Genomic DNA from probands of various Waardenburg syndrome (WS) families were PCR-amplified using primers flanking the 8 exons of PAX3. The PCR fragments were screened for sequence variants, and ...subsequently cycle sequenced. Mutations were detected in exon 6 for 3 probands of WS type 1 families. These mutations all occur in the paired homeodomain DNA-binding motif.
Generation of Digital Elevation Models (DEM) typically requires fine image matching between set of images acquired with a wide-baseline and appropriate B/H ratio. Wide baseline stereo imaging is an ...expensive process since it requires two or more acquisitions at the cost of nominal mono-imaging operations. Due to the wide-baseline, angular separation in views is required, which results in increased occlusion problems leading to holes in the generated DEM. Multiview images taken with wide baselines also have lower overlap area compared to images taken from narrow-baseline systems. Moreover, while making orthorectified maps, large tilts need to be corrected using processing techniques to obtain a top-down view. To alleviate these issues, we propose a novel DEM generation pipeline that utilizes the narrow-baseline information between bands of a single multispectral image. Our method can generate sub-pixel accurate disparity maps while tackling spectral information change. Final DEM is generated from the disparity by using reference Ground Control Points (GCPs) and an iterative control point registration procedure. We demonstrate the effectiveness of our DEM generation pipeline on Resourcesat-2 LISS- IV multispectral image with a BIH ratio as low as 0.018. Our results show that sub pixel disparity of the order of 1/50th of a pixel can be computed. A visual and quantitative comparison of the generated DEM with the wide-baseline DEM from Cartosat-l shows that the elevation information is estimated with good overall agreement even for a hilly region. Our technique makes it possible to extract elevation information from mono-multispectral images with unusually low B/H ratios, potentially enabling the generation of DEMs from multispectral images that would not normall be considered viable for this purpose.
Three studies examined the link between power distance belief(PDB), status, and charity giving. Results suggested that among high(low) PDB consumers, status was positively(negatively) associated with ...charity giving. These results are traced to the differential empathy felt by high and low status people in the two types of systems.
A large repertoire of gene-centric data has been generated in the field of zebrafish biology. Although the bulk of these data are available in the public domain, most of them are not readily ...accessible or available in nonstandard formats. One major challenge is to unify and integrate these widely scattered data sources. We tested the hypothesis that active community participation could be a viable option to address this challenge. We present here our approach to create standards for assimilation and sharing of information and a system of open standards for database intercommunication. We have attempted to address this challenge by creating a community-centric solution for zebrafish gene annotation. The Zebrafish GenomeWiki is a 'wiki'-based resource, which aims to provide an altruistic shared environment for collective annotation of the zebrafish genes. The Zebrafish GenomeWiki has features that enable users to comment, annotate, edit and rate this gene-centric information. The credits for contributions can be tracked through a transparent microattribution system. In contrast to other wikis, the Zebrafish GenomeWiki is a 'structured wiki' or rather a 'semantic wiki'. The Zebrafish GenomeWiki implements a semantically linked data structure, which in the future would be amenable to semantic search. Database URL: http://genome.igib.res.in/twiki.
PDF
