With the deepening of globalization, brand plays an important role in determining the competitiveness of enterprises. It is worth thinking about how to quantify the brand value reasonably to achieve ...the purpose of improving the competitiveness of enterprises. The research of commercial brands based on emotion analysis extracts the views of consumers on the evaluation data of brand attributes, analyzes the emotional tendency of consumers' views, and then helps enterprises adjust their production strategies. The purpose of emotion analysis is to judge users' views and attitudes toward goods or services by analyzing texts. In this paper, the linear support vector machine model is used to extract and study the features in sentiment analysis. Then, the brand based on the fusion model is evaluated, and the experimental conclusions are drawn: the method of fusing the depth features extracted by word vector and the named entity extracted by CRF makes the brand effect of fusing emotional factors better than the feature extraction method only using CRF named entity recognition. It is proved that the model method proposed in this paper has a certain role in actual business. Feature fusion often combines shallow model methods and fuses various shallow feature screening technologies based on word segmentation results. This paper introduces fusion features and supplements feature vectors based on the results of the deep learning word vector model. Support Vector Machine (SVM) maps feature vectors to some sample points in the space, finds a plane that can realize sample classification, and maximizes the distance between the two sample points closest to the plane in two types of samples, to maximize the classification performance and improve the generalization of the model.
Abstract
Since the first dendrimer was reported in 1978 by Fritz Vögtle, dendrimer research has grown exponentially, from synthesis to application in the past four decades. The distinct structure ...characteristics of dendrimers include nanoscopic size, multi-functionalized surface, high branching, cavernous interior, and so on, making dendrimers themselves ideal drug delivery vehicles. This mini review article provides a brief overview of dendrimer’s history and properties and the latest developments of dendrimers as drug delivery systems. This review focuses on the latest progress in the applications of dendrimers as drug and gene carriers, including 1) active drug release strategies to dissociate drug/gene from dendrimer in response to stimuli; 2) size-adaptive and charge reversal dendrimer delivery systems that can better take advantage of the size and surface properties of dendrimer; 3) bulk and micro/nano dendrimer gel delivery systems. The recent advances in dendrimer formulations may lead to the generation of new drug and gene products and enable the development of novel combination therapies.
Chitosan is a nature-based polymer with low toxicity, excellent biocompatibility and biodegradability. However, the intractable solubility of chitosan in water and most conventional solvents hampers ...its biomedical applications. Following the dissolution method for dissolving chitosan in plain water developed by us, chitosan was dissolved in ionic liquid followed by overnight freezing at −20 °C and subsequent solvent exchange with plain water at room temperature. In this study, we fabricated a drug-carrying chitosan film via solution casting and air-drying by using the plain water-based chitosan solution. Specifically, brimonidine tartrate (BT), an antiglaucoma drug, was dissolved in the plain-water based solution and used to prepare BT-loaded chitosan film, i.e., chitosan-BT film. The resulting film is transparent, structurally stable, and mucoadhesive. Micro-sized antiglaucoma BT drug crystals form and are well dispersed in the chitosan film. The chitosan-BT film enables BT to have a high corneal permeability with fast drug release kinetics for potential ocular drug delivery.
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•A drug-carrying chitosan film is made via solution casting and air-drying of plain water-based chitosan solution.•The antiglaucoma drug brimonidine tartrate loaded into the chitosan film forms micro-sized crystals with uniform dispersion.•The chitosan film enables BT to have a high corneal permeability with fast drug release for potential ocular drug delivery.
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•LINC00339 is overexpressed in ovarian cancer.•LINC00339 promotes cell proliferation and invasion of ovarian cancer cells.•LINC00339 interacts with miR-148a-3p/ROCK1 axis.
Ovarian ...cancer is one of the most common malignant tumors of female genital organs. Long non-coding RNAs play an important role in the progression of ovarian cancer. In the present study, we aimed at identifying the role of LINC00339 in the occurrence and metastasis of ovarian cancer.
