Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is ...characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease. Genetic, epigenetic and non-genetic factors might explain the considerable interindividual variation in ALD phenotype. The pathogenesis of ALD includes hepatic steatosis, oxidative stress, acetaldehyde-mediated toxicity and cytokine and chemokine-induced inflammation. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Alcohol abstinence achieved by psychosomatic intervention is the best treatment for all stages of ALD. In the case of advanced disease such as cirrhosis or HCC, liver transplantation may be required. Thus, new therapies are urgently needed.
We recently reported enhanced parasympathetic activation at rest throughout pregnancy associated with regular yoga practice. The present study presents a secondary analysis of data collected within a ...prospective cohort study of 33 pregnant women practicing yoga once weekly throughout pregnancy and 36 controls not involved in formal pregnancy exercise programs. The objective was to assess the impact of prenatal yoga on the autonomic nervous system stress response. Healthy pregnant women with singleton pregnancies were recruited in the first trimester. There was no significant difference in the maternal body mass index (BMI) between the yoga group and the controls (24.06 ± 3.55 vs. 23.74 ± 3.43 kg/m
,
= 0.693). Women practicing yoga were older (28.6 ± 3.9 vs. 31.3 ± 3.5 years,
= 0.005) and more often nulliparous (26 (79%) vs. 18 (50%),
= 0.001). We studied heart rate variability (HRV) parameters in the time domain (SDNN, standard deviation of regular R-R intervals, and RMSSD, square root of mean squared differences of successive R-R intervals) and frequency domain (ln(LF/HF), natural logarithm of low-frequency to high-frequency power), as well as synchronization indices of heart rate, blood pressure and respiration during and immediately following acute psychological stress of a standardized mental challenge test. Measurements were performed once per trimester before and after yoga or a 30 min moderate-intensity walk. Statistical comparison was performed using three-way analyses of variance (
< 0.05 significant). Time domain HRV parameters during and following mental challenge in the yoga group were significantly higher compared to the controls regardless of the trimester (
= 7.22,
= 0.009 for SDNN and
= 9.57,
= 0.003 for RMSSD, respectively). We observed no significant differences in the yoga group vs. the controls in terms of ln(LF/HF) and synchronization indices. Regular prenatal yoga practice was associated with a significantly reduced sympathetic response to mental challenge and quicker recovery after acute psychological stress. These effects persisted throughout pregnancy with regular practice.
Coping with mental challenges is vital to everyday functioning. In accordance with prominent theories, the adaptive and flexible adjustment of the organism to daily demands is well expressed in ...task-related changes of cardiac vagal control. While many mental challenges are associated with increased effort and associated decreased task-related heart rate variability (HRV), some cognitive challenges go along with HRV increases. Especially creativity represents a cognitive process, which not only results from mental effort but also from spontaneous modes of thinking. Critically, creativity and HRV are associated with regular exercising and fitness. Furthermore, the cross-stressor adaptation theory suggests that changes in cardiac reactions to physical challenges may generalize to mental challenges. In line with this idea the amount of regular exercising was hypothesized to moderate the association between HRV changes and creativity. A sample of 97 participants was investigated. They reported the amount of regular exercise and their ECG was measured at baseline and during a creativity task. An association between task-related HRV changes and originality as a function of participants' amount of regular exercise was found. Participants reporting more regular exercising produced more original ideas when they had higher HRV increases during the task, while more sedentary participants showed the opposite association. Results suggest that individuals with a higher amount of regular exercise achieve higher originality probably via the engagement in more spontaneous modes of thinking, while more sedentary people may primarily benefit from increased mental effort. This supports the conclusion that higher creativity can be achieved by different strategies.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Aims
To investigate how a change in body position with light‐intensity physical activity (PA) ‘snacks’ (LIPAS, alternate sitting and standing, walking or standing continuously) compared with ...uninterrupted prolonged sitting affects glucose metabolism and heart rate variability (HRV) parameters in young adults with overweight and obesity.
