We report experimental upper limits on WIMP-nucleon elastic scattering cross sections from the second science run of ZEPLIN-III at the Boulby Underground Laboratory. A raw fiducial exposure of 1344 ...kg⋅days was accrued over 319 days of continuous operation between June 2010 and May 2011. A total of eight events was observed in the signal acceptance region in the nuclear recoil energy range 7–29 keV, which is compatible with background expectations. This allows the exclusion of the scalar cross-section above 4.8×10−8 pb near 50 GeV/c2 WIMP mass with 90% confidence. Combined with data from the first run, this result improves to 3.9×10−8 pb. The corresponding WIMP-neutron spin-dependent cross-section limit is 8.0×10−3 pb. The ZEPLIN programme reaches thus its conclusion at Boulby, having deployed and exploited successfully three liquid xenon experiments of increasing reach.
Based on the analysis of the magnetic state of austenite, changes in thermodynamics and kinetics of the martensitic transformation in carbon steel have been determined. Depending on the strength of ...the external magnetic field, the dimensions of the magnetic inhomogeneity regions in austenite were calculated. It was shown that with an increase in the field strength, the size and the quantity of such regions increase. Changes in free energy of austenite, caused by the appearance of ferromagnetic order fluctuations, have been determined. The free energy of formation of one ferromagnetic cluster in austenite was estimated. Changes in the energy of formation and diameter of the critical martensite nucleus were analyzed depending on the strength of the external magnetic field. Data about an increase in the volumetric martensite transformation rate under the exposure to a magnetic field were obtained.
We studied the application of statistical reconstruction algorithms, namely maximum likelihood and least squares methods, to the problem of event reconstruction in a dual phase liquid xenon detector. ...An iterative method was developed for in-situ reconstruction of the PMT light response functions from calibration data taken with an uncollimated γ -ray source. Using the techniques described, the performance of the ZEPLIN-III dark matter detector was studied for 122 keV γ-rays. For the inner part of the detector ( R <; 100 mm) , spatial resolutions of 13 mm and 1.6 mm FWHM were measured in the horizontal plane for primary and secondary scintillation, respectively. An energy resolution of 8.1% FWHM was achieved at that energy. The possibility of using this technique for improving performance and reducing cost of scintillation cameras for medical applications is currently under study.
Scintillation and ionisation yields for nuclear recoils in liquid xenon above 10 keVnr (nuclear recoil energy) are deduced from data acquired using broadband Am–Be neutron sources. The nuclear recoil ...data from several exposures to two sources were compared to detailed simulations. Energy-dependent scintillation and ionisation yields giving acceptable fits to the data were derived. Efficiency and resolution effects are treated using a light collection Monte Carlo, measured photomultiplier response profiles and hardware trigger studies. A gradual fall in scintillation yield below ∼40 keVnr is found, together with a rising ionisation yield; both are in agreement with the latest independent measurements. The analysis method is applied to the most recent ZEPLIN-III data, acquired with a significantly upgraded detector and a precision-calibrated Am–Be source, as well as to the earlier data from the first run in 2008. A new method for deriving the recoil scintillation yield, which includes sub-threshold S1 events, is also presented which confirms the main analysis.
We present new experimental constraints on the WIMP-nucleon spin-dependent elastic cross sections using data from the first science run of ZEPLIN-III, a two-phase xenon experiment searching for ...galactic dark matter weakly interacting massive particles based at the Boulby mine. Analysis of approximately 450 kg x days fiducial exposure allow us to place a 90%-confidence upper limit on the pure WIMP-neutron cross section of sigma(n)=1.9x10(-2) pb at 55 GeV/c(2) WIMP mass. Recent calculations of the nuclear spin structure based on the Bonn charge-dependent nucleon-nucleon potential were used for the odd-neutron isotopes 129Xe and 131Xe. These indicate that the sensitivity of xenon targets to the spin-dependent WIMP-proton interaction could be much lower than implied by previous calculations, whereas the WIMP-neutron sensitivity is impaired only by a factor of approximately 2.
A
bstract
We present an experimental study of single electron emission in ZEPLIN-III, a two-phase xenon experiment built to search for dark matter WIMPs, and discuss appli-cations enabled by the ...excellent signal-to-noise ratio achieved in detecting this signature. Firstly, we demonstrate a practical method for precise measurement of the free electron lifetime in liquid xenon during normal operation of these detectors. Then, using a realistic detector response model and backgrounds, we assess the feasibility of deploying such an instrument for measuring coherent neutrino-nucleus elastic scattering using the ionisation channel in the few-electron regime. We conclude that it should be possible to measure this elusive neutrino signature above an ionisation threshold of ~3 electrons both at a stopped pion source and at a nuclear reactor. Detectable signal rates are larger in the reactor case, but the triggered measurement and harder recoil energy spectrum afforded by the accelerator source enable lower overall background and fiducialisation of the active volume.
