Onychomatricoma: an infrequent nail tumor Fernández-Sánchez, Mónica; Saeb-Lima, Marcela; Charli-Joseph, Yann ...
Indian journal of dermatology, venereology and leprology,
05/2012, Letnik:
78, Številka:
3
Report
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Este artículo tiene como objetivo comprender los sentidos de las prácticas afectivo-sexuales de usuarios de profilaxis previa a la exposición (PrEP) al virus de la inmunodeficiencia adquirida - VIH ...bajo los riesgos de otras infecciones transmisibles sexualmente (ITS). Adoptamos la perspectiva de la psicología social, prácticas discursivas y producción de sentido como referencial teórico-metodológico y el concepto de vulnerabilidad de la salud pública. Utilizamos como procedimiento de muestreo la técnica de bola de nieve y entrevistamos a 10 Hombres Gay, Bisexuales y otros Hombres que tienen Sexo con Hombres (HSH), en Barcelona-España. Concluimos que la vida afectivo-sexual no cambió con el uso de la PrEP, pero disipó sentimientos como miedo, ansiedad y culpa que sintieron los entrevistados al vivir sus sexualidades bajo la cultura homofóbica. El riesgo de ITS no los amenaza, entienden que son tratables y que la visión moral y los enfoques biomédicos sobre tales infecciones no van a protegerlos de nuevos estigmas y prejuicios, ya presentes en otras fases de la pandemia de VIH.
Este libro recoge una selección de las ponencias presentadas en las II Jornadas Iberoamericanas de Jóvenes Investigadores en Patrimonio Industrial se celebraron en 2020, participantes fueron ...sometidos a un proceso de revisión científica. Os textos abordan tanto la dimensión teórica como la práctica en relación con las temáticas definidas para estas II Jornadas: la documentación, la protección, la rehabilitación, la difusión, la gestión y la participación, que son tareas que contribuyen de manera determinante a elevar las potencialidades del Patrimonio Industrial y al desarrollo de una sociedad más sostenible.
Introduction
In Brazil, more than 487,450 individuals are currently undergoing antiretroviral treatment. In order to monitor the transmission of drug‐resistant strains and HIV subtype distribution in ...the country, this work aimed to estimate its prevalence and to characterize the nationwide pretreatment drug resistance in individuals recently diagnosed with HIV between 2013 and 2015.
Methods
The HIV threshold survey methodology (HIV‐THS, WHO) targeting antiretroviral‐naive individuals with recent HIV diagnosis was utilized, and subjects were selected from 51 highly populated cities in all five Brazilian macroregions. The HIV pol genotypic test was performed by genomic sequencing.
Results
We analysed samples from 1568 antiretroviral‐naive individuals recently diagnosed with HIV, and the overall transmitted drug resistance (TDR) prevalence was 9.5% (150 sequences). The regional prevalence of resistance according to Brazilian geographical regions was 9.4% in the northeast, 11.2% in the southeast, 6.8% in the central region, 10.2% in the north and 8.8% in the south. The inhibitor‐specific TDR prevalence was 3.6% for nucleoside reverse transcriptase inhibitors (NRTIs), 5.8% for non‐nucleoside reverse transcriptase inhibitors (NNRTIs) and 1.6% for protease inhibitors (PIs); 1.0% of individuals presented resistance to more than one class of inhibitors. Overall, subtype B was more prevalent in every region except for the southern, where subtype C prevails.
Conclusions
To the best of our knowledge, this is the first TDR study conducted in Brazil with nationwide representative sampling. The TDR prevalence revealed a moderate rate in the five Brazilian geographical regions, although some cities presented higher TDR prevalence rates, reaching 14% in São Paulo, for example. These results further illustrate the importance of surveillance studies for designing future strategies in primary antiretroviral therapy, aiming to mitigate TDR, as well as for predicting future trends in other regions of the globe where mass antiretroviral (ARV) treatment was implemented.
