•Paleoproterozoic clockwise P-T paths were obtained from metapelites from Dengfeng area, China.•Zricon LA-ICP-MS U-Pb date can record the Paleoproterozoic metamorphic event of ∼ 1.92 Ga.•The Dengfeng ...Complex was related to the Paleoproterozoic orogenic event.
Garnet-bearing metapelites are widely distributed in the Dengfeng Complex situated in the southern segment of the North China Carton (NCC). Petrological studies indicate that garnet-bearing metapelites mainly comprise quartz, muscovite, chlorite, plagioclase, garnet and biotite, with minor ilmenite, zircon, and apatite. Garnet porphyroblasts show obvious growth zoning from the core to inner rim and they are separated by a prominent chemical discontinuity narrow edge. By pseudosection modeling calculations, the P-T conditions of sample 20DF17-C determined by the isopleths of XGrs and XPrp of the garnet core and inner rim are ∼ 530 °C/6.7 kbar and ∼ 560 °C/5.1 kbar, respectively; while the P-T conditions of sample 20DF24 determined by the isopleths of the garnet core and inner rim are ∼ 530 °C/5.2 kbar and ∼ 550 °C/4.5 kbar, respectively. LA-ICP-MS zircon U-Pb dating from the Dengfeng metapelites suggest that the maximum depositional age of their protoliths was ∼ 2.52 Ga. These metapelites were affected by the hydrothermal event immediately after diagenesis. The age of ∼ 1.92 Ga contributed to clockwise P-T paths containing decompression with slight heating segments, which occurred at the Paleoproterozoic and likely were related to a subduction-collision event in the NCC. Combined with the occurrence features of the amphibolites, TTG gneisses, metapelites and quartzites, we inferred that all the Dengfeng metapelites and Songshan Group involved a Paleoproterozoic orogenic event along the Trans-North China Orogen (TNCO)/Jinyu Mobile Belt (JMB).
Objectives
Chronic rhinosinusitis (CRS) reduces the health‐related quality of life and subsequently causes a tremendous socio‐economic impact. Although many studies have been conducted, few have ...identified a relationship between bacteriological characteristics and different phenotypes or endotypes. Therefore, this study aimed to elucidate the recent trends in bacterial cultures from different types of CRS in the Asian population.
Methods
This retrospective case–control study recruited patients diagnosed with CRS who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital in Taiwan. The patients were classified into those with chronic rhinosinusitis with nasal polyps (CRSwNP)/chronic rhinosinusitis without nasal polyps (CRSsNP), eosinophilic chronic rhinosinusitis (eCRS)/non‐eosinophilic chronic rhinosinusitis (NECRS), and central compartment atopic disease (CCAD)/lateral‐dominant nasal polyp (LDNP) groups. The demographic data and bacteriological characteristics of the groups were analyzed.
Results
We included 503 patients, identifying no significant difference between CRSwNP and CRSsNP for several common bacteria in CRS. The number of Staphylococcus epidermidis isolates in culture was significantly higher in the NECRS group (50.46% vs. 32.56%, p = 0.0003) than that in the eCRS group. The number of methicillin‐resistant Staphylococcus aureus (MRSA; 8.51% vs. 2.35%, p = 0.0221) positive isolates was significantly higher in the CCAD group than that in the LDNP group.
Conclusions
This was the first study in Asia to analyze the relationship between bacteriological characteristics and CCAD. MRSA is significantly higher in the CCAD group than that in the LDNP group. Recognizing the unique microbiology of CRSwNP, eCRS, and CCAD is crucial when selecting antimicrobial therapy to lessen the socio‐economic impact.
Level of Evidence
3 Laryngoscope, 134:1071–1076, 2024
Transforming growth factor (TGF‐β) plays an important role in the development of deer antlers. The purpose of this study was to investigate the role of long noncoding RNA in the transcriptional ...regulation of TGF‐β1 and its relationship with the proliferation and differentiation of antler chondrocytes. High‐throughput sequencing was used to screen lncRNAs related to TGF‐β1. Next, the overexpression plasmid and interference sequence of target lncRNA27785.1 were constructed and transfected into chondrocytes. We found that lncRNA27785.1 inhibited the proliferation and migration of chondrocytes and delayed the transition of cells from G1 to S phase. qRT‐PCR and Western blot analysis indicated that the overexpression of lncRNA27785.1 may downregulate mRNA and protein expression of TGF‐BR2, Smad3, pSmad3, and Smad4. Our findings highlight lncRNA27785.1 as an inhibitor of chondrocytes proliferation and differentiation by negatively regulating the TGF‐β/Smad signaling pathway; this implicates an important regulatory role for long noncoding RNA in the regeneration of antler.
lncRNA27785.1 affects deer antler chondrocyte proliferation, migration, and cycle by regulating the TGF‐β/Smad signaling pathway.
Owing to the limitations of cross‐sectional studies, it is unclear whether social media induce brain changes, or if individuals with certain biological traits are more likely to use social media. ...Functional connectivity (FC) can reflect cerebral functional plasticity, and if social media can influence cerebral FC, then the FC of light social media users should be more similar to that of heavy users after they “heavily” used social media for a long period. We combined longitudinal study design and intersubject correlation (ISC) analysis to investigate this similarity. Thirty‐five heavy and 21 light social media users underwent cognitive tests and functional MRIs. The 21 light social media users underwent another functional MRI scan after completing an additional four‐week social media task. We conducted the ISC at the group, individual, and brain‐region levels to investigate the similarity of FC and locate the brain regions most affected by social media. The FC of light social media users was more similar to that of heavy social media users after they completed the four‐week social media task. Then, social media had an impact on half of the brain, involving almost all brain networks. Finally, cerebral FC that mostly affected by social media was associated with selective attention. We concluded that the impact of social media use on cerebral functional connectivity changes is revealed by ISC method and longitudinal design, which may provide guidance for clinical practice. The methods used in the current research could also be applied to similar domains.
