We present the first laser guide star adaptive optics (LGSAO) observations of the Galactic center. LGSAO has dramatically improved the quality and robustness with which high angular resolution ...infrared images of the Galactic center can be obtained with the Keck II 10 m telescope. Specifically, Strehl ratios of 0.7 and 0.3 at L' (3.8 km) and K' (2.1 km), respectively, are achieved in these LGSAO images; these are at least a factor of 2 higher and a factor of 4-5 more stable against atmospheric fluctuations than the Strehl ratios delivered thus far with the Keck natural guide star AO system on the Galactic center. Furthermore, these observations are the first that cover a large area (76 x 76) surrounding the central black hole at diffraction-limited resolution for an 8-10 m class telescope. During our observations, the infrared counterpart to the central supermassive black hole, Sgr A*-IR, showed significant infrared intensity variations, with observed L' magnitudes ranging from 12.6 to 14.5 mag and a decrease in flux density of a factor of 2 over an 8 minute interval. The faintest end of our L' detections, 1.3 mJy (dereddened), is the lowest level of emission yet observed for this source by a factor of 3. No significant variation in the location of Sgr A*-IR is detected as a function of either wavelength or intensity. Previous claims of such positional variations are easily attributable to a nearby (0.09 or 720 AU, projected), extended, very red source, which we suggest arises from a locally heated dust feature. Near a peak in its intensity, we obtained the first measurement of Sgr A*-IR's K'- L' color; its K' - L' of 3.0 c 0.2 mag (observed) or 1.4 c 0.2 (dereddened) corresponds to an intrinsic spectral index of a = -0.5 c 0.3 for F sub( )8 super(a). This is significantly bluer than other recent infrared measurements from the literature, which suggest a = -4 c 1. Because our measurement was taken at a time when Sgr A* was 66 times brighter in the infrared than the other measurements, we posit that the spectral index of the emission arising from the vicinity of our Galaxy's central black hole may depend on the strength of the flare, with stronger flares giving rise to a higher fraction of high-energy electrons in the emitting region.
Satellites of the Largest Kuiper Belt Objects Brown, M. E; van Dam, M. A; Bouchez, A. H ...
Astrophysical journal/The Astrophysical journal,
03/2006, Letnik:
639, Številka:
1
Journal Article
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We have searched the four brightest objects in the Kuiper Belt for the presence of satellites using the newly commissioned Keck Observatory Laser Guide Star Adaptive Optics system. Satellites are ...seen around three of the four objects: Pluto (whose satellite Charon is well-known and whose recently discovered smaller satellites are too faint to be detected), 2003 EL61 (where a second satellite is seen in addition to the previously known satellite), and 2003 UB313 (where a satellite is seen for the first time). The object 2005 FY9, the brightest Kuiper Belt object (KBO) after Pluto, does not have a satellite detectable within 0 4 with a brightness of more than 1% of the primary. The presence of satellites around three of the four brightest KBOs is inconsistent with the fraction of satellites in the Kuiper Belt at large at the 99.2% confidence level, suggesting a different formation mechanism for these largest KBO satellites. The two satellites of 2003 EL61, and the one satellite of 2003 UB313, with fractional brightnesses of 5% and 1.5%, and 2%, of their primaries, respectively, are significantly fainter relative to their primaries than other known KBO satellites, again pointing to possible differences in their origin.
The Keck Observatory began science observations with a laser guide star adaptive optics system, the first such system on an 8–10 m class telescope, in late 2004. This new capability greatly extends ...the scientific potential of the Keck II Telescope, allowing near–diffraction‐limited observations in the near‐infrared using natural guide stars as faint as 19th magnitude. This paper describes the conceptual approach and technical implementation followed for this system, including lessons learned, and provides an overview of the early science capabilities.
The Keck II Telescope is the first 8–10 m class telescope equipped with a laser guide star adaptive optics (LGS AO) system. Under normal seeing conditions, the LGS AO system producesK‐band Strehl ...ratios between 30% and 40% using bright tip‐tilt guide stars, and it works well with tip‐tilt guide stars as faint as
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, with partial correction for stars up to a magnitude fainter. This paper presents the algorithms implemented in the LGS AO system, as well as experimental performance results. A detailed error budget shows excellent agreement between the measured and expected image quality for both bright and faint guide stars.
