We provide the first results from the complete SNAD adaptive learning pipeline in the context of a broad scope of data from large-scale astronomical surveys. The main goal of this work is to explore ...the potential of adaptive learning techniques in application to big data sets. Our SNAD team used Active Anomaly Discovery (AAD) as a tool to search for new supernova (SN) candidates in the photometric data from the first 9.4 months of the Zwicky Transient Facility (ZTF) survey, namely, between March 17 and December 31 2018 (58194 < MJD < 58483). We analysed 70 ZTF fields at a high galactic latitude and visually inspected 2100 outliers. This resulted in 104 SN-like objects being found, 57 of which were reported to the Transient Name Server for the first time and with 47 having previously been mentioned in other catalogues, either as SNe with known types or as SN candidates. We visually inspected the multi-colour light curves of the non-catalogued transients and performed fittings with different supernova models to assign it to a probable photometric class: Ia, Ib/c, IIP, IIL, or IIn. Moreover, we also identified unreported slow-evolving transients that are good superluminous SN candidates, along with a few other non-catalogued objects, such as red dwarf flares and active galactic nuclei. Beyond confirming the effectiveness of human-machine integration underlying the AAD strategy, our results shed light on potential leaks in currently available pipelines. These findings can help avoid similar losses in future large-scale astronomical surveys. Furthermore, the algorithm enables direct searches of any type of data and based on any definition of an anomaly set by the expert.
Cells of human aorta were isolated by dispersing the tissue with collagenase and elastase. The isolated cells were stained in suspension by the acridine orange fluorescent stain. The intensity of red ...fluorescence (greater than 580 nm) corresponding to the RNA content was measured in each individual cell and registered in a FACS II flow cytofluorometer. It was established that a cell population of human aorta is heterogenous with respect to RNA content. In a population of isolated cells, one can distinguish two subpopulations: (A) small cells with low RNA content, and (B) large cells with high RNA content. The ratio of both cell types varies in intima and media, and different types of atherosclerotic lesions. The share of cells belonging to subpopulation A is lower in media compared to intima. In intima, the number of these cells grows with the degree of atherosclerotic lesion. Possible reasons for the discovered metabolic heterogeneity of human aortic cells and prospects for the application of flow cytofluorometry to a research into cellular mechanisms of atherosclerosis is discussed.
Adult human aortic cells have different shapes in situ. To determine whether populations of cultured aortic cells are also polymorphic, a technique for separation of cells from the intimal and medial ...layers of the human aorta by enzymatic dispersion of the vascular tissue was employed. It was established that aortic cells are polymorphic in primary culture, at least within the first 7 days after seeding. Four main morphological cell types were identified--elongated, asymmetric, polygonal, and stellate. Polygonal and stellate cells are found only in cultures of grossly normal intima. Elongated and asymmetric cells are present in practically all cultures. The ratio of elongated to asymmetric cells in cultures obtained from healthy aortas and atherosclerotic plaques is more or less the same and is approximately 3:1. In cultures of fatty streaks, the portion of asymmetric cells exceeds 50%. With immunofluorescent staining and ultra-structural analysis, cells of all four types were identified as smooth muscle. Possible reasons for the cells polymorphism in primary culture and the prospects of utilizing this culture method in the investigation of cellular aspects of atherogenesis are discussed.
There was an unprecedented opportunity to study the inner dust coma environment, where the dust and gas are not entirely decoupled, of comets 45P/Honda-Mrkos-Pajdu\u{s}áková (45P/HMP) from Dec. 26, ...2016 - Mar. 15, 2017, and 46P/Wirtanen from Nov. 10, 2018 - Feb. 13, 2019, both in visible wavelengths. The radial profile slopes of these comets were measured in the R and HB-BC filters most representative of dust, and deviations from a radially expanding coma were identified as significant. The azimuthally averaged radial profile slope of comet 45P/HMP gradually changes from -1.81 \(\pm\) 0.20 at 5.24 days pre-perihelion to -0.35 \(\pm\) 0.16 at 74.41 days post perihelion. Contrastingly, the radial profile slope of 46P/Wirtanen stays fairly constant over the observed time period at -1.05 \(\pm\) 0.05. Additionally, we find that the radial profile of 46P/Wirtanen is azimuthally dependent on the skyplane-projected solar position angle, while that of 45P/HMP is not. These results suggest that comet 45P/HMP and 46P/Wirtanen have vastly different coma dust environments and that their dust properties are distinct. As evident from these two comets, well-resolved inner comae are vital for detailed characterization of dust environments.
We report on the MASTER Global Robotic Net discovery of an eclipsing binary, MASTER OT J095310.04+335352.8, previously known as unremarkable star TYC 2505-672-1, which displays extreme orbital ...parameters. The orbital period P=69.1 yr is more than 2.5 times longer than that of epsilon-Aurigae, which is the previous record holder. The light curve is characterized by an extremely deep total eclipse with a depth of more than 4.5 mag, which is symmetrically shaped and has a total duration of 3.5 yrs. The eclipse is essentially gray. The spectra acquired with the Russian 6 m BTA telescope both at minimum and maximum light mainly correspond to an M0-1III--type red giant, but the spectra taken at the bottom of eclipse show small traces of a sufficiently hot source. The observed properties of this system can be better explained as the red giant eclipsed by a large cloud (the disk) of small particles surrounding the invisible secondary companion.
