We aimed to investigate the prognostic significance of neutrophil, lymphocyte, platelet, mean platelet value (MPV), platelet-lymphocyte ratio (PLR) and neutrophil–lymphocyte ratio (NLR) in patients ...with locally advanced gastric cancer (LAGC). One hundred sixty-eight patients with LAGC who had been followed-up between 2004 and 2008 were included in present study. The results of hematological (platelet, lymphocyte, neutrophil and MPV) and biochemical (uric acid and LDH) parameters were evaluated before treatment. NLR was divided into two groups as <2.56 and ≥2.57 and PLR was also divided into two groups as ≤160 and >160. Platelet counts and lymphocyte counts were also divided into two groups; ≤300.000/mm3 and >300.000/mm3, and <1,500/mm3 and ≥1,500/mm3, respectively. Results were evaluated with Kaplan–Meier and Long-rank tests. The mean age of patients at diagnosis was 60.1 ± 12.1 and 114 of patients (67.8%) were male. For 168 patients, 48 months overall survival (OS) rate was 45.2% and the median OS was 39 months (range 33–44). In patients whose PLR was less than 160 (
n
= 54), the median OS was 45 months (range 38–52) and also for cases whose PRL was greater than 160 (
n
= 114), the median OS was 27 months (range 22–32) (
p
= 0.006). While for fifty patients whose lymphocyte counts were less than 1,500, the median OS was 27 months (range 21–33), in cases with high lymphocyte counts (≥1,500) (
n
= 118), it was 41 months (range 35–48) (
p
= 0.03). The median OS was 41 (range 34–48) and 30 (range 23–37) months in two platelets groups, respectively (
p
= 0.24). However, in the patients whose NLR was less than 2.56 (
n
= 107), median OS was better than with cases whose NLR was greater than or equal to 2.56 (42 vs. 27 months). Routine peripheral blood counts may be useful prognostic factor for evaluating the accuracy of risk stratification in patients with radically resected gastric cancer Our results need to be confirmed by study including larger sample size in future.
The aim of the study is to assess the prognostic value of pretreatment lymphocyte, neutrophil, platelet counts, mean platelet volume (MPV), platelet to lymphocyte ratio (PLR) and neutrophil to ...lymphocyte ratio (NLR) in patients with pancreatic cancer.
A total of 65 eligible patients were included in the study and retrospectively reviewed. Pre-treatment hematological parameters (platelet, lymphocyte, neutrophil counts, and mean platelet volume) and tumor marker (CA 19-9) levels were recorded. NLR was calculated by dividing the neutrophil count value by the number of lymphocytes. PLR was also calculated in a similar manner by dividing the platelet count value by the number of lymphocytes.
One-year survival was 22.3% and the median survival time was 7 months (95% CI, 5.7-8.2) in the study group. Patients with a NLR value of < 5 had a significantly higher median survival duration compared to those with a NLR value of > or = 5 (p = 0.015). All other hematological variables were not significantly different.
In patients with pancreatic cancer, pretreatment NLR may be use as a prognostic factor in pancreatic cancer patients. Further studies with larger patient cohorts are warranted to to better clarify the prognostic value of pre-treatment peripheral blood counts in patients with cancer.
introduction: Gastric cancer is one of the leading cause of death both in men and women. More than two-thirds of the patients were diagnosed in advanced stage. Metastatic gastric cancer has a poor ...prognosis with a reiative 5-years-survivai rate of %7. İn the previous reports, hematological parameters including ieukocyte, thrombocyte counts and ratios between them had been used as prognostic indicators in several tumor types. The aim of the current study was to determine vvhether hematological parameters tike neutrophils, iymphocyte or thrombocyte counts and thrombocyte-iymphocyte ratio (TLR), neutrophii-iymphocyte ratio (NLR) before treatment might predict survival in metastatic gastric cancer. Patients and Methods: A total of 112 patients with metastatic gastric cancer treated and followed-up from 2004 to 2008 were anaiyzed. Hematological parameters measured before treatment were obtained from patients chart and evaluated retrospectively. NLR and TLR were calculated from pre-treatment complete blood counts. Correlation betvveen parameters and survival were made by using log-rank and Kaplan-Meier tests. Results: For 112 patients with metastatic gastric cancer, 2-years survival rate and median survival time were 17% and 12 months, respectively. Although thrombocytosis (> 300.000), TLR (> 160), lymphopenia (< 1500), NLR (> 2.56) had been found predict poor survival time, it was not shown statistically significant. Conclusion: İn present study we could not find any significant correlation between survival and hematological parameters in patients with metastatic gastric cancer, hovevver, further studies including larger sample size may be reçuired to clarify the prognostic value of pre-treatment peripheral blood counts.
