The combination and application of big data and machine learning in the offline consumer market makes the formulation of marketing strategies more scientific. The use of machine learning can make ...statistics and analysis of users’ consumption behavior and classify customers according to users’ consumption behavior, so as to realize the personalized promotion of marketing content. In this context, this paper carries out research on enterprise digital precision marketing strategy based on big data. Starting from the actual application, this paper analyzes the current problems faced by consumption data sharing, as well as the characteristic needs of precision marketing for consumer groups, introduces homomorphic encryption technology, completes the structural design, process design, and algorithm design of the scheme in combination with the actual scenario that enterprises need to carry out precision marketing for customers based on consumption data, describes each design link in detail, and verifies the feasibility of the algorithm in the scheme.
•Probiotics supplementation slowed weight gain in both the high-fat diet (HFD) and high-sucrose diet (HCD) groups.•An HFD is more likely to reduce gut microbiota diversity, whereas an HCD is more ...likely to alter the bacterial composition related to obesity.•Probiotics treatment can mitigate diet-induced obesity partly through modulating intestinal microbiota, especially in HCD-induced obesity.
Gut microbiota plays a crucial role in host energy homeostasis, which is affected by both high-fat diets (HFDs) and high-sucrose diets (HCDs). Probiotics treatment can effectively modulate intestinal microbiota. However, it remains unclear whether probiotics can effectively improve HFD- and HCD-induced microbiota dysbiosis.
Mice were fed either an HFD, HCD, or normal diet for 13 wk and administered probiotics during the last 4 wk of the diet. Fecal and cecal samples were collected and analyzed by high-throughput 16S ribosomal RNA sequencing.
Body weight increased more in the HFD group compared with the HCD group. Probiotics supplementation slowed weight gain in both the HFD and HCD groups. Both the HFD and HCD reduced microbial diversity, abundance of butyric acid–producing bacteria, and some other beneficial bacteria, including Lactobacillus, Clostridium sensu stricto, Prevotella, and Alloprevotella, but increased conditional pathogenic bacteria, such as Bacteroides, Alistipes, and Anaerotruncus. Probiotics markedly restored the proportions of bacteria affected in the HFD and HCD groups and increased the abundance of microbiota negatively associated with obesity, including Bifidobacterium, Lactococcus, and Akkermansia. In addition, Oscillibacter, Escherichia/Shigella, Acinetobacter, and Blautia significantly increased in the HCD group; Allobaculum, Olsenella, and Ruminococcus were significantly changed in the HFD group. HCD-induced microbiota dysbiosis was more susceptible to probiotics treatment compared with the HFD.
Probiotics treatment can mitigate diet-induced obesity partly through modulating intestinal microbiota, especially in HCD-induced obesity.
Rational manipulation of frontier orbital distribution and singlet‐triplet splitting is crucial to exploit the luminescent properties of organic molecules. To realize ultra‐blue luminescence, both ...blue‐shifted wavelength peak (λpeak) and narrow full‐width at half‐maximum (FWHM) are required. Herein, a new thermally activated delayed fluorescence (TADF) skeleton by inserting the diphenyl methylene intramolecular‐lock to adjust the torsion angles and restrict the intramolecular relaxation is developed. Two rigid emitters, incorporating phenoxazine (PXZN‐B) and acridine (DMACN‐B) as donors and mesitylboron as an acceptor, exhibit narrow FWHMs (<50 nm) with deep‐blue (0.133, 0.147) and violet‐blue emission (0.151, 0.045), respectively. In particular, the Commission Internationale de l'Eclairage (CIE) coordinates of a DMACN‐B‐based device closely approach the Rec.2020 standard (0.131, 0.046). Moreover, both of the organic light‐emitting diodes (OLEDs) based on PXZN‐B and DMACN‐B show TADF character, with high external quantum efficiencies (EQEs) exceeding 10%. Furthermore, owing to the large orbital overlap, these TADF emitters own a fast S1–S0 transition rate exceeding 108 s–1, thereby exhibiting marked amplified spontaneous emission (ASE) with low thresholds. Therefore, the intramolecular‐lock strategy provides not only innovation for realizing high‐efficiency deep‐blue TADF emission with high color purity but also an avenue for a TADF‐based ASE and lasing application.
