Teratomas are tumors derived from germ cells, most frequently arising in the gonads. The aim of this study was to determine the number of ovarian teratomas diagnosed in the routine biopsy material at ...Ljudevit Jurak Clinical Department of Pathology, Sestre milosrdnice University Hospital Center during a 5-year period, as well as their clinical, gross and microscopic characteristics. Teratomas accounted for 48.6% (n=166) of primary ovarian tumors. The patient mean age was 34.74±12.37 years. Difference in the incidence of teratoma between the left and right ovary was not significant; bilateral teratoma was found in 13 patients. Teratomas were detected by ultrasonography in 115 (69.27%) cases and the rest were found during surgery performed for other indications. Most teratomas (n=161; 96.9%) were mature and cystic (dermoid cysts). Mature and solid teratomas were diagnosed in 5 (3.01%), ovarian struma in 2 (1.8%) cases and strumal carcinoid in 1 (1.2%) case. Mature cystic teratomas contained sebaceous material in 123 (76.8%) cases, and a total of 16 teeth were found; 157 (94.5%) teratomas measured <10 cm in largest diameter. Microscopically, mature cystic teratomas most frequently contained ectodermal (skin with appendages, mature glia and nerve ganglia) and mesodermal (fi brous, fat tissue, cartilage and bone) tissues. Frequently found tissues of endodermal origin were respiratory and intestinal epithelia. Small foci of thyroid tissue were found in 20 (12%) teratomas. Chronic granulomatous foreign body reaction in the wall of mature cystic teratomas was found in 11 (6.8%) tumors.
Sažetak. Cilj: Utvrditi postoji li povezanost između peritumoralnih pukotina i miofibroblastične reakcije strome u duktalnim invazivnim karcinomima dojke bez posebnih obilježja. Metode: U 100 ...invazivnih duktalnih karcinoma dojke u žena analizirani su postojanje peritumoralnih pukotina i imunohistokemijska izraženost CD34, vimentina i glatkomišićnog aktina (SMA) u tumorskoj stromi. Rezultati: Peritumoralne pukotine nađene su u 92% karcinoma, dok u okolnom tkivu i oko žarišta duktalnog karcinoma in situ nisu nađene. Proširenost pukotina bila je 5 do 100%. Apsolutni postotak peritumoralnih pukotina bio je znatno povezan s količinom SMA+ miofibroblasta u stromi, veličinom tumora i pT-stadijem bolesti, prisutnošću metastaza u aksilarnim limfnim čvorovima i udjelom pozitivnih limfnih čvorova. Tumori s opsežno izraženim peritumoralnim pukotinama (u > 30% tumora) imali su znatno veću količinu SMA+ miofibroblasta u stromi, češće metastaze u aksilarne limfne čvorove i veći udio pozitivnih limfnih čvorova. Zaključak: Peritumoralne pukotine morfološki su izraz promijenjenih osobina tumorske strome u obliku zadobivanja miofibroblastičnog fenotipa.
Uvod: Peritumoralne retrakcijske pukotine više se ne smatraju samo artefaktom, već dodatnim pokazateljem ponašanja invazivnih karcinoma mnogih organa. One predstavljaju morfološki odraz promjena u ...građi i sastavu tumorske strome, a možda i jedan od stadija limfangiogeneze tumora. Hipoteza istraživanja bila je da su u tkivu invazivnog duktalnog karcinoma dojke peritumoralne retrakcijske pukotine povezane s povećanom gustoćom limfnih žila što doprinosi lakšem rasapu
tumorskih stanica i lošijoj prognozi. Materijal i metode: Analizirano je 100 invazivnih duktalnih karcinoma dojke u žena, 41% bez, a 59% s metastazama u limfne čvorove aksile. Osim rutinski, analizirana je imunohistokemijska izraženost CD34, vimentina, glatkomišićnog aktina (SMA) i CD2-40 (podoplanina). Rezultati: Peritumoralne pukotine su nađene u 92% karcinoma, a u okolnom zdravom tkivu i oko žarišta duktalnog karcinoma in situ nisu nađene. Proširenost pukotina bila je 5% do 100%. Gustoća malih limfnih žila unutar tumora i peritumoralno nije pokazala statistički značajnu povezanost s apsolutnim postotkom peritumoralnih pukotina, kao niti s izraženošću peritumoralnih pukotina s obzirom na graničnu vrijednost od 30%. U bolesnica s metastazama peritumoralna limfovaskularna invazija (LVI) je nađena 2 puta češće, a intratumoralna LVI skoro 5 puta češće nego u bolesnica bez metastaza, što je statistički značajno različito. Ni peritumoralna, niti intratumoralna
LVI nisu pokazale statistički značajnu povezanost s apsolutnim postotkom peritumoralnih pukotina, kao niti s izraženošću
peritumoralnih pukotina s obzirom na graničnu vrijednost od 30%. Zaključak: U invazivnom duktalnom karcinomu dojke peritumoralne pukotine predstavljaju morfološki odraz promijenjenih osobina tumorske strome, ali nisu povezane s gustoćom malih krvnih žila kao odrazom limfangiogeneze, čija je patogeneza vjerojatno drugačija.
