The speed meter concept has been identified as a technique that can potentially provide laser-interferometric measurements at a sensitivity level which surpasses the standard quantum limit (SQL) over ...a broad frequency range. As with other sub-SQL measurement techniques, losses play a central role in speed meter interferometers and they ultimately determine the quantum noise limited sensitivity that can be achieved. So far in the literature, the quantum noise limited sensitivity has only been derived for lossless or lossy cases using certain approximations (for instance that the arm cavity round trip loss is small compared to the arm cavity mirror transmission). In this article we present a generalized, analytical treatment of losses in speed meters that allows accurate calculation of the quantum noise limited sensitivity of Sagnac speed meters with arm cavities. In addition, our analysis allows us to take into account potential imperfections in the interferometer such as an asymmetric beam splitter or differences of the reflectivities of the two arm cavity input mirrors. Finally, we use the examples of the proof-of-concept Sagnac speed meter currently under construction in Glasgow and a potential implementation of a Sagnac speed meter in the Einstein Telescope to illustrate how our findings affect Sagnac speed meters with metre- and kilometre-long baselines.
Precision interferometry is the leading method for extremely sensitive measurements in gravitational wave astronomy. Thermal noise of dielectric coatings poses a limitation to the sensitivity of ...these interferometers. To decrease coating thermal noise, new crystalline GaAs/AlGaAs multilayer mirrors have been developed. To date, the surface figure and thickness uniformity of these alternative low-loss coatings has not been investigated. Surface figure errors, for example, cause small angle scattering and thereby limit the sensitivity of an interferometer. Here we measure the surface figure of highly reflective, substrate-transferred, crystalline GaAs/AlGaAs coatings with a custom scanning reflectance system. We exploit the fact that the reflectivity varies with the thickness of the coating. To increase penetration into the coating, we used a 1550 nm laser on a highly reflective coating designed for a center wavelength of 1064 nm. The RMS thickness variation of a two inch optic was measured to be 0.41 ± 0.05 nm. This result is within 10% of the thickness uniformity, of 0.37 nm RMS, achieved with ion-beam sputtered coatings for the aLIGO detector. We additionally measured a lower limit of the laser induced damage threshold of 64 MW/cm
for GaAs/AlGaAs coatings at a wavelength of 1064 nm.
Abstract
High precision interferometers such as gravitational-wave detectors require complex seismic isolation systems in order to decouple the experiment from unwanted ground motion. Improved ...inertial sensors for active isolation potentially enhance the sensitivity of existing and future gravitational-wave detectors, especially below 30 Hz, and thereby increase the range of detectable astrophysical signals. This paper presents a vertical inertial sensor which senses the relative motion between an inertial test mass suspended by a blade spring and a seismically isolated platform. An interferometric readout was used which introduces low sensing noise, and preserves a large dynamic range due to fringe-counting. The expected sensitivity is comparable to other state-of-the-art interferometric inertial sensors and reaches values of
10
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1
at 100 mHz and
10
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m
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at 1 Hz. The potential sensitivity improvement compared to commercial L-4C geophones is shown to be about two orders of magnitude at 10 mHz and 100 mHz and one order of magnitude at 1 Hz. The noise performance is expected to be limited by thermal noise of the inertial test mass suspension below 10 Hz. Further performance limitations of the sensor, such as tilt-to-vertical coupling from a non-perfect levelling of the test mass and nonlinearities in the interferometric readout, are also quantified and discussed.
The Sagnac speed metre topology has been identified as a promising technique to reduce quantum back-action in gravitational-wave interferometers. However, imbalance of the main beamsplitter has been ...shown to increase the coupling of laser noise to the detection port, thus reducing the quantum noise superiority of the speed metre, compared to conventional approaches, in particular at low frequencies. In this paper, we show that by implementing a balanced homodyne readout scheme with a suitable choice of the point from which the local oscillator (LO) is derived, the excess laser noise contribution is partly compensated, and the resulting speed metre can be more sensitive than state-of-the-art position metres. This is achieved by picking-off the LO from either the reflection port of the interferometer or the anti-reflective coating surface of the main beamsplitter. We show that either approach relaxes the relative intensity noise (RIN) requirement of the input laser. For example, for a beam splitter imbalance of 0.1% in the Glasgow speed metre proof of concept experiment, the RIN requirement at frequency of 100 Hz decreases from 4 × 10 − 10 Hz to 4 × 10 − 7 Hz , moving the RIN requirement from a value that is hard to achieve in practice, to one which is routinely obtained.
