Development of the human brain occurs in a number of complex pre- and postnatal stages which are governed by both genetic and environmental factors. Aberrant brain development due to inherited ...defects may result in a wide spectrum of neurological disorders which are commonly encountered in the clinical field of paediatric neurology. In the work for this thesis, I have investigated the molecular basis and defined the clinical features of three autosomal recessive neurological syndromes. I studied a cohort of children with early onset epileptic encephalopathy and, in one family, identified a novel homozygous pathogenic mutation of PLCB1. I have also utilised autozygosity mapping techniques to study consanguineous families with a complex motor disorder, infantile parkinsonism-dystonia, and identified loss-of function mutations in the gene encoding the dopamine transporter (SLC6A3). Subsequent acquisition of a cohort of similarly affected children allowed detailed clinical and molecular characterisation of this novel disorder, dopamine transporter deficiency syndrome. Finally I have delineated the clinical and genetic features of PLA2G6-associated neurodegeneration. The identification of disease-causing genes contributes greatly to understanding the disease mechanisms underlying such early-onset disorders, and also provides novel insights into normal human neurodevelopment.
Development of the human brain occurs in a number of complex pre- and postnatal stages which are governed by both genetic and environmental factors. Aberrant brain development due to inherited ...defects may result in a wide spectrum of neurological disorders which are commonly encountered in the clinical field of paediatric neurology. In the work for this thesis, I have investigated the molecular basis and defined the clinical features of three autosomal recessive neurological syndromes. I studied a cohort of children with early onset epileptic encephalopathy and, in one family, identified a novel homozygous pathogenic mutation of PLCB1. I have also utilised autozygosity mapping techniques to study consanguineous families with a complex motor disorder, infantile parkinsonism-dystonia, and identified loss-of function mutations in the gene encoding the dopamine transporter (SLC6A3). Subsequent acquisition of a cohort of similarly affected children allowed detailed clinical and molecular characterisation of this novel disorder, dopamine transporter deficiency syndrome. Finally I have delineated the clinical and genetic features of PLA2G6-associated neurodegeneration. The identification of disease-causing genes contributes greatly to understanding the disease mechanisms underlying such early-onset disorders, and also provides novel insights into normal human neurodevelopment.
We followed 55 high risk newborns from birth till one year using Trivandrum Development Screening Chart (TDSC) and Denver Development Screening Test (DDST). We also assessed their muscle tone, vision ...and hearing. Babies were classified into mild, moderate, and severe risk groups using a scoring system. Babies with developmental delay were categorized as having mild, moderate, or severe delay. The risk score was significantly associated with the severity of developmental delay (Plt; 0.001). Abnormalities of tone were also associated with development delay (P< 0.001).
This research work reports a systematic analysis of association of age with academic performance in a higher education institution. The correlation coefficient between key parameters of the student ...data were absorbed to derive the attributes that contributed strong positive influence on student results and also to identify the attributes that donated a negative impact. Further, a predictive model was developed to forecast the student performance in higher level modules based on the contextual factors. The outcome of the work showcased that negative correlation exists between age and the academic performance. On the contrary, positive correlation exists between lower level and higher level modules. Further, future research directions are discussed.
My dissertation focuses on the popular fiction produced by British women (mem-sahibs) who lived in India during the latter years of the British Raj (roughly 1880–1914). Just as present day readers ...experience Empire through the texts of the time, so did Britons at “home” in the nineteenth century. Readers around the world experienced imperialism vicariously through the numerous novels and short stories written by the writing mem-sahib. Through the fiction of the Anglo-Indian romance novelist, the imperial adventure came alive with all of its privilege, pain, splendor and sacrifice. The popular culture vehicles of their time, mem-sahib fiction served to disseminate imperial policy in Britain and managed to influence social codes guarding racial privilege in the colonies. The writing mem-sahibs made the late nineteenth century dominant colonial ideology of racial superiority and divine authority guide their romance novels. Whether the European audience read the novels for entertainment or for education, they could revel in the glory of Empire. Rebutting interpretations that have marginalized imperial women, this dissertation demonstrates that Queen Victoria's imperial “daughters” were crucial to the maintenance of Empire during the high imperial period. Mem-sahib fiction, developed out of mid-Victorian domestic ideology, made Britain's housewives and mothers into moral standard-bearers. Not only were they given the power to defend and justify economic and cultural imperialism in India as missionaries and teachers, but through their writing they were allowed to govern sexuality, which lies at the heart of the imperial romance. These writers unravel Orientalist fantasies of India by showing that the colonialist project cannot function without the complicity of women in the domestic sphere, and that women are equally responsible for abuses of imperial power. Through the careful reading of these forgotten novels of the British Empire, this dissertation restores to the post-colonial discussion of colony and Empire the ways in which women's popular fiction contributed, in no small measure, to upholding British notions of racial superiority and gender segregation that continue to complicate our understanding of imperialism.
Thesis (Ph.D.)--Tufts University, 2003.
Director: Modhumita Roy. Submitted to the Dept. of English. Includes bibliographical references (leaves 260-280). Access restricted to members of the Tufts ...University community. Also available via the World Wide Web;
Kurian explains how the written memoirs and autobiographies of other Asian American women have provided her with the self-recognition she has needed in order to tell her own stories.
An investigation on the floral biology of adapathiyan (Holostemma adakodien Schlt.) was undertaken at the college of horticulture, Thrissur during the period 1995-1997. the inflorescence is axillary ...and cymose with bixesual flowers. Flowers open 25 to 28 days after bud initiatian and passes through q12 different developemental phases before anthesis commences at 8.30 a.m. and extends up to 10.00 a.m. Anther dehiscence occurs on the fourth day of flower opening from 9.30 a.m. to 1 p.m. the maximum stigma receptivity was observed on the first day of flower opening. Size of the pollen grains ranged from 50 to 75 um with 90-1005 fertility in Brewbaker and Kwack's medium.
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