As we all know, environmental protection and sustainable energy utilization are significant challenges for us. Due to their many excellent characteristics, carbon materials have been playing a very ...important role in energy and environmental applications. Biomass is the only renewable carbon source and crucial precursor of carbonaceous materials and has the advantages of a unique structure, a wide range of sources, biodegradability, and low cost. Developing high-performance carbonaceous materials from biomass is a significant research subject. Biomass-derived porous graphitic carbon materials (BPGCs) have received extensive attention as novel high-performance sustainable carbon materials owing to its well-developed porous structure, good graphitic structure, and heteroatom doping. Here, this review firstly focuses on the principal synthesis methodologies of BPGCs. Next, three electrochemical energy storage and conversion systems that utilize BPGCs are intensively investigated, including supercapacitors (SCs), lithium-ion batteries (LIBs) and fuel cells (FCs). Then, BPGCs are further reviewed in terms of their application in the field of environmental protection, which is also the first systematic summary of BPGCs in environmental applications. Finally, this review points out the direction that is worthy of further research in the future and the essential issues that have not yet been resolved.
This review presents the applications of biomass-derived porous graphitic carbon materials and their synthetic methods.
Recently, the stable light products and radiance calibrated products from Defense Meteorological Satellite Program's (DMSP) Operational Linescan System (OLS) have been useful for mapping global ...fossil fuel carbon dioxide (CO2) emissions at fine spatial resolution. However, few studies on this subject were conducted with the new-generation nighttime light data from the Visible Infrared Imaging Radiometer Suite (VIIRS) sensor on the Suomi National Polar-orbiting Partnership (NPP) Satellite, which has a higher spatial resolution and a wider radiometric detection range than the traditional DMSP-OLS nighttime light data. Therefore, this study performed the first evaluation of the potential of NPP-VIIRS data in estimating the spatial distributions of global CO2 emissions (excluding power plant emissions). Through a disaggregating model, three global emission maps were then derived from population counts and three different types of nighttime lights data (NPP-VIIRS, the stable light data and radiance calibrated data of DMSP-OLS) for a comparative analysis. The results compared with the reference data of land cover in Beijing, Shanghai and Guangzhou show that the emission areas of map from NPP-VIIRS data have higher spatial consistency of the artificial surfaces and exhibit a more reasonable distribution of CO2 emission than those of other two maps from DMSP-OLS data. Besides, in contrast to two maps from DMSP-OLS data, the emission map from NPP-VIIRS data is closer to the Vulcan inventory and exhibits a better agreement with the actual statistical data of CO2 emissions at the level of sub-administrative units of the United States. This study demonstrates that the NPP-VIIRS data can be a powerful tool for studying the spatial distributions of CO2 emissions, as well as the socioeconomic indicators at multiple scales.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Lysine succinylation is a newly discovered protein post-translational modifications. Predicting succinylation sites helps investigate the metabolic disease treatments. However, the biological ...experimental approaches are costly and inefficient, it is necessary to develop efficient computational approaches. In this paper, we proposed a novel predictor based on ensemble dense blocks and an attention module, called as pSuc-EDBAM, which adopted one hot encoding to derive the feature maps of protein sequences, and generated the low-level feature maps through 1-D CNN. Afterward, the ensemble dense blocks were used to capture feature information at different levels in the process of feature learning. We also introduced an attention module to evaluate the importance degrees of different features. The experimental results show that Acc reaches 74.25%, and MCC reaches 0.2927 on the testing dataset, which suggest that the pSuc-EDBAM outperforms the existing predictors. The experimental results of ten-fold cross-validation on the training dataset and independent test on the testing dataset showed that pSuc-EDBAM outperforms the existing succinylation site predictors and can predict potential succinylation sites effectively. The pSuc-EDBAM is feasible and obtains the credible predictive results, which may also provide valuable references for other related research. To make the convenience of the experimental scientists, a user-friendly web server has been established (http://bioinfo.wugenqiang.top/pSuc-EDBAM/), by which the desired results can be easily obtained.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Chimeric antigen receptor (CAR) T-cell therapy is highly effective in the treatment of B-cell acute lymphoblastic leukemia (ALL) or B-cell lymphoma, providing alternative therapeutic options for ...patients who failed to respond to conventional treatment or relapse. Moreover, it can bridge other therapeutic strategies and greatly improve patient prognosis, with broad applicable prospects. Even so, 30-60% patients relapse after treatment, probably due to persistence of CAR T-cells and escape or downregulation of CD19 antigen, which is a great challenge for disease control. Therefore, understanding the mechanisms that underlie post-CAR relapse and establishing corresponding prevention and treatment strategies is important. Herein, we discuss post-CAR relapse from the aspects of CD19-positive and CD19-negative and provide some reasonable prevention and treatment strategies.
