Molecular docking studies (in Schrödinger and Glide software) showed that the molecule m-Cl-BHU (
meta
-chlorobenzhydrylurea) is complementary to the benzodiazepine binding site of GABA
A
receptors. ...Binding energy was low (-11.14 kcal/mol);
m
-Cl-BHU interacts with the key amino acids at the α1γ2 interface: Tyr159, Tyr209, and H101 Phe77 with high fit to the dG insertion model: 0.741. Binding of
3
Hflunitrazepam with the benzodiazepine site of brain GABA
A
receptors increased in rats with experimental alcoholism treated with
m
-Cl-BHU at a dose of 100 mg/kg for 14 days. Changes in pharmacokinetic parameters (
T
1/2
,
Cl
t
,
MRT
,
MET
, and
AUC
) of the model substrate antipyrine in saliva were seen in healthy volunteers and male patients with alcoholism using Galodif (
m
-Cl-BHU) at a dose of 300 mg/day for 21 days. Elimination of antipyrine in patients with alcoholism was increased due to activation of microsomal cytochrome P450 in the liver oxidase system.
Objective. To study neurophysiological correlates of inhibitory control to determine the features of inhibitionprocesses in alcohol dependence.Materials and methods. 77 patients with alcohol ...dependence were examined (42 men and 35 women) (F10.2 according to ICD-10). Patients were examined using a test to assess inhibitory control – Go/No – go. According to the task performance, patients were divided into two groups: group 1 – without inhibitory control impairments, group 2 – with impaired inhibitory control. During execution of test, electroencephalogram recordings were made according to the 10–20 system. The values of spectral power and coherence of θ-, α- and β-rhythms were analyzed. Statistical processing was carried out using nonparametric Mann–Whitney U-test and Wilcoxon W-test.Results. In patients with impaired inhibitory control, there was a decrease in the spectral power of the α-rhythm in the frontal cortex (p = 0.003), whereas in patients without inhibitory control disorders – in the Central cortex (p = 0.036). Patients with impaired inhibitory control responded by increasing β-power to cognitive stimulus in the occipital (p = 0.014), left temporal (p = 0.009) and right temporal (p = 0.008) cortex, while patients without inhibitory control disorders showed an increase in β-power only in the occipital (p = 0.007) and left temporal (p = 0.002) cortex. According to coherence data, patients with impaired inhibitory control have greater involvement of brain structures during the “Go/No – go” test in all frequency ranges.Conclusions. Patients with and without impaired inhibitory control have regional differences in changes in brain bioelectric activity during the “Go/No – go” test.
Technical design and performance of the NEMO 3 detector Arnold, R.; Augier, C.; Bakalyarov, A.M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
2005, 2005-1-00, Letnik:
536, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The development of the Neutrino Ettore Majorana Observatory (NEMO
∼
3
) detector, which is now running in the Fréjus Underground Laboratory (L.S.M. Laboratoire Souterrain de Modane), was begun more ...than ten years ago. The NEMO 3 detector uses a tracking-calorimeter technique in order to investigate double beta decay processes for several isotopes. The technical description of the detector is followed by the presentation of its performance.
Objectives
. To identify electroencephalographic correlates of decision-making features in patients with alcohol dependence.
Materials and methods
. The clinical group consisted of 40 patients (all ...men) with alcohol dependence; a further 30 subjects formed the control group. The Cambridge Game Task and the Iowa Game Task were used to study decision-making functions. In addition, the background electroencephalogram was recorded and absolute spectral power indicators were calculated.
Results
. Among patients with alcohol dependence, relatively high levels of decision-making logic (65 50; 80%,
p
< 0.05) were found to be associated with greater levels of electroencephalogram θ- and α-band spectral power in the central and parieto-occipital leads (R = 0.426,
p
= 0.019; R = 0.418,
p
= 0.022; R = 0.394,
p
= 0.028 and R = 0.445,
p
= 0.014; R = 0.458,
p
= 0.011; R = 0.382,
p
= 0.035, respectively). Difficulties in making decisions based on emotional learning in patients with alcohol dependence were associated with high spectral power levels in the electroencephalogram β rhythm in the temporal leads.
Conclusions
. This study showed that deficit in decision-making functions in patients with alcoholism may be due to an imbalance in the mechanisms of inhibition and arousal in the brain.
Event reconstruction in the CBM experiment Kisel, I.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
10/2006, Letnik:
566, Številka:
1
Journal Article
Recenzirano
A typical central Au+Au collision in the CBM experiment (GSI, Germany) will produce up to 700 tracks in the inner tracker. The large track density together with the presence of a non-homogeneous ...magnetic field make reconstruction of events complicated.
A cellular automaton method is used to reconstruct tracks in the inner tracker. Track and vertex fitting is done using the Kalman filter technique. A special analytic formula has been derived for fast track extrapolation in a non-homogeneous magnetic field. A standalone ring finding in the RICH detector is based on the elastic net method. Results of tests of the reconstruction procedure are presented.
The paper describes track propagation through non-homogeneous magnetic field using an analytic expression. The analytic formula has been derived under very general assumptions on a magnetic field. ...Precision of extrapolation does not depend on the shape of the magnetic field. Results of the implementation in the CBM track fitting procedure based on the Kalman filter are presented and compared with the extrapolation based on the fourth-order Runge–Kutta method.
Elastic net for stand-alone RICH ring finding Gorbunov, S.; Kisel, I.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2006, Letnik:
559, Številka:
1
Journal Article
Recenzirano
The elastic neural net is implemented for finding rings in Cherenkov detector. The method does not require any prior track information and can be used for triggering. Application of the method to the ...RICH detector of the CBM experiment CBM Collaboration, Compressed baryonic matter experiment, Technical Status Report, GSI, Darmstadt, 2005 shows very good efficiency and extremely high speed.
Objective.
To identify the characteristics and possible differences in the clinical signs and electroencephalographic parameters in alcohol dependence without and with comorbid affective disorders.
...Materials and methods.
A total of 95 patients with established diagnoses of alcohol dependence took part in the study; of these, 74 had no concomitant affective disorders and 21 had comorbid affective disorders. Histories included the duration of alcohol dependence, the duration of affective disorders, the number of hospital admissions, and the number of suicide attempts. Studies of mental state in patients used a number of psychometric instruments: the Hamilton Anxiety and Depression Rating Scales (HARS, HDRS), the Alcohol Use Disorders Identification Test (AUDIT) scale for the risk of alcohol abuse, and the Clinical General Impression scale (CGI-s). Brain bioelectrical activity was investigated using a 16-channel electroencephalograph. Baseline EEG traces were recorded and absolute spectral power levels and coherence in the α, β, and θ ranges were analyzed.
Results and conclusions.
Patients with alcohol dependence and comorbid affective disorders were characterized by high risk of suicidal behavior, a higher frequency of hospitalization, and higher levels of anxiety than patients suffering only alcohol dependence. The electrophysiological data showed that patients with these comorbidities, in contrast to patients without them, had higher spectral power in the α rhythm in all areas of the cerebral cortex (except the temporal lobes) and the β rhythm in the occipital cortex, along with increases in interhemisphere coherence in all frequency ranges.
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