Dengue virus (DENV) is endemic in many parts of the world. Antibody dependent enhancement (ADE) in DENV infections occurs when a person with primary immunity is infected by a second, different DENV ...strain. Antibodies to Zika virus (ZIKV), which emerged in the Western Hemisphere in 2015, are cross reactive with DENV and theoretically could provoke ADE in a DENV naïve individual. We report the first known patient in the United States with a rapidly progressive and fatal case of travel-associated DENV in which prior exposure to ZIKV likely played a role in triggering an ADE phenomenon. This association of prior ZIKV immunity and subsequent new dengue infection is a worrisome phenomenon and an important contribution to the body of knowledge on immunity to flaviviruses.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The classical model of innovation behind closed doors is slowly but surely being challenged by the Open Innovation model that is reshaping the way organizations bring new products and services into ...the market. This paper reports on the results of an International Space University (ISU) Team Project (TP) focused on the potential, limitations and conditions of success of Open Innovation in the space sector using ISU׳s international, interdisciplinary, intercultural (3Is) approach. Open Innovation can be defined as “the process of strategically managing the sharing of ideas and resources among entities to co-create value”. Conventional approaches to technology development for space, such as spin-offs or spin-ins, are no longer sufficient to fully describe the interactions between organizations in today׳s Research and Development (R&D) landscape. Traditionally, conducting space technology development and launching space missions required massive infrastructure investments, long lead times and large teams of experts. However, internal R&D, dedicated marketing departments and closely guarded intellectual property are no longer the only way to achieve success. Smaller, nimbler teams, significant use of crowdfunding, a more aggressive approach to managing risk and a great motivation to leverage intellectual property are just some of their defining characteristics. By using a case study methodology focused on asteroid mining supported by a critical literature review, the project team highlighted the potential of Open Innovation in space by identifying its most promising applications as well as its limitations.
•Open Innovation is a strategic decision and a state of mind.•Space sector leaders deem Open Innovation effective only in early project phases.•Open Innovation can be applied in any project phase.•The current legal framework for space activities must be clarified and extended.•Suitability analyses help organizations operationalize Open Innovation concepts
Féminin/masculin Abderrahim-Laib, Sakina; Bad, Karin Luisa; Barret-Ducrocq, Françoise ...
1999
eBook, Book
Odprti dostop
Les textes réunis dans ce volume rendent compte de la diversité des questions soulevées par les rapports féminin/masculin, en un temps où la participation des femmes à la vie de la cité est devenue ...d’une actualité brûlante, où l’analyse renouvelée de la notion d’identité (et d’identité sexuelle) se trouve au cœur des débats philosophiques. Le développement des études féministes a conduit à examiner les représentations de la femme dans la presse, les arts et les lettres ainsi qu’à s’interroger sur les marques du féminin dans l’écriture, questions dont il convenait d’esquisser un bilan quelque trente ans après le tournant décisif pris par les revendications des femmes dans les années soixante-dix. Les articles présentés dans l’ouvrage Féminin/masculin, sélectionnés à la suite du congrès de la Société des anglicistes de l’enseignement supérieur qui s’est tenu à Rennes en mai 1998, permettent d’aborder ces questions à partir d’études précises, qui interrogent spécifiquement les littératures et les cultures anglo-saxonnes.
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