The fabrication of deformable devices has been explored by interconnecting nonstretchable unit devices with stretchable conductors or by developing stretchable unit devices consisting of all ...stretchable device components such as electrodes, active channels, and dielectric layers. Most researches have followed the first approach so far, and the researches based on the second approach are at the very beginning stage. This paper discusses the perspectives of the second approach, specifically focusing on the polymer semiconductor channel layers, that is expected to facilitate high density device integration in addition to large area devices including polymer solar cells and light-emitting diodes. Three different routes are suggested as separate sections according to the principles imparting stretchability to polymer semiconductor layers: structural configurations of rigid semiconductors, two-dimensional network structure of semiconductors on elastomer substrates, and ductility enhancement of semiconductor films. Each section includes two subsections divided by the methodological difference. This Perspective ends with discussion on the future works for the routes and the challenges related to other device components.
Transposable elements (TEs) are DNA sequences capable of mobilization from one location to another in the genome. Since the discovery of ‘Dissociation (Dc) locus’ by Barbara McClintock in maize (1), ...mounting evidence in the era of genomics indicates that a significant fraction of most eukaryotic genomes is composed of TE sequences, involving in various aspects of biological processes such as development, physiology, diseases and evolution. Although technical advances in genomics have discovered numerous functional impacts of TE across species, our understanding of TEs is still ongoing process due to challenges resulted from complexity and abundance of TEs in the genome. In this mini-review, we briefly summarize biology of TEs and their impacts on the host genome, emphasizing importance of understanding TE landscape in the genome. Then, we introduce recent endeavors especially in vivo retrotransposi-tion assays and long read sequencing technology for identifying de novo insertions/TE polymorphism, which will broaden our knowledge of extraordinary relationship between genomic cohabitants and their host. BMB Reports 2022; 55(7): 305-315
This study uses the Social–Ecological–Technological Systems (SETS) framework to examine the urban disaster management strategies of Toyama City, Japan. The recent seismic shocks on the Noto Peninsula ...highlight the importance of implementing efficient disaster management. Toyama City has incorporated the United Nations’ Sustainable Development Goals into its statutory planning frameworks and urban management policies. This synthesis promotes a cooperative approach to disaster resilience while effectively managing challenging limitations. However, we investigate how Toyama City’s policy may be improved using policy direction evaluation and SETS allomorph coding. This extensive allomorph analysis of the city’s urban planning and disaster management documents shows a dominant focus on social and technical elements, including emergency preparedness, policy, economic criteria, and infrastructure. Nevertheless, the results reveal a significant deficiency in ecological considerations, indicating an asymmetry in the existing policy framework. Our study emphasizes the need for a comprehensive disaster management strategy that considers social, technological, and ecological variables to improve the city’s ability to support sustainable development and socio-hydrological challenges.
Transposable elements (TEs) are DNA sequences capable of mobilization from one location to another in the genome. Since the discovery of ‘
Dissociation
(
Dc
) locus’ by Barbara McClintock in maize ...(1), mounting evidence in the era of genomics indicates that a significant fraction of most eukaryotic genomes is composed of TE sequences, involving in various aspects of biological processes such as development, physiology, diseases and evolution. Although technical advances in genomics have discovered numerous functional impacts of TE across species, our understanding of TEs is still ongoing process due to challenges resulted from complexity and abundance of TEs in the genome. In this mini-review, we briefly summarize biology of TEs and their impacts on the host genome, emphasizing importance of understanding TE landscape in the genome. Then, we introduce recent endeavors especially
in vivo
retrotransposition assays and long read sequencing technology for identifying
de novo
insertions/TE polymorphism, which will broaden our knowledge of extraordinary relationship between genomic cohabitants and their host.
High‐performance UV photodetectors call for sensitive and energy‐efficient signal detection in extreme environments. To satisfy the requirement of a UV detection without an external power ...consumption, self‐powered UV photodetectors must be realized by an optimal combination of heterostructure with maximum built‐in potential using novel wide‐bandgap materials. Here, self‐powered UV photodiodes are designed via the band engineering of a wide‐bandgap Sr(Sn,Ni)O3/BaSnO3 heterojunction for the first time. Based on the theoretical concept of acceptor doping by Ni substitution in SrSnO3, remarkably, this heterojunction with a conduction band offset of 0.94 eV shows strong nonlinear electrical characteristics with extremely low Idark (≈100 fA) owing to the spatial gradient of the potential barrier across the interfaces, outstanding photo‐to‐dark current ratio (>107 at 25 °C and > 104 at 300 °C), and high stability under various extreme conditions upon UV illumination even without external bias (V = 0 V). This study suggests a novel strategy that utilizes band engineering to maximize sensitivity and minimize energy consumption in harsh environments for UV imaging using the newly discovered wide‐bandgap semiconductors.
