A search of a person's residence or other property is one of the most typical and, at the same time, the most complex investigative ( search) actions. Its purpose is to identify, record factual data ...on the event of a criminal offence or related event, find and seize the instruments of a criminal offence, property acquired by illegal means or items excluded from use by law, as well as to establish the location of the wanted persons. This investigative (search) action is associated with the restriction of the rights of the person in whose residence or premises it is conducted, who may not even be involved in the commission of a criminal offence. For this reason, it is important to ensure that the search is conducted in compliance with a number of legal and organisational principles, as well as using a set of effective tactical techniques.
The legal basis for conducting a search is determined by the current criminal procedure legislation of Ukraine and the provisions of international legal treaties ratified by the Verkhovna Rada of Ukraine. With regard to the grounds for conducting a search, the actual grounds are the need to achieve the purpose set out in part 1 of Article 236 of the Criminal Procedure Code of Ukraine, and the legal grounds are the existence of a reasoned court decision in the form of a ruling by an investigating judge. At the same time, a large number of legal and normative regulations are subject to contradictions, which is why it is important to eliminate ambiguity in them, as well as to introduce into the practice of conducting searches proven tactical methods of applying this investigative (search) action.
Today, it is important to resolve the issues of unification of the provisions of the criminal procedural legislation of Ukraine in terms of regulating the procedure for technical recording of a search, determining the scope of recording of actions and circumstances of the search, as well as determining the powers of the defence counsel to involve a specialist in the search, etc. Given the importance and controversy of this issue, it requires further in-depth and comprehensive research.
In this paper we study analogues of the perfect splines for weighted Sobolev classes of functions defined on the half-line. Maximally oscillating splines play important role in the solution of ...certain extremal problems. In particular, using these splines, we characterize the modulus of continuity of the differential operator.
Computation-based drug-repurposing/repositioning approaches can greatly speed up the traditional drug discovery process. To date, systematic and comprehensive computation-based approaches to identify ...and validate drug-repositioning candidates for epithelial ovarian cancer (EOC) have not been undertaken. Here, we present a novel drug discovery strategy that combines a computational drug-repositioning system (DrugPredict) with biological testing in cell lines in order to rapidly identify novel drug candidates for EOC. DrugPredict exploited unique repositioning opportunities rendered by a vast amount of disease genomics, phenomics, drug treatment, and genetic pathway and uniquely revealed that non-steroidal anti-inflammatories (NSAIDs) rank just as high as currently used ovarian cancer drugs. As epidemiological studies have reported decreased incidence of ovarian cancer associated with regular intake of NSAIDs, we assessed whether NSAIDs could have chemoadjuvant applications in EOC and found that (i) NSAID Indomethacin induces robust cell death in primary patient-derived platinum-sensitive and platinum- resistant ovarian cancer cells and ovarian cancer stem cells and (ii) downregulation of β-catenin is partially driving effects of Indomethacin in cisplatin-resistant cells. In summary, we demonstrate that DrugPredict represents an innovative computational drug- discovery strategy to uncover drugs that are routinely used for other indications that could be effective in treating various cancers, thus introducing a potentially rapid and cost-effective translational opportunity. As NSAIDs are already in routine use in gynecological treatment regimens and have acceptable safety profile, our results will provide with a rationale for testing NSAIDs as potential chemoadjuvants in EOC patient trials.
A mild and highly efficient catalytic hydrosilylation protocol for room‐temperature ester reductions has been developed using diethylzinc as the catalyst. The methodology is operationally simple, ...displays high functional group tolerance and provides for a facile access to a broad range of different alcohols in excellent yields.
A mild and highly efficient catalytic hydrosilylation protocol for room‐temperature ester reductions has been developed using diethylzinc as the catalyst. The methodology is operationally simple, displays high functional group tolerance and provides for a facile access to a broad range of different alcohols in excellent yields.
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We present a new method for equilibration of faceted nanoparticles obtained by solid state agglomeration (dewetting) of metal thin films. The method relies on crystalline defects ...introduced in the particles by the atomic force microscopy-based indentation and tapping. The developed method was employed for statistically based determination of the Au {111}/sapphire {0001} interfacial energy, with the result (2.11±0.08J/m2) being in good agreement with the values reported in the literature.
