Highlights • Actual spaceflight considerably decreased BCL-XL gene expression in the hypothalamus. • Long-term spaceflight significantly increased BCL-XL gene expression in the hippocampus. • Actual ...spaceflight considerably reduced BCL-XL gene expression in the striatum. • Shuttle cabin housing also considerably reduced BCL-XL gene expression in the striatum. • Long-term spaceflight failed to affect BAX, BDNF, TrkB and p75 gene expression.
Expression of choline acetyltransferase, 200-kDa neurofilament protein, 28-kDa calbindin, neuronal NO synthase, caspase 3, and Ki-67 in the motor neurons of spinal cord segments T3-T5 in male C57Bl/6 ...mice after 30-day space flight in the Bion-M1 biosatellite was studied by immunohistochemical methods. Under conditions space flight, the size of motoneurons increased, the number of neurons containing choline acetyltransferase and neurofilaments, decreased, and the number of calbindin-positive neurons increased; motoneurons, expressing neuronal NO synthase and caspase 3 appeared, while Ki-67 was not detected. Fragmentation of neurons with the formation structures similar to apoptotic (residual) bodies was observed in individual caspase 3-positive motoneurons.
Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight ...decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT
1A
, and 5-HT
3
receptor genes, though it reduced 5-HT
2A
receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT
2A
receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.
This paper highlights the manufacturing process of two types of betavoltaic cells with a source coated with 63Ni: the flat one and one with a three-dimensional (3D) microchannel structure, obtained ...by anodizing silicon (Si). Thin-layer deposition of a nickel-63 radionuclide was carried out from the ammonium-citrate based electrolyte solution, designed for production until exhaustion.
A
bstract
We present the study of the decay
J/ψ
→
ρπ
. The results are based on of 5.2 million
J/ψ
events collected by the KEDR detector at the VEPP-4M collider. The branching fractions are measured ...to be
B
(
J/ψ
→
ρπ
) = (2
.
072 ± 0
.
017 ± 0
.
062) ∙ 10
−
2
and
B
(
J/ψ
→
π
+
π
−
π
0
) = (1
.
878 ± 0
.
013 ± 0
.
051) ∙ 10
−
2
, where the first uncertainties are statistical and the second systematic. Our results are more precise than the previous relative measurements.
The beam energy measurement system (BEMS) for the upgraded Beijing electron–positron collider BEPC-II is described. The system is based on measuring the energies of Compton back-scattered photons. ...The relative systematic uncertainty of the electron and positron beam energy determination is estimated as 2×10−5. The relative uncertainty of the beam's energy spread is about 6%.
In the paper a manufacturing process of three-dimensional (3D) microchannel structure by silicon (Si) anodic etching was discussed. The possibility of microchannels formation allows to increase the ...active area more than 100 times. In this structure the p-n junction on the whole Si surface was formed. The obtained data allowed to evaluate the characteristics of the betavoltaic converter with a 3D structure by using isotope 63Ni with a specific activity of 10Ci/g.
•The microchannels formation possibility increases the active area more than 100 times.•p-n junction on Si surface was formed.
Using the 1.32
pb
-
1
statistics collected at the
J
/
ψ
peak with the KEDR detector at the VEPP-4M
e
+
e
-
collider, we measured the branching fractions of
J
/
ψ
meson decays to the final states 2(
π
...+
π
-
)
π
0
,
K
+
K
-
π
+
π
-
π
0
, 2(
π
+
π
-
)
and
K
+
K
-
π
+
π
-
. The results obtained for the decays
J
/
ψ
→
2(
π
+
π
-
)
π
0
,
J
/
ψ
→
K
+
K
-
π
+
π
-
π
0
contradict the measurements performed by other groups in the last century, but agree well with recent results of BABAR and BESIII collaborations.
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