Cardiovascular diseases are increasingly recognized as late effects of Hodgkin lymphoma (HL) treatment. The purpose of this study was to identify the risk factors for coronary heart disease (CHD) and ...to quantify the effects of radiation dose to the heart, chemotherapy, and other cardiovascular risk factors.
We conducted a nested case-control study in a cohort of 2,617 5-year HL survivors, treated between 1965 and 1995. Cases were patients diagnosed with CHD as their first cardiovascular event after HL. Detailed treatment information was collected from medical records of 325 cases and 1,204 matched controls. Radiation charts and simulation radiographs were used to estimate in-field heart volume and mean heart dose (MHD). A risk factor questionnaire was sent to patients still alive.
The median interval between HL and CHD was 19.0 years. Risk of CHD increased linearly with increasing MHD (excess relative risk ERR) per Gray, 7.4%; 95% CI, 3.3% to 14.8%). This results in a 2.5-fold increased risk of CHD for patients receiving a MHD of 20 Gy from mediastinal radiotherapy, compared with patients not treated with mediastinal radiotherapy. ERRs seemed to decrease with each tertile of age at treatment (ERR/Gy(<27.5years), 20.0%; ERR/Gy(27.5-36.4years), 8.8%; ERR/Gy(36.5-50.9years), 4.2%; P(interaction) = .149). Having ≥ 1 classic CHD risk factor (diabetes mellitus, hypertension, or hypercholesterolemia) independently increased CHD risk (rate ratio, 1.5; 95% CI, 1.1 to 2.1). A high level of physical activity was associated with decreased CHD risk (rate ratio, 0.5; 95% CI, 0.3 to 0.8).
The linear radiation dose-response relationship identified can be used to predict CHD risk for future HL patients and survivors. Appropriate early management of CHD risk factors and stimulation of physical activity may reduce CHD risk in HL survivors.
Facial expressions are potent social cues that can induce behavioral dispositions, such as approach–avoidance tendencies. We studied these tendencies by asking participants to make whole-body forward ...(approach) or backward (avoidance) steps on a force plate in response to the valence of social cues (happy or angry faces) under affect-congruent and incongruent mappings. Posturographic parameters of the steps related to automatic stimulus evaluation, step initiation (reaction time), and step execution were determined and analyzed as a function of stimulus valence and stimulus–response mapping. The main result was that participants needed more time to initiate a forward step towards an angry face than towards a smiling face (which is evidence of a congruency effect), but with backward steps, this difference failed to reach significance. We also found a reduction in spontaneous body sway prior to the step with the incongruent mapping. The results provide a crucial empirical link between theories of socially induced action tendencies and theories of postural control and suggest a motoric basis for socially guided motivated behavior.
Young women treated with chest radiation therapy (RT) for Hodgkin lymphoma (HL) experience a strongly increased risk of breast cancer (BC). It is unknown whether endogenous and exogenous gonadal ...hormones affect RT-associated BC risk.
We conducted a nested case-control study among female 5-year HL survivors treated before age 41. Hormone exposure and HL treatment data were collected through medical records and questionnaires for 174 BC case patients and 466 control patients. Radiation dose to breast tumor location was estimated based on RT charts, simulation films, and mammography reports.
We observed a linear radiation dose-response curve with an adjusted excess odds ratio (EOR) of 6.1%/Gy (95% confidence interval CI: 2.1%-15.4%). Women with menopause <30 years (caused by high-dose procarbazine or pelvic RT) had a lower BC risk (OR, 0.13; 95% CI, 0.03-0.51) than did women with menopause ≥50 years. BC risk increased by 6.4% per additional year of post-RT intact ovarian function (P<.001). Among women with early menopause (<45 years), hormone replacement therapy (HRT) use for ≥2 years did not increase BC risk (OR, 0.86; 95% CI, 0.32-2.32), whereas this risk was nonsignificantly increased among women without early menopause (OR, 3.69; 95% CI, 0.97-14.0; P for interaction: .06). Stratification by duration of post-RT intact ovarian function or HRT use did not statistically significantly modify the radiation dose-response curve.
BC risk in female HL survivors increases linearly with radiation dose. HRT does not appear to increase BC risk for HL survivors with therapy-induced early menopause. There are no indications that endogenous and exogenous gonadal hormones affect the radiation dose-response relationship.
