Experimental rats were given rations with 100% substitution of fats for phospholipid concentrate, during 1 and 3 months. It was found that such rations produced hypolipidemic and hypocholesterolemic ...effects, that were most pronounced at the end of the experiment. A control ration with sunflower oil containing high levels of unsaturated fatty acids induced accumulation of lipid peroxides in the hepatic tissue and blood plasma of the animals fed with the ration during 3 months. The ration containing the phospholipid concentrate did not produce such an effect. The data obtained have evidenced a positive influence of the phospholipid concentrate on the lipid metabolism parameters studied.
Animals received saccharol adequate (by sweetness) to sugar, and in 10- and 50-fold increased amounts. The data of chronic 10-month experiments studied in the time course after 2, 5, 10 months have ...permitted a conclusion that saccharol included into the ration during long periods, does not produce a significant effect on the parameters of metabolic processes and morphological picture of the internal organs in test animals. Saccharol in 50-fold increased amounts inhibits the activity of oxidative phosphorylation in the hepatic tissue of rats.
A study was made of the internal organs of rats fed the meat of agricultural animals whose diet included non-protein nitrogen-containing compounds--urea, isobutylidene diurea and a polymer, carbamide ...with polyacrylamide. Morphological studies have demonstrated that inclusion into the diet of experimental rats of the meat of young bulls given isobutylidene diurea and urea leads to structural alterations in the internal organs of rats, the most pronounced alterations being detected in experiments with the use of the meat of young bulls given isobutylidene diurea. The feeding of experimental rats with the meat of animals grown with the use of the polymer did not affect the morphofunctional status of their organs.
It has been extablished that in the course of protein starvation in dogs, parenteral administration of amikin or aminozol normalizes, to a greater of less extent, the disturbed metabolism of ...proteins, nucleoproteins, glycogen and lipids. Electron microscopy has shown that the ingredients of the preparations enter the cells at an equal intensity from the microcirculatory bed by means of active transendothelial transport. In the course of utilization of the substances supplied to the cells, no marked changes were seen in protein synthesis or in its participation in intracellular reparative regeneration. There occurs a pronounced cytosegresomal response to unutilized substances accumulated by hepatocytes. The clinical efficacy of the preparations used is related to the processes of gluconeognesis of amino acids supplied as a result of which energy formation does not require structural or endogenously formed protein.
