Detection of molecular level biomedical event extraction plays a vital role in creating and visualizing the applications related to natural language processing. Cystic Fibrosis is an inherited ...genetic and debilitating pathology involving the respiratory and digestive systems. The excessive production of thick sticky mucus on the outside of the cells is the main consequence of such disease. This includes disease prevention and medical search to signify the occurrence and detection of event triggers, which is regarded as a proper step in an event extraction of molecular level in biomedical applications. In this model, use a rich set of extracted features to feed the machine learning classifier that helps in better extraction of events. The study uses an automatic feature selection and a classification model using Radial Belief Neural Network (RBNN) for the optimal detection of molecular biomedical event detection. The Radial Belief Neural Network (RBNN) is the proposed system is implemented and it is the classifier to give accurate result of the disease detection. These three algorithms are used to enhance the generalization performance and scalability of detecting the molecular event triggers. The validation is conducted on the cystic fibrosis event trigger based on the gene ontology bio system using the RBNN model with a lung molecular event-level extraction dataset. The extensive computation shows that the Radial Belief Neural Network (RBNN) is proposed to given the better performance results like Accuracy, Sensitivity, Specificity, F-measure and Execution time.
•Significance of preform optimization in infiltration-growth process.•YBCO sample with current density ⩾103A/cm2 maintained to fields of 6.5T at 77K.•Optimized YBCO sample showed large flux pinning ...force.•Extensive twinning on nano-scale achieved in optimized samples.•Factors influencing current density at low and high fields are investigated.
The effect of compaction pressure applied to the Y2BaCuO5 (Y-211) preform during its fabrication, on the final microstructures and current densities (Jc) is investigated. The necessity for optimizing the sintering conditions in order to provide mechanical stability to the preform prior to the infiltration of liquid phases is demonstrated. The sample fabricated under optimized conditions showed Jc values better than 103Acm−2 up to applied magnetic fields of 6.5 Tesla at 77K. The microstructural factors influencing the field dependence of Jc ‘Jc(H)’ at low and high fields are investigated. Extensive nano-twinning with large number of crossing twins observed in the optimized sample and the associated high defect densities are correlated to be the source of flux pinning to high fields. The fact that YBa2Cu3O7−δ (YBCO, Y-123) superconductor obtained employing the present Preform Optimized Infiltration and Growth Process (POIGP) yields a homogenous and dense distribution of fine Y-211 particles, that creates suitable twin/defect densities to provide flux pinning at high fields, is of technical importance.
Large single-grain bulk high-temperature superconducting materials can trap high magnetic fields in comparison with conventional permanent magnets, making them ideal candidates to develop more ...compact and efficient devices, such as actuators, magnetic levitation systems, flywheel energy storage systems and electric machines. However, macro-segregation of Y-211 inclusions in melt processed Y-Ba-Cu-O (YBCO) limits the macroscopic critical current density Jc of such bulk superconductors, and hence, the potential trapped field. Recently, a new fabrication technique with graded precursor powders has been developed, which results in a more uniform distribution of Y-211 particles, in order to further improve the superconducting properties of such materials. In order to develop this graded fabrication technique further, a 3D finite-element numerical simulation based on the H-formulation is performed in this paper. The trapped field characteristics of a graded YBCO sample magnetized by the field cooling method are simulated to validate the model, and the simulation results are consistent with the experimental measurements. In addition, the influence of the graded technique and various graded Jc distributions for pulsed field magnetization, recognized widely as a practical route for magnetizing samples in bulk superconductor applications, is also investigated, with respect to the trapped field and temperature profiles of graded samples. This modelling framework provides a new technique for assessing the performance of various sizes and geometries of graded bulk superconductors, and by adjusting the Y-211, and hence Jc, distribution, samples can be fabricated based on this concept to provide application-specific trapped field profiles, such as the generation of either a high magnetic field gradient or a high level of uniformity for the traditionally conical, trapped field profile.
A bulk YBa sub(2)Cu sub(3)O sub(7- )delta(YBCO)/Ag superconducting composite with a homogenous distribution of fine and spherical particles of metallic Ag and Y sub(2)BaCuO sub(5) (Y-211) has been ...fabricated by employing Directionally Solidified Preform Optimized Infiltration Growth Process (DS-POIGP). The effect of adding Ag into the liquid phase source (YBa sub(2)Cu sub(3)O sub(7 -)delta placed above the Y-211 preform on the microstructures and current densities is investigated. The addition of Ag led to a significant refinement of Y-211 particle size and, hence, enabled the enhancement of current densities at low fields.
We report a complete procedure to achieve multilayer YBa2Cu3O7−δ (YBCO) thick films by electrophoretic deposition on silver tubes using a suspension of YBCO powder in butanol. With the aim to ...optimize the magnetic shielding performances of the coatings, we have carried out an extensive investigation of the influence of the deposition parameters, the multilayer deposition sequence and the intermediate final heat treatments on the coating microstructure. Using the optimized conditions, a 24-layer YBCO coating has been successfully prepared on an 80 mm long Ag tube: the melt growth processed multilayered YBCO thick film thus obtained can shield an applied magnetic field of 1.9 mT at 77 K, the highest value per thickness unit reported so far in the literature for these materials.