Structural quality and stability of nanocrystals are fundamental problems that bear important consequences for the performances of small-scale devices. Indeed, at the nanoscale, their functional ...properties are largely influenced by elastic strain and depend critically on the presence of crystal defects. It is thus of prime importance to be able to monitor, by noninvasive means, the stability of the microstructure of nano-objects against external stimuli such as mechanical load. Here we demonstrate the potential of Bragg coherent diffraction imaging for such measurements, by imaging in 3D the evolution of the microstructure of a nanocrystal exposed to in situ mechanical loading. Not only could we observe the evolution of the internal strain field after successive loadings, but we also evidenced a transient microstructure hosting a stable dislocation loop. The latter is fully characterized from its characteristic displacement field. The mechanical behavior of this small crystal is clearly at odds with what happens in bulk materials where many dislocations interact. Moreover, this original in situ experiment opens interesting possibilities for the investigation of plastic deformation at the nanoscale.
The initial stages of solid-state dewetting of 25nm-thick Fe films on basal plane-oriented sapphire substrates were found to occur via nucleation and growth of through-thickness craters within the ...film. The rims along these voids were not elevated, in contrast to commonly observed void growth mechanisms. Instead, the material that was consumed during the crater expansion was absorbed by several isolated grains in its vicinity but not adjacent to it. These grains transformed into faceted hillocks that protruded above the original film surface at later stages. A thin film dewetting model is proposed, in which the self-diffusion of Fe atoms along the grain boundaries transports the mass from the expanding cavities to the hillocks and determines the kinetics of this dilation. The grain boundary self-diffusion coefficients of Fe that were estimated based on the experimentally determined crater expansion rates and the proposed model agreed well with the literature.
Photoelectron excitations into unoccupied energy states are fundamental in solid-state physics and many modern applications. The operation of such internal electronic transitions relies not only on ...photon absorption efficiency, which is pivotal in sensing, photovoltaics, active plasmonics, etc., but also on light–matter interactions and near/far-field spectroscopic techniques. Here, we report on a spectroscopic absorption fingerprint in magnetic circular dichroism (MCD) responses of various nanoparticulate systems. MCD spectra acquired at low temperatures on assemblies of uncoupled/coupled Ag and Au nanoparticles reveal asymmetric MCD spectral line shapes strongly depending on the nature and shape of nanoparticles and on their interparticular interactions. Assembling for instance the NPs into 2D networks with interparticle distances allowing dipolar interactions or transforming the spherical nanoparticles into disks was found to significantly alter the magneto-optic response in the spectral line shape. The findings are interpreted within the framework of chiral magneto-plasmonic effects by considering the k-dependent electronic states involved in both inter- and intraband electronic transitions.
A novel electron deficient 4,6-bis(trifluoromethyl)-1,3-phenylene diphosphinite ligand 4 was developed and synthesized. Reaction of Ir precursors with ligand 4 gave chloro(hydride) pincer complex 5, ...which demonstrated a higher TON in alkane dehydrogenation reactions compared to similar phosphinite based pre-catalysts. The formation of cyclooctene (COE) and tert-butylethylene adducts of the 14e catalysts was also studied and the COE adduct is implicated as the resting state of the catalyst. All compounds were characterized by NMR spectroscopy and, in addition, the molecular structures of key complexes were confirmed by X-ray analysis.
The equilibrium crystal shape of iron Kovalenko, O.; Chikli, F.O.; Rabkin, E.
Scripta materialia,
October 2016, 2016-10-00, 20161001, Letnik:
123
Journal Article
Recenzirano
We demonstrate that plastic deformation of submicrometer-size supported Fe particles by a hard diamond tip accelerates the evolution of their shape during annealing at the temperature of 880°C, below ...the α-γ transformation temperature. Employing statistical criteria for equilibration, we found that equilibrated α-Fe crystals exhibit {011}, {001}, {111}, and {112} facets. The work of adhesion of α-Fe to the basal plane of sapphire was found to be 2.3J/m2.
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