The expression of LINC00339 in ovarian cancer was detected by qRT-PCR and FISH. The effect of LINC00339 on cell proliferation, migration, and invasion of ovarian cancer cells was examined by CCK8, wound healing, and transwell assays, respectively. The effect of LINC00339 on in vivo tumor growth was examined using a xenograft mouse model. The mechanism by which LINC00339 regulated cellular biology of ovarian cancer cells was identified by bioinformatics analysis, RIP assay, and dual luciferase reporter assay.
LINC00339 was overexpressed in ovarian cancer tissues, showed a poor prognosis in patients with ovarian cancer, and correlated with tumor size and advanced clinical stages. Upregulation of LINC00339 promoted cell proliferation, migration, and invasion, while downregulation of LINC00339 exhibited an opposite effect. LINC00339 promotedin vivo tumor growth. It interacted with miR-148a-3p/ROCK1, and miR-148a-3p inhibitors rescued the anti-tumor effect of LINC00339 knockdown on proliferation, migration, and invasion of ovarian cancer cells.
LINC00339 regulated ovarian cancer cell proliferation, migration, and invasion by targeting miR-148a-3p/ROCK1 axes, which provided novel insights for ovarian cancer diagnosis and therapy.
Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed embryo of lotus (Nelumbo nucifera), and exhibit potential anti-cancer activity. Here, we explored the ...effects of these alkaloids on triple-negative breast cancer cells and found that among the three alkaloids isoliensinine possesses the most potent cytotoxic effect, primarily by inducing apoptosis. Interestingly, isoliensinine showed a much lower cytotoxicity against MCF-10A, a normal human breast epithelial cell line. Further studies showed that isoliensinine could significantly increase the production of reactive oxygen species (ROS) in triple-negative breast cancer cells, but not in MCF-10A cells. The isoliensinine-induced apoptosis could be attenuated by radical oxygen scavenger N-acetyl cysteine, suggesting that the cytotoxic effect of isoliensinine on cancer cells is at least partially achieved by inducing oxidative stress. We found that both p38 MAPK and JNK signaling pathways were activated by isoliensinine treatment and contributed to the induction of apoptosis. Furthermore, inhibitors or specific siRNAs of p38 MAPK and JNK could attenuate apoptosis induced by isoliensinine. However, only the p38 inhibitor or p38-specific siRNA blocked the elevation of ROS in isoliensinine-treated cells. Our findings thus revealed a novel antitumor effect of isoliensinine on breast cancer cells and may have therapeutic implications.
Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian cells. The distribution of Piezo1 within a cell is essential for various biological processes including ...cytokinesis, cell migration, and wound healing. However, the underlying principles that guide the subcellular distribution of Piezo1 remain largely unexplored. Here, we demonstrate that membrane curvature serves as a key regulator of the spatial distribution of Piezo1 in the plasma membrane of living cells. Piezo1 depletes from highly curved membrane protrusions such as filopodia and enriches to nanoscale membrane invaginations. Quantification of the curvature-dependent sorting of Piezo1 directly reveals the in situ nano-geometry of the Piezo1-membrane complex. Piezo1 density on filopodia increases upon activation, independent of calcium, suggesting flattening of the channel upon opening. Consequently, the expression of Piezo1 inhibits filopodia formation, an effect that diminishes with channel activation.
Background
The number of people with mental disorders is increasing in China, but there are few studies on the temporal trends and population distribution of mental disorder mortality.
Methods
The ...mortality of mental disorders were derived from the China Health Statistics Yearbook published by the National Health and Family Planning Commission. Temporal trends in mortality were examined with a joinpoint regression using annual percent change (APC) and average annual percent change (AAPC). A Poisson regression model was utilized to test the population-level risk factors associated with the death of people with mental disorders.
