Objective We sought to report on laboratory and clinical experience following 6 months of clinical implementation of a single-nucleotide polymorphism–based noninvasive prenatal aneuploidy test in ...high- and low-risk women. Study Design All samples received from March through September 2013 and drawn ≥9 weeks’ gestation were included. Samples that passed quality control were analyzed for trisomy 21, trisomy 18, trisomy 13, and monosomy X. Results were reported as high or low risk for fetal aneuploidy for each interrogated chromosome. Relationships between fetal fraction and gestational age and maternal weight were analyzed. Follow-up on outcome was sought for a subset of high-risk cases. False-negative results were reported voluntarily by providers. Positive predictive value (PPV) was calculated from cases with an available prenatal or postnatal karyotype or clinical evaluation at birth. Results Samples were received from 31,030 patients, 30,705 met study criteria, and 28,739 passed quality-control metrics and received a report detailing aneuploidy risk. Fetal fraction correlated positively with gestational age, and negatively with maternal weight. In all, 507 patients received a high-risk result for any of the 4 tested conditions (324 trisomy 21, 82 trisomy 18, 41 trisomy 13, 61 monosomy X; including 1 double aneuploidy case). Within the 17,885 cases included in follow-up analysis, 356 were high risk, and outcome information revealed 184 (51.7%) true positives, 38 (10.7%) false positives, 19 (5.3%) with ultrasound findings suggestive of aneuploidy, 36 (10.1%) spontaneous abortions without karyotype confirmation, 22 (6.2%) terminations without karyotype confirmation, and 57 (16.0%) lost to follow-up. This yielded an 82.9% PPV for all aneuploidies, and a 90.9% PPV for trisomy 21. The overall PPV for women aged ≥35 years was similar to the PPV for women aged <35 years. Two patients were reported as false negatives. Conclusion The data from this large-scale report on clinical application of a commercially available noninvasive prenatal test suggest that the clinical performance of this single-nucleotide polymorphism–based noninvasive prenatal test in a mixed high- and low-risk population is consistent with performance in validation studies.
ABSTRACT
We investigate how the spectral properties of atomic (H i) and molecular (H2) gas, traced by CO(2−1) , are related in M33 on 80 pc scales. We find the H i and CO(2−1) velocity at peak ...intensity to be highly correlated, consistent with previous studies. By stacking spectra aligned to the velocity of H i peak intensity, we find that the CO line width (σHWHM = 4.6 ± 0.9 ${\rm km\, s^{-1}}$ ; σHWHM is the effective Gaussian width) is consistently smaller than the H i line width (σHWHM = 6.6 ± 0.1 ${\rm km\, s^{-1}}$), with a ratio of ∼0.7, in agreement with Druard et al. The ratio of the line widths remains less than unity when the data are smoothed to a coarser spatial resolution. In other nearby galaxies, this line width ratio is close to unity which has been used as evidence for a thick, diffuse molecular disc that is distinct from the thin molecular disc dominated by molecular clouds. The smaller line width ratio found here suggests that M33 has a marginal thick molecular disc. From modelling individual lines of sight, we recover a strong correlation between H i and CO line widths when only the H i located closest to the CO component is considered. The median line width ratio of the line-of-sight line widths is 0.56 ± 0.01. There is substantial scatter in the H i –CO(2−1) line width relation, larger than the uncertainties, that results from regional variations on <500 pc scales, and there is no significant trend in the line widths, or their ratios, with galactocentric radius. These regional line width variations may be a useful probe of changes in the local cloud environment or the evolutionary state of molecular clouds.
The measured dispersion of a low-loss, hollow-core photonic band-gap fiber is anomalous throughout most of the transmission band, and its variation with wavelength is large compared with that of a ...conventional step-index fiber. For an air-filled fiber, femtosecond self-frequency-shifted fundamental solitons with peak powers greater than 2 megawatts can be supported. For Xe-filled fibers, nonfrequency-shifted temporal solitons with peak powers greater than 5.5 megawatts can be generated, representing an increase in the power that can be propagated in an optical fiber of two orders of magnitude. The results demonstrate a unique capability to deliver high-power pulses in a single spatial mode over distances exceeding 200 meters.
This is the most instructive textbook on the theory and optical effects of semiconductors. It introduces the basic theoretical concepts required for the analysis of the optical response of ...semiconductor systems in the coherent regime.
The limits to tree height Koch, George W; Sillett, Stephen C; Jennings, Gregory M ...
Nature,
04/2004, Letnik:
428, Številka:
6985
Journal Article
Recenzirano
Trees grow tall where resources are abundant, stresses are minor, and competition for light places a premium on height growth. The height to which trees can grow and the biophysical determinants of ...maximum height are poorly understood. Some models predict heights of up to 120 m in the absence of mechanical damage, but there are historical accounts of taller trees. Current hypotheses of height limitation focus on increasing water transport constraints in taller trees and the resulting reductions in leaf photosynthesis. We studied redwoods (Sequoia sempervirens), including the tallest known tree on Earth (112.7 m), in wet temperate forests of northern California. Our regression analyses of height gradients in leaf functional characteristics estimate a maximum tree height of 122-130 m barring mechanical damage, similar to the tallest recorded trees of the past. As trees grow taller, increasing leaf water stress due to gravity and path length resistance may ultimately limit leaf expansion and photosynthesis for further height growth, even with ample soil moisture.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
The first JWST observations of nearby galaxies have unveiled a rich population of bubbles that trace the stellar-feedback mechanisms responsible for their creation. Studying these bubbles ...therefore allows us to chart the interaction between stellar feedback and the interstellar medium, and the larger galactic flows needed to regulate star formation processes globally. We present the first catalog of bubbles in NGC 628, visually identified using Mid-Infrared Instrument F770W Physics at High Angular resolution in Nearby GalaxieS (PHANGS)–JWST observations, and use them to statistically evaluate bubble characteristics. We classify 1694 structures as bubbles with radii between 6 and 552 pc. Of these, 31% contain at least one smaller bubble at their edge, indicating that previous generations of star formation have a local impact on where new stars form. On large scales, most bubbles lie near a spiral arm, and their radii increase downstream compared to upstream. Furthermore, bubbles are elongated in a similar direction to the spiral-arm ridgeline. These azimuthal trends demonstrate that star formation is intimately connected to the spiral-arm passage. Finally, the bubble size distribution follows a power law of index
p
= −2.2 ± 0.1, which is slightly shallower than the theoretical value by 1–3.5
σ
that did not include bubble mergers. The fraction of bubbles identified within the shells of larger bubbles suggests that bubble merging is a common process. Our analysis therefore allows us to quantify the number of star-forming regions that are influenced by an earlier generation, and the role feedback processes have in setting the global star formation rate. With the full PHANGS–JWST sample, we can do this for more galaxies.