An “intramolecular‐lock” is proposed as part of the thermally activated delayed fluorescence (TADF) molecular design for manipulating torsion angles and wave function distributions. The quasi‐planar TADF emitters lead to ultrapure violet‐blue TADF electroluminescence with CIE‐(0.151, 0.045), approaching the Rec. 2020 standard. Furthermore, a TADF‐based amplified spontaneous emission with low thresholds is triggered, which paves the way for future TADF‐based lasing application.
The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA ...gene sequencing, 728 samples are collected to identify microbial markers, and an independent cohort of 310 samples is used to validate the results. Furthermore, species-level and functional analysis are performed by metagenome sequencing using 200 samples. Gut microbial diversity is increased in yCRC. Flavonifractor plautii is an important bacterial species in yCRC, while genus Streptococcus contains the key phylotype in the old-onset colorectal cancer. Functional analysis reveals that yCRC has unique characteristics of bacterial metabolism characterized by the dominance of DNA binding and RNA-dependent DNA biosynthetic process. The random forest classifier model achieves a powerful classification potential. This study highlights the potential of the gut microbiota biomarkers as a promising non-invasive tool for the accurate detection and distinction of individuals with yCRC.
The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing. Here, we aimed to characterise the interactions between gut microbiome, metabolites and microbial enzymes in EO-CRC ...patients and evaluate their potential as non-invasive biomarkers for EO-CRC.
We performed metagenomic and metabolomic analyses, identified multiomics markers and constructed CRC classifiers for the discovery cohort with 130 late-onset CRC (LO-CRC), 114 EO-CRC subjects and age-matched healthy controls (97 LO-Control and 100 EO-Control). An independent cohort of 38 LO-CRC, 24 EO-CRC, 22 LO-Controls and 24 EO-Controls was analysed to validate the results.
Compared with controls, reduced alpha-diversity was apparent in both, LO-CRC and EO-CRC subjects. Although common variations existed, integrative analyses identified distinct microbiome-metabolome associations in LO-CRC and EO-CRC.
enrichment and short-chain fatty acid depletion, including reduced microbial GABA biosynthesis and a shift in acetate/acetaldehyde metabolism towards acetyl-CoA production characterises LO-CRC. In comparison, multiomics signatures of EO-CRC tended to be associated with enriched
and increased tryptophan, bile acid and choline metabolism. Notably, elevated red meat intake-related species, choline metabolites and KEGG orthology (KO) pldB and cbh gene axis may be potential tumour stimulators in EO-CRC. The predictive model based on metagenomic, metabolomic and KO gene markers achieved a powerful classification performance for distinguishing EO-CRC from controls.
Our large-sample multiomics data suggest that altered microbiome-metabolome interplay helps explain the pathogenesis of EO-CRC and LO-CRC. The potential of microbiome-derived biomarkers as promising non-invasive tools could be used for the accurate detection and distinction of individuals with EO-CRC.
A multiple resonance thermally activated delayed fluorescence (MR‐TADF) molecule with a fused, planar architecture tends to aggregate at high doping ratios, resulting in broad full width at half ...maximum (FWHM), redshifting electroluminescence peaks, and low device efficiency. Herein, we propose a mono‐substituted design strategy by introducing spiro‐9,9′‐bifluorene (SBF) units with different substituted sites into the MR‐TADF system for the first time. As a classic steric group, SBF can hinder interchromophore interactions, leading to high device efficiency (32.2–35.9 %) and narrow‐band emission (≈27 nm). Particularly, the shield‐like molecule, SF1BN, seldom exhibits a broadened FWHM as the doping ratio rises, which differs from the C3‐substituted isomer and unhindered parent emitter. These results manifest an effective method for constructing highly efficient MR‐TADF emitters through a spiro strategy and elucidate the feasibility for steric modulation of the spiro structure in π‐framework.
By incorporating a three‐dimensional spiro unit into multiple resonance thermally activated delayed fluorescence emitters, the device efficiency is increased to nearly 1.5 times that of the unhindered emitter. Notably, the linkage pattern with spatial interaction and hindrance can maintain the narrow FWHM and curb unfavorable redshifts at a high doping ratio.
•A new soft robotic gripper with variable stiffness was designed. Its uniqueness lies in the structural decoupling of the deformation actuator for bending and the variable stiffness mechanism of the ...soft robotic gripper.•Based on the Cosserat theory, a grasping force model is built for the proposed soft robotic gripper with variable stiffness.•A series of experimental tests and simulations on the grasping force of the soft robotic gripper are investigated to discuss the modeling properties.