To describe a new method to estimate the mean heart dose for Hodgkin lymphoma patients treated several decades ago, using delineation of the heart on radiation therapy simulation X-rays. Mean heart ...dose is an important predictor for late cardiovascular complications after Hodgkin lymphoma (HL) treatment. For patients treated before the era of computed tomography (CT)-based radiotherapy planning, retrospective estimation of radiation dose to the heart can be labor intensive.
Patients for whom cardiac radiation doses had previously been estimated by reconstruction of individual treatments on representative CT data sets were selected at random from a case-control study of 5-year Hodgkin lymphoma survivors (n=289). For 42 patients, cardiac contours were outlined on each patient's simulation X-ray by 4 different raters, and the mean heart dose was estimated as the percentage of the cardiac contour within the radiation field multiplied by the prescribed mediastinal dose and divided by a correction factor obtained by comparison with individual CT-based dosimetry.
According to the simulation X-ray method, the medians of the mean heart doses obtained from the cardiac contours outlined by the 4 raters were 30 Gy, 30 Gy, 31 Gy, and 31 Gy, respectively, following prescribed mediastinal doses of 25-42 Gy. The absolute-agreement intraclass correlation coefficient was 0.93 (95% confidence interval 0.85-0.97), indicating excellent agreement. Mean heart dose was 30.4 Gy with the simulation X-ray method, versus 30.2 Gy with the representative CT-based dosimetry, and the between-method absolute-agreement intraclass correlation coefficient was 0.87 (95% confidence interval 0.80-0.95), indicating good agreement between the two methods.
Estimating mean heart dose from radiation therapy simulation X-rays is reproducible and fast, takes individual anatomy into account, and yields results comparable to the labor-intensive representative CT-based method. This simpler method may produce a meaningful measure of mean heart dose for use in studies of late cardiac complications.
Phosphatidic acid and lysophosphatidic acid are minor but important anionic bioactive lipids involved in a number of key cellular processes, yet these molecules have a simple phosphate headgroup. To ...find out what is so special about these lipids, we determined the ionization behavior of phosphatidic acid (PA) and lysophosphatidic acid (LPA) in extended (flat) mixed lipid bilayers using magic angle spinning 31P NMR. Our data show two surprising results. First, despite identical phosphomonoester headgroups, LPA carries more negative charge than PA when present in a phosphatidylcholine bilayer. Dehydroxy-LPA 1-oleoyl-3-(phosphoryl)propanediol behaves in a manner identical to that of PA, indicating that the difference in negative charge between LPA and PA is caused by the hydroxyl on the glycerol backbone of LPA and its interaction with the phosphomonoester headgroup. Second, deprotonation of phosphatidic acid and lysophosphatidic acid was found to be strongly stimulated by the inclusion of phosphatidylethanolamine in the bilayer, indicating that lipid headgroup charge depends on local lipid composition and will vary between the different subcellular locations of (L)PA. Our findings can be understood in terms of a hydrogen bond formed within the phosphomonoester headgroup of (L)PA and its destabilization by competing intra- or intermolecular hydrogen bonds. We propose that this hydrogen bonding property of (L)PA is involved in the various cellular functions of these lipids.
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide ...association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including ...type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10
). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (R
= -0.22, P = 5.5 × 10
), T2D (R
= -0.27, P = 1.1 × 10
) and coronary artery disease (R
= -0.30, P = 6.5 × 10
). In addition, using large -cohort datasets, we demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P = 1.9 × 10
). We demonstrate that life-course associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and identify some of the pathways through which these causal genetic effects are mediated.
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•SOC stocks varied more between geological substrates than between forest types.•Lignin yield differences between forest types were more pronounced on acid soils.•Tree species effects ...on lignin degradation seem strongly site-dependent.•Lignin chemistry is influenced by both litter input chemistry and edaphic factors.•The relative importance of parent material and litter quality was site-specific.