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•The escape panics in real-life 2013 Ya’an earthquake are simulated and reproduced.•Differential evolution is used to calibrate the parameters of social force model.•Trained ...evacuation leader is beneficial to maintain the calm and order of crowd.•Different layouts can only change the partial flow in the left and right corridors.•The evacuation efficiency has almost doubled when the back door is open.
Due to the fact that escape panics are unexpected and dangerous, which excludes real-life experiments because of technical difficulties and ethical reasons, the evacuation simulations in real-life disasters are still rare. In this paper, the escape panics of classroom evacuation in real-life 2013 Ya’an earthquake in China are simulated and reproduced using the social force model. Firstly, a robust differential evolution (DE) is employed to calibrate and optimize the parameters of social force model to achieve a desired nonlinear evacuation speed which is consistent with real-life video data. It is demonstrated the DE-calibrated social force model can reproduce the characteristics of pedestrian flow in the real-life earthquake evacuation including the nonlinear evacuation speed curve and the pedestrian position distributions at different time. Moreover, the trained evacuation leader has remarkable impact on the evacuation process which can be beneficial to maintain the calm and order of crowd, decrease the desired velocity of crowd, and thus avoid fatal accident to the most degree. Finally, different layouts of classroom have similar evacuation efficiency because different internal layouts can only change partial flow of pedestrians in the left and right corridors, and total flow aggregating in the exit of classroom is still unchanged. However, total evacuation time can be sharply reduced to 17s from above 36s, and evacuation efficiency has almost doubled when the back door is open, which means we should try to keep all the emergency exits open in order to provide the crowd with more chances to escape when disasters occur.
4-Vinylcyclohexene diepoxide (VCD), an industrial occupational health hazard chemical associated with premature ovarian insufficiency (POI) and reproductive failure. Recently, investigators have paid ...an increasing attention on VCD model of menopause recapitulates the natural, physiological transition through perimenopause to menopause. The current study sought to examining the mechanisms of follicular loss and exploring the effect of the model on systems outside of the ovaries. In this study, 28 days female SD rats were injected with VCD (160 mg/kg) vehicle for 15 consecutive days, euthanized in the diestrus phase approximately 100 days after the onset of treatment. Reproductive system injury, Neuroendocrine, sex hormone levels and receptor were observed, the levels of N6-methyladenosine (m6A) RNA modification and the expression of modulator genes were first measured. The VCD treated rats showing irregular estrous cycles, significantly reduced in the number of primordial follicles, the preantral and antral follicles also decreased significantly, accompanied by the plasma level of FSH increased and anti-Mullerian hormone (AMH) were decreased. The total m6A level was significantly decreased after exposure to VCD. Moreover, ALKBH5-mediated YAP m6A modification changed in VCD - induced premature ovarian insufficiency. These present work provides a new perspective on m6A modification in the VCD-induced POI rat model, which could provide valuable insights into the mechanisms underlying follicle development and finding new therapeutic targets for follicle prematurely exhausted. Also provide novel methodological guidance and endocrine basis to guide research and extend the applications in premature ovarian insufficiency model.
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•VCD exposure induces Premature Ovarian Insufficiency.•VCD exposure activated the YAP/p-YAP to inhibit follicles growth.•Decreased RNA m6A methylation levels following exposure to VCD.•RNA m6A demethylases ALKBH5 controls YAP expression by regulating m6A levels.
We intend to tackle two under-addressed issues in access to healthcare services during the COVID-19 pandemic: first, the spatiotemporal dynamic of access during the pandemic of acute communicable ...disease; second, the demographic and socioeconomic access disparities. We used the two-step floating catchment area (2SFCA) method to measure the spatial access to public hospitals during the second COVID-19 wave (September 28th-February 28th, 2021) in Nottinghamshire, UK. To investigate the temporal variation in access along with the development of the pandemic, we divided our study period into 11 sections and applied the 2SFCA to each of them. The results indicate that western Nottinghamshire is better than the eastern part from a spatial perspective and the north-western urban area represents the highest spatial access; temporally, the accessibility of the public hospitals generally decreased when the number of cases increased. Particular low accessibility was observed at the beginning of the pandemic when the outbreak hit the university region and its vicinities during the back-to-school season. Our disparity analysis found that i) the access of the senior population to public hospitals deviated from that of the general population, ii) the access was positively associated with socioeconomic status, and iii) all disparities were related to the urban-rural discrepancy. These findings can help to plan temporary clinics or hospitals during epidemic emergencies. More generally, they provide scientific support to pandemic-related healthcare resource allocation and policy- making, particularly for people in vulnerable areas.
