The first measurement of lepton-jet momentum imbalance and azimuthal correlation in lepton-proton scattering at high momentum transfer is presented. These data, taken with the H1 detector at HERA, ...are corrected for detector effects using an unbinned machine learning algorithm (multifold), which considers eight observables simultaneously in this first application. The unfolded cross sections are compared with calculations performed within the context of collinear or transverse-momentum-dependent factorization in quantum chromodynamics as well as Monte Carlo event generators.
This Letter describes the measurement of elliptic flow of charged particles in lead–lead collisions at sNN=2.76 TeV using the ATLAS detector at the Large Hadron Collider (LHC). The results are based ...on an integrated luminosity of approximately 7 μb−1. Elliptic flow is measured over a wide region in pseudorapidity, |η|<2.5, and over a broad range in transverse momentum, 0.5<pT<20 GeV. The elliptic flow parameter v2 is obtained by correlating individual tracks with the event plane measured using energy deposited in the forward calorimeters. As a function of transverse momentum, v2(pT) reaches a maximum at pT of about 3 GeV, then decreases and becomes weakly dependent on pT above 7–8 GeV. Over the measured pseudorapidity region, v2 is found to be only weakly dependent on η, with less variation than observed at lower beam energies. The results are discussed in the context of previous measurements at lower collision energies, as well as recent results from the LHC.
Background Cardiac rhythm abnormalities are a leading cause of morbidity and mortality in developed countries. Loss-of-function variants in the ANK2 gene can cause a variety of cardiac rhythm ...abnormalities including sinus node dysfunction, atrial fibrillation and ventricular arrhythmias (called the “ankyrin-B syndrome”). ANK2 encodes ankyrin-B, a molecule critical for the membrane targeting of key cardiac ion channels, transporters, and signalling proteins. Methods and Results Here, we describe a family with a reciprocal chromosomal translocation between chromosomes 4q25 and 9q26 that transects the ANK2 gene on chromosome 4 resulting in loss-of-function of ankyrin-B. Select family members with ankyrin-B haploinsufficiency due to the translocation displayed clinical features of ankyrin-B syndrome. Furthermore, evaluation of primary lymphoblasts from a carrier of the translocation showed altered levels of ankyrin-B as well as a reduced expression of downstream ankyrin-binding partners. Conclusions Thus, our data conclude that, similar to previously described ANK2 loss-of-function “point mutations”, large chromosomal translocations resulting in ANK2 haploinsufficiency are sufficient to cause the human cardiac ankyrin-B syndrome. The unexpected ascertainment of ANK2 dysfunction via the discovery of a chromosomal translocation in this family, the determination of the familial phenotype, as well as the complexities in formulating screening and treatment strategies are discussed.
The article presents new high-quality continuous stratospheric aerosol observations spanning 1994–2015 at the French Observatoire de Haute-Provence (OHP, 44° N, 6° E) obtained by two independent, ...regularly maintained lidar systems operating within the Network for Detection of Atmospheric Composition Change (NDACC). Lidar series are compared with global-coverage observations by Stratospheric Aerosol and Gas Experiment (SAGE II), Global Ozone Monitoring by Occultation of Stars (GOMOS), Optical Spectrograph and InfraRed Imaging System (OSIRIS), Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP), and Ozone Mapping Profiling Suite (OMPS) satellite instruments, altogether covering the time span of OHP lidar measurements. Local OHP and zonal-mean satellite series of stratospheric aerosol optical depth are in excellent agreement, allowing for accurate characterization of stratospheric aerosol evolution and variability at northern midlatitudes during the last 2 decades. The combination of local and global observations is used for a careful separation between volcanically perturbed and quiescent periods. While the volcanic signatures dominate the stratospheric aerosol record, the background aerosol abundance is found to be modulated remotely by the poleward transport of convectively cleansed air from the deep tropics and aerosol-laden air from the Asian monsoon region. The annual cycle of background aerosol at midlatitudes, featuring a minimum during late spring and a maximum during late summer, correlates with that of water vapor from the Aura Microwave Limb Sounder (MLS). Observations covering two volcanically quiescent periods over the last 2 decades provide an indication of a growth in the nonvolcanic component of stratospheric aerosol. A statistically significant factor of 2 increase in nonvolcanic aerosol since 1998, seasonally restricted to late summer and fall, is associated with the influence of the Asian monsoon and growing pollution therein.