The Trojan population consists of two swarms of asteroids following the same orbit as Jupiter and located at the L4 and L5 stable Lagrange points of the Jupiter-Sun system (leading and following ...Jupiter by 60 degrees ). The asteroid 617 Patroclus is the only known binary Trojan. The orbit of this double system was hitherto unknown. Here we report that the components, separated by 680 km, move around the system's centre of mass, describing a roughly circular orbit. Using this orbital information, combined with thermal measurements to estimate the size of the components, we derive a very low density of 0.8(- 0.1)+0.2 g cm(-3). The components of 617 Patroclus are therefore very porous or composed mostly of water ice, suggesting that they could have been formed in the outer part of the Solar System.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract Background Transversal epidemiological data on adenovirus infections in a hospital setting, including both immuno-competent and transplanted patients, are limited and rarely contain the ...application of molecular virology. Objectives To describe the clinical characteristics and molecular epidemiology of adenovirus infections in Bordeaux University Hospital from 2008 to 2010 (clinical data, viral load and adenovirus species distribution). Study design Adenovirus DNA quantification (qPCR) and typing (sequencing of hexon and protein VI genes and protein VI polymerase chain reaction (PCR) product analysis) were applied retrospectively to 215 clinical samples from 105 adenovirus-infected patients (2008–2010, Bordeaux University Hospital). Clinical data were recovered and analysed for 73 children and 25 adults. Results Viral loads were measured in stools, upper and lower respiratory fluids, blood, urine and digestive tract biopsies; the highest values were observed in stools and respiratory samples. Stool viral loads were comparable whatever the immune status. Adenovirus was typed in 57 patients: species Human adenovirus (HAdV) C dominated ( n = 36), followed by B ( n = 15), F ( n = 5) and D ( n = 1). We could demonstrate no association between HAdV species and load or clinical severity (observed in most patients). In the immuno-compromised, in contrast to immuno-competent patients, adenovirus infections presented no seasonal variation. Co-infections were frequent: mostly bacterial in immuno-competent children (33%) and viral in immuno-compromised people (34%). Conclusions The species HAdV C dominates the local ecology, in both respiratory and digestive tract infections, independently of the patient's immune status. Adenovirus infections, often associated with co-infection of bacterial or viral agents, frequently lead to severe clinical consequences in hospital patients.
The aim of the present article is to expose a new method based on TGA-FTIR coupling to quantify the different steps of the thermal degradation of EVA in the presence of HNT. Moreover, this ...quantification of the thermal degradation was also correlated to the color change. EVA/HNT composites were processed with different processing conditions: solvent casting in THF or melt blending at different temperatures. The HNT fillers content (from 10 wt% up to 30 wt%) and the melt blending temperature (at 130 °C, 150 °C, 170 °C and 190 °C) were varied. The thermal degradation of EVA in the presence of HNT presents three noticeable steps as evidenced by TG analysis: i) P1, which was identified as the catalytic degradation of vinyl acetate (VA) part of EVA occurring during the heating ramp (around 250 °C), ii) P2, which is the main degradation of VA (around 350 °C) and iii) P3, which is the degradation of the polyethylene chain of EVA (around 500 °C). Nevertheless, in the case of melt blended EVA/HNT composites, macroscopic changes (strong smell and browning color) indicate a thermal degradation occurring during the melt blending process, namely P0. FTIR-TGA coupling allows to quantify the contribution of P0, P1 and P2 (thermal degradation of VA units of EVA) using Gram Schmidt curves of released acetic acid gas which are obtained from the COac. band of acetic acid at 1795 cm−1. The contribution of each thermal degradation step of the VA part of EVA (named P0 to P2) was then quantified and reported as A0 to A2, respectively. The blending process (solvent or melt) such as the HNT fillers content and the melt blending temperatures have a significant influence on the EVA thermal degradation catalyzed by HNT. For example, it was shown that the thermal degradation of VA units occurring during the processing of EVA+ 30HNT composite (named A0 and catalyzed by the HNT) was of 40% for melt blending process (at 170 °C), whereas it was close to 0% for solvent casting process. Moreover, the macroscopic changes were evaluated by color measurements and an interesting correlation could be made between A0 and ΔE* which is the total color deviation. When a significant catalytic effect, during the melt process was observed (A0 values higher than 5%), the total color deviation ΔE* was increased linearly with A0. Finally, in order to avoid the catalytic effect of HNT on the EVA thermal degradation, a functionalization strategy has been developed with an organosilane leading to the suppression of P1, the catalytic degradation of VA in TG analyses.
