In this paper, the pipeline with guide vanes was taken as the research object, the flow noise was studied based on the hybrid calculation method, then the acoustic-structure coupling method was ...introduced to study the vibration and radiation noise, and then explored the best position of the guide vanes. Based on the pipeline experimental platform and improved experimental methods, it was found that the guide vanes had a better noise reduction effect on the elbows; based on that, a simulation study was carried out on the elbow with guide vanes, and the mechanism of the guide vanes on the velocity field and pulsating pressure of the pipeline was explored. Finally, the noise reduction effect at different positions of the guide vanes under different flow speeds was studied. The results indicated that the guide vane at the middle of the elbow had the best effect on improving the flow field and reducing noise in the working conditions studied in this article, providing a calculation basis for the design of the guide vane.
Matrine (MAT) is an active alkaloid extracted from Radix Sophora flavescens. The present study was to investigate whether MAT could effectively treat Adriamycin-induced nephropathy (AIN). AIN was ...induced in rats using a single injection of Adriamycin (ADR). Renal interleukin-6 (IL-6), IL-10, IL-17 and transforming growth factor-β (TGF-β) levels, and the expression of forkhead box protein 3 (Foxp3) and retinoid-related orphan nuclear receptor γt (Rorγt) was measured. AIN rats developed severe albuminuria, hypoalbuminaemia, hyperlipidaemia and podocyte injury. Daily administration of MAT (100mg/kg or 200mg/kg) significantly prevented ADR-induced podocyte injury, decreased AIN symptoms and improved renal pathology manifestations. Of note, treatment with MAT (100mg/kg) plus prednisone (Pre, 5mg/kg) had equivalent efficacy to that of Pre alone (10mg/kg). Additional findings showed that ADR triggered a disordered cytokine network and abnormal expression of Foxp3 and Rorγt in rats, as reflected by increased levels of IL-6, IL-10, TGF-β, Rorγt and decreased levels of IL-10 and Foxp3. Interestingly, MAT weakened the disordered cytokine network and normalized the expression of Foxp3 and Rorγt. In addition, a significant negative correlation was observed between the values of Foxp3/Rorγt and renal pathology scores. Finally, MAT normalized regulatory T cells (Treg)/ T-helper17 cells (Th17) ratio in peripheral blood mononuclear cells of AIN rats. These data indicate MAT prevents AIN through the modification of disordered plasma lipids and recovery of renal function, and this bioactivity is at least partly attributed to the suppression of renal inflammation and the regulation of the Treg/Th17 imbalance.
Based on the Precise Transfer Matrix Method (PTMM), the dynamic model is constructed to observe the vibration behaviour of cylindrical shells with variable thickness by solving a set of first-order ...differential equations. The free vibration of stiffened cylindrical shells with variable thickness can be obtained to compare with the exact solution and FEM results. The reliability of the present method of free vibration is well proved. Furthermore, the effect of thickness on the vibration responses of the cylindrical shell is also discussed. The acoustic response of immersed cylindrical shells is analyzed by a Pluralized Wave Superposition Method (PWSM). The sound pressure coefficient can be gained by collocating points along the meridian line to satisfy the Neumann boundary condition. The mode convergence analysis of the cylindrical shell is carried out to guarantee calculation precision. Also, the reliability of the present method on sound radiation is verified by comparing with experimental results and numerical results.
•The dynamic model of stiffened cylindrical shells with variable thickness is established by PTMM.•The vibro-acoustic model of immersed stiffened cylindrical shells with variable thickness is developed by PWSM.•Different cylindrical shells are prepared to verify the validity and reliability of the present method.
Type 1 diabetes mellitus (T1DM) is one of the most common endocrine and metabolic diseases in children. Pancreatic β cells are thought to be critical cells involved in the progression of T1DM, and ...their injury would directly lead to impaired insulin secretion.
To investigate the protective effects of allicin on pancreatic β cell injury and elucidate the underlying mechanism.
The streptozotocin (STZ)-induced mouse T1DM model
and STZ-induced pancreatic β cell Min6 model in vitro were used to explore the effects of allicin on T1DM. The experiments include fasting blood glucose test, oral glucose tolerance detection, HE staining, immunohistochemistry, immunofluorescence, TUNEL staining, western blot, real-time quantitative PCR (RT-qPCR), and flow cytometry.
Allicin could significantly decrease blood glucose level, improve islet structure and insulin expression, and inhibit apoptosis to reduce STZ-induced pancreatic β cell injury and loss through activating AMPK/mTOR mediated autophagy pathway.
