In this paper, we present the first observations of the Ophiuchus molecular cloud performed as part of the James Clerk Maxwell Telescope (JCMT) Gould Belt Survey (GBS) with the SCUBA-2 instrument. We ...demonstrate methods for combining these data with previous HARP CO, Herschel, and IRAM N2H+ observations in order to accurately quantify the properties of the SCUBA-2 sources in Ophiuchus. We produce a catalogue of all of the sources found by SCUBA-2. We separate these into protostars and starless cores. We list all of the starless cores and perform a full virial analysis, including external pressure. This is the first time that external pressure has been included in this level of detail. We find that the majority of our cores are either bound or virialized. Gravitational energy and external pressure are on average of a similar order of magnitude, but with some variation from region to region. We find that cores in the Oph A region are gravitationally bound prestellar cores, while cores in the Oph C and E regions are pressure-confined. We determine that N2H+ is a good tracer of the bound material of prestellar cores, although we find some evidence for N2H+ freeze-out at the very highest core densities. We find that non-thermal linewidths decrease substantially between the gas traced by C18O and that traced by N2H+, indicating the dissipation of turbulence at higher densities. We find that the critical Bonnor–Ebert stability criterion is not a good indicator of the boundedness of our cores. We detect the pre-brown dwarf candidate Oph B-11 and find a flux density and mass consistent with previous work. We discuss regional variations in the nature of the cores and find further support for our previous hypothesis of a global evolutionary gradient across the cloud from south-west to north-east, indicating sequential star formation across the region.
Background. Anal cancer is one of the most common cancers affecting individuals infected with human immunodeficiency virus (HIV), although few have evaluated rates separately for men who have sex ...with men (MSM), other men, and women. There are also conflicting data regarding calendar trends. Methods. In a study involving 13 cohorts from North America with follow-up between 1996 and 2007, we compared anal cancer incidence rates among 34 189 HIV-infected (55% MSM, 19% other men, 26% women) and 114 260 HIV-uninfected individuals (90% men). Results. Among men, the unadjusted anal cancer incidence rates per 100 000 person-years were 131 for HIV-infected MSM, 46 for other HIV-infected men, and 2 for HIV-uninfected men, corresponding to demographically adjusted rate ratios (RRs) of 80.3 (95% confidence interval CI, 42.7—151.1) for HIV-infected MSM and 26.7 (95% CI, 11.5—61.7) for other HIV-infected men compared with HIV-uninfected men. HIV-infected women had an anal cancer rate of 30/100 000 person-years, and no cases were observed for HIV-uninfected women. In a multivariable Poisson regression model, among HIV-infected individuals, the risk was higher for MSM compared with other men (RR, 3.3; 95% CI, 1.8—6.0), but no difference was observed comparing women with other men (RR, 1.0; 95% CI, 0.5—2.2). In comparison with the period 2000—2003, HIV-infected individuals had an adjusted RR of 0.5 (95% CI, .3—.9) in 1996—1999 and 0.9 (95% CI, .6—1.2) in 2004—2007. Conclusions. Anal cancer rates were substantially higher for HIV-infected MSM, other men, and women compared with HIV-uninfected individuals, suggesting a need for universal prevention efforts. Rates increased after the early antiretroviral therapy era and then plateaued.
The goal of this study was to determine the predictive value of cardiac T2* magnetic resonance for heart failure and arrhythmia in thalassemia major.
We analyzed cardiac and liver T2* magnetic ...resonance and serum ferritin in 652 thalassemia major patients from 21 UK centers with 1442 magnetic resonance scans. The relative risk for heart failure with cardiac T2* values <10 ms (compared with >10 ms) was 160 (95% confidence interval, 39 to 653). Heart failure occurred in 47% of patients within 1 year of a cardiac T2* <6 ms with a relative risk of 270 (95% confidence interval, 64 to 1129). The area under the receiver-operating characteristic curve for predicting heart failure was significantly greater for cardiac T2* (0.948) than for liver T2* (0.589; P<0.001) or serum ferritin (0.629; P<0.001). Cardiac T2* was <10 ms in 98% of scans in patients who developed heart failure. The relative risk for arrhythmia with cardiac T2* values <20 ms (compared with >20 ms) was 4.6 (95% confidence interval, 2.66 to 7.95). Arrhythmia occurred in 14% of patients within 1 year of a cardiac T2* of <6 ms. The area under the receiver-operating characteristic curve for predicting arrhythmia was significantly greater for cardiac T2* (0.747) than for liver T2* (0.514; P<0.001) or serum ferritin (0.518; P<0.001). The cardiac T2* was <20 ms in 83% of scans in patients who developed arrhythmia.
