The Deep Underground Neutrino Experiment (DUNE) is a leading-edge experiment designed to perform neutrino science and proton decay searches. In particular, the far detector will consist of four ...10-kton Liquid Argon (LAr) Time Projection Chambers using both single and dual-phase technologies. The latter provides charge amplification in the gaseous phase. In order to optimize these designs, two large prototypes are taking data at CERN since 2018. Previously, a dual-phase 4-tonne demonstrator was constructed and exposed to cosmic muons in 2017 and exhibited good performance in terms of charge and light collection. The light detection system is important to provide a trigger to the charge acquisition system and to obtain additional information from the scintillation light produced in the particle interaction. In the demonstrator, five cryogenic photo-multipliers were installed with different base polarity configurations and wavelength shifting methods. During the detector operation, scintillation light data were collected in different drift and amplification field conditions. An overview of the light detection system performance and results on the light production and propagation are presented. Our studies allowed us to improve the understanding of some LAr properties.
Persistence of breathlessness after recovery from SARS-CoV-2 pneumonia is frequent. Recovery from acute respiratory failure (ARF) is usually determined by normalized arterial blood gases (ABGs), but ...the prevalence of persistent exercise-induced desaturation (EID) and dyspnea is still unknown.
We investigated the prevalence of EID in 70 patients with normal arterial oxygen at rest after recovery from ARF due to COVID-19 pneumonia. Patients underwent a 6-min walking test (6MWT) before discharge from hospital. We recorded dyspnea score and heart rate during 6MWT. We also investigated the possible role of lung ultrasound (LU) in predicting EID. Patients underwent a LU scan and scores for each explored area were summed to give a total LU score.
In 30 patients (43%), oxygen desaturation was >4% during 6MWT. These patients had significantly higher dyspnea and heart rate compared to non-desaturators. LU score >8.5 was significantly able to discriminate patients with EID.
In SARS-CoV-2 pneumonia, ABGs at discharge cannot predict the persistence of EID, which is frequent. LU may be useful to identify patients at risk who could benefit from a rehabilitation program.
The Deep Underground Neutrino Experiment (DUNE) is a dual-site experiment for long-baseline neutrino oscillation studies, and for neutrino astrophysics and nucleon decay searches. The far detector is ...a 40-kton underground liquid argon time-projection-chamber (LAr TPC), in which the photon detector system adds precise timing capabilities. The ProtoDUNE Dual-Phase detector will consist of a 6×6×6 m3 LAr TPC to be operated at the CERN Neutrino Platform and the photon detection system will be formed by 8-inch cryogenic photomultipliers from Hamamatsu. The PMT model (R5912-20Mod) performance at cryogenic temperature is studied including dark current, gain, and linearity with the light intensity and pulse rate. In addition, the PMT base design is validated. At cold, a decrease of the PMT amplification, or fatigue effect, is measured as the PMT output current increases, either, due to high gain, light intensity or rate. Also, the characterization results of the 40 photomultipliers to be used in ProtoDUNE Dual-Phase are presented.
The Dermatology Life Quality Index (DLQI) is the most commonly used instrument for clinical evaluation of the impact on health-related quality of life (HRQOL) in dermatological research protocols. ...The DLQI's classical psychometric properties have been considered adequate in validation studies from several countries. However, the structure of the DLQI is a matter of discussion, especially concerning the dimensionality and informative properties of its questions according to the item response theory (IRT). Pooled data from studies in Brazil that utilized the DLQI to assess HRQOL in 14 dermatoses were reanalyzed. Classical psychometrical analysis, dimensionality assessment through parallel analysis and IRT (Samejima's ordinal model) analysis were performed. The sample consisted of 1286 patients with a mean age of 47 years (SD = 16), and the proportion of women was 59% (765). The DLQI scores ranged from 0 to 29, with a median (p.sub.25-p.sub.75) of 5 (2-11). All items indicated significant correlations with the total DLQI score (rho > 0.54). The Cronbach's alpha result was 0.90 (CI 95% 0.89-0.91). Parallel analysis indicated a unidimensional factor structure. According to IRT analysis, items q6 (sports) and q7 (work/study) exhibited insufficient fit to the model (p < 0.01), while the items that indicated the best discrimination and information functions were q2 (embarrassment), q3 (shopping/gardening), q4 (clothing) and q5 (social/leisure). The ordination of the scores was confirmed for all items. Most items revealed non-uniform behavior according to sex, age and type of disease. The DLQI exhibits adequate psychometric reliability and a unidimensional structure for assessing HRQOL in Brazilian dermatological patients. The DLQI's performance varies in the assessment of HRQOL in heterogeneous samples.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
ProtoDUNE-DP is a <inline-formula> <tex-math notation="LaTeX">6\times 6\times 6\,\,\text{m}^{3} </tex-math></inline-formula> liquid argon time-projection-chamber operated at the CERN Neutrino ...Platform in 2019-2020 as a prototype of the dual phase concept for the Deep Underground Neutrino Experiment (DUNE) far detector. The photon detection system (PDS) is based on 36 8-in photomultiplier tubes (PMTs) and allows triggering on the scintillation light signals produced by cosmic rays and other charged particles traversing the detector. The acquisition and calibration software specifically developed for the ProtoDUNE-DP PDS is described in this article. This software controls the high-voltage power supplies, the calibration system, and the PDS DAQ. It has been developed with Qt Creator and features different operation modes and a graphical user interface. This software has already been validated and used during the ProtoDUNE-DP operation.