The aim of our retrospective study was to compare the performance of transvaginal sonography in relation to histologic diagnosis of samples obtained by hysteroscopy through analysis of data collected ...over 16 years. Data on suspected formation of endometrial polyp or submucosal fibroid found on ultrasound examination were extracted. The study included a total of 3679 women examined during the 2000-2015 period. All women underwent ultrasound examination preoperatively for better planning the type and scope of operation to be performed. The study included only women with samples for histopathologic analysis collected during the operation. Ultrasound diagnosis of polyps compared with histology showed 89.6% sensitivity and 39.1% specificity. For submucosal myomas, sensitivity was 69.2% and specificity 91.3%. In conclusion, ultrasound is not reliable method for definitive diagnosis but it is an excellent orientation method.
The aim of our study was to determine the prevalence of endometrial premalignant and malignant lesions in women undergoing hysteroscopy and to identify anthropologic factors related to the presence ...of malignancy. Data on 3470 women with submucosal myomas or endometrial polyps suspected on ultrasound were retrospectively analyzed. Hysteroscopy was performed in all these women in order to make a more precise diagnosis. Histologic analysis of endometrial samples obtained during hysteroscopy was used to confirm the diagnosis. Statistical analysis was performed using the SPSS 20.0.0 software. The mean age of study women was 49.1±13.3 years. The number of procedures performed due to the referral diagnosis of endometrial or submucosal myoma significantly increased over the 16-year study period. A significantly higher number of women had a benign histopathologic diagnosis. Histologic analysis revealed malignancy in 67 women. The youngest woman and oldest woman with malignant findings was aged 32 and 75, respectively. A significantly higher number of women with atypical hyperplasia and malignancy were in menopause. A comparable number of women with different histologic findings lived in urban and rural areas. There were a significantly larger proportion of widows among women with the histologic diagnosis of atypical hyperplasia or malignancy. The prevalence rate of malignancy in women having undergone hysteroscopy for polyps and myoma found by ultrasound was 1.93%. Postmenopausal status and older age were associated with an increased risk of malignancies, but premalignant changes and malignancies were also found in young and premenopausal women. Therefore, diagnostic hysteroscopy can be recommended in women of all age groups.
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths among female population worldwide. Metastases are the common cause of morbidity and mortality in ...breast cancer and can remain latent for several years after surgical removal of the primary tumour. Thus, the identification and functional characterisation of molecular factors that promote oncogenic signalling in mammary tumour development and progression could provide new entry points for designing targeted therapeutic strategies for metastatic breast cancer. In the present study, we investigated the expression of proteins involved in cell signalling (growth hormone receptor (GHR) and NEDD9) and cell-cell adhesion (plakoglobin) in epithelial and stromal compartments of primary ductal invasive breast carcinomas and their axillary lymph node metastases versus non-metastatic tumours. Obtained data revealed remarkable increase in the expression levels of GHR and NEDD9 proteins in both epithelial and stromal components of axillary lymph node metastases in comparison with those of non-metastatic tumours, suggesting that the expression of these two proteins may provide biomarkers for tumour aggressiveness.
Ovarian leiomyoma is a rare benign tumor that accounts for 0.5 to 1% of all benign ovarian tumors. It probably arises from smooth muscle cells in the ovarian hilar blood vessels but there are other ...possible origins including cells in the ovarian ligament, smooth muscle cells or multipotential cells in the ovarian stroma, undifferentiated germ cells, or cortical smooth muscle metaplasia. Additionally, smooth muscle metaplasia of endometriotic stroma, smooth muscle present in mature cystic teratomas, and smooth muscle in the walls of mucinous cystic tumor may explain their occurrence in the ovary in some cases.
A 31-year-old woman was admitted to our surgical emergency service with a one-day history of appendicitis-like symptoms. Upon laparotomy, there was a solid, oval left-sided ovarian tumor located behind the uterus. The tumor was sent to the pathology department. A diagnosis of primary ovarian leiomyoma associated with an endometriotic cyst was established.
The origin of ovarian leiomyoma is still unresolved. In our case, the tumor probably arose from smooth muscle cells derived from myofibroblasts that originate from metaplastic ovarian stromal cells present in the rim of the endometriotic cyst. Despite its rarity, ovarian leiomyoma should be considered in the differential diagnosis of ovarian spindle cell tumors. Appropriate diagnosis may require additional immunohistochemical analysis in some cases.
Iznenadna smrt najčešće nastaje kao posljedica oštećenja kardiovaskularnog sustava, ponajprije zbog koronarne bolesti ili kardiomiopatije, a izuzetno rijetko može biti uzrokovana primarnim tumorom ...srca. Tri četvrtine primarnih novotvorina srca čine benigni tumori, a četvrtinu maligni koji su redovito sarkomi i rijetko limfomi. Najčešći histološki tip primarnog sarkoma srca jest angiosarkom, obično smješten u desnom atriju ili rjeđe u perikardu. U ovom radu prikazujemo slučaj bolesnice koja je primljena u teškom općem stanju, pod sumnjom na septički šok, a preminula je nekoliko sati nakon prijma. Obdukcijom je nađen tumor desne pretklijetke koji je, prema morfološkim i imunohistokemijskim karakteristikama, odgovarao angiosarkomu. Infiltracija epikarda i krvarenje u perikardijalnu šupljinu doveli su do tamponade srca i smrti. Uz prikaz bolesnice rad pruža kratki pregled epidemioloških i kliničkih značajka te mogućnosti dijagnostike i liječenja primarnog angiosarkoma srca.
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