This study investigates the impact of environmental knowledge and perceived product quality on purchasing intention and purchasing behavior of recycled products: A4 paper, mobile phones and printers. ...The intent is to understand how to move future generations toward more sustainable behavior, as currently unsustainable amounts of waste are generated across the Far East. Expectancy value theory and the theory of reasoned action are applied to the purchase of products with recovered and/or recycled content (n = 215). The study indicates: (1) a significant positive relationship was found between both the intention to purchase and the purchase of recycled products; (2) the perception of recycled product risk has a significant negative impact on the perception of recycled product quality and the attitude toward environmental protection; (3) perceived quality of recycled product is positively related to attitude toward environmental protection; (4) perceived quality of recycled product and attitude to environmental protection are positively related to intention to purchase recycled products; and (5) surprisingly, knowledge regarding environmental damage and pollution is unrelated to attitude toward environmental protection. This study offers new insights into the impact of education on environmental protection, purchasing of greener products and the need for environmental education to move from a goal of understanding to that of action.
This paper carries out probabilistic approach to quantify the benefit-risk analysis for foods (BRAFO) of omega-3 polyunsaturated fatty acid and methylmercury (MeHg) for the people who eat the ...mercury-contaminated fish in Taiwan. We applied the hazard quotient (HQ) model to assess the risk of developmental neuropsychological impairment effect and the desirable dose index (DI) model to quantify the health benefits. Besides, we also applied the disability adjusted life years (DALY) model to assess the number of years lost by incidence of affected infants' intelligence quotient (IQ) and coronary heart disease (CHD) or Stroke for adult. The results of this study show that although the risk of cod and scad are higher, Taiwan residents do not need to reduce intake rate based on benefit considerations. Furthermore, according to the benefits of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), this study suggests that more intake of saury and salmon.
•The probabilistic BRAFO approach quantified the EPA/DHA benefit versus methylmercury risk.•Although the risk of cod and scad are higher, Taiwanese do not need to reduce intake rate based on benefit analysis.•According to the benefits analysis of EPA/DHA, we suggest that more intake of saury and salmon.
Long‐term preservation of sperm, oocytes, and gonadal tissues at ambient temperatures has the potential to lower the costs and simplify biobanking in human reproductive medicine, as well as for the ...management of animal populations. Over the past decades, different dehydration protocols and long‐term storage solutions at nonfreezing temperatures have been explored, mainly for mammalian sperm cells. Oocytes and gonadal tissues are more challenging to dehydrate so little to no progress have been made. Currently, the detrimental effects of the drying process itself are better characterized than the impact of long‐term storage at nonfreezing temperatures. While structural and functional properties of germ cells can be preserved after dehydration, a long list of damages and stresses in nuclei, organelles, and cytoplasmic membranes have been reported and sometimes mitigated. Characterizing those damages and better understanding the response of germ cells and tissues to the stress of dehydration is fundamental. It will contribute to the development of optimal protocols while proving the safety of alternative storage options for fertility preservation. The objective of this review is to (1) document the types of damages and stress responses, as well as their mitigation in cells dried with different techniques, and (2) propose new research directions.
This study proposes an approach for visualizing a knowledge structure, the proposed approach creates a three-dimensional “Research focused parallelship network”, a “Keyword Co-occurrence Network”, ...and a two-dimensional knowledge map to facilitate visualization of the knowledge structure created by journal papers from different perspectives. The networks and knowledge maps can be depicted differently by choosing different information as the network actor, e.g. author, institute or country keyword, to reflect knowledge structures in micro-, meso-, and macro-levels, respectively. Technology Foresight is selected as an example to illustrate the method proposed in this study. A total of 556 author keywords contained in 181 Technology Foresight related papers have been analyzed. European countries, China, India and Brazil are located at the core of Technology Foresight research. Quantitative ways of mapping journal papers are investigated in this study to unveil emerging elements as well as to demonstrate dynamics and visualization of knowledge. The quantitative method provided in this paper shows a possible way of visualizing and evaluating knowledge structure; thus a computerized calculation is possible for potential quantitative applications, e.g. R&D resource allocation, research performance evaluation, science map, etc.
