Ausstellungen entwickeln sich ständig weiter, insbesondere durch interdisziplinäre Impulse. Vor diesem Hintergrund diskutieren die Beiträger*innen neue, selbstreflexive Herangehensweisen aus ...Forschung und Praxis. Den Ausgangspunkt dafür bildet das Projekt der DASA Arbeitswelt Ausstellung zum Thema Storytelling. Im Fokus stehen zum einen innovative Ansätze des Kuratierens und Gestaltens von Ausstellungen, zum anderen deren Evaluation und Analyse. Die Beiträge fordern dazu auf, unter der Devise »Neues ausprobieren, Ziele evaluieren, Zusammenhänge analysieren« weiter über »besseres« Ausstellen nachzudenken.
Materialitäten lassen sich in Figuren des Zyklischen denken: Dinge sind in eine Reihe von zyklisch ablaufenden Prozessen involviert und haben selbst Lebenszyklen, die sich der Wahrnehmung entziehen. ...Kulturelle Zyklographie der Dinge untersucht Verfahren/Techniken der Darstellung, Erzählung und Visualisierung von Lebenszyklen der Artefakte. Von fiktiven Ding-Autobiographien und Genres wie den It-Narratives über Reportagen bis hin zu wissenschaftlichen Objektbiographien und Technologien wie Dingtracking und dem Internet of Things reichen die Strategien, mit denen versucht wird, die stummen Dinge zum Sprechen zu bringen. Der Band vereint kultur-, medien-, und literaturwissenschaftliche Ansätze einer Betrachtung von Dingen in Kreisläufen. Dabei geraten Prozesse und Operationen in den Blick, in denen das Dingfeste und Formstabile der Kultur ins ,,Schwimmen" gerät. The book argues for theorizing material culture in categories cyclical and circular processes underlying the materiality and mediality of things. The basic assumption is that a constantly shifting formation of devices, methods, techniques, and technologies is responding to a need to overcome the opacity of the circulation and life cycles of artifacts. The book explores thing-cyclographical formats such as It-Narratives, the avant-gardist literatura fakta, scientific, aesthetic, documentarist object biographies in different media, and tracking-technologies in logistics.
Textile work can be interpreted as physical evidence of human thought and actions. Generally artifacts are examined and interpreted as a material expression of culture. This article offers another ...way of looking at textile patterns, focusing on their production processes. Consequently, textile techniques need to be described in order to demonstrate the constitutional skills of textile patterns. The analysis of textile pattern is, according to this thesis, not undertaken within a style or design history or as part of theories on ornament. A techno-morphological description reflects on spatial conditions and production techniques.
The formulated definition of the term "pattern" introduces the ideas of rhythm, symmetry, repetition, and dimension. These keywords lead to further reflections on patterns of more general interest. Research in different disciplines, predominantly in the natural sciences, deals with all kind of patterns. Cognitive sciences state that pattern matching and pattern construction are required means of complexity reduction, a key function of human behavior. The prerequisites for pattern recognition, the significance of patterns, and its cultural implications within scientific theory are usually not discussed. Here, pattern analysis is proposed as an analytical tool in the search for subjective influences, e.g. in scientific display. Formulating the epistemological function of patterns may benefit interdisciplinary research and support the interface between cultural and natural sciences.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A comparison of overlapping proximity captures at the head region of the ribosomal 40S subunit (
) in
from four adjacent perspectives, namely Asc1/RACK1, Rps2/uS5, Rps3/uS3, and Rps20/uS10, ...corroborates dynamic co-localization of proteins that control activity and fate of both ribosomes and mRNA. Co-locating factors that associate with the
are involved in (i) (de)ubiquitination of ribosomal proteins (Hel2, Bre5-Ubp3), (ii) clamping of inactive ribosomal subunits (Stm1), (iii) mRNA surveillance and vesicular transport (Smy2, Syh1), (iv) degradation of mRNA (endo- and exonucleases Ypl199c and Xrn1, respectively), (v) autophagy (Psp2, Vps30, Ykt6), and (vi) kinase signaling (Ste20). Additionally, they must be harmonized with translation initiation factors (eIF3, cap-binding protein Cdc33, eIF2A) and mRNA-binding/ribosome-charging proteins (Scp160, Sro9). The Rps/uS-BioID perspectives revealed substantial Asc1/RACK1-dependent
configuration indicating a function of the β-propeller in context-specific spatial organization of this microenvironment. Toward resolving context-specific constellations, a Split-TurboID analysis emphasized the ubiquitin-associated factors Def1 and Lsm12 as neighbors of Bre5 at
. These shuttling proteins indicate a common regulatory axis for the fate of polymerizing machineries for the biosynthesis of proteins in the cytoplasm and RNA/DNA in the nucleus.
Abstract
Recent oncological studies identified beneficial properties of radiation applied at ultrahigh dose rates, several orders of magnitude higher than the clinical standard of the order of Gy min
...–1
. Sources capable of providing these ultrahigh dose rates are under investigation. Here we show that a stable, compact laser-driven proton source with energies greater than 60 MeV enables radiobiological in vivo studies. We performed a pilot irradiation study on human tumours in a mouse model, showing the concerted preparation of mice and laser accelerator, dose-controlled, tumour-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumour growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source. The results demonstrate a complete laser-driven proton research platform for diverse user-specific small animal models, able to deliver tunable single-shot doses up to around 20 Gy to millimetre-scale volumes on nanosecond timescales, equivalent to around 10
9
Gy s
–1
, spatially homogenized and tailored to the sample. The platform provides a unique infrastructure for translational research with protons at ultrahigh dose rates.
Abstract
The ongoing SARS-CoV-2 pandemic necessitates the fast development of vaccines. Recently, viral mutants termed variants of concern (VOC) which may escape host immunity have emerged. The ...efficacy of spike encoding mRNA vaccines (CVnCoV and CV2CoV) against the ancestral strain and the VOC B.1.351 was tested in a K18-hACE2 transgenic mouse model. Naive mice and mice immunized with a formalin-inactivated SARS-CoV-2 preparation were used as controls. mRNA-immunized mice develop elevated SARS-CoV-2 RBD-specific antibody and neutralization titers which are readily detectable, but significantly reduced against VOC B.1.351. The mRNA vaccines fully protect from disease and mortality caused by either viral strain. SARS-CoV-2 remains undetected in swabs, lung, or brain in these groups. Despite lower neutralizing antibody titers compared to the ancestral strain BavPat1, CVnCoV and CV2CoV show complete disease protection against the novel VOC B.1.351 in our studies.
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