Background:
Health-related quality of life (HRQOL) outcomes are often included as secondary outcomes in clinical trials in secondary progressive MS (SPMS), but little is known about the longitudinal ...association of HRQOL and clinical and imaging outcome measures in SPMS.
Objective:
To assess the association of change in clinical and imaging outcomes with HRQOL in people with SPMS.
Methods:
We used data from ASCEND, a large randomized controlled trial (n = 889), to investigate the association of significant worsening on the Expanded Disability Status Scale (EDSS), Timed 25 Foot Walk (T25FW), Nine Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and change in lesional and volumetric imaging outcomes with significant worsening on the 36-Item Short Form Health Survey (SF-36) and the Multiple Sclerosis Impact Scale (MSIS-29) during 2 years of follow-up using logistic regression models.
Results:
HRQOL measures were most associated with EDSS and T25FW, less so with NHPT and SDMT, and not associated with lesional and volumetric imaging outcomes.
Discussion:
Worsening of the EDSS and T25FW was associated with two commonly used HRQOL measures. These outcomes therefore appear to be more patient relevant than either the NHPT or SDMT in the context of a 2-year clinical trial.
We simulate and elucidate the self-channeling of high-power 10 μm infrared pulses in atomic gases. The major new result is that the peak intensity can remain remarkably stable over many Rayleigh ...ranges. This arises from the balance between the self-focusing, diffraction, and defocusing caused by the excitation induced dephasing due to many-body Coulomb effects that enhance the low-intensity plasma densities. This new paradigm removes the Rayleigh range limit for sources in the 8-12 μm atmospheric transmission window and enables transport of individual multi-TW pulses over multiple kilometer ranges.
Carbon uptake by forests is a major sink in the global carbon cycle, helping buffer the rising concentration of CO2 in the atmosphere, yet the potential for future carbon uptake by forests is ...uncertain. Climate warming and drought can reduce forest carbon uptake by reducing photosynthesis, increasing respiration, and by increasing the frequency and intensity of wildfires, leading to large releases of stored carbon. Five years of eddy covariance measurements in a ponderosa pine (Pinus ponderosa)‐dominated ecosystem in northern Arizona showed that an intense wildfire that converted forest into sparse grassland shifted site carbon balance from sink to source for at least 15 years after burning. In contrast, recovery of carbon sink strength after thinning, a management practice used to reduce the likelihood of intense wildfires, was rapid. Comparisons between an undisturbed‐control site and an experimentally thinned site showed that thinning reduced carbon sink strength only for the first two posttreatment years. In the third and fourth posttreatment years, annual carbon sink strength of the thinned site was higher than the undisturbed site because thinning reduced aridity and drought limitation to carbon uptake. As a result, annual maximum gross primary production occurred when temperature was 3 °C higher at the thinned site compared with the undisturbed site. The severe fire consistently reduced annual evapotranspiration (range of 12–30%), whereas effects of thinning were smaller and transient, and could not be detected in the fourth year after thinning. Our results show large and persistent effects of intense fire and minor and short‐lived effects of thinning on southwestern ponderosa pine ecosystem carbon and water exchanges.
Disturbances alter ecosystem carbon dynamics, often by reducing carbon uptake and stocks. We compared the impact of two types of disturbances that represent the most likely future conditions of ...currently dense ponderosa pine forests of the southwestern United States: (1) high-intensity fire and (2) thinning, designed to reduce fire intensity. High-severity fire had a larger impact on ecosystem carbon uptake and storage than thinning. Total ecosystem carbon was 42% lower at the intensely burned site, 10 years after burning, than at the undisturbed site. Eddy covariance measurements over two years showed that the burned site was a net annual source of carbon to the atmosphere whereas the undisturbed site was a sink. Net primary production (NPP), evapotranspiration (ET), and water use efficiency were lower at the burned site than at the undisturbed site. In contrast, thinning decreased total ecosystem carbon by 18%, and changed the site from a carbon sink to a source in the first post-treatment year. Thinning also decreased ET, reduced the limitation of drought on carbon uptake during summer, and did not change water use efficiency. Both disturbances reduced ecosystem carbon uptake by decreasing gross primary production (55% by burning, 30% by thinning) more than total ecosystem respiration (TER; 33-47% by burning, 18% by thinning), and increased the contribution of soil carbon dioxide efflux to TER. The relationship between TER and temperature was not affected by either disturbance. Efforts to accurately estimate regional carbon budgets should consider impacts on carbon dynamics of both large disturbances, such as high-intensity fire, and the partial disturbance of thinning that is often used to prevent intense burning. Our results show that thinned forests of ponderosa pine in the southwestern United States are a desirable alternative to intensively burned forests to maintain carbon stocks and primary production.
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