To improve the pedestrian outflow in panic situations by suitably placing an obstacle in front of the exit, it is vital to understand the physical mechanism behind the evacuation efficiency ...enhancement. In this paper, a robust differential evolution is firstly employed to optimize the geometrical parameters of different shaped obstacles in order to achieve an optimal evacuation efficiency. Moreover, it is found that all the geometrical parameters of obstacles could markedly influence the evacuation efficiency of pedestrians, and the best way for achieving an optimal pedestrian outflow is to slightly shift the obstacle from the center of the exit which is consistent with findings of extant literature. Most importantly, by analyzing the profiles of density, velocity and specific flow, as well as the spatial distribution of crowd pressure, we have proven that placing an obstacle in panic situations does not reduce or absorb the pressure in the region of exit, on the contrary, promotes the pressure to a much higher level, hence the physical mechanism behind the evacuation efficiency enhancement is not a pressure decrease in the region of exit, but a significant reduction of high density region by effective separation in space which finally causes the increasing of escape speed and evacuation outflow. Finally, it is clearly demonstrated that the panel-like obstacle is considerably more robust and stable than the pillar-like obstacle to guarantee the enhancement of evacuation efficiency under different initial pedestrian distributions, different initial crowd densities as well as different desired velocities.
•Differential evolution is used to optimize the geometrical parameters of obstacles.•Profiles of density, velocity, specific flow as well as crowd pressure are analyzed.•Placing an obstacle in panic situations promotes the pressure to a much higher level.•Physical mechanism of efficiency enhancement is a reduction of high density region.•Panel is more robust than pillar to guarantee the enhancement of pedestrian outflow.
Accumulated evidence suggests that RING finger proteins (RNFs) are involved in the carcinogenesis of cancers. However, RNF38, a member of the RNF protein family, has not been studied in ...nasopharyngeal carcinoma (NPC).
RNF38 expression was analyzed by RT-PCR, Western blotting and Immunohistochemistry. Biological functions of RNF38 were evaluated by cell growth, colony formation, apoptosis, migration and invasion assays in vitro. Xenograft growth and lung metastasis models were conducted to investigate the effect of RNF38 in vivo. Liquid chromatography coupled with tandem mass spectrometry, co-immunoprecipitation, and CHX assay were implemented to detect the interaction among RNF38 and ACTN4.
RNF38 was significantly downregulated in NPC cells and tissues. Immunohistochemistry implied that loss of RNF38 was an independent prognostic factor for poor outcomes of NPC patients. Gain- and loss-of-function experiments showed that RNF38 inhibited proliferation and metastasis in NPC in vitro and in vivo. Upregulation of RNF38 promoted apoptosis of NPC cells to etoposide but not cisplatin. ACTN4 was upregulated in NPC and negatively correlated with RNF38. Mechanistic investigations suggested that RNF38 inactivates the NF-𝛋B and ERK1/2 signaling pathways by inducing ubiquitination and degradation of ACTN4. RNF38 suppress the development of NPC by interacting with ACTN4.
RNF38 plays a potential cancer suppressor gene role in NPC tumorigenesis and is a prognostic biomarker in NPC.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Epstein-Barr virus (EBV) encoded microRNA BART8-3p (miR-BART8-3p) was significantly associated with the metastasis in nasopharyngeal carcinoma (NPC). To explore the clinical values of plasma ...miR-BART8-3p in patients with early NPC. We retrospectively analyzed 126 patients with stage I and II NPC. A receiver operating characteristic curve was used to examine the diagnostic performance. Kaplan‒Meier analysis was applied to determine survival differences. Cox regression was used for univariate and multivariate analyses. Compared to healthy subjects, plasma EBV miR-BART8-3p was highly expressed in early NPC patients. The sensitivity, specificity, and area under the curve value of plasma miR-BART8-3p combined with plasma EBV DNA was up to 88.9%, 94.4%, and 0.931. Compared to patients with low expression of miR-BART8-3p, patients with high expression of miR-BART8-3p had poorer 5-year overall survival (OS) (98.9% vs. 91.1%, P = 0.025), locoregional recurrence-free survival (LRRFS) (100% vs. 83.9%, P < 0.001) and distant metastasis-free survival (DMFS) (98.9% vs. 88.0%, P = 0.006). Risk stratification analysis revealed that high-risk patients (with high levels of EBV DNA and miR-BART8-3p) had inferior OS, LRRFS, and DMFS than low-risk patients (without high levels of EBV DNA and miR-BART8-3p). Multivariate analysis verified that the high-risk group was an unfavorable factor for OS, LRRFS, and DMFS. A combination of plasma EBV miR-BART8-3p and EBV DNA could be a potential biomarker for the diagnosis and prognosis in early NPC.
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