First Ln(
ii
) ring-expanded NHC complexes (er-NHC)LnN(SiMe
3
)
2
2
(Ln = Sm, Yb) are synthesized and proved to be highly efficient pre-catalysts for the intermolecular hydrophosphination of such ...indolent substrates as 1-alkenes, cyclohexene and norbornene.
First Ln(
ii
) ring-expanded NHC complexes (er-NHC)LnN(SiMe
3
)
2
2
(Ln = Sm, Yb) are synthesized and proved to be highly efficient pre-catalysts for the intermolecular hydrophosphination of such indolent substrates as 1-alkenes, cyclohexene and norbornene.
A series of amido Ca and Yb(II) complexes LMN(SiMe3)2(THF) (1Yb, 1–4Ca) coordinated by amidine-amidopyridinate ligands L 1–4 were synthesized via a transamination reaction between proligands L ...1–4 H and bisamido complexes MN(SiMe3)22(THF)2 (M = Yb, Ca). The reactions of YbN(SiMe3)22(THF)2 with proligands L 2 H-L 4 H containing CF3 and C6H4F fragments do not allow for preparing the target Yb(II) complexes, while the Ca analogues were synthesized in good yields. Complexes 1Yb and 1–4Ca were evaluated as precatalysts for hydrophosphination of styrene, p-substituted styrenes, α-Me-styrene, and 2,3-dimethylbutadiene with various primary and secondary phosphines (PhPH2, 2,4,6-Me3C6H2PH2, 2-C5NH4PH2, Ph2PH, Cy2PH). Complexes 1Yb, 1–4Ca performed high catalytic activities in styrene hydrophosphination with PhPH2 and Ph2PH and demonstrated high regioselectivity affording exclusively the anti-Markovnikov addition products. For primary PhPH2 the reactions (1:1 molar ratio of substrates) catalyzed by 1Yb, 1Ca, and 2Ca proved to be highly chemoselective affording the secondary phosphine Ph(PhCH2CH2)PH; however, complexes 3Ca and 4Ca led to the formation of both secondary and tertiary phosphines in 80:20 and 86:14 ratios. Styrene hydrophosphinations with 2,4,6-Me3C6H2PH2 and 2-pyridylphosphine for all complexes 1Yb and 1–4Ca proceeded much more slowly compared to PhPH2. Addition of 2-C5NH4PH2 to styrene catalyzed by complex 1Yb turned out to be non-regioselective and led to the formation of a mixture of Markovnikov and anti-Markovnikov addition products, while all Ca complexes enabled regioselective anti-Markovnikov addition. Complexes 1Ca and 1Yb containing catalytic centers featuring similar ionic radii performed different catalytic activity: the ytterbium analogue proved to be a more active catalyst for intermolecular hydrophosphination of styrene with Cy2PH, 2-C5NH4PH2, and PhPH2, but less active with sterically demanding 2,4,6-Me3C6H2PH2. Styrenes containing in p-position electron-donating groups (Me, tBu, OMe) performed with noticeably lower rates in the reactions with PhPH2 compared to styrene. Complexes 1Yb, 1Ca, 2Ca, 3Ca, and 4Ca enabled addition of PhPH2 toward the double CC bond of α-Me-styrene, and the reaction rate for this substrate is noticeably lower; however quantitative conversions were reached in ∼40 h. Complexes 1Ca and 2Ca promoted 1,2-addition of PhPH2 to 2,3-dimethyl butadiene with excellent regio- and chemoselectivity to afford linear secondary phosphines. Hydrophosphination of inert 1-nonene with Ph2PH with 40% conversion becomes possible due to the application of complex 2Ca (40 h, 70 °C). The rate law for the hydrophosphination of styrene with Ph2PH catalyzed by 1Ca was found to agree with the idealized equation: v = kstyrene11Ca1.
The first example of intermolecular hydrophosphination of styrene, 2‐vinylpyridine and phenylacetylene with PH3 catalyzed by bis‐(amido) complexes (Me3Si)2N2M(NHC)2 (M=Ca, Yb, Sm) coordinated by NHC ...ligands is described. The reactions of styrene with PH3 proceed under mild conditions in quantitative yields to afford only anti‐Markovnikov product and allow for the chemoselective synthesis of primary, secondary and tertiary phosphines. Addition of phenylacetylene to PH3 regardless the initial molar substrates ratio results in the exclusive formation of a tertiary tris‐(Z‐styryl)‐phosphine. Crucial effect of the Lewis base coordinated to the metal ion in precatalyst on catalytic activity in styrene hydrophosphination with PH3 was demonstrated. Free NHCs were also found to be able to promote addition of PH3 to styrene, however they provide much lower reaction rates compared to the metal complexes.
Any phosphine you like: The first example of intermolecular hydrophosphination of styrene, 2‐vinylpyridine and phenylacetylene with PH3 catalyzed by CaII, YbII and SmII bis(amido) complexes coordinated by NHC ligands is described. The reactions of styrene with PH3 proceed under mild conditions in quantitative yields to afford only anti‐Markovnikov product and allow for the chemoselective synthesis of primary, secondary and tertiary phosphines.
