Context. A study of the mass loss enhancement for very close "Hot Jupiters" due to the gravitational field of the host star is presented. Aims. The influence of the proximity to a planet of the Roche ...lobe boundary on the critical temperature for blow-off conditions for estimating the increase of the mass loss rate through hydrodynamic blow-off for close-in exoplanets is investigated. Methods. We consider the gravitational potential for a star and a planet along the line that joins their mass centers and the energy balance equation for an evaporating planetary atmosphere including the effect of the stellar tidal force on atmospheric escape. Results. By studying the effect of the Roche lobe on the atmospheric loss from short-periodic gas giants we derived reasonably accurate approximate formulas to estimate atmospheric loss enhancement due to the action of tidal forces on a "Hot Jupiter" and to calculate the critical temperature for the onset of "geometrical blow-off", which are valid for any physical values of the Roche lobe radial distance. Using these formulas, we found that the stellar tidal forces can enhance the hydrodynamic evaporation rate from TreS-1 and OGLE-TR-56b by about 2 fold, while for HD 209458b we found an enhancement of about 50%. For similar exoplanets which are closer to their host star than OGLE-TR-56b, the mass loss enhancement can be even larger. Moreover, we showed that the effect of the Roche lobe allows "Hot Jupiters" to reach blow-off conditions at temperatures which are less than expected due to the stellar X-ray and EUV heating.
A new method of obtaining magnetic porous composite materials is described, which is based on the self-propagating high-temperature synthesis (SHS) in the form of solid-phase combustion. The SHS ...process involves transformation of the nonmagnetic α-Fe
2
O
3
particles (contained in the initial mixture) into magnetic Fe
3
O
4
particles. The synthesized material comprises a porous carbonaceous matrix with immobilized Fe
3
O
4
particles. The obtained composite has been characterized by electron microscopy, X-ray diffraction, Mössbauer spectroscopy, and magnetic measurements. The sorption capacity of the porous material has been studied.
What makes a planet habitable? Lammer, H.; Bredehöft, J. H.; Coustenis, A. ...
The Astronomy and astrophysics review,
06/2009, Letnik:
17, Številka:
2
Journal Article
Recenzirano
This work reviews factors which are important for the evolution of habitable Earth-like planets such as the effects of the host star dependent radiation and particle fluxes on the evolution of ...atmospheres and initial water inventories. We discuss the geodynamical and geophysical environments which are necessary for planets where plate tectonics remain active over geological time scales and for planets which evolve to one-plate planets. The discoveries of methane–ethane surface lakes on Saturn’s large moon Titan, subsurface water oceans or reservoirs inside the moons of Solar System gas giants such as Europa, Ganymede, Titan and Enceladus and more than 335 exoplanets, indicate that the classical definition of the habitable zone concept neglects more exotic habitats and may fail to be adequate for stars which are different from our Sun. A classification of four habitat types is proposed. Class I habitats represent bodies on which stellar and geophysical conditions allow Earth-analog planets to evolve so that complex multi-cellular life forms may originate. Class II habitats includes bodies on which life may evolve but due to stellar and geophysical conditions that are different from the class I habitats, the planets rather evolve toward Venus- or Mars-type worlds where complex life-forms may not develop. Class III habitats are planetary bodies where subsurface water oceans exist which interact directly with a silicate-rich core, while class IV habitats have liquid water layers between two ice layers, or liquids above ice. Furthermore, we discuss from the present viewpoint how life may have originated on early Earth, the possibilities that life may evolve on such Earth-like bodies and how future space missions may discover manifestations of extraterrestrial life.
We investigated the phasing of pulsed two- and fourchannel laser beams due to phase conjugation upon transient stimulated Brillouin scattering (SBS) in a double-pass amplification scheme. A high ...quality of beam phasing was experimentally demonstrated with the use of a microlens raster and an angular selector in the SBS-mirror scheme. The data obtained in the numerical simulation of transient SBS are in good agreement with experimental ones.
The origin and evolution of Venus’, Earth’s, Mars’ and Titan’s atmospheres are discussed from the time when the active young Sun arrived at the Zero-Age-Main-Sequence. We show that the high EUV flux ...of the young Sun, depending on the thermospheric composition, the amount of IR-coolers and the mass and size of the planet, could have been responsible that hydrostatic equilibrium was not always maintained and hydrodynamic flow and expansion of the upper atmosphere resulting in adiabatic cooling of the exobase temperature could develop. Furthermore, thermal and various nonthermal atmospheric escape processes influenced the evolution and isotope fractionation of the atmospheres and water inventories of the terrestrial planets and Saturn’s large satellite Titan efficiently.
Parkinson's disease (PD) is the most common age-related movement disorder characterized by the progressive loss of nigrostriatal dopaminergic neurons. To date, PD treatment strategies are mostly ...based on dopamine replacement medicines, which can alleviate motor symptoms but do not slow down the progression of neurodegeneration. Thus, there is a need for disease-modifying PD therapies. The aim of this work was to evaluate the neuroprotective effects of the novel compound PA96 on dopamine neurons in vivo and in vitro, assess its ability to alleviate motor deficits in MPTP- and haloperidol-based PD models, as well as PK profile and BBB penetration. PA96 was synthesized from (1
,2
,6
)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol (Prottremin) using the original three-step stereoselective procedure. We found that PA96: (1) supported the survival of cultured näive dopamine neurons; (2) supported the survival of MPP
-challenged dopamine neurons in vitro and in vivo; (3) had chemically appropriate properties (synthesis, solubility, etc.); (4) alleviated motor deficits in MPTP- and haloperidol-based models of PD; (5) penetrated the blood-brain barrier in vivo; and (6) was eliminated from the bloodstream relative rapidly. In conclusion, the present article demonstrates the identification of PA96 as a lead compound for the future development of this compound into a clinically used drug.