High precision measurements in various applications rely on active seismic isolation to decouple the experiment from seismic motion; therefore, closed feed-back control techniques such as sensor ...blending and sensor correction are commonly implemented. This paper reviews the active isolation techniques of the Albert Einstein Institute seismic attenuation system (AEI-SAS). Two approaches to improve the well known techniques are presented. First, the influence of the sensor basis for the signal-to-noise ratio in the chosen coordinate system is calculated and second, a procedural optimization of blending filters to minimize the optical table velocity is performed. Active isolation techniques are adapted to the mechanical properties and the available sensors and actuators of the AEI-SAS. The performance of the final isolation is presented and limitations to the isolation are analyzed in comparison to a noise model. The optical table motion reaches approximately 8 × 1 0 − 10 m / H z at 1 Hz, reducing the ground motion by a factor of approximately 100.
A strong association exists between nutritional status and morbidity and mortality in patients with end-stage renal disease who are treated with hemodialysis. Described here is the predictive value ...for mortality over 5 years of follow-up of a number of risk factors, recorded at baseline, in a national sample of 3,607 hemodialysis patients. Among the variables studied were case-mix covariates, caregiver classifications of nutritional status, serum albumin concentration, and body mass index (BMI). The Case Mix Adequacy special study of the United States Renal Data System (USRDS) provided these measurements as of December 31, 1990. The USRDS patient standard analysis file provided follow-up data on mortality for all patients through December 31, 1995, by which time 64.7% of the patients had died. BMI is a simple anthropometric measurement that has received little attention in dialysis practice. Caregiver classification refers to documentation in a patient's dialysis facility medical records that stated an individual to be “undernourished/cachectic,” “obese/overweight,” or “well- nourished.” The mean serum albumin was 3.7 +/- 0.45 (SD) g/dL, and the mean BMI was 24.4 +/- 5.3 (SD) kg/m2. By caregiver classification, 20.1% of patients were undernourished, and 24.9% obese. In hazard regression models, including but not limited to the Cox proportional hazards model, low BMI, low serum albumin, and the caregiver classification “undernourished” were independently and significantly predictive of increased mortality. In analyses allowing for time- varying relative mortality risks (ie, nonproportional hazards), the greatest predictive value of all three variables occurred early during follow-up, but the independent predictive value of baseline serum albumin and BMI measurements on mortality risk persisted even 5 years later. No evidence of increasing mortality risk was found for higher values of BMI. Serum albumin was confirmed to be a useful predictor of mortality risk in hemodialysis patients; BMI was established as an independently important predictor of mortality; both serum albumin and BMI, measured at baseline, continue to possess predictive value 5 years later; the subjective caregiver classification of nutritional status “undernourished” has independent value in predicting mortality risk beyond the information gained from two other markers of nutritional status–BMI and serum albumin. (Am J Kidney Dis 1998 Jun;31(6):997-1006)
Speedmeters are known to be quantum non-demolition devices and, by potentially providing sensitivity beyond the standard quantum limit, become interesting for third generation gravitational wave ...detectors. Here we introduce a new configuration, the sloshing-Sagnac interferometer, and compare it to the more established ring-Sagnac interferometer. The sloshing-Sagnac interferometer is designed to provide improved quantum noise limited sensitivity and lower coating thermal noise than standard position meter interferometers employed in current gravitational wave detectors. We compare the quantum noise limited sensitivity of the ring-Sagnac and the sloshing-Sagnac interferometers, in the frequency range, from 5 Hz to 100 Hz, where they provide the greatest potential benefit. We evaluate the improvement in terms of the unweighted noise reduction below the standard quantum limit, and by finding the range up to which binary black hole inspirals may be observed. The sloshing-Sagnac was found to give approximately similar or better sensitivity than the ring-Sagnac in all cases. We also show that by eliminating the requirement for maximally-reflecting cavity end mirrors with correspondingly-thick multi-layer coatings, coating noise can be reduced by a factor of approximately 2.2 compared to conventional interferometers.
