To solve the toxicity problem of blue light emissive three-dimensional lead halide perovskite, zero-dimensional lead-free hybrid halides with low cost and high emission efficiency have become one of ...the most promising solid-state light emitting materials. Herein, by utilizing discrete ZnBr42− tetrahedrons as optical center, a new series of organic–inorganic hybrid zinc halides of AZnBr4 (A = NMPz, MPz, and AMPd) were presented as blue light emitters. Excitingly, these zero dimensional halides exhibit bright blue-light emission with the highest photoluminescence quantum yield of 17.28%, acting as down-conversion phosphors to assembly high-performance white-light emitting diode.
•Three new kind of Zn2+-based hybrid halide based on discrete ZnBr42– tetrahedrons.•Bright blue-light emission with highest photoluminescence quantum yield of 17.28%.•High color rendering index value (>90) and considerable optical stability.
Knot structures exist ubiquitously in young stellar object (YSO) jets, which are a key tracer in astronomical observation to estimate the jet properties and eventually the YSO's parameters (age, ...size, mass and so on). Using 2D and 3D radiation magnetohydrodynamic simulations of the laser-produced plasma jets in external poloidal magnetic fields, we present a systematic analysis on the formation mechanism and characteristics of knot structures in collimated jets. The simulations demonstrate that the multi-knot pattern in jets can be formed by the oblique internal shocks in only single ejection. It is found that the distance L between different knots in jet is determined by the ratio of its thermal pressure to magnetic pressure β as L∝Dβ1/2, where D is the jet transverse diameter. There is a factor about 0.4-0.6 between the knot and jet velocities. And radiation cooling effect can alleviate the intensity of the external magnetic field required for collimating jets. These findings are scaled to the conditions of YSO jets, and can be applied to explore some characteristics of the astrophysical jets.
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and ...field of view of current methodologies precludes their systematic application to analyze relatively large and three-dimensional mid- and late-gestation embryos. Here, we combined DNA nanoball (DNB)-patterned arrays and in situ RNA capture to create spatial enhanced resolution omics-sequencing (Stereo-seq). We applied Stereo-seq to generate the mouse organogenesis spatiotemporal transcriptomic atlas (MOSTA), which maps with single-cell resolution and high sensitivity the kinetics and directionality of transcriptional variation during mouse organogenesis. We used this information to gain insight into the molecular basis of spatial cell heterogeneity and cell fate specification in developing tissues such as the dorsal midbrain. Our panoramic atlas will facilitate in-depth investigation of longstanding questions concerning normal and abnormal mammalian development.
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•Stereo-seq enables large field-of-view spatial transcriptomics at cellular resolution•Stereo-seq reveals the spatial cell-type heterogeneity of mouse embryonic tissues•Stereo-seq maps the spatiotemporal transcriptomic dynamics during mouse organogenesis•Stereo-seq defines the spatiotemporal window of developmental disease vulnerability
Stereo-seq combines DNA nanoball-patterned arrays and tissue RNA capture to achieve large field-of-view spatial transcriptomics at cellular resolution, enabling the dissection of spatial cell-type heterogeneity of mouse embryonic tissues.
We present the structural and photovoltaic properties of Sr-doped polycrystalline BiFeO
3
thin films prepared by sol-gel method. The result shows that all the BiFeO
3
thin films doped with 0 ∼ 20 ...at.% Sr are rhombohedral distortion perovskite structure and the lattice constant decreases with increasing Sr amount. The addition of Sr can effectively inhibit the grain growth and enhance the uniformity of BFO films, besides, the band gap can be tuned availably as well. As Sr content increases, both the short circuit photocurrent density and the open circuit photovoltage begins to increase and then decrease, the maximum values achieved when 15 at.% Sr-doped. The power conversion efficiency accordingly increases first and then drops with Sr content increases, reaching 0.011% when the Sr-doped content is 15%, which results from the decreased band gap and oxygen vacancies.
Highlights
All the BiFeO
3
thin films are rhombohedral distortion perovskite structure.
Addition of Sr decreases the band gap of BFO thin films.
The power conversion efficiency increases as Sr content increases.
The maximal power conversion efficiency is 0.011%
Cyclin‐dependent kinase (CDK) is a serine/threonine protein kinase family that cooperates with cyclin and plays an important role in the regulation of cell cycle. Cyclin‐dependent kinase 2 is an ...important member of the CDK family and holds great promise as an anti‐cancer drug target. In this study, we used molecular docking and physics‐based binding free energy calculation method AS‐IE that explicitly calculated protein‐ligand binding entropy to discover novel inhibitors of CDK2. A total of 17 inhibitors were discovered with the best IC50 reaching ~2 μM. Decomposition of the binding free energy using AS‐IE reveals key protein‐ligand interactions that determines the activity. These results provided a good example of drug design using physics‐based free energy calculation method such as AS‐IE and the novel compounds offered a good start point for further development of CDK2 inhibitors.
