Intrinsically stretchable bioelectronic devices based on soft and conducting organic materials have been regarded as the ideal interface for seamless and biocompatible integration with the human ...body. A remaining challenge is to combine high mechanical robustness with good electrical conduction, especially when patterned at small feature sizes. We develop a molecular engineering strategy based on a topological supramolecular network, which allows for the decoupling of competing effects from multiple molecular building blocks to meet complex requirements. We obtained simultaneously high conductivity and crack-onset strain in a physiological environment, with direct photopatternability down to the cellular scale. We further collected stable electromyography signals on soft and malleable octopus and performed localized neuromodulation down to single-nucleus precision for controlling organ-specific activities through the delicate brainstem.
Next-generation light-emitting displays on skin should be soft, stretchable and bright
. Previously reported stretchable light-emitting devices were mostly based on inorganic nanomaterials, such as ...light-emitting capacitors, quantum dots or perovskites
. They either require high operating voltage or have limited stretchability and brightness, resolution or robustness under strain. On the other hand, intrinsically stretchable polymer materials hold the promise of good strain tolerance
. However, realizing high brightness remains a grand challenge for intrinsically stretchable light-emitting diodes. Here we report a material design strategy and fabrication processes to achieve stretchable all-polymer-based light-emitting diodes with high brightness (about 7,450 candela per square metre), current efficiency (about 5.3 candela per ampere) and stretchability (about 100 per cent strain). We fabricate stretchable all-polymer light-emitting diodes coloured red, green and blue, achieving both on-skin wireless powering and real-time displaying of pulse signals. This work signifies a considerable advancement towards high-performance stretchable displays.
Tuberculosis (TB), an infectious remains a global health burden till date. Considering immense importance of theoretical tools in computer aided-drug designing, the current study focuses on common ...pharmacophore and QSAR analysis of 38 imidazopyridine analogues as anti-TB agents. Our developed atom-based, field-based, and multilinear regression based-QSAR models showed high values for statistical robustness for internal as well as external validations (a correlation coefficient:
R
2
> 0.9, least standard deviations, higher Fischer coefficient, and cross-validation correlation coefficient:
Q
2
> 0.5). From our ZINC-Drug-like analysis, we were retained with 5 hits (VS1-VS-5), among them VS-4 molecule was found to have high potency (predicted pIC
50
(μM) value: 7.96 (against MTB H37Rv ATCC 27,294)) with good theoretical properties (high softness, and low hardness values). From our designed analogues (S1-S10), analogue S-10 was retained with high potency as well as good pharmacokinetics to act as good anti-mycobacterial agent in future.
A highly efficient blue‐light emitter, 2‐tert‐butyl‐9,10‐bis4′‐(diphenyl‐phosphoryl)phenylanthracene (POAn) is synthesized, and comprises electron‐deficient triphenylphosphine oxide side groups ...appended to the 9‐ and 10‐positions of a 2‐tert‐butylanthracene core. This sophisticated anthracene compound possesses a non‐coplanar configuration that results in a decreased tendency to crystallize and weaker intermolecular interactions in the solid state, leading to its pronounced morphological stability and high quantum efficiency. In addition to serving as an electron‐transporting blue‐light‐emitting material, POAn also facilitates electron injection from the Al cathode to itself. Consequently, simple double‐layer devices incorporating POAn as the emitting, electron‐transporting, and ‐injecting material produce bright deep‐blue lights having Commission Internationale de L'Eclairage coordinates of (0.15,0.07). The peak electroluminescence performance was 4.3% (2.9 cd A−1). For a device lacking an electron‐transport layer or alkali fluoride, this device displays the best performance of any such the deep‐blue organic light‐emitting diodes reported to date.
A blue‐light‐emitting material POAn, which contains a 2‐tert‐butyl‐anthracene core functionalized with two triphenylphos phine oxide units, exhibits excellent electroluminescence (EL) performance when incorporated into a simple double‐layer EL device possessing high‐work‐function Al as the cathode. The EL efficiency reaches as high as 4.3% (2.9 cd A−1), together with a satisfying blue emission (CIE coordinates: (0.15,0.07)).
Endoscopy-assisted breast surgery (EABS) performed through minimal axillary and/or periareolar incisions is a possible alternative to open surgery for certain patients with breast cancer. In this ...study, we report the early results of an EABS program in Taiwan.
The medical records of patients who underwent EABS for breast cancer during the period May 2009 to December 2014 were collected from the Taiwan Endoscopic Breast Surgery Cooperative Group database. Data on clinicopathologic characteristics, type of surgery, method of breast reconstruction, complications and recurrence were analyzed to determine the effectiveness and oncologic safety of EABS in Taiwan.
A total of 315 EABS procedures were performed in 292 patients with breast cancer, including 23 (7.8%) patients with bilateral disease. The number of breast cancer patients who underwent EABS increased initially from 2009 to 2012 and then stabilized during the period 2012-2014. The most commonly performed EABS was endoscopy-assisted total mastectomy (EATM) (85.4%) followed by endoscopy-assisted partial mastectomy (EAPM) (14.6%). Approximately 74% of the EATM procedures involved breast reconstruction, with the most common types of reconstruction being implant insertion and autologous pedicled TRAM flap surgery. During the six-year study period, there was an increasing trend in the performance of EABS for the management of breast cancer when total mastectomy was indicated. The positive surgical margin rate was 1.9%. Overall, the rate of complications associated with EABS was 15.2% and all were minor and wound-related. During a median follow-up of 26.8 (3.3-68.6) months, there were 3 (1%) cases of local recurrence, 1 (0.3%) case of distant metastasis and 1 (0.3%) death.