Gastrik kanser, kadın ve erkekte en sık ölüme neden olan kanserlerdendir. Hastaların 2/3 den fazlasına ileri evrede tanı konabilir. Metastatik mide kanserinin beş yıllık sağkalımı %7 civarındadır. Daha önceki çalışmalarda, beyaz küre, trombosit sayısı ve aralarındaki oranlar farklı kanser türlerinde prognostik gösterge olarak kullanılmıştır. Biz çalışmamızda beyaz küre, trombosit sayısı, trombosit/lenfosit oranı (TLO), nötrofil/lenfosit (NLO) oranı gibi hematolojik parametrelerin metastatik mide kanserinde yeri olup olmadığını değerlendirdik. Hastalar ve Yöntem: 2004-2008 yılları arasında tedavi ve takip edilen toplam 112 metastatik mide kanserli hastayı inceledik. Tedaviden önce ölçülen hematolojik parametreleri hasta kartlarından elde ettik. TLO ve LTO tedavi öncesi parametrelerden hesapladık. Parametrelerle sağkalım arasındaki ilişkiyi log-rank ve Kaplan-Meier analizleriyle değerlendirdik. Bulgular: Metastatik mide kanserli 112 hastanın iki yıllık sağkalım oranı ve ortalama sağkalım süresi ayrı ayrı %17 ve 12 aydı. Trombositoz, (> 300.000), TLO (> 160), lenfopeni (< 1500), NLO(> 2.56) kötü sağkalımı predikte etse de istatistiksel olarak anlamlılık saptanmadı. Sonuç: Çalışmamızda, metastatik mide kanserli sağkalım ve hematolojik parametreler arasında istatistiksel olarak anlamlı bağlantı bulamadık, ileride tedavi öncesi he
In this multicenter prospective study, we aimed to evaluate the use of holmium:yttrium-- aluminum-garnet laser during retrograde intrarenal surgery for kidney stones and the relationship between ...laser-related parameters and procedure-related perioperative parameters.
The 769 patients whose laser setting parameters (fiber thickness, number of shots, frequency (max.), laser power (max.), and total energy) were completely registered were included in this study program. The intraoperative ureteral lesions were evaluated using postureteroscopic lesion scale (PULS) scores and the postoperative complications with the modified Clavien-Dindo classification system.
The maximum levels of laser power and the frequency were used in the middle calyceal stones; the value of total energy consumed was found to be higher gain in cases with multiple stones (all parameters P < .05). There was a significant positive correlation among (mean number of shots P < .001, r ¼ 0.46, frequency P ¼ .009, r ¼ 0.1, maximum power P < .001, r ¼ 0.11, total energy P < .001, r ¼ 0.25), anesthesia time (P < .001, r ¼ 0.42), surgery time (P < .001, r ¼ 0.47), and stone size. The mean number of shots increased (P < .001, r ¼ 0.25), and the frequency level decreased (P < .001, r ¼ -0.17) significantly with increasing Hounsfield unit (HU) values. Again, the mean number of shots and maximum laser power increased in correlation with the increasing hospitalization time (P ¼ .004, r ¼ 0.09 and P ¼ .02, r ¼ 0.07, respectively). In addition, it was observed that higher laser subparameter values and thicker fibers were used in PULS grade 2.
As the stone size and HU values increased, laser-setting parameters were found to show significant variability. The increase in different parameters of the laser setting was found to be associated with longer anesthesia time, surgery time, and hospitalization period and increased risk of local trauma with PULS grade.
Turkey remains among the countries where hydatid disease is endemic. In this study, it was aimed to determine the number of operations performed for the treatment of pulmonary hydatid disease in ...Turkey during 2014 and to present the distribution of these operations according to the different regions of the country.
The Turkish Thoracic Society Thoracic Surgery Study Group connected with the thoracic surgeons in each city through telephone. A data set was sent by email. The age, sex, contact with animals that might be a risk of gaining the hydatid disease, the side of the disease, the type of surgical method, other organ involvement were recorded and collected from each data set to form the final data, and the results were evaluated. Turkey comprises of 81 cities that are grouped in seven different regions. The number of operations was calculated for each city and region to present the distribution.
Overall, 101 centers from 81 cities were considered in the study. A total of 715 pulmonary hydatid cyst operations were performed in 690 patients during the study period. The most common operation technique was cystotomy and capitonnage through thoracotomy (76%). The highest incidence rate of operated patients was in the Eastern Anatolian Region (2.15 patients per 100 000 person-years).
Pulmonary hydatid disease still has a high incidence rate particularly in the southeast and east of Turkey, which are mainly rural areas and where stockbreeding is very common. Cystotomy and capitonnage is still the most common surgical method used to treat pulmonary hydatid cysts. Preventive methods should be performed strictly in these cities and regions to decrease the risk of infection.
Dams and hydraulic structures are used for the supply and control of water, which have great importance on human life. The sluice gate is one of the hydraulic control structures. Sluice gates release ...excess water from the reservoir to the downstream side in a controlled manner with a certain discharge for controlling the level of the reservoir. A hydraulic jump is created to dissipate the energy of flow coming from under the gates. A hydraulic jump occurs when the flow regime is changed from subcritical to supercritical. However, the position of the hydraulic jump in the channel should be known exactly to prevent damage to surrounding structures. In this study, an open channel system with a sluice gate is used to produce a hydraulic jump. Experiments are conducted for two different gate openings (a1=1.5 cm and a2=2 cm) and 16 discharge values. For each case, the position of the hydraulic jump is determined. In addition, flow depths at 5 different points were measured including before and after the hydraulic jump. The results obtained from the experimental study were compared with the numerical model in terms of the position of hydraulic jump and flow depths. According to the results obtained, the numerical model and the physical model showed between 80 and 91% consistency.
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