By storing carbon in the soil, forests contribute to climate change mitigation. Edaphic (soil-related) factors, such as soil pH, as well as tree species affect forest carbon cycles, but are difficult to disentangle. We studied how conversion of deciduous stands to mono-culture spruce plantations affected the soil organic matter (SOM) composition along a lithological gradient in the Mullerthal (Luxembourg) and Gaume (south-east Belgium) regions. Parent materials in these regions range from decalcified sands to calcareous marls. A twin plot setup of adjacent deciduous and coniferous stands on the same parent material was used to evaluate the effect of edaphic factors versus litter input differences on SOM composition and soil organic carbon (SOC) stocks. Lignin and cutin/suberin molecular proxies were identified with thermally assisted hydrolysis and methylation (THM), to distinguish litter sources (coniferous vs deciduous and leaf litter vs roots) in the studied stands. In this study, SOC stocks were influenced more by parent material than by forest type. Lignin yield, composition and degradation state were influenced both by litter input chemistry and edaphic context. There appear to be important interaction effects between the two, as the relative importance of parent material and litter quality was site specific. We therefore advice that carbon stock models include data on both vegetation history as well as edaphic context.
Prevention of hypertriglyceridemia is one of the biomedical targets in Glycogen Storage Disease type Ia (GSD Ia) patients, yet it is unclear how hypoglycemia links to plasma triglyceride (TG) levels. ...We analyzed whole‐body TG metabolism in normoglycemic (fed) and hypoglycemic (fasted) hepatocyte‐specific glucose‐6‐phosphatase deficient (L‐G6pc−/−) mice. De novo fatty acid synthesis contributed substantially to hepatic TG accumulation in normoglycemic L‐G6pc−/− mice. In hypoglycemic conditions, enhanced adipose tissue lipolysis was the main driver of liver steatosis, supported by elevated free fatty acid concentrations in GSD Ia mice and GSD Ia patients. Plasma very‐low‐density lipoprotein (VLDL) levels were increased in GSD Ia patients and in normoglycemic L‐G6pc−/− mice, and further elevated in hypoglycemic L‐G6pc−/− mice. VLDL‐TG secretion rates were doubled in normo‐ and hypoglycemic L‐G6pc−/− mice, while VLDL‐TG catabolism was selectively inhibited in hypoglycemic L‐G6pc−/− mice. In conclusion, fasting‐induced hypoglycemia in L‐G6pc−/− mice promotes adipose tissue lipolysis and arrests VLDL catabolism. This mechanism likely contributes to aggravated liver steatosis and dyslipidemia in GSD Ia patients with poor glycemic control and may explain clinical heterogeneity in hypertriglyceridemia between GSD Ia patients.
Book Reviews Claessen, H.J.M.; Kirch, Patrick Vinton; Claessen, H.J.M. ...
Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia,
1986, Letnik:
142, Številka:
1
Book Review
Recenzirano
G.J. Abbink, Serena Nanda, Cultural anthropology, Belmont: Wadsworth Publishing Company (second edition), 1985, 398 pp. - H.J.M. Claessen, Patrick Vinton Kirch, The evolution of the Polynesian ...Chiefdoms, Cambridge University Press, Cambridge etc. Series: New Studies in Archaeology, edited by Colin Renfrew and Jeremy Sabloff, 1984. 314 pp., index, glossary, bibliography, maps, and figures. - H.J.M. Claessen, Jarich O. Oosten, The war of the gods. The social code in Indo-European myths, London etc.: Routledge and Kegan Paul, 1985. 