The Hamamatsu R5912-02Mod photomultiplier tube (PMT) will be used in the DUNE dual-phase module, a 10-kton fiducial volume liquid-argon time-projection chamber, which is one of the four projected ...far-detector modules of the DUNE long-baseline neutrino experiment. In the DUNE dual-phase module, the liquid argon places high pressure on the photo-detectors located at the bottom of the 14-m cryostat. Four Hamamatsu R5912-02Mod PMTs were tested at 4-bar absolute pressure and cryogenic temperature (in liquid nitrogen) for the first time. No mechanical or electrical damage is reported, validating the use of this PMT model in the DUNE dual-phase module and in other large scale cryogenic liquid detectors. The differences observed in their behavior are expected for the change in the PMT operating temperature.
A LED-based fiber calibration system for the ProtoDUNE-Dual Phase (DP) photon detection system (PDS) has been designed and validated. ProtoDUNE-DP is a 6x6x6 m3 liquid argon time-projection-chamber ...(LAr TPC) currently being installed at the Neutrino Platform at CERN. The PDS is based on 36 8-inch photomultiplier tubes (PMTs) and will allow triggering on cosmic rays. The system serves as prototype for the PDS of the final DUNE DP far detector in which the PDS also has the function to allow the 3D event reconstruction on non-beam physics. For this purpose an equalized PMT response is desirable to allow using the same threshold definition for all PMT groups, simplifying the determination of the trigger efficiency. The light calibration system (LCS) described in this paper is developed to provide this and to monitor the PMT performance in-situ.
Background Primary cutaneous cryptococcosis is an uncommon infectious disease caused by Cryptococcus neoformans or Cryptococcus gattii affecting immunosuppressed as well as immunocompetent patients. ...It is often misdiagnosed as it may mimic other cutaneous diseases.
Materials and methods We report a series of cases diagnosed from 2005 to 2010 in two general hospitals. The diagnosis in all patients was made on the basis of histopathology and culture. Phenoloxidase and canavanine‐glycine‐bromothymol blue tests were used in order to identify the Cryptococcus species. Systematic investigation ruled out the systemic involvement in every case.
Results Eleven patients, 81.8% male, were diagnosed during this study. The immunosuppression status was identified in 54.5% of patients, and all of them were under corticosteroid therapy due to a variable set of diseases. All patients presented with circumscribed lesions on their upper limbs. Most lesions showed an infiltrative or tumoral aspect with up to 40 cm diameter. Fluconazole, up to 400 mg/daily, was the main therapeutic regimen and proved to be efficient.
Conclusions Primary cutaneous cryptococcosis has been diagnosed in both immunosuppressed and immunocompetent patients. Its peculiar clinical aspect could facilitate early diagnosis. Culture and biochemical tests should be performed in order to define the species involved.
A
bstract
A
θ
13
oscillation analysis based on the observed antineutrino rates at the Double Chooz far and near detectors for different reactor power conditions is presented. This approach provides a ...so far unique simultaneous determination of
θ
13
and the total background rates without relying on any assumptions on the specific background contributions. The analysis comprises 865 days of data collected in both detectors with at least one reactor in operation. The oscillation results are enhanced by the use of 24.06 days (12.74 days) of reactor-off data in the far (near) detector. The analysis considers the
ν
¯
e
interactions up to a visible energy of 8.5 MeV, using the events at higher energies to build a cosmogenic background model considering fast-neutrons interactions and
9
Li decays. The background-model-independent determination of the mixing angle yields sin
2
(2
θ
13
) = 0
.
094 ± 0
.
017, being the best-fit total background rates fully consistent with the cosmogenic background model. A second oscillation analysis is also performed constraining the total background rates to the cosmogenic background estimates. While the central value is not significantly modified due to the consistency between the reactor-off data and the background estimates, the addition of the background model reduces the uncertainty on
θ
13
to 0.015. Along with the oscillation results, the normalization of the anti-neutrino rate is measured with a precision of 0.86%, reducing the 1.43% uncertainty associated to the expectation.
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