The purpose of this research is to present a grasping force model for a soft robotic gripper with variable stiffness. The soft robotic gripper was made of shape memory alloys (SMAs) with contraction and variable stiffness properties. A variable stiffness mechanism with embedded sets of SMA fibers was developed; however, the response characteristics of its backbone did not comply with the constant-curvature model when it was subjected to complex forces/torques, such as gravity, grasping forces and driving torques. In this case, the Cosserat theory was used to implement real-time computations of the grasping force of the soft robotic gripper that was subjected to complex forces. Finally, a series of tests were conducted on the grasping force of the soft finger and the gripper. The elicited results showed that the grasping force is related to the stiffness and to the object's offset and friction coefficient. Moreover, experimental results showed that the grasping force of the soft robotic gripper increased by 48.7% when the Young's modulus of the SMA-2 wires increased from 25 GPa to 48 GPa.
In the field of phosphorescent organic light-emitting diodes (PhOLEDs), designing high-efficiency universal host materials for red, green and blue (RGB) phosphors has been quite a challenge. To date, ...most of the high-efficiency universal hosts reported incorporate heteroatoms, which have a crucial role in the device performance. However, the introduction of different kinds of heterocycles increases the design complexity and cost of the target material and also creates potential instability in the device performance. In this work, we show that pure aromatic hydrocarbon hosts designed with the 9,9′-spirobifluorene scaffold are high-efficiency and versatile hosts for PhOLEDs. With external quantum efficiencies of 27.3%, 26.0% and 27.1% for RGB PhOLEDs respectively, this work not only reports the first examples of high-efficiency pure hydrocarbon materials used as hosts in RGB PhOLEDs but also the highest performance reported to date for a universal host (including heteroatom-based hosts). This work shows that the PHC design strategy is promising for the future development of the OLED industry as a high-performance and low-cost option.
In this work, we propose pure hydrocarbon materials as universal hosts for high-efficiency red, green and blue phosphorescent organic light-emitting diodes.
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet regimen that mimics the metabolism of the fasting state to induce the production of ketone bodies. The KD has ...long been established as a remarkably successful dietary approach for the treatment of intractable epilepsy and has increasingly garnered research attention rapidly in the past decade, subject to emerging evidence of the promising therapeutic potential of the KD for various diseases, besides epilepsy, from obesity to malignancies. In this review, we summarize the experimental and/or clinical evidence of the efficacy and safety of the KD in different diseases, and discuss the possible mechanisms of action based on recent advances in understanding the influence of the KD at the cellular and molecular levels. We emphasize that the KD may function through multiple mechanisms, which remain to be further elucidated. The challenges and future directions for the clinical implementation of the KD in the treatment of a spectrum of diseases have been discussed. We suggest that, with encouraging evidence of therapeutic effects and increasing insights into the mechanisms of action, randomized controlled trials should be conducted to elucidate a foundation for the clinical use of the KD.
The oral microbiome may play an important role in colorectal carcinogenesis. However, few studies have investigated the association between oral microbiome and the development of colorectal cancer ...(CRC). We aimed to investigate whether oral health-colorectal tumor association has an underlying microbial basis, in the quest for novel non-invasive biomarkers for CRC.
We collected oral swab samples from 161 patients with CRC, 34 patients with colorectal adenoma (CRA), and 58 healthy volunteers. The oral microbiota was assessed using 16S rRNA sequencing. We characterized oral microbiome, identified microbial markers, constructed and validated colorectal tumor (CRA and CRC) classifier.
Oral microbial composition and diversity were significantly different among the three groups, and the CRA group had the highest diversity. Analysis of the functional potential of oral microbiota demonstrated that the pathway involving cell motility was overrepresented in the CRA and CRC groups relative to that in the healthy controls. Moreover, a random forest model was constructed based on oral microbial markers, which could distinguish the colorectal tumor groups from the healthy controls and achieve a powerful classification potential in the discovery and validation cohorts.
This study suggests a potential association between oral microbiome dysbiosis and colorectal cancer. Oral microbiota-based biomarkers may be helpful in predicting the risks for the development of CRA and CRC.
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