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•FTIR-TGA coupling is used to quantify the different vinyl acetate thermal degradation steps of EVA.•EVA thermal degradation is catalyzed by HNT that priorly degrades the vinyl acetate parts of EVA.•Blending process, HNT% and melt blending temperature have an influence on the VA departure of EVA thermal degradation.•A correlation is found between the color change and the catalytic effect during melt processing.
Study Objective. To evaluate the pharmacokinetics and safety of atovaquone suspension in volunteers infected with the human immunodeficiency virus ((HIV).
Design. Open‐label, nonrandomized study.
...Setting. Two clinical research centers.
Patients. Twenty‐two HIV‐infected volunteers with a median CD4 cell count of 37 cells/mm3.
Interventions. Patients received atovaquone suspension fasting or fed for 2‐week periods with crossover at dosages of 500 mg/day, and randomization to fasting or fed at dosages of 750 and 1000 mg/day. A subset of patients also received 750 mg twice/day with food, and a subset of those who received 1000 mg/day fasting also received 1000 mg with food. During a long‐term dosing phase, a subset of subjects were evaluated for an interaction between atovaquone and trimethoprim‐sulfamethoxazole (TMP‐SMX).
Measurements and Main Results. Average steady‐state atovaquone concentrations at 500 mg were 6.7 ± 3.2 μg/ml fasted and 11.3 ± 5.0 μg/ml with food; at 750 mg, 9.9 ± 7.1 μg/ml fasted and 12.5 ± 5.9 μg/ml with food; at 1000 mg, 9.7 ± 4.3 μg/ml fasted and 13.6 ± 5.0 μg/ml with food; and at 1500 mg, 21.1 ± 5.0 μg/ml with food. Thus, plasma concentrations were not proportional to dose. Concomitant food ingestion resulted in a 1.3‐ to 1.7‐fold increase in values. Average steady‐state concentrations were less than 10 μg/ml in 21% and more than 15 μg/ml in 36% of patients at 1000 mg/day with food; at 750 mg twice/day, all five patients had levels above 15 μg/ml. Atovaquone suspension was well tolerated; diarrhea, nausea, fatigue, and rash were the most common adverse events. Concomitant administration of TMP‐SMX did not change atovaquone concentrations and resulted in small decreases in concentrations of TMP (16%) and SMX (10%).
Conclusion. Plasma concentrations are significantly higher when atovaquone suspension is administered with food compared with fasting. Total doses of 1500 mg/day are likely to achieve concentrations effective for prophylaxis of Pneumocystis carinii pneumonia.
Hypogammaglobulinemia (serum IgG levels < 7.0 g/L) has been associated with increased risk of COPD exacerbations but has not yet been shown to predict hospitalizations.
To determine the relationship ...between hypogammaglobulinemia and the risk of hospitalization in patients with COPD.
Serum IgG levels were measured on baseline samples from four COPD cohorts (n = 2,259): Azithromycin for Prevention of AECOPD (MACRO, n = 976); Simvastatin in the Prevention of AECOPD (STATCOPE, n = 653), Long-Term Oxygen Treatment Trial (LOTT, n = 354), and COPD Activity: Serotonin Transporter, Cytokines and Depression (CASCADE, n = 276). IgG levels were determined by immunonephelometry (MACRO; STATCOPE) or mass spectrometry (LOTT; CASCADE). The effect of hypogammaglobulinemia on COPD hospitalization risk was evaluated using cumulative incidence functions for this outcome and deaths (competing risk). Fine-Gray models were performed to obtain adjusted subdistribution hazard ratios (SHR) related to IgG levels for each study and then combined using a meta-analysis. Rates of COPD hospitalizations per person-year were compared according to IgG status.
The overall frequency of hypogammaglobulinemia was 28.4%. Higher incidence estimates of COPD hospitalizations were observed among participants with low IgG levels compared with those with normal levels (Gray's test, P < .001); pooled SHR (meta-analysis) was 1.29 (95% CI, 1.06-1.56, P = .01). Among patients with prior COPD admissions (n = 757), the pooled SHR increased to 1.58 (95% CI, 1.20-2.07, P < .01). The risk of COPD admissions, however, was similar between IgG groups in patients with no prior hospitalizations: pooled SHR = 1.15 (95% CI, 0.86-1.52, P =.34). The hypogammaglobulinemia group also showed significantly higher rates of COPD hospitalizations per person-year: 0.48 ± 2.01 vs 0.29 ± 0.83, P < .001.
Hypogammaglobulinemia is associated with a higher risk of COPD hospital admissions.
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