One side effect of the immunomodulatory effect of interferon is the possible triggering or exacerbation of systemic or cutaneous sarcoidosis. We report two new cases and offer an exhaustive review of ...the literature. A 39-year-old man with type C chronic active hepatitis developed new respiratory symptoms and pulmonary infiltrates with hilar and mediastinal adenopathy after 7 months of treatment with pegylated interferon. The evolution was favourable after stopping treatment. The second patient developed cutaneous lesions after 6 months of treatment. Resolution occurred after the discontinuation of the treatment. In these two cases ribavirin was stopped before the first signs of sarcoidosis.
Le mécanisme de formation du granulome sarcoïdosique est peu clair. L’activation des lymphocytes CD4+ et l’interféron gamma semblent jouer un rôle important. L’interféron par ses effets ...immunomodulateurs pourrait induire ou aggraver une sarcoïdose. Nous rapportons deux cas de sarcoïdose sous interféron retard. Le premier malade âgé de 39 ans développait une sarcoïdose pulmonaire (syndrome interstitiel et adénopathies médiastinales) après sept mois de traitement. L’évolution était favorable après arrêt de l’interféron. Le deuxième malade présentait une forme cutanée après six mois et demi de traitement. L’évolution était favorable à l’arrêt du traitement et sans corticothérapie.
One side effect of the immunomodulatory effect of interferon is the possible triggering or exacerbation of systemic or cutaneous sarcoidosis. We report two new cases and offer an exhaustive review of the literature. A 39-year-old man with type C chronic active hepatitis developed new respiratory symptoms and pulmonary infiltrates with hilar and mediastinal adenopathy after 7 months of treatment with pegylated interferon. The evolution was favourable after stopping treatment. The second patient developed cutaneous lesions after 6 months of treatment. Resolution occurred after the discontinuation of the treatment. In these two cases ribavirin was stopped before the first signs of sarcoidosis.
The conception and performances of a 60 GHz active antenna, reconfigurable in terms of radiation pattern is described in this paper. This antenna is based on a plate inhomogeneous Luneburg lens fed ...by several ridged waveguide sources. The manufacturing technique of the plate lens is briefly described and its measured radiation patterns are given, showing the good performances of this lens. Simulated and measured radiation patterns are given for a passive lens antenna fed by several sources. The results show the beam scanning capability of this antenna. The active antenna is described and measurements of radiation patterns for several beams are given and demonstrate the beam scanning and beam shaping reconfigurability.
Head and neck cancer during pregnancy Le Guevelou, Jennifer; Lebars, Sabrina; Kammerer, Emmanuel ...
Head & neck,
October 2019, Letnik:
41, Številka:
10
Journal Article
Recenzirano
Background
The incidence of cancer during pregnancy is low but is slightly increasing. Data on incidence and etiology of head and neck (HN) cancers in pregnant women are rare. We evaluated the ...frequency, tumor type, associated factors, and specific biomarkers in HN cancers occurring in pregnant (and peripartum) women.
Methods
A systematic literature search was performed on PubMed, for any HN tumor site occurring in pregnant women.
Results
Sixty cases of HN cancers occurring during pregnancy were identified. Most of them were oral cavity cancers. Relationships with oncogenic viruses, hormonal disturbance, and shift in maternal immunity profile were identified.
Conclusion
Carcinogenesis of HN cancers in pregnant women may be led by different cancer type–specific hallmarks. Relevance of these etiological factors with respect to treatments and birth control recommendations is being investigated by the REFCOR in an ambispective study.
Globus pallidus internus (GPi) deep brain stimulation (DBS) increasingly shows promising efficacy in the treatment of severe primary generalized dystonia. Functional imaging studies have shown ...previously that dystonia could be related to abnormal cortical activation during voluntary movement. In the present study, the effects of GPi DBS on regional cerebral blood flow (rCBF) during a motor task were studied in patients with primary generalized dystonia. rCBF was measured using H sub(2) super(15)O and PET in eight control subjects and six patients with dystonia treated with bilateral GPi DBS. Subjects were scanned at rest and while performing joystick movements. Dystonic patients were tested in two conditions: 'OFF' (stimulator bilaterally switched off) and 'ON' (unilateral stimulation). In the 'OFF' condition, compared with rest, motor activation of the most dystonic hand was associated with overactivity in the contralateral dorsolateral prefrontal cortex, gyrus frontalis medialis, superior frontal gyrus (area 10), frontoorbital cortex and thalamus. In the 'ON' condition, GPi DBS contralaterally to the most dystonic hand induced a decrease of the overactivation in the same areas, as well as the putamen. According to the present study, generalized dystonia is associated with prefrontal overactivation which can be reversed by effective GPi DBS.
Globus pallidus internus (GPi) deep brain stimulation (DBS) increasingly shows promising efficacy in the treatment of severe primary generalized dystonia. Functional imaging studies have shown ...previously that dystonia could be related to abnormal cortical activation during voluntary movement. In the present study, the effects of GPi DBS on regional cerebral blood flow (rCBF) during a motor task were studied in patients with primary generalized dystonia. rCBF was measured using H215O and PET in eight control subjects and six patients with dystonia treated with bilateral GPi DBS. Subjects were scanned at rest and while performing joystick movements. Dystonic patients were tested in two conditions: ‘OFF’ (stimulator bilaterally switched off) and ‘ON’ (unilateral stimulation). In the ‘OFF’ condition, compared with rest, motor activation of the most dystonic hand was associated with overactivity in the contralateral dorsolateral prefrontal cortex, gyrus frontalis medialis, superior frontal gyrus (area 10), frontoorbital cortex and thalamus. In the ‘ON’ condition, GPi DBS contralaterally to the most dystonic hand induced a decrease of the overactivation in the same areas, as well as the putamen. According to the present study, generalized dystonia is associated with prefrontal overactivation which can be reversed by effective GPi DBS.
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