With the development and application of "Internet +", intelligent technology has been widely and deeply integrated into various fields, and has become an important driving force for social ...development. Under the background of the new Internet, art education and communication have formed a new form of "online and offline". Under the modern social scene, in order to give full play to the function of art education, we need to take the new social scene as the foundation, and reflect the value of the function of art education in modern society, put forward the concrete realization path of the function of art education.
Heterostructures composed of ferromagnetic metal and nonmagnetic metal with strong spin‐orbit coupling are shown to be powerful broadband THz emitters, whose field strength can be maximized by ...optimizing the thickness of both ferromagnetic and nonmagnetic films, and the heterostructure layers. Furthermore, the THz spectrum and its intensity are tunable by the magnetic field orientation applied on the patterned magnetic Fe/Pt heterostructures.
Centrifuge is a promising tool for underwater explosion （UNDEX） research as both Mach and Froude similitudes could be satisfied with hyper-gravity in models, which would result in similarities in ...both shock wave and bubble oscillation. Scaling laws for UNDEX in centrifuge have been proposed based on dimensional analysis. Two dimensionless numbers, i.e., π3 and π4, are used to characterize shock wave and bubble oscillation, respectively. To validate scaling laws, 17 UNDEX tests are designed by varying accelerations or explosive weights and positions in centrifuge. The tests are classified into different groups to validate scaling laws as well as calibrate coefficients in empirical formulae for both shock wave and bubble oscillation. The results show that changes of gravity acceleration or hydrodynamic pressure almost has no influence on shock wave peak pressure and time constant as long as π3 is constant. The dimensionless bubble period and maximum radius agreed with each other when π4 is constant. Based on the research, an example is exhibited to suggest method for the computation of initial loading conditions for a submerged obstacle subjected to UNDEX.
New Media is the witness of rural culture revitalization, and also an important force to promote rural culture revitalization. With the development and application of new media becoming more and more ...mature, it will be on the basis of enriching rural cultural life in an all-round way by giving full play to the advantages of new media carrier and communication, and promoting the deep integration of the revitalization of art and rural culture, keep the vitality of artistic creation, and consolidate the ideological foundation of rural revitalization. Based on the study of new media communication, this paper systematically discusses the development value and implementation strategy of art and rural culture revitalization and integration.
Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in ...RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest that m6A modifications play a crucial role in regulating biological processes of all kinds of diseases, such as malignancy. Recently studies have revealed that as the most abundant epigentic modification, m6A is involved in the progression of SSD. However, the function of m6A modification in SSD is not fully illustrated. Therefore, make clear the relationship between m6A modification and SSD pathogenesis might provide novel sights for prevention and targeted treatment of SSD. This article will summarize the recent advances of m6A regulation in the biological processes of SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis and osteoarthritis, and discuss the potential clinical value, research challenge and future prospect of m6A modification in SSD.
This paper aims to characterize the seismic behavior of concrete-faced rock-fill dams. A series of dynamic centrifuge tests were carried out. The experimental results demonstrate that the stress ...evolution in the face slab is related to the pattern of energy buildup and that the overall stress evolution pattern is highly affected by pre-shaking. For the dams which have not experienced a relatively strong earthquake, compressive and tensile stress increments due to shaking are developed on the outer and inner faces, respectively. However, for the dams which have experienced a relatively strong earthquake, the inner face exhibits an overall tensile stress increment with time while the stress on the outer face only fluctuate around zero with minor overall variation. As for the failure mode under an extremely strong earthquake, slight surface sliding initially occurs, and then rock-fill particles move towards downstream direction, leading to deep sliding and significant dam deformation.
•Dynamic centrifuge modelling on concrete-faced rock-fill dams.•Characterization of the stress evolution in the face slab.•Failure mode and damage evolution under an extremely strong earthquake.•Determination of the effect of pre-shaking on the seismic response.
With the development of science and technology, many optimization problems in real life have developed into high-dimensional optimization problems. The meta-heuristic optimization algorithm is ...regarded as an effective method to solve high-dimensional optimization problems. However, considering that traditional meta-heuristic optimization algorithms generally have problems such as low solution accuracy and slow convergence speed when solving high-dimensional optimization problems, an adaptive dual-population collaborative chicken swarm optimization (ADPCCSO) algorithm is proposed in this paper, which provides a new idea for solving high-dimensional optimization problems. First, in order to balance the algorithm's search abilities in terms of breadth and depth, the value of parameter
is given by an adaptive dynamic adjustment method. Second, in this paper, a foraging-behavior-improvement strategy is utilized to improve the algorithm's solution accuracy and depth-optimization ability. Third, the artificial fish swarm algorithm (AFSA) is introduced to construct a dual-population collaborative optimization strategy based on chicken swarms and artificial fish swarms, so as to improve the algorithm's ability to jump out of local extrema. The simulation experiments on the 17 benchmark functions preliminarily show that the ADPCCSO algorithm is superior to some swarm-intelligence algorithms such as the artificial fish swarm algorithm (AFSA), the artificial bee colony (ABC) algorithm, and the particle swarm optimization (PSO) algorithm in terms of solution accuracy and convergence performance. In addition, the APDCCSO algorithm is also utilized in the parameter estimation problem of the Richards model to further verify its performance.
The development of cancer treatments requires continuous exploration and improvement, in which the discovery of new drugs for the treatment of cancer is still an important pathway. In this study, ...based on the molecular hybridization strategy, a new structural framework with an N-aryl-N’-arylmethylurea scaffold was designed, and 16 new target compounds were synthesized and evaluated for their antiproliferative activities against four different cancer cell lines A549, MCF7, HCT116, PC3, and human liver normal cell line HL7702. The results have shown seven compounds with 1-methylpiperidin-4-yl groups having excellent activities against all four cancer cell lines, and they exhibited scarcely any activities against HL7702. Among them, compound 9b and 9d showed greatly excellent activity against the four kinds of cells, and the IC50 for MCF7 and PC3 cell lines were even less than 3 μM.
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