The review introduces the stages of formation and experimental confirmation of the hypothesis regarding the mutual potentiation of neuroprotective effects of hypoxia and hypercapnia during their ...combined influence (hypercapnic hypoxia). The main focus is on the mechanisms and signaling pathways involved in the formation of ischemic tolerance in the brain during intermittent hypercapnic hypoxia. Importantly, the combined effect of hypoxia and hypercapnia exerts a more pronounced neuroprotective effect compared to their separate application. Some signaling systems are associated with the predominance of the hypoxic stimulus (HIF-1α, A1 receptors), while others (NF-κB, antioxidant activity, inhibition of apoptosis, maintenance of selective blood-brain barrier permeability) are mainly modulated by hypercapnia. Most of the molecular and cellular mechanisms involved in the formation of brain tolerance to ischemia are due to the contribution of both excess carbon dioxide and oxygen deficiency (ATP-dependent potassium channels, chaperones, endoplasmic reticulum stress, mitochondrial metabolism reprogramming). Overall, experimental studies indicate the dominance of hypercapnia in the neuroprotective effect of its combined action with hypoxia. Recent clinical studies have demonstrated the effectiveness of hypercapnic-hypoxic training in the treatment of childhood cerebral palsy and diabetic polyneuropathy in children. Combining hypercapnic hypoxia with pharmacological modulators of neuro/cardio/cytoprotection signaling pathways is likely to be promising for translating experimental research into clinical medicine.
The review discusses the potential relationship between hypoxia resistance and longevity, the influence of carbon dioxide on the mechanisms of aging of the mammalian organism, and intermittent ...hypercapnic–hypoxic effects on the signaling pathways of aging mechanisms. In the article, we focused on the potential mechanisms of the gero-protective efficacy of carbon dioxide when combined with hypoxia. The review summarizes the possible influence of intermittent hypoxia and hypercapnia on aging processes in the nervous system. We considered the perspective variants of the application of hypercapnic–hypoxic influences for achieving active longevity and the prospects for the possibilities of developing hypercapnic–hypoxic training methods.
Striatal-enriched protein tyrosine phosphatase (STEP) is a signal transduction protein involved in the pathogenesis of neuropathologies. A STEP inhibitor (TC-2153) has antipsychotic and ...antidepressant effects. Here, we evaluated the role of STEP in fear-induced aggression using Norway rats selectively bred for 90 generations for either high aggression toward humans (aggressive rats) or its absence (tame rats). We studied the effects of acute administration of TC-2153 on behavior and STEP expression in the brain of these animals and the influence of chronic treatment with TC-2153 on the behavior and STEP expression in aggressive rats in comparison with classic antidepressant fluoxetine, which is known to exert antiaggressive action. Acute TC-2153 administration decreased the aggressive reaction to humans in aggressive rats, while having no impact on the friendly behavior of tame rats. Moreover, in the elevated plus-maze test, the drug had an anxiolytic effect on both aggressive and tame rats. Aggressive rats demonstrated elevated levels of a STEP isoform (STEP46) as compared to tame animals, whereas acute TC-2153 administration significantly reduced STEP46 protein concentration in the brain of aggressive rats. Chronic treatment of aggressive rats with either TC-2153 or fluoxetine attenuated fear-induced aggression. Chronic administration of fluoxetine enhanced the exploratory activity in the elevated plus-maze test and decreased the STEP46 protein level in aggressive rats’ hippocampus, whereas chronic TC-2153 administration did not affect these parameters. Thus, STEP46 can play an important role in the mechanisms of aggression and may mediate antiaggressive effects of TC-2153 and fluoxetine.
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•STEP46 is involved in genetically determined fear-induced aggressive behavior.•STEP inhibitor TC-2153 reduced fear-induced aggression in Norway rats.•Acute administration of TC-2153 had an anxiolytic effect on rats.•This acute TC-2153 treatment decreased the STEP46 protein level in the brain.•Fluoxetine downregulated aggression and STEP46 in aggressive rats’ hippocampus.
We study experimentally stimulated Brilluoin scattering (SBS) of vortex laser beams, namely, the LG{sub 1}{sup 1} and LG{sub 0}{sup 1} Laguerre -Gaussian modes. The wave front transformation is ...experimentally demonstrated in the case of SBS of the LG{sub 1}{sup 1} laser mode, directly focused into the SBS cell, when the fundamental Gaussian mode LG{sub 0}{sup 0} rather than the conjugate mode is selected from the Stokes beam. It is shown that optical vortices become phase conjugate by destroying the laser mode structure in the SBS cell. Phase conjugation (PC) of the LG{sub 0}{sup 1} and LG{sub 1}{sup 1} modes is obtained in the SBS mirror using a regular aberrator (microlens raster) in the system of laser beam focusing into the SBS cell.
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