The electrochemical synthesis of hetero7helicenes including pyrrole and furan rings has been established. A single electrochemical operation led to an oxidative heterocoupling and dehydrative ...cyclization sequence to afford oxaza7helicenes in 50–86% yields with 45–77% Faradic efficiencies. Their derivatization and chiroptical properties were also investigated.
A designed chiral thiourea‐iminophosphorane catalyst was developed to afford α‐acyloxythioesters through enantioselective acyl‐transfer/protonation of α‐acyloxy‐β‐ketosulfides. The desired reaction ...proceeded in good yields with high enantioselectivities using a chiral thiourea‐iminophosphorane bearing a pyrrolidine scaffold.
The electrochemical synthesis of hetero7helicenes including pyrrole and furan rings has been established. A single electrochemical operation led to an oxidative heterocoupling and dehydrative ...cyclization sequence to afford oxaza7helicenes in 50–86% yields with 45–77% Faradic efficiencies. Their derivatization and chiroptical properties were also investigated.
Although the impact of burnout on general health has been well documented, the impact on cognitive functions has only recently started to attract attention. Burnout has been shown to affect both ...quality of life and professional efficacy. The present review focused on the links between burnout and cognitive deterioration, with two main objectives: (a) identify the cognitive functions affected by burnout and the underlying processes (i.e., factors explaining apparently heterogeneous consequences of burnout); and (b) explore possible ways of restoring these cognitive functions. We followed the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines, in order to find as exhaustive a set of articles as possible. The majority of studies were cross-sectional, with few longitudinal studies on the subject. Moreover, the majority of studies featured comparison groups, but these were not always created in identical ways. The main results of these studies indicated that impairments of memory, attention, and executive functions are related to burnout and these impairments vary over time. However, whether they described the impact of burnout in its early stages or over time, results were divergent. These divergences can be explained by the multiplicity of burnout definitions, ways of measuring burnout, and individual circumstances (e.g., type of job, personal characteristics). We suggest ways of tackling this multiplicity, including using stricter control groups, assessing social variables, and devising new methods for diagnosing burnout. Finally, several promising remediation strategies are recommended, based on the results of this literature review, such as cognitive training and mindfulness.
This study aimed to investigate the relationship between burnout and cognitive functions, particularly memory, attention, and executive functions, which have been found to be negatively affected in ...most studies. However, the results are not consistent across studies, and there is often a discrepancy between self-reported cognitive function and objective assessment. Two possible explanations for this discrepancy are the heterogeneous profiles of individuals in burnout and their personality traits. The study administered neuropsychological tests and questionnaires to 29 participants with clinical burnout to assess their cognitive functions and the impact of perfectionism, neuroticism, and emotion suppression on subjective and objective cognitive scores. The main findings showed little or no deterioration in memory or executive functions, despite patients reporting severely impaired executive function. The study found that neuroticism and perfectionism were related to poorer self-reported executive function, while emotion suppression was related to better self-reported executive function. No relationship was found between personality traits and neuropsychological test scores, indicating a discrepancy between self-perception and objective evaluation.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Molecular beacons (MBs) are fluorescent nucleic acid probes with a hairpin-shaped structure in which the 5‘ and 3‘ ends are self-complementary. Due to a change in their emissive properties upon ...recognition with complementary sequences, MBs allow the diagnosis of single-stranded DNA or RNA with high mismatch discrimination, in vitro and in vivo. Whereas the stems of MB hairpins usually rely on the formation of a Watson−Crick duplex, we demonstrate in this report that the preceding structure can be replaced by a G-quadruplex motif (G4). Intramolecular quadruplexes may still be formed with a central loop composed of 12 to 21 bases, therefore extending the sequence repertoire of quadruplex formation. G4-MB can efficiently be used for oligonucleotide discrimination: in the presence of a complementary sequence, the central loop hybridizes and forms a duplex that causes opening of the quadruplex stem. The corresponding G4-MB unfolding can be detected by a change in its fluorescence emission. We discuss the thermodynamic and kinetic opportunities that are provided by using G4-MB instead of traditional MB. In particular, the intrinsic feature of the quadruplex motif facilitates the design of functional molecular beacons by independently varying the concentration of monovalent or divalent cations in the medium.