Materials and Methods
We conducted a four‐arm randomized controlled crossover trial. The following conditions were tested during an 8‐h simulated workday: uninterrupted prolonged sitting (SIT), alternate sitting and standing (SIT‐STAND; 2.5 h total), continuous standing (STAND), and continuous walking (1.0 mph; WALK). The primary outcome was to investigate how a change in body position (alternate sitting and standing, walking or standing continuously) compared with uninterrupted sitting affects mean 8‐h glucose metabolism. Secondary outcomes included the effects on 2‐h postprandial glucose concentrations, as well as on 8‐h/24‐h heart rate and HRV parameters, in the respective study arms. Capillary blood samples were drawn from an hyperemised earlobe in the fasted state and once every hour during each trial intervention by puncturing the earlobe with a lancet and collecting 20 μL of blood (Biosen S‐Line Lab+; EKF diagnostics, Barleben, Germany). HRV was assessed for 24 h including the 8‐h intervention phase, and a home phase by means of a Holter electrocardiogram. All participants received the same standardized non‐relativised breakfast and lunch during the four trial visits.
Results
Seventeen individuals (eight women, mean age 23.4 ± 3.3 years, body mass index 29.7 ± 3.8 kg/m2, glycated haemoglobin level 34.8 ± 3.1 mmol/mol 5.4 ± 0.3%, body fat 31.8 ± 8.2%) completed all four trial arms. Compared with SIT (89.4 ± 6.8 mg/dL), 8‐h mean glucose was lower in all other conditions (p < 0.05) and this was statistically significant compared with WALK (86.3 ± 5.2 mg/dL; p = 0.034). Two‐hour postprandial glucose after breakfast was approximately 7% lower for WALK compared with SIT (p = 0.002). Furthermore, significant time × condition effects on HRV parameters favouring light‐intensity walking were observed (p < 0.001).
Conclusions
Replacement and interruption of prolonged sitting with light‐intensity walking showed a significant blood glucose‐lowering effect and improved HRV during an 8‐h work environment in young adults with overweight and obesity.
While some students try to give their best in an achievement situation, others show disengagement and just want to get the situation over and done with. The present study investigates the role of ...students' tendencies for approach or avoidance motivation while anticipating tasks and the corresponding activation of the approach/avoidance motivational system as indicated by transient changes of EEG alpha asymmetry. Overall, 62 students (50 female; age:
= 23.8,
= 3.5) completed a goal orientation questionnaire (learning goals, performance-approach, performance-avoidance, and work avoidance). They joined a laboratory experiment where EEG was recorded during resting condition as well as when students were anticipating tasks. Standard multiple regression analysis showed that higher values on performance-avoidance were related to a higher activation of the approach system whereas higher values on work avoidance were related to a higher activation of the avoidance system. Results question present assumptions about avoidance related goal orientations.
Evidence suggests that in dyadic conversations some alignment occurs at the physiological level, but relatively little is known about the conditions that may facilitate physiological synchrony of two ...interlocutors. In the present interdisciplinary study, the impact of specific linguistic features of ongoing dialogues—the use of humor‐related communication elements—was examined in 24 male dyads who were meeting for the first time. Heart rate synchrony was quantified using phase synchronization, which reflects the degree of moment‐to‐moment adjustments that occur between the two persons of a dyad. Comical hypotheticals and verbal amplifiers were identified and quantified using cognitive‐linguistic methods of corpus analysis. Additionally, smiles following these communication elements were identified using the Facial Action Coding System. The data showed that the heart rate time series of the two interlocutors were to some extent synchronized in phase, and that the magnitude of this synchronization exceeded what had to be expected by chance. The strength of heart rate synchrony in a dyad was the higher the more comical hypotheticals were produced, independently from how much the two conversation partners were in sum talking to each other. A similar observation was made for verbal amplifiers, but their effect depended on whether they were perceived (and acknowledged by a smile) as humorous. The findings are in line with the more general notion that physiological synchrony may be enhanced by shared experience and suggest that the use of (reciprocated) humor may speed up the building of rapport among communication partners.
Little is known about the conditions that facilitate physiological synchrony of two interlocutors. In this study, the impact of specific linguistic features of ongoing dialogues—the use of humor‐related communication elements—was examined. In view of the importance that is attached to the magnitude of interpersonal physiological synchrony in terms of states of relationships, the findings suggest that the use of (reciprocated) humor may speed up the building of rapport among communication partners. The process might be profitably employed in encounters where the fast establishment of a good communication basis is desirable, for instance, in psychotherapy or in collaborative teams.
As compared to negative affect, only a small number of studies have examined influences of positive affect on cardiovascular stress responses, of which only a few were concerned with cardiovascular ...recovery. In this study, heart rate, low- and high-frequency heart rate variability, blood pressure, and levels of subjectively experienced stress were obtained in 65 students before, during and after exposure to academic stress in an ecologically valid setting. Higher trait positive affect was associated with more complete cardiovascular and subjective post-stress recovery. This effect was independent of negative affect and of affective state during anticipation of the stressor. In contrast, a more positive affective state during anticipation of the challenge was related to poor post-stress recovery. The findings suggest that a temporally stable positive affect disposition may be related to adaptive responses, whereas positive emotional states in the context of stressful events can also contribute to prolonged post-stress recovery.