The influence of rare earth (RE - Ce, Gd) doping at the Nd site in the NdFeAsO
0.7
F
0.3
superconductor wherein Ce and Gd have ionic radii in the order Ce > Nd > Gd is investigated. The structural ...and superconductivity characterization of the pure and doped samples show that Ce doping enhances the
T
C
of Nd
1−
x
RE
x
FeAsO
0.7
F
0.3
to a maximum of 53.6 K at
x
= 0.1 while Gd doping attains a
T
C
of 55.1 K at
x
= 0.15. Interestingly, both Ce and Gd doping create neither secondary phases nor precipitates within the detection limit of XRD. However, the lattice defects due to Ce and Gd doping modifies NdFeAsO
0.7
F
0.3
and assists in pinning the flux lines on these defects thereby exhibiting an enhanced
J
C
(
H
) performance especially at high fields. It is also observed that the relatively small ionic size of Gd is more effective in
T
C
enhancement, while the lattice defects due to larger ionic size of Ce favor the remarkable enhancement of
J
C
(
H
).
The influence of rare earth (RE - Ce, Gd) doping at the Nd site in the NdFeAsO
0.7
F
0.3
superconductor wherein Ce and Gd have ionic radii in the order Ce > Nd > Gd is investigated.
► Effect of varying Infiltration temperature in IG Processing of Y-123, is discussed. ► Infiltration below the seed crystal melting point causes single grain growth. ► Infiltration above MP, at ...1100°C, gives high Jc samples with 103 texture. ► Lowered infiltration temperature lowers hardness and increases brittleness.
The importance of optimizing the fabrication of the Y2BaCuO5 (Y-211) preform in achieving high current densities to high magnetic fields has recently been established. We report the effect of the choice of infiltration temperature 1040°C (sample A) and 1100°C (sample B) on the microstructure, magnetic properties and mechanical strength. Both the samples showed 103 texture after slow cooling through peritectic temperature. Infiltration at higher temperature is found to yield highly dense composites with minimal macrodefects and higher hardness of 18.73GPa in sample B. Both the samples show uniform distribution of Y-211and comparable zero-field critical current density. High current densities are retained to a higher field of 7T in sample B, unlike 2T in sample A. The occurrence of 103 texture promoting higher hardness, simultaneous with retention of considerably high current density to high fields in sample B has definite advantages for trapped field applications.
Vegetative insecticidal protein (Vip) is now being used for transgenic expression in several crops; conferring resistance against lepidopteron pests. A rapid, single step, sensitive and specific ...immunochromatographic (IC) strip test for the detection of recombinant Vip-S protein in the transgenic samples was developed. Polyclonal rabbit anti-Vip-S IgG conjugated to nanocolloidal gold served as a probe to detect Vip protein in test samples. The detection limit for the developed IC strip was 100
ng/ml (100
ppb) and on addition of gold enhancer the sensitivity increased to 1
ng/ml (1
ppb) of Vip-S protein. The assay was validated with transgenic brinjal samples. The assay time was less than 10
min, suitable for rapid on-site testing. No cross-reactivity was observed with other transgenic plant proteins employed for pest and weed management, i.e. Cry1Ac, Cry1Ab, and CP4-EPSPS. This on-site test offers rapid screening for a genetically modified crops having relatively new transgene (
vip) entering the global market.
Objective: Aprepitant (APR) is a water insoluble drug approved for the treatment of chemotherapy induced nausea and vomiting (CINV) and post-operative nausea and vomiting (PONV). The innovator Emend® ...is a formulation incorporating drug nanoparticles with good bioavailability (~67%). The objective of the current work was to evaluate the feasibility of formulating a cyclodextrin complex of APR with enhanced solubility/dissolution rate and concomitantly bioavailability.
Methods: The complex was prepared using two approaches: kneading and slurry method. The formulated complex was evaluated using DSC, XRPD and FT-IR studies.
Results: DSC, XRPD and FT-IR studies confirmed the interaction of β-cyclodextrin with APR indicating formation of a true complex wherein the drug was encapsulated in the cyclodextrin cavity (inclusion phenomenon). In addition to inclusion complexation, non inclusion phenomenon viz., interaction among hydroxyl groups of cyclodextrin and APR was also observed. The saturation solubility and dissolution rate of drug complex was higher than that of aprepitant API. The rate (Cmax) and extent of absorption (AUC) of APR from the complex were found to be comparable to that of Emend® (Reference product).
Conclusion: These studies established that cyclodextrin complexation may provide another viable and cost effective option for enhancing solubility and bioavailability of APR.
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