Metal–organic framework-derived materials are now considered potential next-generation electrode materials for supercapacitors. In this present investigation, Co3O4@MnO2 nanosheets are synthesized ...using ZIF-67, which is used as a sacrificial template through a facile hydrothermal method. The unique vertically grown nanosheets provide an effective pathway for rapidly transporting electrons and ions. As a result, the ZIF-67 derived Co3O4@MnO2-3 electrode material shows a high specific capacitance of 768 C g−1 at 1 A g−1 current density with outstanding cycling stability (86% retention after 5000 cycles) and the porous structure of the material has a good BET surface area of 160.8 m2 g−1. As a hybrid supercapacitor, Co3O4@MnO2-3//activated carbon exhibits a high specific capacitance (82.9 C g−1) and long cycle life (85.5% retention after 5000 cycles). Moreover, a high energy density of 60.17 W h kg−1 and power density of 2674.37 W kg−1 has been achieved. This attractive performance reveals that Co3O4@MnO2 nanosheets could find potential applications as an electrode material for high-performance hybrid supercapacitors.
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•A porous NiO nanocrystal was synthesised by the hydrothermal method.•NiO nanocrystal is analyzed using various aqueous electrolyte solutions.•NiO nanocrystal delivers a high capacity ...of CP is 200 F/g at 1 A/g using 1 M Na2SO4.•Good cyclic stability around 2000 cycles with capacity retention of 91% at 10 A/g.
The electrochemical performance of porous Nickel oxide nanocrystals synthesised by the hydrothermal method is discussed here. In this porous Nickel oxide, crystal structure and morphology were investigated by XRD, FT-Raman, FE-SEM and HR-TEM. The electrochemical performance of porous Nickel oxide electrode examined by various aqueous electrolytes such as 1 M Na2SO4, 0.5 M KOH and 1 M Na2SO4 + 0.5 M KOH solution. The electrode material delivers high specific capacitance found as 200 F/g at 1 A/g using a single aqueous electrolyte 1 M Na2SO4. The porous Nickel oxide nanocrystals electrode performed the long-term good cyclic stability around 2000 cycles with 91% capacity retention. Here, 1 M Na2SO4 electrolyte achieves high capacity among various electrolytes can be considered as promising electrode material for supercapacitor applications.
Cardiac hypertrophy is the underlying cause of heart failure and is characterized by excessive oxidative stress leading to collagen deposition. Therefore, understanding the signalling mechanisms ...involved in excessive extracellular matrix deposition is necessary to prevent cardiac remodelling and heart failure. In this study, we hypothesized that hesperetin, a flavanone that elicits the activation of Nrf2 signalling and thereby suppresses oxidative stress, mediated pathological cardiac hypertrophy progression. A cardiac hypertrophy model was established with subcutaneous injection of isoproterenol in male Wistar rats. Oxidative stress markers, antioxidant defense status, and its upstream signalling molecules were evaluated to discover the impacts of hesperetin in ameliorating cardiac hypertrophy. Our results implicate that hesperetin pretreatment resulted in the mitigation of oxidative stress by upregulating antioxidant capacity of the heart. This curative effect might be owing to the activation of the master regulator of antioxidant defense system, known as Nrf2. Further, analysis of Nrf2 revealed that hesperetin enhances its nuclear translocation as well as the expression of its downstream targets (GCLC, NQO1, and HO-1) to boost the antioxidative status of the cells. To support this notion, in vitro studies were carried out in isoproterenol-treated H9c2 cells. Immunocytochemical analysis showed augmented nuclear localization of Nrf2 implicating the action of hesperetin at the molecular level to maintain the cellular redox homeostasis. Thus, it is conceivable that hesperetin could be a potential therapeutic candidate that enhances Nrf2 signalling and thereby ameliorates pathological cardiac remodelling.
