Summary Oncocytic mucoepidermoid carcinoma poses diagnostic challenge because of its histologic overlap with other oncocytic salivary gland lesions, including Warthin tumor. Although the prognostic ...value of the t(11;19) MECT1-MAML2 fusion gene has been established in mucoepidermoid carcinoma, its diagnostic use in discriminating oncocytic mucoepidermoid carcinoma from histologic mimics is unexplored. We evaluated the translocation status in 14 cases of oncocytic mucoepidermoid carcinoma using a MAML2 -11q21 break-apart probe spanning the entire chromosome region of the MAML2 gene and correlated these findings with clinicopathologic parameters including age, sex, stage, predominant growth pattern, grade, and p63 immunostaining pattern. All oncocytic mucoepidermoid carcinomas were parotid tumors with a mean patient age of 54.6 years (range, 9-85) and a female to male ratio of 5:2. Grade distribution was as follows: low grade, 9; intermediate grade, 2; and high grade, 3. The histologic patterns observed were as follows: solid, 4; cystic, 8 (of these, 5 had Warthin-like lymphoid stroma); and mixed, 2. Solid oncocytic mucoepidermoid carcinomas showed a diffuse p63 staining pattern, whereas cystic oncocytic mucoepidermoid carcinomas showed staining of the outer layer of intermediate cells ranging from a bilayer to areas of complex multilayering and plaque-like proliferation. Ten (71%) of the 14 cases showed a MAML2 rearrangement by fluorescence in situ hybridization. No correlation was seen between rearrangement status and histologic grade, growth pattern, or p63 staining pattern. However, we demonstrate that the presence of MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions.
The Petrochemistry of Jake_M: A Martian Mugearite Stolper, E. M.; Baker, M. B.; Newcombe, M. E. ...
Science (American Association for the Advancement of Science),
09/2013, Letnik:
341, Številka:
6153
Journal Article
Recenzirano
Odprti dostop
"Jake_M," the first rock analyzed by the Alpha Particle X-ray Spectrometer instrument on the Curiosity rover, differs substantially in chemical composition from other known martian igneous rocks: It ...is alkaline (>15% normative nepheline) and relatively fractionated. Jake_M is compositionally similar to terrestrial mugearites, a rock type typically found at ocean islands and continental rifts. By analogy with these comparable terrestrial rocks, Jake_M could have been produced by extensive fractional crystallization of a primary alkaline or transitional magma at elevated pressure, with or without elevated water contents. The discovery of Jake_M suggests that alkaline magmas may be more abundant on Mars than on Earth and that Curiosity could encounter even more fractionated alkaline rocks (for example, phonolites and trachytes).
SETTING: A community in Southern Mexico with a high prevalence of tuberculosis.OBJECTIVE: To characterize the transmission dynamics in a region with a DOTS-based tuberculosis control program.DESIGN: ...Community-based screening of chronic coughers between 1 March 1995 and 31 August
1996. Individuals with acid-fast bacilli (AFB) in their sputum were enrolled, interviewed, and had mycobacterial cultures and fingerprinting performed. In-depth interviews were conducted on all persons with DNA fingerprintingRESULTS: AFB smears were performed on 1424 individuals, 124 of
whom were microbiologically confirmed. Of the 95 cases for whom bacterial DNA fingerprints were available, 38 were in clusters. The largest cluster involved seven individuals who were members of a social network centered on a series of unlicensed bars.CONCLUSION: This population-based
molecular epidemiologic study showed that a focus of transmission within a social network accounted for one fourth of transmission which rapidly progressed to disease. These observations raise questions about the potential benefit of targeted tuberculosis control interventions in health jurisdictions
approaching WHO-defined DOTS benchmarks.
Abstract
Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): National Institute of Cardiology of Mexico “Ignacio Chávez”.
Background
Global longitudinal ...strain (GLS) has important prognostic value in different clinical scenarios. However, evidence regarding the value of GLS use during stress echocardiography is currently limited.
Purpose
To evaluate the prognostic value of GLS during stress echocardiography to predict hospitalization for heart failure or acute coronary syndrome.
Methods
We prospectively studied 62 patients with suspected ischemic heart disease referred for dipyridamole stress echocardiography with good images for GLS quantification. Datasets with at least 50 frames per second were obtained.
Results
Overall, 60 patients with baseline and stress GLS were included. 56% were men, BMI was 27.9 (18.5–47.7), age 60 ± 13 years, 31% had diabetes and 71.7% hypertension, ejection fraction was 59.97 (±9.83). Baseline GLS was 20.3 ± 3.7, and stress GLS 23.4 ± 4. Patients with hospitalization for heart failure or ACS had lower GLS values during stress 21.7 ± 3 vs 24.6 ± 4 (p = 0.022). Baseline GLS was non statistically significant in patients with hospitalization for heart failure or ACS 19 ± 2.7 vs 21.2 ± 3.8 (p = 0.06). A cut off value of GLS < 22.1 during stress echocardiography was useful to identify patients with increased risk of hospitalization for heart failure or ACS. AUC 0.75, sensibility 69.3%, specificity 82.4%, +LR 3.9, -LR0.37, Youden index 0.56.