Home haemodialysis in Ireland Kennedy, C; Connaughton, D M; Murray, S ...
QJM : An International Journal of Medicine,
04/2018, Letnik:
111, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Abstract
Background
Home haemodialysis (HHD) has the potential to impact positively on patient outcomes and health resource management. There has been rejuvenated international interest in HHD in ...recent years.
Aim
We aimed to review the activity and outcomes of the Irish HHD Programme since inception (2009–16).
Design
Retrospective review.
Methods
Patient data were collected using the national electronic Renal Patient database (eMEDRenal version 3.2.1) and individual centre records. All data were recorded in a coded fashion on a Microsoft Excel Spread-sheet and analysed with Stata SE software.
Results
One hundred and one patients completed training and commenced HHD; a further fourty-five patients were assessed for HHD suitability but did not ultimately dialyse at home. Twenty patients switched to nocturnal HHD when this resource became available. The switch from conventional in-centre dialysis to HHD led to an increase in the mean weekly hours on haemodialysis (HD) and a reduction in medication burden for the majority of patients. The overall rate of arteriovenous fistula (AVF) as primary vascular access was 62%. Most HHD complications were related to access function or access-related infection. Over the 7-years, 29 HHD patients were transplanted and 9 patients died. No deaths resulted directly from a HHD complication or technical issue.
Conclusions
Patient and technique survival rates compared favourably to published international reports. However, we identified several aspects that require attention. A small number of patients were receiving inadequate dialysis and require targeted education. Ongoing efforts to increase AVF and self-needling rates in HD units must continue. Psychosocial support is critical during the transition between dialysis modalities.
Optical rigidity will play an important role in improving the sensitivity of future generations of gravitational wave (GW) interferometers, which employ high laser power in order to reach and exceed ...the standard quantum limit. Several experiments have demonstrated the combined effect of two optical springs on a single system for very low-weight mirror masses or membranes. In this paper we investigate the complex interactions between multiple optical springs and the surrounding apparatus in a system of comparable dynamics to a large-scale GW detector. Using three 100 g mirrors to form a coupled cavity system capable of sustaining two or more optical springs, we demonstrate a number of different regimes of opto-mechanical rigidity and measurement techniques. Our measurements reveal couplings between each optical spring and the control loops that can affect both the achievable increase in sensitivity and the stability of the system. Hence this work establishes a better understanding of the realisation of these techniques and paves the way to their application in future GW observatories, such as upgrades to Advanced LIGO.
Type of vascular access and mortality in U.S. hemodialysis patients.
Vascular access (VA) complications account for 16 to 25% of hospital admissions. This study tested the hypothesis that the type of ...VA in use is correlated with overall mortality and cause-specific mortality.
Data were analyzed from the U.S. Renal Data System Dialysis Morbidity and Mortality Study Wave 1, a random sample of 5507 patients, prevalent on hemodialysis as of December 31, 1993. The relative mortality risk during a two-year observation was analyzed by Cox-regression methods with adjustments for demographic and comorbid conditions. Using similar methods, cause-specific analyses also were performed for death caused by infection and cardiac causes.
In diabetic mellitus (DM) patients with end-stage renal disease, the associated relative mortality risk was higher for those with arteriovenous graft (AVG; RR = 1.41, P < 0.003) and central venous catheter (CVC; RR = 1.54, P < 0.002) as compared with arteriovenous fistula (AVF). In non-DM patients, those with CVC had a higher associated mortality (RR = 1.70, P < 0.001), as did to a lesser degree those with AVG (RR = 1.08, P = 0.35) when compared with AVF. Cause-specific analyses found higher infection-related deaths for CVC (RR = 2.30, P < 0.06) and AVG (RR = 2.47, P < 0.02) compared with AVF in DM; in non-DM, risk was higher also for CVC (RR = 1.83, P < 0.04) and AVG (RR = 1.27, P < 0.33). In contrast to our hypothesis that AV shunting increases cardiac risk, deaths caused by cardiac causes were higher in CVC than AVF for both DM (RR = 1.47, P < 0.05) and non-DM (RR = 1.34, P < 0.05) patients.
This case-mix adjusted analysis suggests that CVC and AVG are correlated with increased mortality risk when compared with AVF, both overall and by major causes of death.
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