Until recently, uncertainty quantification in low energy nuclear theory was typically performed using frequentist approaches. However in the last few years, the field has shifted toward Bayesian ...statistics for evaluating confidence intervals. Although there are statistical arguments to prefer the Bayesian approach, no direct comparison is available. In this work, we compare, directly and systematically, the frequentist and Bayesian approaches to quantifying uncertainties in direct nuclear reactions. Starting from identical initial assumptions, we determine confidence intervals associated with the elastic and the transfer process for both methods, which are evaluated against data via a comparison of the empirical coverage probabilities. Expectedly, the frequentist approach is not as flexible as the Bayesian approach in exploring parameter space and often ends up in a different minimum. We also show that the two methods produce significantly different correlations. In the end, the frequentist approach produces significantly narrower uncertainties on the considered observables than the Bayesian. Our study demonstrates that the uncertainties on the reaction observables considered here within the Bayesian approach represent reality more accurately than the much narrower uncertainties obtained using the standard frequentist approach.
The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, ...but some have also been detected in reptiles, amphibians and fish. Many picornaviruses are important human and veterinary pathogens and may cause diseases of the central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. Most picornaviruses are transmitted by the faecal-oral or respiratory routes. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Picornaviridae, which is available at www.ictv.global/report/picornaviridae.
Spin-valley locking is ubiquitous among transition metal dichalcogenides with local or global inversion asymmetry, in turn stabilizing properties such as Ising superconductivity, and opening routes ...towards 'valleytronics'. The underlying valley-spin splitting is set by spin-orbit coupling but can be tuned via the application of external magnetic fields or through proximity coupling. However, only modest changes have been realized to date. Here, we investigate the electronic structure of the V-intercalated transition metal dichalcogenide V
NbS
using microscopic-area spatially resolved and angle-resolved photoemission spectroscopy. Our measurements and corresponding density functional theory calculations reveal that the bulk magnetic order induces a giant valley-selective Ising coupling exceeding 50 meV in the surface NbS
layer, equivalent to application of a ~250 T magnetic field. This energy scale is of comparable magnitude to the intrinsic spin-orbit splittings, and indicates how coupling of local magnetic moments to itinerant states of a transition metal dichalcogenide monolayer provides a powerful route to controlling their valley-spin splittings.
We study an extended 2 Higgs doublet model (2HDM) in which the Standard Model (SM) Yukawa interactions are forbidden due to a global U(1)' symmetry, but may arise via mixing with vectorlike families. ...In this model, the hierarchical structure of Yukawa couplings of quarks and leptons in the SM arises from the heavy masses of the fourth and fifth vectorlike families. Within this model, we consider various nonstandard contributions to the electron and muon anomalous magnetic moments. We first consider the W exchange at one-loop level, consistent with the μ → eγ constraint, and show that it yields a negligible contribution to both electron and muon anomalous magnetic moments. We then consider Higgs scalar exchange, together with vectorlike leptons, at one-loop level and show that it is possible to have nonstandard contributions to the electron and muon anomalous magnetic moments within the 1σ constraint of certain experiments. We present some benchmark points for both the muon and the electron anomalies, together with some numerical scans around these points, which indicate the mass regions of the Higgs scalars of the 2HDM in this scenario.
Galaxy clusters are the most massive virialized structures in the Universe and are formed through the gravitational accretion of matter over cosmic time
. The discovery
of an evolved galaxy cluster ...at redshift z = 2, corresponding to a look-back time of 10.4 billion years, provides an opportunity to study its properties. The galaxy cluster XLSSC 122 was originally detected as a faint, extended X-ray source in the XMM Large Scale Structure survey and was revealed to be coincident with a compact over-density of galaxies
with photometric redshifts of 1.9 ± 0.2. Subsequent observations
at millimetre wavelengths detected a Sunyaev-Zel'dovich decrement along the line of sight to XLSSC 122, thus confirming the existence of hot intracluster gas, while deep imaging spectroscopy from the European Space Agency's X-ray Multi-Mirror Mission (XMM-Newton) revealed
an extended, X-ray-bright gaseous atmosphere with a virial temperature of 60 million Kelvin, enriched with metals to the same extent as are local clusters. Here we report optical spectroscopic observations of XLSSC 122 and identify 37 member galaxies at a mean redshift of 1.98, corresponding to a look-back time of 10.4 billion years. We use photometry to determine a mean, dust-free stellar age of 2.98 billion years, indicating that star formation commenced in these galaxies at a mean redshift of 12, when the Universe was only 370 million years old. The full range of inferred formation redshifts, including the effects of dust, covers the interval from 7 to 13. These observations confirm that XLSSC 122 is a remarkably mature galaxy cluster with both evolved stellar populations in the member galaxies and a hot, metal-rich gas composing the intracluster medium.