Conclusions
GLS during stress echocardiography is related to increased risk of hospitalization for heart failure or ACS. A cut of value of < 22.1% during stress echocardiography might be useful to identify patients with higher risk.
Objectives The goal of this study was to determine whether a less-invasive approach to aortic valve replacement (AVR) improves clinical outcomes in diabetic patients with aortic stenosis (AS). ...Background Diabetes is associated with increased morbidity and mortality after surgical AVR for AS. Methods Among treated patients with severe symptomatic AS at high risk for surgery in the PARTNER (Placement of Aortic Transcatheter Valve) trial, we examined outcomes stratified according to diabetes status of patients randomly assigned to receive transcatheter or surgical AVR. The primary outcome was all-cause mortality at 1 year. Results Among 657 patients enrolled in PARTNER who underwent treatment, there were 275 patients with diabetes (145 transcatheter, 130 surgical). There was a significant interaction between diabetes and treatment group for 1-year all-cause mortality (p = 0.048). Among diabetic patients, all-cause mortality at 1 year was 18.0% in the transcatheter group and 27.4% in the surgical group (hazard ratio: 0.60 95% confidence interval: 0.36 to 0.99; p = 0.04). Results were consistent among patients treated via transfemoral or transapical routes. In contrast, among nondiabetic patients, there was no significant difference in all-cause mortality at 1 year (p = 0.48). Among diabetic patients, the 1-year rates of stroke were similar between treatment groups (3.5% transcatheter vs. 3.5% surgery; p = 0.88), but the rate of renal failure requiring dialysis >30 days was lower in the transcatheter group (0% vs. 6.1%; p = 0.003). Conclusions Among patients with diabetes and severe symptomatic AS at high risk for surgery, this post-hoc stratified analysis of the PARTNER trial suggests there is a survival benefit, no increase in stroke, and less renal failure from treatment with transcatheter AVR compared with surgical AVR. (The PARTNER Trial: Placement of AoRTic TraNscathetER Valve Trial; NCT00530894 )
Aboriginal manufacture and use of pottery was unknown in Australia prior to European settlement, despite well-known ceramic-making traditions in southern Papua New Guinea, eastern Indonesia, and the ...western Pacific. The absence of ancient pottery manufacture in mainland Australia has long puzzled researchers given other documented deep time Aboriginal exchange networks across the continent and the close proximity of pottery-bearing Lapita and post-Lapita maritime communities in the western Pacific with ocean-going watercraft and sophisticated navigation abilities. We report the oldest securely dated ceramics found in Australia from archaeological excavations on Jiigurru (Lizard Island Group) on the Great Barrier Reef, northeast Australia. Comprehensive radiocarbon dating and Bayesian modelling constrains ceramic deposition to between 2950–2545 cal BP and 1970–1815 cal BP. This timing overlaps with late Lapita and post-Lapita ceramic traditions of southern Papua New Guinea. Geological characterisation of the sherds strongly suggests local manufacture as the vessels belong to three temper and clay groups locally sourced to northeast Australia, and most likely to Jiigurru. The oldest occupation layers date to 6510–5790 cal BP, making Jiigurru the earliest offshore island occupied on the northern Great Barrier Reef. The results demonstrate that northeast Australian First Nations communities had sophisticated canoe voyaging technology and open-sea navigational skills and were intimately engaged in ancient maritime networks, connecting them with peoples, knowledges, and technologies across the Coral Sea region.
•We report the oldest securely dated ceramics found in Australia.•Earliest known offshore island occupation on the northern Great Barrier Reef.•Ceramic analysis suggests local raw material sources and manufacture.•Results demonstrate that Australia was intimately engaged in ancient maritime networks.
Homogeneous composite fibers of poly(3-hexylthiophene) (P3HT)-polyethylene oxide (PEO)-Cadmium Sulfide (CdS) were manufactured by electrospinning technique using chloroform as solvent. The ...incorporation of CdS in the composite fibers was determined by SEM, FTIR and TGA techniques. SEM and confocal microscopy have been used to determine size, surface morphology and distribution of the fluorescence phase in the fibers. A morphology change in P3HT/PEO fibers was caused by the presence of CdS: porous morphology was obtained for low CdS concentration (3.8wt% and less) and when the content of CdS nanoparticles is higher, they were concentrated at the center of the fibers. The photoluminescence response was modified with CdS inside the P3HT-PEO fibers. By XRD it was determined that the introduction of CdS nanoparticles in the P3HT-PEO fibers caused disorder in P3HT chains. The obtained composite fibers are promising materials for optic and electronic applications.
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