A search for neutral Higgs bosons decaying to pairs of τ leptons with the ATLAS detector at the LHC is presented. The analysis is based on proton–proton collisions at a center-of-mass energy of 7 ...TeV, recorded in 2010 and corresponding to an integrated luminosity of 36 pb−1. After signal selection, 276 events are observed in this data sample. The observed number of events is consistent with the total expected background of 269±36 events. Exclusion limits at the 95% confidence level are derived for the production cross section of a generic Higgs boson ϕ as a function of the Higgs boson mass and for A/H/h production in the Minimal Supersymmetric Standard Model (MSSM) as a function of the parameters mA and tanβ.
This Letter presents a search for high mass e+e− or μ+μ− resonances in pp collisions at s=7 TeV at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total ...integrated luminosity of ∼40 pb−1. No statistically significant excess above the Standard Model expectation is observed in the search region of dilepton invariant mass above 110 GeV. Upper limits at the 95% confidence level are set on the cross section times branching ratio of Z′ resonances decaying to dielectrons and dimuons as a function of the resonance mass. A lower mass limit of 1.048 TeV on the Sequential Standard Model Z′ boson is derived, as well as mass limits on Z⁎ and E6-motivated Z′ models.
Objective: This study was undertaken to compare rates and severity of gestational hypertension and preeclampsia, as well as perinatal outcomes when these complications develop, between women with ...twin gestations and those with singleton gestations.
Study Design: This was a secondary analysis of prospective data from women with twin (n = 684) and singleton (n = 2946) gestations enrolled in two separate multicenter trials of low-dose aspirin for prevention of preeclampsia. End points were rates of gestational hypertension, rates of preeclampsia, and perinatal outcomes among women with hypertensive disorders.
Results: Women with twin gestations had higher rates of gestational hypertension (relative risk, 2.04; 95% confidence interval, 1.60-2.59) and preeclampsia (relative risk, 2.62; 95% confidence interval, 2.03-3.38). In addition, women with gestational hypertension during twin gestations had higher rates of preterm delivery at both <37 weeks’ gestation (51.1% vs 5.9%;
P < .0001) and <35 weeks’ gestation (18.2% vs 1.6%;
P < .0001) and also had higher rates of small-for-gestational-age infants (14.8% vs 7.0%;
P = .04). Moreover, when outcomes associated with preeclampsia were compared, women with twin gestations had significantly higher rates of preterm delivery at <37 weeks’ gestation (66.7% vs 19.6%;
P < .0001), preterm delivery at <35 weeks’ gestation (34.5% vs 6.3%;
P < .0001), and abruptio placentae (4.7% vs 0.7%;
P = .07). In contrast, among women with twin pregnancies, those who remained normotensive had more adverse neonatal outcomes than did those in whom hypertensive complications developed.
Conclusions: Rates for both gestational hypertension and preeclampsia are significantly higher among women with twin gestations than among those with singleton gestations. Moreover, women with twin pregnancies and hypertensive complications have higher rates of adverse neonatal outcomes than do those with singleton pregnancies. (Am J Obstet Gynecol 2000;182:938-42.)
A search for squarks and gluinos in events containing jets, missing transverse momentum and no electrons or muons is presented. The data were recorded in 2011 by the ATLAS experiment in s=7 TeV ...proton–proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation is observed in 1.04 fb−1 of data. Gluino and squark masses below 700 GeV and 875 GeV respectively are excluded at the 95% confidence level in simplified models containing only squarks of the first two generations, a gluino octet and a massless neutralino. The exclusion limit increases to 1075 GeV for squarks and gluinos of equal mass. In MSUGRA/CMSSM models with tanβ=10, A0=0 and μ>0, squarks and gluinos of equal mass are excluded for masses below 950 GeV. These limits extend the region of supersymmetric parameter space excluded by previous measurements.
Using the ATLAS detector, a centrality-dependent suppression has been observed in the yield of J/ψ mesons produced in the collisions of lead ions at the Large Hadron Collider. In a sample of ...minimum-bias lead–lead collisions at a nucleon–nucleon centre of mass energy sNN=2.76 TeV, corresponding to an integrated luminosity of about 6.7 μb−1, J/ψ mesons are reconstructed via their decays to μ+μ− pairs. The measured J/ψ yield, normalized to the number of binary nucleon–nucleon collisions, is found to significantly decrease from peripheral to central collisions. The centrality dependence is found to be qualitatively similar to the trends observed at previous, lower energy experiments. The same sample is used to reconstruct Z bosons in the μ+μ− final state, and a total of 38 candidates are selected in the mass window of 66 to 116 GeV. The relative Z yields as a function of centrality are also presented, although no conclusion can be inferred about their scaling with the number of binary collisions, because of limited statistics. This analysis provides the first results on J/ψ and Z production in lead–lead collisions at the LHC.
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