During its four years of photometric observations, the Kepler space telescope detected thousands of exoplanets and exoplanet candidates. One of Kepler's greatest heritages has been the confirmation ...and characterization of hundreds of multi-planet systems via Transit Timing Variations (TTVs). However, there are many interesting candidate systems displaying TTVs on such long time scales that the existing Kepler observations are of insufficient length to confirm and characterize them by means of this technique. To continue with Kepler's unique work we have organized the "Kepler Object of Interest Network" (KOINet). The goals of KOINet are, among others, to complete the TTV curves of systems where Kepler did not cover the interaction timescales well. KOINet has been operational since March, 2014. Here we show some promising first results obtained from analyzing seven primary transits of KOI-0410.01, KOI-0525.01, KOI-0760.01, and KOI-0902.01 in addition to Kepler data, acquired during the first and second observing seasons of KOINet. While carefully choosing the targets we set demanding constraints about timing precision (at least 1 minute) and photometric precision (as good as 1 part per thousand) that were achieved by means of our observing strategies and data analysis techniques. For KOI-0410.01, new transit data revealed a turn-over of its TTVs. We carried out an in-depth study of the system, that is identified in the NASA's Data Validation Report as false positive. Among others, we investigated a gravitationally-bound hierarchical triple star system, and a planet-star system. While the simultaneous transit fitting of ground and space-based data allowed for a planet solution, we could not fully reject the three-star scenario. New data, already scheduled in the upcoming 2018 observing season, will set tighter constraints on the nature of the system.
Having a need to perform differential photometry for tens of thousands stars in a several square degrees field, we developed Astrokit program. The software corrects the star brightness variations ...caused by variations of atmospheric transparency: to this end, the program selects for each star an individual ensemble of reference stars having similar magnitudes and positions in the frame. With ten or more reference stars in the ensemble, the differences between their spectral types and the spectral type of the object studied become unimportant. Astrokit searches for variable stars using Robust Median Statistics criterion, which allows candidate variables to be selected more efficiently than by analyzing the standard deviation of star magnitudes. The software allows very precise automatic analysis of long inhomogeneous sets of photometric observations of a large number of objects to be performed, making it possible to find "hot Jupiter" type exoplanet transits and low-amplitude variables. We describe the algorithm of the program and the results of its application to reduce the data of the photometric sky survey in Cygnus as well as observations of the open cluster NGC188 and the transit of the exoplanet WASP-11 b / HAT-P-10 b, performed with the MASTER-II-URAL telescope of the Kourovka Astronomical Observatory of the Ural Federal University.
Cells isolated from a fixed adult human aorta by alcoholic-alkaline dissociation retain their intrinsic shape. They are represented by four major morphological types: stellate, elongated, elongated ...with side processes, and irregularly shaped cells. All the four types of cells were found in the elastic-hyperplastic intimal sublayer ; elongated and irregularly shaped cells were mainly observed in the musculoelastic sublayer and in the media. Cell density in the atherosclerotic lesion is higher than normal, the number of stellate cells being increased more substantially compared to other cell types. The origin of stellate cells and other morphological cell types, and reasons for their disproportionate accumulation in the atherosclerotic intima are discussed.
A technique has been developed for isolating cells from the intimal and medial layers of the human aorta by enzymatic dispersion. After mechanical separation of intima, media and adventitia the ...intima and the media were dispersed by collagenase and elastase. Enzyme-isolated cells seeded in the culture with at a frequency of 30 to 50%. In the primary culture differentiated aortic cells were morphologically heterogenous. It was possible to define four main types of cells according to their shape: polygonal, elongated, asymmetrical and stellate. Polygonal and stellate cells are found only in cultures of grossly normal intima, whereas elongated and asymmetric cells are found in practically all cultures. The ratio of elongated to asymmetric cells in cultures obtained from healthy aorta and atherosclerotic plaque is more or less the same at approximately 3:1. In cultures of fatty streaks the proportion of asymmetric cells exceeds 50%. Using immunofluorescence, all four types of cell were identified as smooth muscle cells. The possible reasons for the cellular polymorphism in primary culture and the prospects of utilizing this culture for the study of cellular aspects of atherosclerosis' pathogenesis are discussed.
In this paper we present the high resolution spectral observations of the fragment of lunar surface during the total lunar eclipse of December 10, 2011. The observations were carried out with the ...fiber-fed echelle spectrograph at 1.2-m telescope in Kourovka Astronomical observatory (Ural mountains, central Russia). The observed radiation is transferred by tangent trajectory through the southern polar stratosphere before the reflection from the Moon and spectra contain a number of absorption bands of atmospheric gases (O2, O3, O4, NO2, H2O). High resolution analysis of three O2 bands and O4 absorption effects is used to trace the effective trajectory of solar emission through the stratosphere and to detect the contribution of scattered light. Bands of other gases allow us to measure their abundances along the trajectory.