Results
The mortality of mental disorders in rural Chinese residents showed a decreasing trend from 2002 to 2020 AAPC –2.06%, 95% confidence interval (CI) –3.16 to –0.91%. The mortality of mental disorders in urban Chinese residents declined between 2005 and 2011 (APC –13.01%, 95% CI –21.08 to –4.13%). The mortality rate of mental disorders has decreased for urban males with an APC of –2.71% (95% CI –4.52 to –0.71) from 2002 to 2020. Urban women showed an increase in mental disorder mortality from 2002 to 2005 and from 2012 to 2020 with APCs of 19.65% (95% CI 0.64–42.32%) and 6.16% (95% CI 2.22–10.33%), respectively. Age was a significant risk factor for mental disorder mortality (odds ratio 1.28, 95% CI 1.23–1.32).
Conclusion
The dissemination of medical and health information, investment in medical and health resources, and the modification and optimization of regulations have led to a decrease in mental disorder mortality in China. It is vital to devote greater attention to elderly individuals suffering from mental disorders.
According to several studies, a specific dietary pattern can reduce the risk of dementia and cognitive impairment. However, the robustness of these results has not been tested. The study intends to ...investigate the association between nutrition intake and cognitive impairment in middle-aged and older adults (≥45-years) and provide reliable, evidence-based references for healthcare decision-makers, researchers, and policymakers.
Are the dietary characteristics of community-dwelling adults (≥45-years) associated with the occurrence of cognitive impairment?
The primary objective of this protocol is to synthesize the longitudinal observational evidence on the relationship between nutrition intake patterns and the incidence of cognitive impairment in middle-aged and older adults (≥45-years), and to provide detailed dietary recommendations for the prevention of cognitive impairment in this population.
Cohort studies conducted among adults (≥45-years) will be included. The following electronic databases will be searched for relevant records published by July 2023, with a restriction on language to English: Pubmed, Medline, Embase, Web of science, Cochrane Library. The studies will be selected, the data will be extracted, and the bias risk will be assessed by two independent investigators. The Meta-analysis of Observational Studies in Epidemiology guidelines will be followed to summarize observational studies, and the protocol will adhere to the recommendations from the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement. Endnote X9 will be used to manage data screening. We will use Review Manager 5.4 and Stata 16.0 to conduct data analysis, and a random-effects model will be applied to pool clinically homogenous studies. The results will be presented based on the form of nutrition intake. For assessing publication bias, Egger's test and visual inspection of funnel plots will be utilized.
As this study does not involve primary data, ethical approval is not required. The final report will be published in a peer-reviewed journal.
A registration number of DOI 10.17605/OSF.IO/NAKC3 was assigned to it on October 15, 2022 on Prospero.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Surface oxidation is found to improve the osseointegration of titanium nitride (TiN) coatings on implantable titanium devices; nevertheless, systematic studies on effects of oxidation are still ...needed. In this study, multi-arc ion plated (MAIP) titanium nitride (TiN) coating was hydrothermally oxidized in pure water and then the structural, corrosion and wear properties of the coating were studied. A dense oxide layer of 20–50 nm in thickness is formed on TiN after hydrothermal oxidation above 200 °C. The layer is composed of flat anatase particles with a length of 50–150 nm and smaller anatase nanocrystallines located on their surface. The passivation behavior of TiN becomes much stronger in simulated saliva after oxidation treatment, showing a wider passivation range, a lower corrosion current and greatly improved impedance. In addition, the open circuit potential (OCP) of oxidized TiN remains much higher than that of untreated after 50 days of immersion. Sliding friction experiments against zirconia (ZrO2) ceramic balls show that the wear type for the untreated TiN coating involves severe plowing and deformation. In contrast, only slight plowing is found on the surface of TiN covered with a compact anatase layer; the friction coefficient decreases sharply and the wear loss decreases obviously.
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1.Anatase nanolayer forms on TiN coating after hydrothermal oxidation in water.2.Hydrothermal oxidation improves corrosion resistance of TiN in artificial saliva.3.Anatase nanolayer contributes to obvious lubrication and wear reduction.
Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or ...motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (GABAergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. These findings can provide targets for clinical treatment and perspectives for further studies.
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