The first example of intermolecular hydrophosphination of styrene, 2-vinylpyridine and phenylacetylene with PH
catalyzed by bis-(amido) complexes (Me
Si)
N
M(NHC)
(M=Ca, Yb, Sm) coordinated by NHC ...ligands is described. The reactions of styrene with PH
proceed under mild conditions in quantitative yields to afford only anti-Markovnikov product and allow for the chemoselective synthesis of primary, secondary and tertiary phosphines. Addition of phenylacetylene to PH
regardless the initial molar substrates ratio results in the exclusive formation of a tertiary tris-(Z-styryl)-phosphine. Crucial effect of the Lewis base coordinated to the metal ion in precatalyst on catalytic activity in styrene hydrophosphination with PH
was demonstrated. Free NHCs were also found to be able to promote addition of PH
to styrene, however they provide much lower reaction rates compared to the metal complexes.
A series of NHC-stabilized amido compounds (NHC) n MN(SiMe3)22 (M = Yb(II), Sm(II), Ca(II); n = 1, 2) showed remarkable catalytic efficiency in addition of PhPH2 and PH3 to alkenes under mild ...conditions and low catalyst loading. The effect of σ-donor capacity of NHCs on catalytic activity in hydrophosphination of styrene with PhPH2 and PH3 was revealed. For the series of three-coordinate complexes 1–4M, a tendency to increase the catalytic activity with growth of σ-donating strength of the carbene ligand was clearly demonstrated. The complex (NHC)2SmN(SiMe3)22 (NHC = 1,3-diisopropyl-2H-imidazole-2-ylidene) (5Sm) proved to be the most efficient catalyst, which enabled hardly realizable transformations such as PhPH2 addition across internal CC bonds of norbornene and cis- and trans-stilbenes, providing the highest reaction rate for addition of PH3 to styrene. Excellent regio- and chemoselectivities of alkylation of PH3 with styrenes allow for a selective and good-yield synthesis of desired organophosphineseither primary, secondary, or tertiary. Stepwise alkylation of PH3 with various substituted styrenes can be efficiently applied as an approach to nonsymmetric secondary phosphines. The rate equation of the addition of styrene to PH3 promoted by 5Sm was found: rate = kstyrene15Sm1.
The first example of intermolecular highly regio‐ and chemoselective hydrophosphination of olefins and acetylenes with PH3 catalyzed by CaII, YbII, and SmII bis‐(amido) complexes coordinated by NHC ...ligands is described. The molecules of styrene, phosphine, and primary, secondary, and tertiary phosphines are symbolically depicted in the form of the puppets driven by a green catalyst controlling the chemoselectivity of the hydrophosphination process. More information can be found in the Communication by A. A. Trifonov et al. on page 459.
The treatment of 4,5-dimethyl-1,3-bis(2-pyridylmethyl)-1H-imidazolium chloride with MN(SiMe3)22(THF)2 (M = Ca, Yb) in 1:2 molar ratio results in the formation of a carbene fragment, activation of ...the picolyl CH bond, and dearomatization of one of the pyridine rings and affords bis(amido) complexes (NHC)MN(SiMe3)22 (M = Ca (2), Yb (3)) coordinated by a μ2-bridging pincer NHC amido ligand. Complexes 2 and 3 demonstrate high catalytic activity and excellent regio- and chemoselectivities in the intermolecular hydrophosphination of styrene with both primary and secondary phosphines. Complexes 2 and 3 enable selective addition of PhPH2, Ph2PH, (CH2)4NH, and (CH2)5NH to para-divinylbenzene with high conversions under mild conditions. Tandem hydrophosphination/hydroamination of para-divinylbenzene was also performed.
The half-sandwich fluorenyl-amido complex 2,7-tBu2-9-SiMe3C13H6YbN(SiMe3)2(DME) was synthesized by the reaction of (Me3Si)2N2Yb(THF)2 with 2,7-tBu2-9-SiMe3C13H7 (1:1 molar ratio) in 83% yield. ...The analogous reaction of (Me3Si)2N2Sm(THF)2 affords a mixture of equimolar amounts of the half-sandwich complexes 2,7-tBu2-9-SiMe3C13H6SmN(SiMe3)2(DME) (2a) and heteroligand sandwich 2,7-tBu2-9-SiMe3C13H6Sm2,7-tBu2C13H7(DME) (2b). The heteroligand sandwich complex 2,7-tBu2-9-SiMe3C13H6Sm2,7-tBu2-C13H7(THF)2 (3) was synthesized in 60% yield by reacting (Me3Si)2N2Sm(THF)2 with 2 equiv of 2,7-tBu2-9-SiMe3C13H7. Complexes 2b and 3 result from competitive abstraction of H or SiMe3 from 2,7-tBu2-9-SiMe3-fluorene by an amido group. In contrast, the homoligand sandwich complex 2,7-tBu2-9-SiMe3C13H62Sm(DME) (5) could be synthesized in 80% yield when (p-tBuC6H4)2 CH2Sm(DME)2 was used as a precursor. The complex (2,7-tBu2C13H7)2Sm(THF)2 (6) was synthesized by the reaction of 2,7-tBu2C13H8 with (Me3Si)2N2Sm(THF)2 (2:1) in 65% yields. The crystal structures of complexes 1, 2a,b, 3, 5, and 6 were established by X-ray analyses.
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