Purpose
Since the end of 2016, “fake news” has had a clear meaning in the USA. After years of scholarship attempting to define “fake news” and where it fits among the larger schema of media hoaxing ...and deception, popular culture and even academic studies converged following the 2016 US presidential election to define “fake news” in drastically new ways. The paper aims to discuss these issues.
Design/methodology/approach
In light of the recent elections in the USA, many fear “fake news” that have gradually become a powerful and sinister force, both in the news media environment as well as in the fair and free elections. The scenario draws into questions how the general public interacts with such outlets, and to what extent and in which ways individual responsibility should govern the interactions with social media.
Findings
Fake news is a growing threat to democratic elections in the USA and other democracies by relentless targeting of hyper-partisan views, which play to the fears and prejudices of people, in order to influence their voting plans and their behavior.
Originality/value
Essentially, “fake news” is changing and even distorting how political campaigns are run, ultimately calling into question legitimacy of elections, elected officials and governments. Scholarship has increasingly confirmed social media as an enabler of “fake news,” and continues to project its potentially negative impact on democracy, furthering the already existing practices of partisan selective exposure, as well as heightening the need for individual responsibility.
Megaherbivore carcasses represent sporadic but energetically rewarding resources for carnivores, offering a unique opportunity to study coexistence dynamics between facultative scavengers. South ...African fenced protected areas, such as Madikwe Game Reserve (Madikwe hereafter), host viable populations of large carnivores and high densities of elephants, Loxodonta africana. However, high carnivore densities can lead to potentially fatal interspecific encounters and increased competition, particularly around high‐quality trophic resources. This study explores the temporal partitioning and co‐detection strategies of carnivores at six elephant carcasses in Madikwe, aiming to understand how the increased carrion biomass available at elephant carcasses influences coexistence dynamics. Camera traps were deployed to monitor carcasses during two periods (2019 and 2020), revealing occurrences of six carnivore species. Carnivores, particularly black‐backed jackals, Lupulella mesomelas, (hereafter jackal), lions, Panthera leo, and spotted hyaenas, Crocuta crocuta, comprised 56.7% of carcass observations, highlighting their pivotal roles in scavenging dynamics. Pairwise co‐detection analysis demonstrated consistent association and shared peak activity periods between jackals and spotted hyaenas, indicating potential resource sharing. However, the minimal co‐detection rates between lions and other carnivores highlight their resource domination. There was some evidence of temporal partitioning between carnivores, with most species exhibiting earlier peaks in nocturnal activity to avoid temporal overlap with lions. This study emphasises the importance of elephant carcasses in the diet of multiple species and coexistence techniques utilised to exploit this ephemeral resource. As fenced protected areas become crucial for conserving intact carnivore guilds globally, further research into carnivore behavioural adaptations at carcasses is recommended to shed light on their coexistence strategies.
Megaherbivore carcasses represent sporadic but energetically rewarding resources for carnivores and it is poorly understood how these carrion resources impact interspecific interactions. We studied elephant carcasses in Madikwe Game Reserve, South Africa, to investigate temporal partitioning and co‐occurrence between the carnivore guild. Co‐occurrence was high between some carnivores, suggesting aggressive interactions may be reduced by abundant food resources.