The preliminary results from the EABS program in Taiwan show that EABS is a safe procedure and results in acceptable cosmetic outcome. These findings could help to promote this under-used surgical technique in the field of breast cancer.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor ...suppressor genes. Tea polyphenols may inhibit DNMT activity. We designed a case-control study to evaluate the combined effects of smoking, green tea consumption, DNMT3B - 149 polymorphism, and DNA damage on lung cancer occurrence.
Questionnaires were administered to obtain demographic characteristics, life styles, and family histories of lung cancer from 190 primary lung cancer cases and 380 healthy controls. Genotypes and cellular DNA damage were determined by polymerase chain reaction and comet assay, respectively.
The mean DNA tail moment for lung cancer cases was significantly higher than that for healthy controls. Compared to nonsmokers carrying the DNMT3B - 149 CT genotype, smokers carrying the TT genotype had a greater lung cancer risk (odds ratio OR: 2.83, 95% confidence interval CI: 1.62-4.93). DNA damage levels were divided by the tertile of the healthy controls' values. Compared to nonsmokers with low DNA damage, smokers with moderate DNA damage (OR: 2.37, 95% CI: 1.54-3.63) and smokers with high DNA damage (OR: 3.97, 95% CI: 2.63-5.98) had elevated lung cancer risks. Interaction between smoking and DNA damage significantly affected lung cancer risk.
Our study suggested that the DNMT3B - 149 TT genotype, which has higher promoter activity, can increase the lung cancer risk elicited by smoking, and DNA damage may further promote smoking related lung cancer development.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Highly efficient blue electrophosphorescent organic light‐emitting diodes incorporating a bipolar host, 2,7‐bis(diphenylphosphoryl)‐9‐4‐(N,N‐diphenylamino)phenyl‐9‐phenylfluorene (POAPF), doped with ...a conventional blue triplet emitter, iridium(III) bis(4,6‐difluoro‐phenyl)pyridinato‐N,C2´picolinate (FIrpic) are fabricated. The molecular architecture of POAPF features an electron‐donating (p‐type) triphenylamine group and an electron‐accepting (n‐type) 2,7‐bis(diphenyl‐phosphoryl)fluorene segment linked through the sp3‐hybridized C9 position of the fluorene unit. The lack of conjugation between these p‐ and n‐type groups endows POAPF with a triplet energy gap (ET) of 2.75 eV, which is sufficiently high to confine the triplet excitons on the blue‐emitting guest. In addition, the built‐in bipolar functionality facilitates both electron and hole injection. As a result, a POAPF‐based device doped with 7 wt% FIrpic exhibits a very low turn‐on voltage (2.5 V) and high electroluminescence efficiencies (20.6% and 36.7 lm W−1). Even at the practical brightnesses of 100 and 1000 cd m−2, the efficiencies remain high (20.2%/33.8 lm W−1 and 18.8%/24.3 lm W−1, respectively), making POAPF a promising material for use in low‐power‐consumption devices for next‐generation flat‐panel displays and light sources.
Devices incorporating the novel host POAPF, which possesses a high value of ET, satisfactory thermal stability, and bipolar characteristics, display highly efficient blue electrophosphorescence. The 7 wt% FIrpic‐doped device exhibits a very low turn‐on voltage (2.5 V) and high electroluminescence efficiencies (20.6% and 36.7 lm W−1).
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•Synthesis and characterization of novel Cu (II) and Zn (II) complexes of 5-{(2-Hydroxyethyl) sulfanyl methyl}-8-hydroxyquinoline.•Both inhibitors are mixed type.•The anticorrosive ...activity of two complexes is achieved by an experimental electrochemical (EIS and PDP) and Theoretical (DFT and MD) techniques.
Two new complexes were synthesized, characterized and tested as inhibitors for mild steel corrosion in 1.0 M HCl. The anticorrosive effect has been studied using the potentiodynamic polarization (PDP) and impedance spectroscopy (EIS). The inhibitory efficiency increases with increasing concentration to reach 96.0% for Q-Cu and 94.6% for Q-Zn at 10−3 M. The two inhibitors are mixed type and follows the Langmuir isotherm adsorption. The surface of the mild steel has been examined by SEM/EDS and the corrosive solution by ICP-OES. DFT calculations and molecular dynamic simulation (MD) show a good correlation with the experimental results for both complexes.
•In this study, the synthesis of (E)−4-(4-methylbenzyl)−6-styrylpyridazin-3(2H)-one (MBSP) is presented.•MBSP is subsequently characterized by several spectroscopies and the DFT-B3LYP study.•The ...docking and ADME study are performed to investigate whether MBSP is a therapeutic for COVID-19.
In this study, we present the synthesis of novel pyridazin-3(2H)-one derivative namely (E)-4-(4-methylbenzyl)-6-styrylpyridazin-3(2H)-one (MBSP). The chemical structure of MBSP was characterized using spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR, UV–Vis, ESI-MS, and finally, the structure was confirmed by single X-ray diffraction studies. The DFT calculation was performed to compare the gas-phase geometry of the title compound to the solid-phase structure of the title compound. Furthermore, a comparative study between theoretical UV–Vis, IR, 1H- and 13C NMR spectra of the studied compound and experimental ones have been carried out. The thermal behavior and stability of the compound were analyzed by using TGA and DTA techniques which revealed that the compound is thermostable up to its melting point. Finally, the in silico docking and ADME studies are performed to investigate whether MBSP is a potential therapeutic for COVID-19.
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