175 pp., bibl., figs. - H.J. Duller, P.W. Preston, New trends in development theory. Essays in development and social theory, Routledge & Kegan Paul, London 1985, 200 pages. - H.J. Duller, M. Stiefel, Production, equality and participation in rural China, UNRISD, Geneva & Red Press, London, 1983, 172 pp., W.F. Wertheim (eds.) - M. Grijns, Kirsten Hastrup, Basisboek culturele antropologie. Bewerkt door Yme Kuiper & Nellejet Zorgdrager. Groningen: Wolters-Noordhoff, 1983, 353 pp., Jan Ovesen (eds.) - Simon Kooijman, Jelle Miedema, De kabar 1855-1980. Sociale structuur en religie in de Vogelkop van West-Nieuw-Guinea. Dissertatie Katholieke Universiteit van Nijmegan, Dordrecht 1984: ICG printing BV. Gelijktijdig verschenen als Verhandelingen 105 van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde, Leiden, Dordrecht 1984: Foris publications. - Adam Kuper, R.H. Barnes, Two crows denies it: A history of controversy in Omaha sociology, Lincoln, Nebraska: University of Nebraska press, 1984. - C.L.J. van der Meer, Steven Piker, A peasant community in changing Thailand, Anthropological research papers, no. 30, Arizona State University, 1983. - J. Miedema, Mark S. Mosko, Quadripartite structures: Categories, relations, and homologies in Bush Mekeo culture, Cambridge: University Press, 1985, XIII + 298 pp. - David S. Moyer, Rodney Needham, Against the tranquility of Axioms, University of California Press, Berkeley, 1983, xi + 182 pp. - Anke Niehof, Imke Swart, Die Traditionellen Grundlagen der Erziehung im Zentralen Java, Wiesbaden: Franz Steiner Verlag, 1983. (130 pp.) - J.H.B. den Ouden, R.S. Khare, The untouchable as himself. Ideology, identity and pragmatism among the Lucknow Chamars, Cambridge studies in cultural systems, Cambridge University Press, 1984. - Rien Ploeg, James A. Boon, Other tribes, other scribes; symbolic anthropology in the comparitive study of cultures, histories, religions, and texts, Cambridge: Cambridge University Press, 1982. xiv + 303 pp., appendixes. - Frank N. Pieke, Rubie S. Watson, Inequality among brothers: Class and kinship in South China, Cambridge: Cambridge University Press, 1985. xiii + 193 pp., 3 maps. - Rien Ploeg, Durk Hak, Watching the seaside. Essays on maritime anthropology. A. H. J. Prins; Festschrift on the occasion of his retirement from the Chair of Anthropology, University of Groningen, University of Groningen, 1984, 251 pp., ill.,
diagr., Ybeltje Kroes, Hans Schneymann (eds.) - Rien Ploeg, Ladislav Holy, Actions, norms and representations. Foundations of anthropological inquiry. Cambridge: Cambridge University Press, 1983. VIII + 134 pp., Milan Stuchlik (eds.) - Rien Ploeg, Nancy L. Hamblin, Animal use by the Cozumel Maya, Tucson, Arizona: The University of Arizona Press, 1984. 206 pp. - Ronald H. Poelmeijer, Lilly Eversdijk Smulders, Een jaar bij de yogiýs van India en Tibet, Deventer 1983. - Ype H. Poortinga, Dean Peabody, National characteristics, Cambridge/Paris: Camnbridge University Press/Editions de la Maison des Sciences de lýHomme, 1985. - Karen Portier, Khin Thitsa, Nuns, mediums and prostitutes in Chiengmai: A study of some marginal categories of women (41 pp.). - Karen Portier, Signe Howell, Chewong women in transition: The effects of monetization on a hunter-gatherer society in Malaysia (34 pp.). - Karen Portier, Maila Stivens, Sexual politics in Rembau: Female autonomy, matriliny and agrarian change in Negeri Sembilan, Malaysia (50 pp.) - R. de Ridder, Dennis Tedlock, The spoken word and the work of interpretation, Philadelphia: University of Pennsylvania Press, 1983. ix + 365 pp., 8 ill. - R. de Ridder, Dennis Tedlock, Popol Vuh, The definitive edition of the Mayan Book of the Dawn of Life and the Glories of Gods and Kings, New York: Simon and Schuster, 1985. 380 pp., 32 ill. - G. van Roon, Dietmar Rothermund, Die Peripherie in der Weltwirtschaftskrise: Afrika, Asien und Lateinamerika 1929-1939, Paderborn: Ferdinand Schýningh, 1983, 295 pp. - Thilo C. Schadeberg, Gýnter Dabitz, Geschichte der erforschung der Nuba-Berge, Arbeiten aus dem Seminar fýr Výlkerkunde der Johann Wolfgang Goethe-Universitýt Frankfurt am Main, Band 17, Wiesbaden: Franz Steiner Verlag, 1985. 280 pp., maps, tables, illus. - L. van Vroonhoven, Ger van Roon, Derde Wereld in depressie, Leiden: Nijhoff, 1985, 139 p. - Wim van Zanten, Nigel Phillips, Sijobang, sung narrative poetry of West Sumatra, Cambridge Studies in Oral and Literate Culture, no. 1, Cambridge: Cambridge University Press, 1981. xi + 255 pp., photos, texts and translations, short glossary of Minangkabau words, Bibliography, index.
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