Cardiac T2* magnetic resonance identifies patients at high risk of heart failure and arrhythmia from myocardial siderosis in thalassemia major and is superior to serum ferritin and liver iron. Using cardiac T2* for the early identification and treatment of patients at risk is a logical means of reducing the high burden of cardiac mortality in myocardial siderosis. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00520559.
This is a catalogue of ∼70 X-ray emitting binary systems in the Small Magellanic Cloud (SMC) that contain a Be star as the mass donor in the system and a clear X-ray pulse signature from a neutron ...star. The systems are generally referred to as Be/X-ray binaries. It lists all their known binary characteristics (orbital period, eccentricity), the measured spin period of the compact object, plus the characteristics of the Be star (spectral type, size of the circumstellar disc, evidence for non-radial pulsations behaviour). For the first time data from the Spitzer Observatory are combined with ground-based data to provide a view of these systems out into the far-IR. Many of the observational parameters are presented as statistical distributions and compared to other similar populations (e.g. isolated Be & B stars) in the SMC, and to other Be/X-ray systems in the Milky Way. In addition, previous important results are re-investigated using this excellently homogenous sample. In particular, the evidence for a bimodality in the spin period distribution is shown to be even stronger than first proposed, and the correlation between orbital period and circumstellar disc size seen in galactic sources is shown to be clearly present in the SMC systems and quantized for the first time.
The existence of cryovolcanic features on Titan has been the subject of some controversy. Here we use observations from the Cassini RADAR, including Synthetic Aperture Radar (SAR) imaging, ...radiometry, and topographic data as well as compositional data from the Visible and Infrared Mapping Spectrometer (VIMS) to reexamine several putative cryovolcanic features on Titan in terms of likely processes of origin (fluvial, cryovolcanic, or other). We present evidence to support the cryovolcanic origin of features in the region formerly known as Sotra Facula, which includes the deepest pit so far found on Titan (now known as Sotra Patera), flow‐like features (Mohini Fluctus), and some of the highest mountains on Titan (Doom and Erebor Montes). We interpret this region to be a cryovolcanic complex of multiple cones, craters, and flows. However, we find that some other previously supposed cryovolcanic features were likely formed by other processes. Cryovolcanism is still a possible formation mechanism for several features, including the flow‐like units in Hotei Regio. We discuss implications for eruption style and composition of cryovolcanism on Titan. Our analysis shows the great value of combining data sets when interpreting Titan's geology and in particular stresses the value of RADAR stereogrammetry when combined with SAR imaging and VIMS.
Key PointsEvidence to support volcanic origin of features on TitanSeveral Cassini data sets used to support the argumentSotra patera and associated features provide strongest evidence of cryovolcanism
ABSTRACT
We present spectral energy distributions (SEDs) of 41 active galactic nuclei, derived from multiwavelength photometry and archival spectroscopy. All of the SEDs span at least 0.09 to 30 ...$\mu$m, but in some instances wavelength coverage extends into the X-ray, far-infrared, and radio. For some active galactic nuclei (AGNs) we have fitted the measured far-infrared photometry with greybody models, while radio flux density measurements have been approximated by power laws or polynomials. We have been able to fill some of the gaps in the spectral coverage using interpolation or extrapolation of simple models. In addition to the 41 individual AGN SEDs, we have produced 72 Seyfert SEDs by mixing SEDs of the central regions of Seyferts with galaxy SEDs. Relative to the literature, our templates have broader wavelength coverage and/or higher spectral resolution. We have tested the utility of our SEDs by using them to generate photometric redshifts for 0 < z ≤ 6.12 AGNs in the Boötes field (selected with X-ray, IR, and optical criteria) and, relative to SEDs from the literature, they produce comparable or better photometric redshifts with reduced flux density residuals.