Biomarkers of anaphylaxis Esakova, N. V.; Lebedenko, A. A.; Pampura, A. N.
Medicinskij vestnik Ûga Rossii,
09/2022, Letnik:
13, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Anaphylaxis is a severe, life-threatening, systemic hypersensitivity reaction that develops rapidly and can lead to death. The diagnosis of anaphylaxis continues to be primarily clinical. Therefore, ...a large number of studies are initiated annually aimed at a deeper study of the mechanisms of the development of this disease and the search for its biomarkers, which could become an important tool to facilitate the verification of diagnosis, prevention and risk assessment of repeated episodes of anaphylaxis, stratification of the severity of its course, the risk of life-threatening episodes of systemic reactions, and be important in the development of new therapeutic strategies. This review provides information on the currently available data on potential biomarkers of anaphylaxis.
Objective : to evaluate the role of some indicators of antioxidant system and adipose tissue metabolism in predicting preterm birth in pregnant women with isthmic-cervical insufficiency. Materials ...and methods : the study included 117 pregnant women divided in two clinical groups: group I — 57 pregnant women with isthmic-cervical insufficiency, who underwent surgical cerclage, group II — 60 women with a physiological pregnancy. Using enzyme immunoassay, we determined the levels of superoxide dismutase, catalase, ceruloplasmin, leptin, homocysteine, ghrelin, resistin and adiponectin in the blood serum of pregnant women of clinical groups. Results: it has been established that catalase has the greatest prognostic significance in relation to isthmic-cervical insufficiency on the part of the antioxidant system, and leptin, resistin and homocysteine on the part of adipose tissue metabolism indicators. Conclusions : determination of the level of some isthmic-cervical insufficiency associated indicators of oxidative stress and lipid metabolism in the first trimester of pregnancy can be successfully used to form a risk group, early prediction and timely prevention of isthmic-cervical insufficiency.
► We examine backgrounds from radioactivity in the ZEPLIN-III dark matter experiment. ► Electron recoil rates are predicted accurately by Monte Carlo simulation. ► Nuclear recoil rates from neutron ...scattering are also presented. ► We analyse rare background topologies which can affect the sensitivity of direct WIMP searches.
We examine electron and nuclear recoil backgrounds from radioactivity in the ZEPLIN-III dark matter experiment at Boulby. The rate of low-energy electron recoils in the liquid xenon WIMP target is 0.75±0.05 events/kg/day/keV, which represents a 20-fold improvement over the rate observed during the first science run. Energy and spatial distributions agree with those predicted by component-level Monte Carlo simulations propagating the effects of the radiological contamination measured for materials employed in the experiment. Neutron elastic scattering is predicted to yield 3.05±0.5 nuclear recoils with energy 5–50keV per year, which translates to an expectation of 0.4 events in a 1yr dataset in anti-coincidence with the veto detector for realistic signal acceptance. Less obvious background sources are discussed, especially in the context of future experiments. These include contamination of scintillation pulses with Cherenkov light from Compton electrons and from β activity internal to photomultipliers, which can increase the size and lower the apparent time constant of the scintillation response. Another challenge is posed by multiple-scatter γ-rays with one or more vertices in regions that yield no ionisation. If the discrimination power achieved in the first run can be replicated, ZEPLIN-III should reach a sensitivity of ∼1×10−8pb·yr to the scalar WIMP–nucleon elastic cross-section, as originally conceived.
A measurement is presented of the neutron production rate in lead by high energy cosmic-ray muons at a depth of 2850m water equivalent (w.e.) and a mean muon energy of 260GeV. The measurement ...exploits the delayed coincidences between muons and the radiative capture of induced neutrons in a highly segmented tonne scale plastic scintillator detector. Detailed Monte Carlo simulations reproduce well the measured capture times and multiplicities and, within the dynamic range of the instrumentation, the spectrum of energy deposits. By comparing measurements with simulations of neutron capture rates a neutron yield in lead of (5.78-0.28+0.21) ×10-3neutrons/muon/(g/cm2) has been obtained. Absolute agreement between simulation and data is of order 25%. Consequences for deep underground rare event searches are discussed.
PDF