Allicin treatment significantly reduced STZ-induced T1DM progression, suggesting that allicin may be a potential therapy option for T1DM patients.
The White-eared Night-Heron (Gorsachius magnificus, G. magnificus) is a critically endangered heron that is very poorly known and only found in southern China and northern Vietnam, with an estimated ...population of 250 to 999 mature individuals. However, the lack of a reference genome has hindered the implementation of conservation management efforts. In this study, we present the first high-quality chromosome-scale reference genome, which was assembled by integrating PacBio long-reads sequencing, Illumina paired-end sequencing, and Hi-C technology. The genome has a total length of 1.176 Gb, with a scaffold N50 of 84.77 Mb and a contig N50 of 18.46 Mb. Utilizing Hi-C data, we anchored 99.89% of the scaffold sequences onto 29 pairs of chromosomes. Additionally, we identified 18,062 protein-coding genes in the genome, with 95.00% of which were functionally annotated. Notably, BUSCO assessment confirmed the presence of 97.2% of highly conserved Aves genes within the genome. This chromosome-level genome assembly and annotation will be valuable for future investigating the G. magnificus's evolutionary adaptation and conservation.
School urinary screening programming can be useful for the early detection of renal and urinary disorders. However, urine screening is not included in the school health check-up in our region. ...Therefore, from February 2012 to March 2021, 12,497 school students were screened for urinalysis, and a long-term follow-up took place
an electronic medical record system. Among these screened students, 719 (5.75%) positive individuals received a repeat urinalysis 2 weeks later. During the 9-year medical record system follow-up period, 5 children had renal biopsies and 2 children had a diagnosis of IgA nephropathy (IgAN), while the remaining 3 children were diagnosed with thin basement membrane disease (TBM), primary nephrotic syndrome (PNS), and were suspected of C3 glomerulopathy, respectively. By this, calling for the school urine screening program as a physical examination item for primary and secondary school-aged students will contribute to enabling early detection of urine abnormalities and allow for early treatment.
We introduce a generic scheme for accelerating gradient-based optimization methods in the sense of Nesterov. The approach, called Catalyst, builds upon the inexact accelerated proximal point ...algorithm for minimizing a convex objective function, and consists of approximately solving a sequence of well-chosen auxiliary problems, leading to faster convergence. One of the key to achieve acceleration in theory and in practice is to solve these sub-problems with appropriate accuracy by using the right stopping criterion and the right warm-start strategy. In this paper, we give practical guidelines to use Catalyst and present a comprehensive theoretical analysis of its global complexity. We show that Catalyst applies to a large class of algorithms, including gradient descent, block coordinate descent, incremental algorithms such as SAG, SAGA, SDCA, SVRG, Finito/MISO, and their proximal variants. For all of these methods, we provide acceleration and explicit support for non-strongly convex objectives. We conclude with extensive experiments showing that acceleration is useful in practice, especially for ill-conditioned problems.
Hypoxic-ischemic encephalopathy (HIE) is caused by perinatal hypoxia and subsequent reductions in cerebral blood flow and is one of the leading causes of severe disability or death in newborns. ...Despite its prevalence, we currently lack an effective drug therapy to combat HIE. Celastrol (Cel) is a pentacyclic triterpene extracted from Tripterygium Wilfordi that can protect against oxidative stress, inflammation, and cancer. However, whether Cel can alleviate neonatal hypoxic-ischemic (HI) brain damage remains unclear.
Here, we established both in vitro and in vivo models of HI brain damage using CoCl
-treated PC12 cells and neonatal rats, respectively, and explored the neuroprotective effects of Cel in these models.
Analyses revealed that Cel administration reduced brain infarction size, microglia activation, levels of inflammation factors, and levels of oxidative stress markers by upregulating levels of p-AMPKα, Nrf2, HO-1, and by downregulating levels of TXNIP and NLRP3. Conversely, these beneficial effects of Cel on HI brain damage were largely inhibited by AMPKα inhibitor Compound C and its siRNA.
We present compelling evidence that Cel decreases inflammation and oxidative stress through the AMPKα/Nrf2/TXNIP signaling pathway, thereby alleviating neonatal HI brain injury. Cel therefore represents a promising therapeutic agent for treating HIE.
We firstly report that celastrol can ameliorate neonatal hypoxic-ischemic brain injury both in in vivo and in vitro, which represents a promising therapeutic agent for treating related brain injuries. Celastrol activates the AMPKα/Nrf2/TXNIP signaling pathway to relieve oxidative stress and inflammation and thereby alleviates neonatal hypoxic-ischemic brain injury.
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