Sphingolipid biosynthesis generates lipids for membranes and signaling that are crucial for many developmental and physiological processes. In some cases, large amounts of specific sphingolipids must ...be synthesized for specialized physiological functions, such as during axon myelination. How sphingolipid synthesis is regulated to fulfill these physiological requirements is not known. To identify genes that positively regulate membrane sphingolipid levels, here we employed a genome-wide CRISPR/Cas9 loss-of-function screen in HeLa cells using selection for resistance to Shiga toxin, which uses a plasma membrane-associated glycosphingolipid, globotriaosylceramide (Gb3), for its uptake. The screen identified several genes in the sphingolipid biosynthetic pathway that are required for Gb3 synthesis, and it also identified the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor widely involved in development and physiology, as being required for Gb3 biosynthesis. AHR bound and activated the gene promoter of serine palmitoyltransferase small subunit A (SPTSSA), which encodes a subunit of the serine palmitoyltransferase that catalyzes the first and rate-limiting step in de novo sphingolipid biosynthesis. AHR knockout HeLa cells exhibited significantly reduced levels of cell-surface Gb3, and both AHR knockout HeLa cells and tissues from Ahr knockout mice displayed decreased sphingolipid content as well as significantly reduced expression of several key genes in the sphingolipid biosynthetic pathway. The sciatic nerve of Ahr knockout mice exhibited both reduced ceramide content and reduced myelin thickness. These results indicate that AHR up-regulates sphingolipid levels and is important for full axon myelination, which requires elevated levels of membrane sphingolipids.
A range of existing statistical approaches for reconstructing historical temperature variations from proxy data are compared using both climate model data and real-world paleoclimate proxy data. We ...also propose a new method for reconstruction that is based on a state-space time series model and Kalman filter algorithm. The state-space modelling approach and the recently developed RegEM method generally perform better than their competitors when reconstructing interannual variations in Northern Hemispheric mean surface air temperature. On the other hand, a variety of methods are seen to perform well when reconstructing surface air temperature variability on decadal time scales. An advantage of the new method is that it can incorporate additional, non-temperature, information into the reconstruction, such as the estimated response to external forcing, thereby permitting a simultaneous reconstruction and detection analysis as well as future projection. An application of these extensions is also demonstrated in the paper.
We note thanatological behavioural displays by clan members of a deceased spotted hyaena, Crocuta crocuta (Erxleben, 1777) in a fenced reserve. A matriarch had a lethal altercation with lions, ...Panthera leo (Linnæus 1758), on 10.V.2022. The carcass was monitored with a camera trap that recorded videos until the carcass was completely decayed. Four instances of clan members were recorded observing and sniffing the genitalia of the deceased hyaena over a period of six days. Within one month, the clan killed the deceased’s cubs and moved their den location. We recommend further research be conducted into thanatological behaviours of spotted hyaenas as these behaviours could affect ethical considerations of management practices.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
In this trial comparing less-tight control of hypertension (target diastolic blood pressure, 100 mm Hg) with tight control (85 mm Hg) among pregnant women, rates of pregnancy loss, high-level ...neonatal care, and serious maternal complications were similar between groups.
Almost 10% of pregnant women have hypertension; hypertension is preexisting in 1%, gestational hypertension without proteinuria develops in 5 to 6%, and preeclampsia develops in 2%.
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Preexisting hypertension and gestational hypertension before 34 weeks are associated with an increased risk of perinatal and maternal complications.
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Blood-pressure targets for women with nonsevere hypertension during pregnancy are much debated. Relevant randomized, controlled trials have been small and of moderate or poor quality; tight control (the use of antihypertensive therapy to normalize blood pressure) has been associated with maternal benefits (e.g., a decrease in the frequency of severe hypertension and possibly in . . .
Prevention of vertical HIV transmission has evolved significantly in Canada over the last two decades. The aim of this analysis is to describe the surveillance programme used, rate of vertical HIV ...transmission and changing epidemiology of HIV-affected pregnancies in Canada.
National perinatal HIV surveillance programme.
From 1990, annual retrospective data was collected on demographic and clinical characteristics of HIV-infected mothers and their infants referred to 22 participating sites across Canada either before/during pregnancy or within 3 months after delivery. Factors impacting HIV transmission and demographic features were explored.
Two thousand, six hundred and ninety-two mother-infant pairs were identified. The overall rate of vertical HIV transmission was 5.2%, declining to 2.9% since 1997. The rate of transmission for mothers who received HAART was 1%, and 0.4% if more than 4 weeks of HAART was given. Forty percent of women delivered by caesarean section, with no difference in transmission rate compared with vaginal delivery for women treated with HAART (1.4 vs. 0.6%, P = 0.129) but significant risk reduction for those who did not receive HAART (3.8 vs. 10.3%, P = 0.016). Black women were the largest group; proportions of black and aboriginal women increased significantly over time (P < 0.001 for both). Heterosexual contact was the most common risk category for maternal infection (65%), followed by injection drug use (IDU) (25%).