By using virtual screening, MD simulation, and inhibition experiment, we found a new series compounds of CDK2 inhibition, best IC50 of which reached ~2 μM.
Two subtractive complementary DNA libraries were constructed from Nile tilapia Oreochromis niloticus vaccinated with formalin‐killed Streptococcus iniae cells, and a further two constructed from O. ...niloticus infected with S. iniae. Of the 68 distinct expressed sequence tag (EST) contigs and singletons, 45 and 13 EST shared high similarities with genes of known and unknown functions, respectively. Ten EST contigs and singletons had no significant similarity to any sequences. Five putative immune‐relevant genes, β2m, α‐ha, mmp9, pgrn and cxcr4, were selected for quantitative reverse‐transcription polymerase chain reaction in four strains of Oreochromis spp.: genetically improved farmed tilapia (O. niloticus), Oreochromis aureus, O. niloticus and O. niloticus×O. aureus, with different disease resistance following infection with S. iniae. pgrn was up‐regulated more significantly in disease‐resistant strains than in the susceptible. α‐ha was markedly down‐regulated, and no significant differences in the expression level of β2m were detected. A negative correlation was observed between the expression of mmp9 and that of cxcr4. The results provide insight into the molecular response of O. niloticus to S. iniae infection.
Flexible batteries as one of the most promising technologies for the application of wearable and soft electronic devices have attracted great attention in recent years. Similar to conventional ...secondary batteries, cyclability, and high rate capacities are also required for application of flexible electronics. In this paper, a flexible surface modified carbon cloth architecture is designed as a current collector and prepared for the application in Li and Na batteries. Owing to the design of rough structure on carbon fibers, the surface area for active materials to nucleate and grow can be increased, and the rough surface ensures a good contact between the active material and carbon fibers. The binder free Li4Ti5O12/surface modified carbon cloth electrodes exhibit excellent cycle ability for both Li and Na storages. The electrode delivers a small capacity loss of 9.5% after 6000 cycles at 10C with a capacity retention of 131 mA h g−1 for Li storage. And a capacity of 124 mA h g−1 is obtained after 1000 cycles for Na storage.
•The surface modified carbon cloth (SMCC) as flexible substrates are designed.•The rough structure of SMCC increases the hydrophilicity of carbon fibers.•The light weight of SMCC allows high gravimetric capacity of energy storage devices.•The binder free LTO/SMCC exhibit excellent cycle ability for both LIBs and SIBs.
•The MEL can be significantly tuned from 19.3% to −1.0% at room temperature.•The tunable MEL was by the way of controlling the competition between SF and TF.•We doped different concentration of DCJTB ...into rubrene as an emissive layer.•Changing the working temperature is another method to tune the MEL.
We report a tunable magneto-electroluminescence (MEL) in doped organic light-emitting diodes (OLEDs) with narrow energy gap molecule of 4-dicyanomethylene-2-t-butyl-6-1,1,7,7-tetramethy-ljulolidyl-9-4H-pyran (DCJTB) doped rubrene as active layers. It is noted that the MEL at 500mT alters significantly from 19.3% to −1.0% by controlling the doping concentration of DCJTB in the active layer at room temperature. The results might be caused by the conversion from singlet fission to triplet fusion depending on the competition between energy transfer and charge trapping channels in doped layer. Moreover, the MEL can also be tuned by changing the working temperatures for the devices with certain doping concentration. Therefore, this work provides a feasible pathway to tune the MEL by controlling the competition between singlet fission and triplet fusion in OLEDs.
Although multiple, complex molecular studies have been done for understanding the development and progression of pulmonary hypertension (PAH), little is known about the metabolic heterogeneity of ...PAH. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we found bile acid metabolites, which are normally product derivatives of the liver and gallbladder, were highly increased in the PAH lung. Microarray showed that the gene encoding cytochrome P450 7B1 (CYP7B1), an isozyme for bile acid synthesis, was highly expressed in the PAH lung compared with the control. CYP7B1 protein was found to be primarily localized on pulmonary vascular endothelial cells suggesting de novo bile acid synthesis may be involved in the development of PAH. Here, by profiling the metabolomic heterogeneity of the PAH lung, we reveal a newly discovered pathogenesis mechanism of PAH.
Amplitude analysis of the decays and Amoroso, A.; Calcaterra, A.; Chang, W. L. ...
Chinese physics C,
08/2024, Letnik:
48, Številka:
8
Journal Article
Recenzirano
Abstract Using annihilation data corresponding to an integrated luminosity of 2.93 taken at the center-of-mass energy GeV with the BESIII detector, a joint amplitude analysis is performed on the ...decays and (non- η ). The fit fractions of individual components are obtained, and large interferences among the dominant components of the decays , , , and are observed in both channels. With the obtained amplitude model, the -even fractions of and (non- η ) are determined to be % and %, respectively. The branching fractions of and (non- η ) are measured to be % and %, respectively. The amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of when used to determine the CKM angle via the decay.
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