While the internet provides abundant information, it often leads to information overload of users when purchasing goods. Tripadvisor.com, despite having a date sorting function, struggles to ...effectively filter relevant comments to users and neglects that consumer preferences may change over time. Therefore, this study aims to develop a website with visual charts showing changes in sentiment over time in reviews. The goal is to determine if this website improves user efficiency compared to the original website, reducing search time and aiding decision-making. The chart generation process involves four stages: collecting and preprocessing comments, constructing a hotel feature dictionary, classifying sentences and computing sentiment scores, and embedding charts on the website. 36 Tripadvisor.com users participate in experiments to evaluate the impact of old and new interfaces on answer quantity and search time. The NASA.tlx scale is used to assess the mental load experienced with both interfaces.
Background and Aims
Atezolizumab plus bevacizumab (AtezoBev) is the standard of care for first‐line treatment of unresectable HCC. No evidence exists as to its use in routine clinical practice in ...patients with impaired liver function.
Approach and Results
In 216 patients with HCC who were consecutively treated with AtezoBev across 11 tertiary centers, we retrospectively evaluated treatment‐related adverse events (trAEs) graded (G) according to Common Terminology Criteria for Adverse Events v5.0, including in the analysis all patients treated according to label (n = 202, 94%). We also assessed overall survival (OS), progression‐free survival (PFS), overall response (ORR), and disease control rates (DCR) defined by Response Evaluation Criteria in Solid Tumors v1.1. Disease was mostly secondary to viral hepatitis, namely hepatitis C (n = 72; 36%) and hepatitis B infection (n = 35, 17%). Liver function was graded as Child‐Pugh (CP)‐A in 154 patients (76%) and CP‐B in 48 (24%). Any grade trAEs were reported by 143 patients (71%), of which 53 (26%) were G3 and 3 (2%) G4. Compared with CP‐A, patients with CP‐B showed comparable rates of trAEs. Presence and grade of varices at pretreatment esophagogastroduodenoscopy did not correlate with bleeding events. After a median follow‐up of 9.0 months (95% CI, 7.8–10.1), median OS was 14.9 months (95% CI, 13.6–16.3), whereas median PFS was 6.8 months (95% CI, 5.2–8.5). ORR and DCR were respectively 25% and 73%, with no difference across CP classes.
Conclusions
This study confirms reproducible safety and efficacy of AtezoBev in routine practice. Patients with CP‐B reported similar tolerability compared with CP‐A, warranting prospective evaluation of AtezoBev in this treatment‐deprived population.
In this retrospective study on a real‐life cohort of 216 patients treated with Atezolizumab plus Bevacizumab, the combination did not show any unexpected safety signals. Treatment‐related adverse events were comparable across Child‐Pugh (CP) classes. CP‐B patients achieved similar response rates to CP‐A patients, despite inferior survival outcomes.
We conceptualized security-related stress (SRS) and proposed a theoretical model linking SRS, discrete emotions, coping response, and information security policy (ISP) compliance. We used an ...experience sampling design, wherein 138 professionals completed surveys. We observed that SRS had a positive association with frustration and fatigue, and these negative emotions were associated with neutralization of ISP violations. Additionally, frustration and fatigue make employees more likely to follow through on their rationalizations of ISP violations by decreased ISP compliance. Our findings provide evidence that neutralization is not a completely stable phenomenon but can vary within individuals from one time point to another.
For regularized optimization that minimizes the sum of a smooth term and a regularizer that promotes structured solutions, inexact proximal-Newton-type methods, or successive quadratic approximation ...(SQA) methods, are widely used for their superlinear convergence in terms of iterations. However, unlike the counter parts in smooth optimization, they suffer from lengthy running time in solving regularized subproblems because even approximate solutions cannot be computed easily, so their empirical time cost is not as impressive. In this work, we first show that for partly smooth regularizers, although general inexact solutions cannot identify the active manifold that makes the objective function smooth, approximate solutions generated by commonly-used subproblem solvers will identify this manifold, even with arbitrarily low solution precision. We then utilize this property to propose an improved SQA method, ISQA
+
, that switches to efficient smooth optimization methods after this manifold is identified. We show that for a wide class of degenerate solutions, ISQA
+
possesses superlinear convergence not only in iterations, but also in running time because the cost per iteration is bounded. In particular, our superlinear convergence result holds on problems satisfying a sharpness condition that is more general than that in existing literature. We also prove iterate convergence under a sharpness condition for inexact SQA, which is novel for this family of methods that could easily violate the classical relative-error condition frequently used in proving convergence under similar conditions. Experiments on real-world problems support that ISQA
+
improves running time over some modern solvers for regularized optimization.
