In this paper, a novel bulk-driven cross-coupled charge pump designed in standard 90 nm CMOS technology is presented. The proposed charge pump is based on a dynamic threshold voltage inverter and is ...suitable for integrated ultra-low voltage converters. Due to a latchup risk, bulk-driven charge pumps can safely be used only in low-voltage applications. For the input voltage below 200 mV and output current of 1 uA, the proposed bulk-driven topology can achieve about 10 % higher efficiency than the conventional gate-driven cross-coupled charge pump. Therefore, it can be effectively used in DC-DC converters, which are the basic building blocks of on-chip energy harvesting systems with ultra-low supply voltage.
The CMS detector is a general-purpose apparatus that detects high-energy collisions produced at the LHC. Online data quality monitoring of the CMS electromagnetic calorimeter is a vital operational ...tool that allows detector experts to quickly identify, localize, and diagnose a broad range of detector issues that could affect the quality of physics data. A real-time autoencoder-based anomaly detection system using semi-supervised machine learning is presented enabling the detection of anomalies in the CMS electromagnetic calorimeter data. A novel method is introduced which maximizes the anomaly detection performance by exploiting the time-dependent evolution of anomalies as well as spatial variations in the detector response. The autoencoder-based system is able to efficiently detect anomalies, while maintaining a very low false discovery rate. The performance of the system is validated with anomalies found in 2018 and 2022 LHC collision data. In addition, the first results from deploying the autoencoder-based system in the CMS online data quality monitoring workflow during the beginning of Run 3 of the LHC are presented, showing its ability to detect issues missed by the existing system.
Improvements in meat quality are sought through sources of variation along the meat chain, including breed and production system. Hence, the aim of this study was to determine slaughter weight and ...sex effects on the meat quality of the indigenous Krškopolje pig breed reared in a feed-enriched indoor environment for the growing-finishing periods. Raised in this enriched environment, the intramuscular fat (IMF) content of the loin was 1.5–2.5% higher than previously reported for other production systems. Slaughter weight (119–132 kg or >135–170 kg) influences on meat colour and IMF composition were observed. Animals from the light group had lighter coloured meat with lower Japanese colour scores as well as higher saturated fatty acid (SFA) and lower monounsaturated fatty acid (MUFA) proportions in the IMF. A lower proportion of MUFA was also observed in the IMF from gilts than barrows. Furthermore, a higher proportion of SFA was found in the IMF from the gilts. However, the lower IMF content in the gilts negates any apparent compositional advantages between the sexes. The IMF content and composition of the Krškopolje pig reared in an enriched environment suggests good commercial potential of this breed.
Measurements of the cosmic microwave background (CMB) radiation can reveal with remarkable precision the conditions of the Universe when it was approximately 400,000 years old. The three most ...fundamental properties of the CMB are its frequency spectrum (which determines the temperature), and the fluctuations in both the temperature and polarization across a range of angular scales. The frequency spectrum has been well determined, and considerable progress has been made in measuring the power spectrum of the temperature fluctuations. But despite many efforts to measure the polarization, detection of this property of the CMB has hitherto been beyond the reach of even the most sensitive observations. Here we describe the Degree Angular Scale Interferometer (DASI), an array of radio telescopes, which for the past two years has conducted polarization-sensitive observations of the CMB from the Amundsen-Scott South Pole research station.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Minimal residual disease (MRD) detection using quantification of clone-specific Ig or TCR rearrangements before and after transplantation in children with high-risk ALL is an important predictor of ...outcome. The method and guidelines for its interpretation are very precise to avoid both false-negative and -positive results. In a group of 21 patients following transplantation, we observed detectable MRD positivities in Ig/TCR-based real-time quantitative PCR (RQ-PCR) leading to no further progression of the disease (11 of 100 (11%) total samples). We hypothesized that these positivities were mostly the result of nonspecific amplification despite the application of strict internationally agreed-upon measures. We applied two non-self-specific Ig heavy chain assays and received a similar number of positivities (20 and 15%). Nonspecific products amplified in these RQ-PCR systems differed from specific products in length and sequence. Statistical analysis proved that there was an excellent correlation of this phenomenon with B-cell regeneration in BM as measured by flow cytometry and Ig light chain-kappa excision circle quantification. We conclude that although Ig/TCR quantification is a reliable method for post transplant MRD detection, isolated positivities in Ig-based RQ-PCR systems at the time of intense B-cell regeneration must be viewed with caution to avoid the wrong indication of treatment.
Background: Long term Rehabilitation, Chronic Care, Palliative Dept. Physiotherapy Units accumulate elderly debilitated polymorbide sometimes homeless patients and hypomobile individuals with ...different levels of personal hygiene. Ectoparasites increase suffering from long term care and social services. Patients and Methods: The aim of this study was to compare the incidence of scabies among different types of hypomobile and vulnerable populations and compare homeless and elderly to refugees and migrants containing of hypermobile and wounded populations. Results: Among 22 homeless elderly, Group A; 42 homeless non-elderly high threshold Group B; 55 hypermobile migrants visiting a Rehabilitation and Physiotherapy Center, scabies was massively present in Group C. Among the first two Groups, Homeless A and Homeless B was rare. Increasing personal hygiene in stationary versus mobile Units, better Social Services and hygiene for homeless versus migrants, may be responsible for these unexpected findings. Conclusion: Scabies has to be considered as the commonest ectoparasite followed by louse and mice among physiotherapy and rehabilitation dependent hypomobile elderly homeless clients. However, its incidence among homeless in CEE among migrants via the Balkan Route is incomparably low.
Abstract
In concrete structures, we identify deformation fields of nodes with applied concentrated stress, which are accompanied by a change in the density and shape of force trajectories. These ...changes are caused by the presence of large grains of aggregate and/or reinforcing bars (inclusions) in the concrete, clumps of grains of normal size, or the presence of a cavern around the grain of the aggregate. These internal imperfections are among the important parameters that affect the failure process of concrete test specimens, and thus the initiation and development of cracks in concrete and can have a negative impact on the strength of concrete elements. This paper deals with the influence of the number of inclusions in their symmetrical arrangement on a series of test specimens of three different sizes, which are subjected to uniaxial compression. Attention is paid to the selection of a suitable standardization parameter, which will consider the different quality of concrete test specimens
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