The existing methods for recycling electronic wastes such as the printed circuit boards (PCB), which contains a large number of components and elements, face significant challenges when considering ...environmentally benign and easily separable disposal targets. We report here a low-temperature ball milling method that breaks down PCBs all the way into nanoscale particles which further enables enhanced separation of its different base constituent materials that are the polymer, oxide, and metal. The recovered materials are easy to be beneficiated as the nanoscale particles produced from milling are mostly single phase particles, compared to the larger particles obtained by other methods that are multiphase mixtures of various constituents. In addition, the recovered nano size particles can be used as starting material for making useful products such as polymer nanocomposites. Our method demonstrates a new and simple nanoparticles beneficiation route for the processing and recycling of electronic wastes into fully separable constituents.
Summary
Seasonal flowering involves responses to changes in day length. In Arabidopsis thaliana, the CONSTANS (CO) transcription factor promotes flowering in the long days of spring and summer. Late ...flowering in short days is due to instability of CO, which is efficiently ubiquitinated in the dark by the CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase complex. Here we show that CO is also phosphorylated. Phosphorylated and unphosphorylated forms are detected throughout the diurnal cycle but their ratio varies, with the relative abundance of the phosphorylated form being higher in the light and lower in the dark. These changes in relative abundance require COP1, because in the cop1 mutant the phosphorylated form is always more abundant. Inactivation of the PHYTOCHROME A (PHYA), CRYPTOCHROME 1 (CRY1) and CRYPTOCHROME 2 (CRY2) photoreceptors in the phyA cry1 cry2 triple mutant most strongly reduces the amount of the phosphorylated form so that unphosphorylated CO is more abundant. This effect is caused by increased COP1 activity, as it is overcome by introduction of the cop1 mutation in the cop1 phyA cry1 cry2 quadruple mutant. Degradation of CO is also triggered in red light, and as in darkness this increases the relative abundance of unphosphorylated CO. Finally, a fusion protein containing truncated CO protein including only the carboxy‐terminal region was phosphorylated in transgenic plants, locating at least one site of phosphorylation in this region. We propose that CO phosphorylation contributes to the photoperiodic flowering response by enhancing the rate of CO turnover via activity of the COP1 ubiquitin ligase.
Significance Statement
Photoperiodic flowering involves post‐translational modification of the transcription factor CONSTANS; the CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) ubiquitin ligase complex ubiquitinates CONSTANS and thereby promotes its degradation in the dark. Here we demonstrate that CONSTANS is also phosphorylated and that this increases the rate of its COP1‐mediated turnover in the dark.
In the past few years, FDM basedpolymer3D printing process has flourished mainly with ABS filaments as a thermoplastic source. Food packing, medical, marine and agriculture industries employdevices ...and other usable items made of polymers. Utilizing layered fabrication components in these areascompelthem to have self-cleansing, anti-freezing and corrosion resistant surfaces. It is generally complex and expensive to prepare hydrophobic coatings. The present work is related to the development of a surface coating on 3D printed ABS specimens with the mentioned properties. 3D printed specimens were fabricated using Flash Forge 3D printer without any modifications, and the hydrophobic coatings were achieved by dip coating process using Tricalcium phosphate-chitin solutions with a ratio of 70:30. Static contact angle measurement was employedin gaging wettability impact on dip coated 3D printed specimens. By using digital vernier calipers and profilometer (SJ410), dimensional accuracy and surface roughness were assessed pre and post-coating. According to ASTM D570-98, water absorption tests were conducted at different time intervals. Results of the experiment showed that the hydrophobic solutions had been successfully synthesized. The maximum contact angle was achieved for solution 1(4g of tricalcium phosphate solution with 0.3g chitin solution) i.e., 109.3°. Improvement in the textureof 3D printed ABS surfaceswasobserved after dip coating. Dip-coated 3D printed ABS specimens exhibited minimal absorption based on their weight gain per area.