IMPORTANCE Acetaminophen (paracetamol) is the most commonly used medication for pain and fever during pregnancy in many countries. Research data suggest that acetaminophen is a hormone disruptor, and ...abnormal hormonal exposures in pregnancy may influence fetal brain development. OBJECTIVE To evaluate whether prenatal exposure to acetaminophen increases the risk for developing attention-deficit/hyperactivity disorder (ADHD)–like behavioral problems or hyperkinetic disorders (HKDs) in children. DESIGN, SETTING, AND PARTICIPANTS We studied 64 322 live-born children and mothers enrolled in the Danish National Birth Cohort during 1996-2002. EXPOSURES Acetaminophen use during pregnancy was assessed prospectively via 3 computer-assisted telephone interviews during pregnancy and 6 months after child birth. MAIN OUTCOMES AND MEASURES To ascertain outcome information we used (1) parental reports of behavioral problems in children 7 years of age using the Strengths and Difficulties Questionnaire; (2) retrieved HKD diagnoses from the Danish National Hospital Registry or the Danish Psychiatric Central Registry prior to 2011; and (3) identified ADHD prescriptions (mainly Ritalin) for children from the Danish Prescription Registry. We estimated hazard ratios for receiving an HKD diagnosis or using ADHD medications and risk ratios for behavioral problems in children after prenatal exposure to acetaminophen. RESULTS More than half of all mothers reported acetaminophen use while pregnant. Children whose mothers used acetaminophen during pregnancy were at higher risk for receiving a hospital diagnosis of HKD (hazard ratio = 1.37; 95% CI, 1.19-1.59), use of ADHD medications (hazard ratio = 1.29; 95% CI, 1.15-1.44), or having ADHD-like behaviors at age 7 years (risk ratio = 1.13; 95% CI, 1.01-1.27). Stronger associations were observed with use in more than 1 trimester during pregnancy, and exposure response trends were found with increasing frequency of acetaminophen use during gestation for all outcomes (ie, HKD diagnosis, ADHD medication use, and ADHD-like behaviors; P trend < .001). Results did not appear to be confounded by maternal inflammation, infection during pregnancy, the mother’s mental health problems, or other potential confounders we evaluated. CONCLUSIONS AND RELEVANCE Maternal acetaminophen use during pregnancy is associated with a higher risk for HKDs and ADHD-like behaviors in children. Because the exposure and outcome are frequent, these results are of public health relevance but further investigations are needed.
The recent progress of efficiency improvement, emission color tuning, and lifetime elongation of blue organic light-emitting diodes (OLEDs) is reviewed. The latter is one of the most important ...bottlenecks for OLED development. The current status of blue light-emitting material design with emission mechanisms such as fluorescence (F), phosphorescence (Ph), thermally activated delayed fluorescence (TADF), and hybridized local and charge transfer (HLCT) is introduced in the first part of this review. Compared to red and green devices, the long exciton lifetime of the high energy triplet exciton in a blue OLED is the one of the main issues. To avoid the accumulation of high energy triplet excitons in the emitter for blue OLEDs, assisted triplet-triplet fluorescence (TTF) and Hyperfluorescence™ are employed to harvest the triplet excitons. In the second part of this review, we focus on issues from an application viewpoint: what are the requirements of blue OLEDs for display and lighting technologies in terms of efficiency, color, and lifetime? Key performance metrics of blue OLEDs with different technologies over time are summarized. Independent of technology, the trend is similar: the external quantum efficiency improves for the first stage of research, followed by color tuning, and then finally lifetime elongation. The state-of-the-art device performance of blue OLEDs with various emission mechanisms is illustrated. Although Ph- and TADF-emission based devices show satisfactory efficiency and electroluminescence (EL) spectra, despite having a lower efficiency TTF-emission based devices are the mainstream for real applications due to their relatively long operation lifetime. Blue Ph-OLEDs have the potential for lighting applications with suitable material selection and device design. We collected the published results and tried our best to make a fair comparison of the operation lifetime among different technologies. Finally, we discuss the possible future outlook from different viewpoints including new materials, device designs, and applications of blue OLEDs.
Emission mechanisms for OLEDs and their characteristics.
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