The features of the repair and construction work during the overhaul of buildings are reflected in the development of organizational and technological design documents, which include calendar plans. ...Organizational and technological models represent the basis for the development and calculation of calendar plans, as well as for determining resource requirements. They for prevention works, the order of their implementation, the nature of the relationship between individual works, reflecting the specifics of the selected technology for the production of work and the features of the simulated object. The scheduling of overhaul works is carried out on the basis of the developed methodology, which allows obtaining rational organizational and technological solutions with a low level of certainty of the initial information. To evaluate the final set of alternative options for calendar plans and choose the best option in accordance with the described methodology, it is recommended to use quasi metric methods. This allows us to lay the foundation for the rhythmic and coordinated work of all units involved in overhaul at the stage of scheduling, as well as to keep track of the possibility of ensuring timely completion of the planned work.
A study has been carried out on the spectral and photophysical parameters of a series of hydrophobic metallocomplexes of phthalocyanine and porphyrins encapsulated in polymeric micelles in aqueous ...solution at 293 K. The fluorescence characteristics of the free bases and metallocomplexes with light ions Mg(II) and Zn(II) are only slightly altered upon going from solution in organic solutions to aqueous micellar media. In contradistinction, encapsulation of porphyrin compounds with heavy ions Pd(II) and Pt(II) in polymeric micelles leads to much greater quantum yields and phosphorescence lifetimes in aqueous micellar media in comparison with these parameters in organic solvents. This behavior was attributed to enhancement of the spin-orbital interaction for the compounds with Pd(II) and Pt(II) compounds as well as to a significant reduction of quenching in the polymeric micelles. The luminescence parameters of the compounds studied depend on their structure and the nature of the polymeric micelles.
Abstract Physiologically high levels of circulating estradiol enhance the use of place learning and impair the use of response learning to find food on a land maze. These two types of learning are ...impaired by lesions of distinct neuronal structures, i.e. the hippocampus and striatum, respectively. Moreover, it has been shown in male rats that compromising hippocampal function can promote the use of response learning, while compromising striatal function can promote place learning. These findings suggest an ongoing competition between the hippocampus and striatum during cognition, such that intact functioning of one structure somehow obstructs the relative participation of the other. The goal of this study was to determine if estrogen’s opposing effects on place and response learning in female rats are due to direct actions, either independent or interacting, at the hippocampus and striatum. We infused 0.5 μM 17β-estradiol 3-sulfate sodium or vehicle bilaterally into the dorsal hippocampus or dorsolateral striatum of ovariectomized young adult female rats, 48, 24 and 2 h before training. Rats were tested on one of three appetitive tasks in a Y-maze: place learning, response learning, or response learning with reduced visual cues (cue-poor condition). Intrahippocampal estradiol infusions enhanced place learning, reversing a cannula-induced impairment, whereas intrastriatal infusions had no effects on place learning. Estradiol infusions into neither structure significantly affected response learning when extramaze cues were visible. However, in the response task, cue-poor condition, intrastriatal but not intrahippocampal infusions impaired learning. These data demonstrate that estrogen modulates place and response learning at the hippocampus and striatum respectively, most likely through independent actions at these two structures.
Assessment of quality and safety of red caviar of salmon fish Korol-Bezpala, L.; Bezpalyi, I.; Bondarenko, L. ...
Naukovij vìsnik Lʹvìvsʹkogo nacìonalʹnogo unìversitetu veterinarnoï medicini ta bìotehnologìj ìmenì S.Z. Gžicʹkogo. Serìâ: Harčovì tehnologìï,
04/2024, Letnik:
26, Številka:
101
Journal Article
Recenzirano
Odprti dostop
The health of the body largely depends on the necessary goods in the human diet. Therefore, quality and safety indicators are essential in monitoring their suitability. Red salmon caviar is no ...exception; it is considered a valuable food product and, due to its high price – a delicacy. Typically, this type of product must meet all regulatory requirements, which allows it to be safely used in the human diet. In terms of nutritional value, red caviar contains complete proteins, easily digestible fats, minerals, and vitamins, and its content is superior to that of some types of food products, even fish meat. The article presents the results of studies of organoleptic, physico-chemical, and microbiological indicators and the content of preservatives in salmon red granular salted caviar of 1st and 2nd grades sold in retail chains and markets in the Kyiv region. The study was carried out in laboratory conditions at the Research Institute of Food Technologies and Technologies for processing livestock products of the BNAU and the central testing state laboratory of the State Consumer Service (Vishnevoe). All indicators were determined using different methods intended for each indicator. Therefore, it was found that the organoleptic indicators of red caviar in both varieties corresponded to standard values. The mass fraction of sodium chloride and hexamine was within the normal range and did not exceed the standard indicators: sodium chloride – 8,57 % and 7,14 %, respectively (grades 1 and 2); methenamine – 70 % and 60 %, respectively (grades 1 and 2). According to microbiological indicators, the experimental samples showed that the number of MAFAnM did not exceed 1×102 CFU/g in both varieties, and the presence of yeast and mold fungi was detected no more than 10 CFU 1,0 g, which is 3 times less than the norm. The content of preservatives E200 1st and 2nd grades of red caviar was 0,07 % and 0,04 %, and E210 (1st and 2nd grades) 0,05 % and 0,03 %. Thus, all studied samples of red granular salmon caviar meet standard values for all indicators of quality and food safety.
Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent more than 10,000 years ago. Identifying genetic ...modifications underlying wheat’s domestication requires knowledge about the genome of its allo-tetraploid progenitor, wild emmer (T. turgidum ssp. dicoccoides). We report a 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity. With this fully assembled polyploid wheat genome, we identified the causal mutations in Brittle Rachis 1 (TtBtr1) genes controlling shattering, a key domestication trait. A study of genomic diversity among wild and domesticated accessions revealed genomic regions bearing the signature of selection under domestication. This reference assembly will serve as a resource for accelerating the genome-assisted improvement of modern wheat varieties.
Recently, increasingly more microsatellites, or simple sequence repeats (SSRs) have been found and characterized within protein-coding genes and their untranslated regions (UTRs). These data provide ...useful information to study possible SSR functions. Here, we review SSR distributions within expressed sequence tags (ESTs) and genes including protein-coding, 3'-UTRs and 5'-UTRs, and introns; and discuss the consequences of SSR repeat-number changes in those regions of both prokaryotes and eukaryotes. Strong evidence shows that SSRs are nonrandomly distributed across protein-coding regions, UTRs, and introns. Substantial data indicates that SSR expansions and/or contractions in protein-coding regions can lead to a gain or loss of gene function via frameshift mutation or expanded toxic mRNA. SSR variations in 5'-UTRs could regulate gene expression by affecting transcription and translation. The SSR expansions in the 3'-UTRs cause transcription slippage and produce expanded mRNA, which can be accumulated as nuclear foci, and which can disrupt splicing and, possibly, disrupt other cellular function. Intronic SSRs can affect gene transcription, mRNA splicing, or export to cytoplasm. Triplet SSRs located in the UTRs or intron can also induce heterochromatin-mediated-like gene silencing. All these effects caused by SSR expansions or contractions within genes can eventually lead to phenotypic changes. SSRs within genes evolve through mutational processes similar to those for SSRs located in other genomic regions including replication slippage, point mutation, and recombination. These mutational processes generate DNA changes that should be connected by DNA mismatch repair (MMR) system. Mutation that has escaped from the MMR system correction would become new alleles at the SSR loci, and then regulate and/or change gene products, and eventually lead to phenotype changes. Therefore, SSRs within genes should be subjected to stronger selective pressure than other genomic regions because of their functional importance. These SSRs may provide a molecular basis for fast adaptation to environmental changes in both prokaryotes and eukaryotes.
The current status of the effects of ovarian steroids on learning and memory remains somewhat unclear, despite a large undertaking to evaluate these effects. What is emerging from this literature is ...that estrogen, and perhaps progesterone, influences learning and memory, but does so in a task-dependent manner. Previously, we have shown that ovariectomized rats given acute treatments of estrogen acquire allocentric or “place” tasks more easily than do rats deprived of estrogen, but acquire egocentric or “response” learning tasks more slowly than do those deprived of hormone, suggesting that estrogen treatment may bias the strategy a rat is able to use to solve tasks. To determine if natural fluctuations in ovarian hormones influence cognitive strategy, we tested whether strategy use fluctuated across the estrous cycle in reproductively intact female rats. We found that in two tasks in which rats freely choose the strategy used to solve the task, rats were more likely to use place strategies at proestrous, that is, when ovarian steroids are high. Conversely, estrous rats were biased toward response strategies. The data suggest that natural fluctuations in ovarian steroids may bias the neural system used and thus the cognitive strategies chosen during learning and memory.
Significant advances in deep learning have led to more widely used and precise neural network-based generative models such as Generative Adversarial Networks (GANS). We introduce a post-hoc ...correction to deep generative models to further improve their fidelity, based on the Deep neural networks using the Classification for Tuning and Reweighting (DCTR) protocol. The correction takes the form of a reweighting function that can be applied to generated examples when making predictions from the simulation. We illustrate this approach using GANS trained on standard multimodal probability densities as well as calorimeter simulations from high energy physics. We show that the weighted GAN examples significantly improve the accuracy of the generated samples without a large loss in statistical power. This approach could be applied to any generative model and is a promising refinement method for high energy physics applications and beyond.
Abstract
Double white dwarf (DWD) binaries are expected to be very common in the Milky Way, but their intrinsic faintness challenges the detection of these systems. Currently, only a few tens of ...detached DWDs are know. Such systems offer the best chance of extracting the physical properties that would allow us to address a wealth of outstanding questions ranging from the nature of white dwarfs and thermonuclear supernovae, over stellar and binary evolution to mapping the Galaxy. In this paper, we explore the prospects for detections of ultra-compact (with binary separations of a few solar radii or less) detached DWDs in (1) optical radiation with Gaia and the Large Synoptic Survey Telescope (LSST) and (2) gravitational wave radiation with Large Synoptic Survey Telescope (LISA). We show that Gaia, LSST and LISA have the potential to detect, respectively, around a few hundred, a thousand and 25 thousand DWD systems. Moreover, Gaia and LSST data will extend by, respectively, a factor of 2 and 7 the guaranteed sample of LISA verification sources, binaries detectable in electromagnetic and gravitational wave radiation, opening the era of multimessenger astronomy for these sources.
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