In order to address this question, we consider a simple renormalizable and gauge invariant model in which the Z′ only has couplings to the electron and muon and their associated neutrinos, arising ...from mixing with a heavy vectorlike fourth family of leptons. Within this model we discuss the contributions to the electron and muon anomalous magnetic moments from Z′ exchange, subject to the constraints from μ → e γ and neutrino trident production. Using analytic and numerical arguments, we find that such a Z′ model can account for either the electron or the muon g − 2 anomalies, but not both, while remaining consistent with the experimental constraints from μ → eγ and neutrino trident production.
Background. Gambling and gaming disorders have been included as “disorders due to addictive behaviors” in the International Classification of Diseases (ICD-11). Other problematic behaviors may be ...considered as “other specified disorders due to addictive behaviors (6C5Y).” Methods. Narrative review, experts' opinions. Results. We suggest the following meta-level criteria for considering potential addictive behaviors as fulfilling the category of “other specified disorders due to addictive behaviors”: 1. Clinical relevance: Empirical evidence from multiple scientific studies demonstrates that the specific potential addictive behavior is clinically relevant and individuals experience negative consequences and functional impairments in daily life due to the problematic and potentially addictive behavior. 2. Theoretical embedding: Current theories and theoretical models belonging to the field of research on addictive behaviors describe and explain most appropriately the candidate phenomenon of a potential addictive behavior. 3. Empirical evidence: Data based on self-reports, clinical interviews, surveys, behavioral experiments, and, if available, biological investigations (neural, physiological, genetic) suggest that psychological (and neurobiological) mechanisms involved in other addictive behaviors are also valid for the candidate phenomenon. Varying degrees of support for problematic forms of pornography use, buying and shopping, and use of social networks are available. These conditions may fit the category of “other specified disorders due to addictive behaviors”. Conclusion. It is important not to over-pathologize everyday-life behavior while concurrently not trivializing conditions that are of clinical importance and that deserve public health considerations. The proposed meta-level-criteria may help guide both research efforts and clinical practice.
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD ...heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h
) for European-American females of 29% that is similar to h
for schizophrenia and is substantially higher than h
in European-American males (estimate not distinguishable from zero). We found strong evidence of overlapping genetic risk between PTSD and schizophrenia along with more modest evidence of overlap with bipolar and major depressive disorder. No single-nucleotide polymorphisms (SNPs) exceeded genome-wide significance in the transethnic (overall) meta-analysis and we do not replicate previously reported associations. Still, SNP-level summary statistics made available here afford the best-available molecular genetic index of PTSD-for both European- and African-American individuals-and can be used in polygenic risk prediction and genetic correlation studies of diverse phenotypes. Publication of summary statistics for ∼10 000 African Americans contributes to the broader goal of increased ancestral diversity in genomic data resources. In sum, the results demonstrate genetic influences on the development of PTSD, identify shared genetic risk between PTSD and other psychiatric disorders and highlight the importance of multiethnic/racial samples. As has been the case with schizophrenia and other complex genetic disorders, larger sample sizes are needed to identify specific risk loci.
► Demonstrating the influence of new technologies on human behavior. ► Social Phobia patient used the computer “to defend himself” from personal contact. ► Communication dependency by virtual ...environments (nomophobia) could reveal a disorder. ► Nomophobia as a behavior to investigate the presence of other mental disorders.
The increasing use of new technologies and virtual communication involving personal computers (PCs), tablets and mobile phones are causing changes in individuals’ daily habits and behavior. We report the case of an individual with social phobia who developed a dependency on communication through virtual environments (i.e., nomophobia), and used a PC as a form of relating to the outside world to reduce stress and to avoid direct social relations. Nomophobia refers to the discomfort or anxiety caused by the non-availability of a mobile phone, PC or any another virtual communication device. Social phobia is described as an anxiety disorder of chronic evolution.
To study nomophobia as a manifest behavior that might serve as an indication of a possible anxiety disorder.
The treatment consisted of the use of medication, cognitive-behavioral therapy (CBT) and the application of evaluation tools (interviews, scales, inventories and questionnaires).
The individual responded satisfactorily to medication and CBT treatment, which reduced his time using the PC and increased his exposure to real-life situations.
Nomophobic behavior produces changes in daily habits and can reveal other aspects to be investigated, such as the presence of comorbid mental disorders.
PDF