Vertical HIV transmission in Canada has decreased dramatically for women treated with HAART therapy. All pregnant women should be evaluated for HIV infection and programmes expanded to reach vulnerable populations including aboriginal, immigrant and IDU women.
Property Rights Anderson, Terry L; McChesney, Fred S
2018, 2018., 20180626, 2002
eBook
The institution of property is as old as mankind, and property rights are today deemed vital to a prosperous economic system. Much has been written in the last decade on the economics of the legal ...institutions protecting such rights. This unprecedented book provides a magnificent introduction to the subject. Terry Anderson and Fred McChesney have gathered twelve leading thinkers to explore how property rights arise, and how they bolster economic development. As the subtitle indicates, the book examines as well how controversies over valuable property rights are resolved: by agreement, by violence, or by law. The essays begin by surveying the approaches to property taken by early political economists and move to colorful applications of property rights theory concerning the Wild West, the Amazon, endangered species, and the broadcast spectrum. These examples illustrate the process of defining and defending property rights, and demonstrate what difference property rights make. The book then considers a number of topics raised by private property rights, analytically complex topics concerning pollution externalities, government taking of property, and land use management policies such as zoning. Overall, the book is intended as an introduction to the economics and law of property rights. It is divided into six parts, with each featuring an introduction by the editors that integrates prior chapters and material in coming chapters. In the end, the book provides a fresh, comprehensive overview of an intriguing subject, accessible to anyone with a minimal background in economics. With chapters written by noted experts on the subject, Property Rights offers the first primer on the subject ever produced. In addition to the editors, the contributors are Louise De Alessi, Yoram Barzel, Harold Demsetz, Thráinn Eggertsson, Richard A. Epstein, William A. Fischel, David D. Haddock, Peter J. Hill, Gary D. Libecap, Dean Lueck, Edwin G. West, and Bruce Yandle.
Bacterial oxidation of arsenite As(III) is a well-studied and important biogeochemical pathway that directly influences the mobility and toxicity of arsenic in the environment. In contrast, little is ...known about microbiological oxidation of the chemically similar anion antimonite Sb(III). In this study, two bacterial strains, designated IDSBO-1 and IDSBO-4, which grow on tartrate compounds and oxidize Sb(III) using either oxygen or nitrate, respectively, as a terminal electron acceptor, were isolated from contaminated mine sediments. Both isolates belonged to the Comamonadaceae family and were 99% similar to previously described species. We identify these novel strains as Hydrogenophaga taeniospiralis strain IDSBO-1 and Variovorax paradoxus strain IDSBO-4. Both strains possess a gene with homology to the aioA gene, which encodes an As(III)-oxidase, and both oxidize As(III) aerobically, but only IDSBO-4 oxidized Sb(III) in the presence of air, while strain IDSBO-1 could achieve this via nitrate respiration. Our results suggest that expression of aioA is not induced by Sb(III) but may be involved in Sb(III) oxidation along with an Sb(III)-specific pathway. Phylogenetic analysis of proteins encoded by the aioA genes revealed a close sequence similarity (90%) among the two isolates and other known As(III)-oxidizing bacteria, particularly Acidovorax sp. strain NO1. Both isolates were capable of chemolithoautotrophic growth using As(III) as a primary electron donor, and strain IDSBO-4 exhibited incorporation of radiolabeled (14)Cbicarbonate while oxidizing Sb(III) from Sb(III)-tartrate, suggesting possible Sb(III)-dependent autotrophy. Enrichment cultures produced the Sb(V) oxide mineral mopungite and lesser amounts of Sb(III)-bearing senarmontite as precipitates.
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