The plasticity of functional connectivity could reflect the impact of social media on human brain. The intersubject correlation analysis is combined with longitudinal design to detect the plasticity of functional connectivity. This research is robust due to a comprehensive sensitivity analysis.
Skin infection is a major health issue that usually is caused by the continuous proliferation of bacteria in wounds. With the abuse of antibiotics worldwide, the battle against skin infection is ...becoming more and more difficult. Therefore, the development of new ways with different antibacterial mechanisms to current antibiotics is urgently needed. Inspired by the powerful inhibition of ferroptosis used in cancer therapy, here in our study, ferric-loaded lipid nanoparticles (Fe-LNPs) with unform size (∼130 nm) and surface charge (∼12 mV) were constructed and found to effectively inhibit the growth of both Gram positive (Staphylococcus aureus, S. aureus) and negative (Escherichia coli, E. coli) strains, possibly due to induction of ferroptosis-like cell death mechanisms. Most importantly, Fe-LNPs can also effectively inhibit the proliferation of S. aureus in a skin infection model and promote the healing of wounds. The Fe-LNPs can be applied as a powerful antibacterial formulation for future application in clinic.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Abstract
Background
Dinutuximab β can be used to treat children with high‐risk neuroblastoma (NB). Due to its high price, whether dinutuximab β is cost‐effective for the treatment of high‐risk NB ...remains uncertain. Therefore, assessing the cost‐effectiveness of dinutuximab β in children with high‐risk NB is of high importance.
Methods
The health utilities and economic outcomes in children with high‐risk NB were projected using a partitioned survival model. The individual patient data (IPD) of add‐on treatment with dinutuximab β (GD2 group) were derived from the literature, while the IPD of traditional therapy (TT group) were obtained from retrospective data of Shanghai Children's Medical Center. Treatment costs included drugs, adverse event‐related expenses, and medical resource use. Utility values were obtained from the literature. Costs and quality‐adjusted life‐years (QALYs) were measured over a 10‐year time horizon. Deterministic sensitivity analyses (DSA) and probabilistic sensitivity analyses (PSA) were also conducted.
Results
Compared with the TT group, QALY increased in the GD2 group by 0.72 with an increased cost of $171,269.70, leading to an incremental cost‐effectiveness ratio of 236,462.75$/QALY. DSA showed that the price of dinutuximab β was the main factor on the results than other parameters. Compared with the TT group, the GD2 group could not be cost‐effective in the PSA at the $37,920/QALY threshold.
Conclusion
Results found that dinutuximab β is not a cost‐effective treatment option for children with high‐risk NB unless its price is significantly reduced.
Conjugated polymers (CPs) have recently gained increasing attention as photocatalysts for sunlight-driven hydrogen evolution. However, they suffer from insufficient electron output sites and poor ...solubility in organic solvents, severely limiting their photocatalytic performance and applicability. Herein, solution-processable all-acceptor (A
-A
)-type CPs based on sulfide-oxidized ladder-type heteroarene are synthesized. A
-A
-type CPs showed upsurging efficiency improvements by two to three orders of magnitude, compared to their donor-acceptor -type CP counterparts. Furthermore, by seawater splitting, PBDTTTSOS exhibited an apparent quantum yield of 18.9% to 14.8% at 500 to 550 nm. More importantly, PBDTTTSOS achieved an excellent hydrogen evolution rate of 35.7 mmol h
g
and 150.7 mmol h
m
in the thin-film state, which is among the highest efficiencies in thin film polymer photocatalysts to date. This work provides a novel strategy for designing polymer photocatalysts with high efficiency and broad applicability.
Polyethylene terephthalate (PET), as the most widely utilized polyester, causes global environmental problems due to its massive and durable accumulation in natural environments. The glycolysis of ...PET is an attractive alternative to mechanical recycling, but there remains a strong demand for efficient, convenient, and inexpensive catalysts. Herein, we present a spray-drying-assisted way to construct magnetic hollow micro-sized nanoaggregates (HMNAs) by assembling composite metal oxide nanoparticles to depolymerize PET synergistically. The as-prepared ZnO-Fe
3
O
4
HMNAs completely depolymerized PET with a high monomer yield of 92.3% in a short period of 30 min at 190 °C, far above individual ZnO and Fe
3
O
4
nanoparticles (NPs). The composite HMNAs can be magnetically separated in a few minutes and maintain a high activity for 5 cycles. DFT study reveals that the HMNAs effectively facilitated glycolysis by the high content of Lewis acid sites as well as the stronger adsorption between PET and the catalyst owing to the structural synergy effect of ZnO-Fe
3
O
4
HMNAs. Furthermore, this spray drying strategy as a versatile and scalable methodology is extended to fabricate other HMNAs, exhibiting a similarly enhanced efficiency of glycolysis. The HMNAs are expected to open up avenues for the design of catalysts for upcycling of discarded plastics.
The glycolysis of PET catalyzed by hollow micro-sized nanoaggregates is a highly effective and sustainable way to tackle the escalating plastic waste problem and create a circular plastic economy.
Novel organic pyridinium ylide sensitizers (NO109–111) consisting of various anchoring groups were synthesized and characterized for applications in dye sensitized solar cells. Compared with the ...pyridine-N-oxide dye (NO108), the ylide sensitizers with strong electron-withdrawing acceptors exhibited dominant ultraviolet absorption properties and efficient binding abilities to the TiO2 surface. Among these dyes, the pyridinium ylide NO111 sensitized solar cell showed the highest efficiency (5.15%), which was improved to 7.41% by employing coadsorbent chenodeoxycholic acid.
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