High performance self‐powered np photodiodes have been demonstrated using perovskite stannate BaSnO3/Sr(Sn,Ni)O3 heterojunction. Outstanding photo‐to‐dark current ratio (> 107 at 25 °C) even at high temperature (> 104 at 300 °C) without an external power supply is achieved by exploiting excellent thermal/chemical stability of perovskite stannate and band engineering at the interface of np junction.
Dibutyl phthalate (DBP) is commonly used plasticizer and a known endocrine disruptor that can cause birth defects and developmental disorders. Although several studies have reported that DBP has ...neurotoxic effects on neurite outgrowth and on learning and memory, its neurotoxic effects on neural progenitor cells (NPCs) have not been investigated. The present study was undertaken to determine the effects of DBP on NPCs and hippocampal neurogenesis. At high concentration DBP (500 μM) retarded NPC proliferation without affecting cell viability by arresting the cell cycle at G1 but did not cause cell death. DNA damage was observed by examining p53 expression and by γH2AX staining. DBP-treated cells had elevated ROS levels and exhibited mitochondrial dysfunction, which can cause DNA damage. Adult hippocampal neurogenesis was investigated using BrdU immunohistochemistry in young C57BL/6 mice intraperitoneally administrated with vehicle or DBP (10 or 50 mg/kg) for 2 weeks. DBP administered mice were found to have significantly fewer newly generated neurons in hippocampi, and the Morris water maze test revealed that DBP (50 mg/kg) impaired spatial learning and memory. Taken together, these findings suggest that DBP has harmful effects on NPCs and hippocampal neurogenesis and that DBP exposure could lead to learning and memory dysfunctions.
•DBP caused cell cycle arrest without cell death.•DBP-induced DNA damage and mitochondrial dysfunction are associated with oxidative stress.•DBP impaired hippocampal neurogenesis.•DBP had adverse effects on the hippocampus-dependent learning and memory.
We propose a technique that allows designers to develop energy-efficient buildings focused on occupants from the early design stage. The technique integrates the physiological responses of occupants ...and the energy performance of buildings. Among the architectural design elements, we considered the aspect ratio, ceiling height, and window-to-wall ratio as design variables and created 30 design alternatives for a single-occupancy room in a postpartum care center. These design alternatives were recreated in virtual reality, allowing 33 female participants to immerse themselves in the designed rooms. During the experiment, we collected electroencephalography (EEG) data from the participants. Furthermore, we used DesignBuilder to simulate 30 design alternatives and calculated the primary energy consumption per unit area for each alternative. By integrating the EEG data and energy performance analysis, we identified the design alternative among the 30 options that positively influenced the physiological responses of occupants while also being energy efficient. The selected alternative was designed with an aspect ratio of 1:1.6, a ceiling height of 2.3 m, and a window-to-wall ratio of 60%. This research represents a creative exploration that demonstrates how studies combining human physiological responses and architecture can evolve through integration with other subjects. Our findings provide a robust framework to explore the relationship between physiological responses and energy optimization for detailed architectural design elements.
We previously isolated pseudane-VII from the secondary metabolites of
sp. M2 in marine water, and demonstrated its anti-inflammatory efficacy on macrophages. However, the molecular mechanism by which ...pseudane-VII suppresses neuroinflammation has not yet been elucidated in brain microglia. Microglia is activated by immunological stimulation or brain injury. Activated microglia secrete proinflammatory mediators which damage neurons. Neuroinflammation appears to be associated with certain neurological diseases, including Parkinson's disease and Alzheimer's disease. Natural compounds that suppress microglial inflammatory responses could potentially be used to prevent neurodegenerative diseases or slow their progression. In the present study, we found that pseudane-VII suppresses neuroinflammation in lipopolysaccaride (LPS)-stimulated BV-2 microglial cells and brain. Pseudane-VII was shown to inhibit the LPS-stimulated NO, ROS production and the expression of iNOS and COX-2. To identify the signaling pathway targeted by pseudane-VII, we used western blot analysis to assess the LPS-induced phosphorylation state of p38, ERK1/2, JNK1/2, and nuclear factor-kappaB (NF-κB). We found that pseudane-VII attenuated LPS-induced phosphorylation of MAPK and NF-κB. Moreover, administration of pseudane-VII in mice significantly reduced LPS-induced iNOS expression and microglia activation in brain. Taken together, our findings suggest that pseudane-VII may represent a potential novel target for treatment for neurodegenerative diseases.
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