Over 15% of probands in a large cohort of more than 1500 inherited retinal degeneration patients present with a clinical diagnosis of Stargardt disease (STGD1), a recessive form of macular dystrophy ...caused by biallelic variants in the ABCA4 gene. Participants were clinically examined and underwent either target capture sequencing of the exons and some pathogenic intronic regions of ABCA4, sequencing of the entire ABCA4 gene or whole genome sequencing. ABCA4 c.4539 + 2028C > T, p.= ,Arg1514Leufs*36 is a pathogenic deep intronic variant that results in a retina-specific 345-nucleotide pseudoexon inclusion. Through analysis of the Irish STGD1 cohort, 25 individuals across 18 pedigrees harbour ABCA4 c.4539 + 2028C > T and another pathogenic variant. This includes, to the best of our knowledge, the only two homozygous patients identified to date. This provides important evidence of variant pathogenicity for this deep intronic variant, highlighting the value of homozygotes for variant interpretation. 15 other heterozygous incidents of this variant in patients have been reported globally, indicating significant enrichment in the Irish population. We provide detailed genetic and clinical characterization of these patients, illustrating that ABCA4 c.4539 + 2028C > T is a variant of mild to intermediate severity. These results have important implications for unresolved STGD1 patients globally with approximately 10% of the population in some western countries claiming Irish heritage. This study exemplifies that detection and characterization of founder variants is a diagnostic imperative.
•The presence of biochar material reduced the impact of limonene on AD.•Wood biochar had the shortest microbial lag phase.•Increasing the biochar citrus peel ratio reduced lag phase prior to the ...onset of methanogenesis.•Biochar supported the colonization of methanogenic microflora.
In this study, the impact of different types of biochar and biochar ratios on the anaerobic digestion of citrus peel waste was investigated. Citrus peel has an inhibitory effect on anaerobic digestion. The presence of biochar had two effects: a reduction in the length of the lag phase and greater production of methane relative to citrus peel waste only incubations. The microbial lag phases decreased with increase in citrus peel to biochar ratios, with 2:1 having the longest lag phase of 9.4days and 1:3, the shortest, with the value of 7.5days. The cumulative methane production in incubations containing biochar and citrus peel ranged from 163.9 to 186.8ml CH4 gVS−1, while citrus peel only produced 165.9ml CH4 gVS−1. Examination of the biochar material revealed colonies of putative methanogens. The synergy of d-limonene adsorption and microbial immobilization by biochar appears to improve the performance of anaerobic digestion.
We present a catalogue of dense cores in a ∼4° × 2° field of the Taurus star-forming region, inclusive of the L1495 cloud, derived from Herschel SPIRE and PACS observations in the 70 μm, 160 μm, 250 ...μm, 350 μm, and 500 μm continuum bands. Estimates of mean dust temperature and total mass are derived using modified blackbody fits to the spectral energy distributions. We detect 525 starless cores of which ∼10–20 per cent are gravitationally bound and therefore presumably prestellar. Our census of unbound objects is ∼85 per cent complete for M > 0.015 M⊙ in low-density regions (A
V ≲ 5 mag), while the bound (prestellar) subset is ∼85 per cent complete for M > 0.1 M⊙ overall. The prestellar core mass function (CMF) is consistent with lognormal form, resembling the stellar system initial mass function, as has been reported previously. All of the inferred prestellar cores lie on filamentary structures whose column densities exceed the expected threshold for filamentary collapse, in agreement with previous reports. Unlike the prestellar CMF, the unbound starless CMF is not lognormal, but instead is consistent with a power-law form below 0.3 M⊙ and shows no evidence for a low-mass turnover. It resembles previously reported mass distributions for CO clumps at low masses (M ≲ 0.3 M⊙). The volume density PDF, however, is accurately lognormal except at high densities. It is consistent with the effects of self-gravity on magnetized supersonic turbulence. The only significant deviation from lognormality is a high-density tail which can be attributed unambiguously to prestellar cores.
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