Oxidative stress, cellular damage, and neuronal apoptosis are believed to underlie the progressive cognitive decline that accompanies natural aging and to be exacerbated in neurodegenerative ...diseases. Over the years, we have consistently demonstrated that iron neonatal treatment induces oxidative stress and memory deficits in adult rats, but the mechanisms underlying these effects remained undefined. The purpose of this study was to examine whether neonatal iron overload was associated with apoptotic cell death in adult and old rats. We analyzed Par-4 and caspase-3 immunoreactivity in specific brain areas including the hippocampus CA1, CA3 and dentate gyrus (DG), the adjacent cortex and the striatum in adult (3 months-old) and aged (24 months-old) rats from control (vehicle-treated) and neonatally iron-treated groups. Neonatal iron treatment consisted of a daily oral administration of 10 mg/kg of Fe
+2
, for three consecutive days, from post-natal 12–14. Control aged animals showed increased levels of both markers when compared to untreated adult animals. When adults were compared, iron-treated animals presented significantly higher Par-4 and caspase-3 immunoreactivities in CA1, CA3 and cortex. In the DG, this effect was statistically significant only for Par-4. Interestingly, when control and iron-treated aged animals were compared, a significant decrease in both apoptotic markers was observed in the later groups in the same areas. These results may be interpreted as an acceleration of aging progressive damages caused by iron overload and may contribute to a better understanding of the damaging potential of iron accumulation to brain function and the resulting increased susceptibility to neurodegeneration.
Verificar a presença de dimorfismo sexual por meio de medidas lineares de TCs cranianas, bem como, a criação de um modelo matemático para estimativa do sexo. Foram utilizados 200 Tomografias ...Computadorizadas (TCs) do Biobanco Osteológico e Tomográfico da região sudeste brasileira. Para a pesquisa foram realizadas seis medidas lineares (Porção anterior da sela turca a sutura naso-frontal, Porção anterior da sela turca ao bregma, Forame incisivo ao ponto básio, Porção anterior da sela turca a meato acústico externo (direito), Porção anterior da sela turca a meato acústico externo (esquerdo) e Porção anterior da sela turca a meato acústico externo (esquerdo) a porção anterior da sela turca a meato acústico externo (direito), utilizando o software OnDemand3D ™. Para a calibração foi utilizado o teste estatístico ICC, segundo Szklo e Nieto (2000) obtendo-se correlação FORTE e a análise dos dados foi utilizado o teste de Kolmogorov-Smirnov, teste t, Teste de Shapiro-Wilke e Levene e uma regressão logística pelo método de Stepwise-Forward (Wald), para analisar a distribuição e igualdade das variâncias. Foi constatado dimorfismo sexual em todas as medidas realizadas. Sendo possível criar um modelo de regressão logística Logito= -41.7732 + 0.2636*PAST-SFN + 0.0601*PAST-B, onde foi obtido o valor de sensibilidade (80.2%), especificidade (70.2%) e uma acurácia de (76%). Conclui-se que o modelo obtido de regressão logística possibilita a estimativa do sexo de brasileiros, podendo ser utilizado como uma metodologia auxiliar no processo de identificação humana.
This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of ...environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administration of iron (10 mg/kg) between 12th and 14th post-natal days; nine rats received vehicle (sorbitol 5% in water) in the same period. Five iron-treated and three sorbitol-treated rats were killed at the age of 3 months while five iron-treated and six sorbitol-treated rats were killed at age of 24 months and their brains processed for immunohistochemistry. Increased astrocytosis, revealed by densitometry of GFAP-immunoreactive astrocytes, was found in aged (24 months) iron-treated rats in the substantia nigra and striatum and in the hippocampus of adult (3 months) iron-treated rats when compared to age-matching controls. Decreased densitometry of neurons, revealed by neuronal nucleus immunohistochemistry, was found in aged (24 months) iron-treated rats in substantia nigra and striatum when compared to age-matching controls. These findings suggest that transient dietary iron supplementation during the neonatal period is associated to cellular imprinting in the brain later in life.
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