate) clearly reduced under acidification, in particular, when phytoplankton were exposed to high light levels. However, PBmax (maximum photosynthetic rate) was the same in the ambient and acidification conditions. Thus, phytoplankton utilized less light under acidification condition, but could still assimilate a similar amount of carbon compared to the ambient condition. The PBmax and α (photosynthetic efficiency) under greenhouse condition were significantly higher than those under ambient condition without any difference in ΦPSII, rETRm,LC and α,LC (electron transport efficiency) between the treatments. Therefore, phytoplankton utilized the same amount of light under greenhouse condition, but could assimilate more carbon than under ambient condition. As a result, Chl a normalized primary production was higher in greenhouse than in other conditions. Nevertheless, the community production did not change between the experimental treatments. The main reason for the lack of a change in primary production under future climate conditions is the control of autotrophic phytoplankton biomass by grazing. Consequently, acidification and greenhouse environments have a potential to increase growth and primary production of phytoplankton by enhancing inorganic carbon assimilation efficiency when top-down regulation is negligible.
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