Doxorubicin (Dox) is an anthracycline used to effectively treat several forms of cancer. Unfortunately, the use of Dox is limited due to its association with cardiovascular complications which are ...manifested as acute and chronic cardiotoxicity. The pathophysiological mechanism of Dox induced cardiotoxicity appears to involve increased expression of the tumor suppressor protein p53 in cardiomyocytes, followed by cellular apoptosis. It is not known whether downregulation of p53 expression in cardiomyocytes would result in decreased rates of myocardial fibrosis which occurs in response to cardiomyocyte loss. Further, it is not known whether Dox can induce perivascular necrosis and associated fibrosis in the heart. In this study we measured the effects of acute Dox treatment on myocardial and perivascular apoptosis and fibrosis in a conditional knockout (CKO) mouse model system which harbours inactive p53 alleles specifically in cardiomyocytes. CKO mice treated with a single dose of Dox (20 mg/kg), did not display lower levels of myocardial apoptosis or reactive oxygen and nitrogen species (ROS/RNS) compared to control mice with intact p53 alleles. Interestingly, CKO mice also displayed higher levels of interstitial and perivascular fibrosis compared to controls 3 or 7 days after Dox treatment. Additionally, the decrease in levels of the microtubule protein α-tubulin, which occurs in response to Dox treatment, was not prevented in CKO mice. Overall, these results indicate that selective loss of p53 in cardiomyocytes is not sufficient to prevent Dox induced myocardial ROS/RNS generation, apoptosis, interstitial fibrosis and perivascular fibrosis. Further, these results support a role for p53 independent apoptotic pathways leading to Dox induced myocardial damage and highlight the importance of vascular lesions in Dox induced cardiotoxicity.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This work presents a scanning tunneling microscopy (STM) based study of benzenetribenzoic acid (BTB) monolayer structures at the liquid−solid interface. On graphite(0001) the tailored molecules ...self-assemble into 2D supramolecular host systems, suitable for the incorporation of other nanoscopic objects. Two crystallographically different BTB structures were foundboth hydrogen bonded networks. A specific structure was deliberately selected by solvent identity. One of the BTB polymorphs is a 6-fold chicken-wire structure with circular, approximately 2.8 nm wide cavities. The other structure exhibits an oblique unit cell and a different hydrogen bonding pattern. The large cavity size of the chicken-wire structure was made possible through comparatively strong 2-fold hydrogen bonds between carboxylic groups. In addition, the low conformational flexibility of BTB was supportive to combat the tendency for dense packing.
Argyreia
is one of the dominant genera of the family Convolvulaceae and is mainly distributed in the tropical and sub-tropical regions of Southeast Asia, the Indian subcontinent and China. In the ...present study,
Argyreia elliptica
(Roth) Choisy (Convolvulaceae) is investigated histologically, which showed the development of various kinds of variant secondary growth (multiple cambia, inter-and intraxylary phloem, internal/medullary cambium and inversely oriented successive cambia). The first ring of successive cambium in the main stem and branches initiated from the cells located on the inner margin of pericyclic fibres while subsequent cambia initiated from parenchyma cells external to the phloem formed by earlier cambium. During the initiation, either a few cells become meristematic and directly differentiated into lignified xylem element followed by the cambium became noticeable or the cambium initiates first and formed xylem first followed by phloem. Primary intraxylary phloem initiates concomitant to the protoxylem and protophloem. Additional secondary intraxylary phloem originated from the pith cells and the activity of the internal cambium. In thick stems, interxylary phloem differentiated within the parenchyma islands located within the secondary xylem. A unique and hitherto unreported feature observed is the development of xylem cylinders (without phloem) from the parenchyma cells located external to the phloem of the earlier formed successive cambium. These strands were exclusively composed of fibres and fibriform vessels while wide vessels were observed occasionally. The development of various types of cambial variants is elucidated in detail and compared with the available literature on the family Convolvulaceae.
Government of India (GOI) initialized financial inclusion campaign to quell exclusion. The campaign did not gain expected progress. Government employed technologies to speed up the process. Among ...banking technologies, mobile banking appeared as a possible solution for financial exclusion with wide mobile phone coverage. Inputs on rural people’s intention toward technologies for effective financial inclusion were essential. Technology adoption factors, performance expectancy, effort expectancy, social influence, attitude, perceived risk, and behavioral intention (BI), were short listed after literature review. Factors were subjected to reliability, exploratory factor analysis (EFA), multiple regression, and interaction analysis. Rural provinces in Karnataka state were surveyed. We used mixed sampling technique to reach 959 samples. Multiple regression–interaction analysis revealed age and gender moderated attitude’s path toward BI.
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