The experience of social exclusion may provoke prosocial, avoidant, or antisocial (aggressive) behaviors. Multiple situational and personal factors seem to affect which course of action people adopt, ...and to which degree. The present study examined the relevance of the most spontaneous initiation of more passive, avoidant (disengagement) or action-oriented (engagement) coping immediately following a social exclusion experience to subsequent aggressive behavior. In a sample of n = 85 healthy female students, an ostensible discussion group excluded (versus included) the participant on the basis of her personal traits and preferences. The dynamics of heart rate changes immediately following the social exclusion episode yielded information on the most spontaneous preparation for passive, avoidant coping (sustained heart rate deceleration, indicating temporary behavioral inhibition and vigilance, “freezing”) or action-oriented coping (heart rate acceleration, indicating mobilization for action, “fighting”). Aggressive tendencies following social exclusion were assessed using the hot sauce paradigm. On average, social exclusion was followed by heart rate deceleration, indicating the spontaneous drive to avoid directly dealing with the threat (F(time by condition) = 3.3, p = .017, η2 = 0.038). A less pronounced cardiac slowing or even accelerative response to the exclusion, however, was associated with more subsequent aggressive behavior (r = 0.35, p = .023). The results indicate that individual differences in exclusion-related antisocial responding are in part already initiated instantaneously following the exclusion experience, before conscious interpretation and regulation efforts can take effect and modulate the behavioral outcome. The findings point to a potentially important factor that, in concert with other determinants, may explain interindividual differences in changes of social behavior following the experience of social exclusion.
•Aggressive behavior after social exclusion assessed by hot sauce paradigm•Transient heart rate response provided indicator of spontaneous initiation of coping.•Passive, avoidant coping (“freezing”) vs. action-oriented coping (“fighting”)•On average, social exclusion was followed by sustained heart rate deceleration•Less pronounced deceleration associated with more aggressive behavior
LEDs simplify the personalization of lighting. However, research on the effects of personalizable lighting is in its infancy. The present study investigates the impact of personalizable workplace ...lighting on subjective parameters, cognition, and physiological stress while performing cognitive tests. In a cross-over design, 22 participants were randomly assigned to standard workplace lighting and lighting with adjustable illuminance and color temperature for two hours on two separate days. Subjective outcome measures were sleepiness, affect, and asthenopic complaints. We further assessed vigilance and three cognitive domains (task switching, working memory, and information processing) and derived heart rate variability parameters from an electrocardiogram. Some beneficial effects of personalizable lighting on cognitive performance were observed, although the overall results remain inconclusive. Standard and personalizable lighting did not differ in subjective ratings and physiological stress responses. Exploratory analysis of personalizable lighting revealed significant variation in self-selected workplace illuminances and limited variation in self-selected correlated color temperatures. Despite the preference for increased workplace illuminance under personalizable lighting, no visual impairment was observed compared to standard lighting. Personalizable workplace lighting is a promising new design feature to support individual visual and nonvisual lighting needs in daylight-deprived environments.
•PID-5 traits related to motivational responses to other people’s affect expressions.•Antagonism: relative approach vs avoidance motivation in response to aggression.•Detachment: relative avoidance ...vs approach motivation in response to crying.•Motivational tendencies were physiologically obtained (EEG alpha asymmetry responses).
Expressions of affect communicate social messages, which trigger approach and withdrawal/avoidance motivational tendencies in the observer. The present study investigated relationships between inter-individual differences in the motivational responses to other people’s affect expressions and DSM-5 personality trait domains. State-dependent, transient EEG alpha asymmetry responses provided indicators of the relative activation of withdrawal versus approach motivation in the respective social-emotional contexts. The Personality Inventory for the DSM-5 (PID-5) was used for the assessment of personality traits in a non-clinical sample. Individuals with higher levels of Antagonism showed relative activation of approach versus withdrawal motivation (as indicated by less relative right frontal activation) in response to confrontation with auditory expressions of angry aggression, whereas participants with higher levels of Detachment showed relative activation of withdrawal versus approach motivation (as indicated by greater relative right frontal activation) to the perception of other people’s desperate crying.
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