BACKGROUND AND OBJECTIVE:Epidural volume extension via a combined spinal-epidural is the enhancement of a small-dose intrathecal block by an epidural injection of physiological saline solution. We ...evaluated the effect of epidural volume extension on the combined spinal-epidural technique of providing spinal anaesthesia for Caesarean section with hyperbaric or plain 0.5% bupivacaine.
METHODS:Patients (n = 240) with height >163 cm received 9 mg and patients <163 cm received 8 mg of bupivacaine. Each study drug was combined with 20 μg fentanyl. Using the combined spinal-epidural technique, Group A (n = 60) received hyperbaric bupivacaine, and Group B (n = 60) received hyperbaric bupivacaine and 10 mL saline epidurally 5 min after subarachnoid injection. Group C (n = 60) received plain bupivacaine and Group D (n = 60) received plain bupivacaine and 10 mL saline epidurally 5 min after subarachnoid injection. An anaesthetist blinded to the anaesthetic solution injected examined the level of analgesia by the pinprick method and motor block with the modified Bromage scale for 30 min after subarachnoid injection, during the intraoperative period and subsequently every 15 min for 135 min during the recovery period.
RESULTS:Time to reach a sensory block at T4 was significantly shorter in Groups C and D than in Groups A (P = 0.003 and 0.017) and B (P = 0.006 and 0.048), respectively. During the intraoperative period, sensory block levels were significantly higher in Group C than in Group A. Recovery was similar in all groups; only onset was faster in Groups C and D.
CONCLUSION:There was no effect of epidural volume extension on the profile of spinal anaesthesia with the combined spinal-epidural technique for Caesarean section using hyperbaric or plain bupivacaine.
We investigated whether epidural magnesium sulfate administration can produce motor blockade and/or sensory blockade in rabbits. Control animals (group C) received 1.2 ml isotonic saline, group M ...received 1 ml 15% (150 mg) magnesium sulfate and 0.2 ml isotonic saline (to flush the catheter), while group L received 1 ml 1% lignocaine and 0.2 ml isotonic saline. On the 1st day, somatosensory evoked potentials (SEPs) were recorded; on the 2nd day, motor blockade was evaluated, and the heart rate, mean arterial pressure (MAP), serum PaCO2, and serum magnesium level were measured. Compared with groups C and M, the MAP in group L was significantly reduced at the 2nd–5th, 15th, and 30th min. Significant motor blockade was found only in group L. No significant difference was found in a comparison of the latencies and amplitudes of SEP waves P and N between groups. Comparisons within the groups showed that the P1 wave latency in group C significantly increased at the 15th min, while the latency of wave N1 showed a significant decrease at the 60th min in group M. The latencies of the N1 and P1 waves showed significant increases at the 5th min in group L. Thus, our study showes that epidural administration of 150 mg magnesium sulfate in rabbits produces no motor or sensory blockade.
Epidural volume extension and role of baricity Kucukguclu, S; Gunenc, F; Kuvaki, B ...
European journal of anaesthesiology,
2008-July, 2008-07-00, Letnik:
25, Številka:
7
Journal Article
Summary
We investigated whether insertion of the disposable Soft Seal laryngeal mask airway (SSLM) was successful without intra‐oral digital manipulation. One hundred patients undergoing anaesthesia ...using the SSLM were randomly assigned into two groups. Insertion was performed by either a direct or a rotational technique, both without intra‐oral digital manipulation. The primary outcome measure was successful insertion at first attempt. Other outcomes included insertion time, fibreoptic assessment of the airway view and airway morbidity. The first attempt success rate was higher (98%) with the direct technique than with the rotational technique (75%; p = 0.002) but insertion time was faster with the latter method (mean range 15 8–50 s) than with the direct method (20 8–56 s; p = 0.035). Fibreoptic assessment and airway morbidity were similar in both groups. We conclude that the SSLM can be successfully inserted without intra‐oral digital manipulation.
Background: Multiple-dose activated charcoal may enhance the enterocapillary clearance of vancomycin. Case Report: A 17-day-old female neonate born with congenital meningomyelocele and Arnold-Chiari ...malformation was iatrogenically overdosed with a 500 mg intravenous bolus of vancomycin during a shunt operation. The Red Man's Syndrome developed within minutes, characterized by sudden hypotension, skin rash and cyanosis. Serum vancomycin level at one hour after the injection was 165.7 μg/mL, as measured by an enzyme immunoassay method (EMIT
9
). Multiple dose activated charcoal, 1 g/kg, was first given five hours after injection, and continued every four hours for 12 doses. The half-life of vancomycin during charcoal administration was calculated to be 9.4 h or less than the reported 13.4-33. 7h half-life in normal neonates. The neonate's renal function tests and brainstem auditory responses remained normal. Conclusions: Gastrointestinal dialysis with multiple-dose activated charcoal without cathartics appeared to shorten the elimination half-life of vancomycin.
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